ChemInform Abstract: Development of Antiviral Therapeutic Agents from Traditional Medicines

ChemInform ◽  
2010 ◽  
Vol 30 (7) ◽  
pp. no-no
Author(s):  
T. NAMBA ◽  
M. KUROKAWA ◽  
S. KADOT ◽  
K. SHIRAKI
Keyword(s):  
Therapeutic Agents ◽  
Traditional Medicines

scholarly journals Ethnobotanical plants and their tradomedicinal values: A review

2021 ◽  
Vol 5 (1) ◽  
pp. 066-088
Author(s):  
Olugbenga Kayode Popoola ◽  
Kayode Damilola Adekeye ◽  
Eunice Damilola Akinbinu ◽  
Lanre Tope Adekeye ◽  
Michael Bolaji Afolayan ◽  
...  
Keyword(s):  
Health Care ◽  
Developing Nations ◽  
Therapeutic Agents ◽  
Herbal Remedies ◽  
Traditional Practices ◽  
Traditional Medicines ◽  
Scientific Investigations ◽  
Ancient Times ◽  
Medicinal Properties ◽  
Review Study

Since ancient times, plants with medicinal properties possessing no or little toxicological potentials have been relevant for the treatment of several diseases and healing purposes. Medicinal plants serve as important therapeutic agents and valuable resources for manufacturing numerous modern and traditional medicines. Many developing nations still rely on herbal remedies as their mainstay of health-care. This review study is aimed to report the trado-medicinal values of some ethnobotanical plants commonly used in traditional formulations as well as the scientific investigations of these plants for their acclaimed use in traditional practices. Essential phytochemicals and bioactive compounds of these plants are also reviewed.

Prevention of Cardiovascular Disease – Will We Ever Have Time?

2016 ◽  
pp. 20-24
Author(s):  
Iryna Davydova ◽  
Nataliia Kozhuharova ◽  
Larysa Konoplianyk ◽  
Tetiana Simagina
Keyword(s):  
Cardiovascular Disease ◽  
Primary Prevention ◽  
Significant Role ◽  
Adverse Reactions ◽  
Therapeutic Agents ◽  
Functional Changes ◽  
Traditional Medicines ◽  
Medication Therapy ◽  
Adherence To Medication ◽  
Prevention Of Cardiovascular Disease

In recent years, the rapidly growing incidence of cardiovascular diseases, which are beginning to  appear in younger people. There is a need for the primary prevention of cardiovascular disease, i.e. measures to prevent the occurrence of heart disease in healthy people. However, adherence to medication therapy, prescribed as primary prevention, our population is very low. Development of adverse reactions to medication drugs as they are hypersensitive, allergic addiction, negative reaction on the part of other organs and systems, significantly reduces the effectiveness of treatment. The way out of this situation may be drugs of medicinal plants, which continue to play a significant role in the arsenal of therapeutic agents. For example, patients with neuro dystonia is considered an advantage of prevention with the use of traditional medicines, the effect of which is aimed at the normalization of the nervous system. One such drug is Neokardil. Correction of functional changes and move them into organic when NDCs via Neokardin can play a significant role in the prevention of cardiovascular disease.

scholarly journals Endophytes and the microbial genetics of traditional medicines

2010 ◽  
Vol 31 (2) ◽  
pp. 60
Author(s):  
Kristin I Miller ◽  
Shane D Ingrey ◽  
Alfonsus Alvin ◽  
Man Yuen Daniel Sze ◽  
Basil D Roufogalis ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Traditional Medicine ◽  
Healthcare Systems ◽  
Therapeutic Agents ◽  
African Countries ◽  
Microbial Genetics ◽  
Traditional Medicines ◽  
Australian Aboriginal ◽  
Healthcare Needs ◽  
Culturally Based

Traditional medicine continues to play an essential role in the healthcare systems of many cultures. In some Asian and African countries up to 80% of the population depend on these ancient and culturally based medicinal practices for their primary healthcare needs. Plants and their derived natural products are frequently employed as traditional medicine and such plants are viewed as attractive targets for the discovery of novel therapeutic agents in natural product investigations. A variety of useful drugs has been discovered following the investigation of traditional herbs, such as morphine (analgesic), digitoxin (cariotonic) and ephedrine (sympathomimetic). These ethnopharmacology approaches to drug discovery are based on the premise that plants used as traditional medicines have shown some form of bioactivity and have the increased likelihood of containing bioactive compounds in comparison to plants selected at random. Three systems of traditional medicine that are relevant to Australian drug discovery researchers include the Chinese, Australian Aboriginal and Indonesian systems.

scholarly journals Development of Antiviral Therapeutic Agents from Traditional Medicines

1998 ◽  
Vol 118 (9) ◽  
pp. 383-400 ◽  
Author(s):  
Tsuneo NAMBA ◽  
Masahiko KUROKAWA ◽  
Shigetoshi KADOTA ◽  
Kimiyasu SHIRAKI
Keyword(s):  
Therapeutic Agents ◽  
Traditional Medicines

scholarly journals Review of Pharmacological Properties of Channa Striatus (Haruan) In Diabetes and Cardiovascular Complications

2021 ◽  
Author(s):  
Ahmad Khusairi Azemi ◽  
Sagir Mustapha ◽  
Mustapha Mohammed ◽  
Aida Hanum Ghulam Rasool ◽  
Reezal Ishak ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Essential Amino Acids ◽  
Cardiovascular Complications ◽  
Therapeutic Agents ◽  
Pharmacological Properties ◽  
Comprehensive Overview ◽  
Channa Striatus ◽  
Traditional Medicines ◽  
And Control ◽  
Control Diabetes

Diabetes mellitus remains a major risk factor for developing cardiovascular diseases, resulting in increased morbidity and mortality associated with cardiovascular complications. Given the burden of diabetes-related cardiovascular complications, there is a need to identify strategies, safe and effective therapeutic agents that could effectively prevent and control diabetes. Presently, many patients living with diabetes depends on traditional medicines as an alternative cure. Channa striatus (Haruan) is a freshwater fish traditionally used to treat wounds, inflammations, and pains. Several pharmacological investigations have supported the folkloric claims of C. striatus extracts, including hypoglycemic, hypolipidemic, antioxidant, anti-inflammatory, and pro-platelet aggregation activities. The therapeutic potentials of C. striatus were demonstrated to be associated with the presence of high content essential amino acids and good fatty acids known to improve cell growth and facilitate wound healing. Therefore, C. striatus bioactive compounds have great potentials to serve as lead candidates in developing novel therapeutic agents for the management of diabetes and related cardiovascular diseases. This review aims to provide a comprehensive overview of the pharmacological properties and therapeutic potentials of C. striatus for the management of diabetes and associated cardiovascular complications.

scholarly journals Commonly used medicinal plants in N. Mualcheng, Mizoram, India

2020 ◽  
Vol 20 (4) ◽  
pp. 156-161
Author(s):  
Lalbiakngheti Tlau ◽  
Lucy Lalawmpuii
Keyword(s):  
Diabetes Mellitus ◽  
Gastric Ulcer ◽  
Medicinal Plants ◽  
Complex Diseases ◽  
Therapeutic Agents ◽  
Mimosa Pudica ◽  
Traditional Medicines ◽  
Traditional Medicinal Plants ◽  
Plantago Asiatica

Medicinal plants are the source of therapeutic agents in traditional medicines. The present study investigated Mizo traditional medicinal plants commonly used and available at N. Mualcheng, a village in Mizoram, India. The most important plants in terms of usage and availability as 10 species belonging to 9 families, of which Asteraceae contributes two species (such as Blumea lanceolaria, Acmella sp.), while Fabaceae, Acanthaceae, Costaceae, Orobanchaceae, Proteaceae, Elaeagnaceae, Smilacaceae and Plantaginaceae contribute one species each such as Mimosa pudica, Thunbergia grandiflora, Chamaecostus cuspidatus, Aeginetia indica, Helicia robusta, Elaeagnus caudata, Smilax perfoliata and Plantago asiatica respectively. An important feature of these medicinal plants is that some of them are used for complex diseases including kidney problem, gastric ulcer and diabetes mellitus.

scholarly journals Comprehensive Pharmacognostical Profile of Drynaria quercifolia (L.) J. Sm.

2020 ◽  
Vol 11 (4) ◽  
pp. 672-678
Author(s):  
Sunil Kumar K N ◽  
Divya K G ◽  
Susikumar S ◽  
Abdul Khader S ◽  
Senthilkumar M
Keyword(s):  
Therapeutic Agents ◽  
Ground Tissue ◽  
Traditional Medicines ◽  
Medicinal Properties ◽  
Silica Crystals ◽  
Powdered Drug ◽  
Wide Usage

Pteridophytes are gaining importance as therapeutic agents due to the presence of various phytochemicals and their promising bioactivities. Drynaria quercifolia (L.) J. Sm., a Polypodiaceae member is endowed with numerous medicinal properties and finds wide usage in ethno as well as traditional medicines. The rhizome of D. quercifolia (L.) J. Sm. was subjected to macro-microscopic, physicochemical, phytochemical and HPTLC analysis to derive a standard for this drug. The microscopic detailing showed a wavy outline due to the presence of ridges and furrows and a broad ground tissue with diffusely arranged steles. The powdered drug showed trichomes, stellar tissue and silica crystals while the physicochemical and phytochemical screenings gave substantial values of different parameters. The rhizome extracts were subjected to HPTLC studies with Linomat 5 TLC applicator and diagnostic peaks were recorded under UV 254 nm, 366 nm and 620 nm. The study put forward an exclusive identity profile of this medicinal rhizome. 

A Pattern of Acute Poisoning in Children in Urban Zimbabwe: Ten Years Experience

1992 ◽  
Vol 11 (5) ◽  
pp. 335-340 ◽  
Author(s):  
Ossy M.J. Kasilo ◽  
Charles' F.B. Nhachi
Keyword(s):  
Age Groups ◽  
Signs And Symptoms ◽  
Acute Poisoning ◽  
Therapeutic Agents ◽  
Age Group ◽  
Traditional Medicines ◽  
Direct Benefits ◽  
Household Products ◽  
Snake Bites ◽  
Poisoning In Children

1 A retrospective analysis was performed to evaluate the epidemiology of poisoning in children based on admissions to six of Zimbabwe's main urban hospitals over a 10-year period from 1980 to 1989 inclusive. 2 A total of 2873 cases were children aged between 0-15 years. This constituted 47.8% of poisoning cases from all age groups (6018) recorded during the study period. 3 All of the children (0-15 years) had signs and symptoms of poisoning on admission and, depending on their severity, were admitted to a ward or to an intensive care unit. A total of 4.9% (141) died. Most of those who died were suicide cases among the 11-15 year age group and accidental poisonings among the 0-15 year old group. 4 The under 0-5 age group constituted the majority of cases (75.4%) in the 0-15 age group, and most were between 1 and 3 years old. The 6-10 and 11-15 age groups formed 12.6% and 12% of the cases, respectively. The sex distribution showed that 53.1% were male. 5 Most incidences were accidental (93.2%). Suicides and parasuicides accounted for 1.9% and there were only two homicides. 6 The commonest toxic agents were: household products (27.2%), traditional medicines (23.%), venoms from snake bites and insect stings (16%) and therapeutic agents (12.4%). Of the therapeutic agents the most frequently implicated were antipsychotics 18.9%, analgesics 16.8%, anti-infectives 11.7%, anticonvulsants (8.2%) and benzodiazepines (7.7%). 7 The incidence of poisoning could be significantly reduced by health education directed at parents with emphasis on the safe storage of paraffin, drugs and household chemicals. An improvement in living conditions would also offer direct benefits.

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

2020 ◽  
Vol 56 (65) ◽  
pp. 9332-9335
Author(s):  
Sandra Estalayo-Adrián ◽  
Salvador Blasco ◽  
Sandra A. Bright ◽  
Gavin J. McManus ◽  
Guillermo Orellana ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Water Soluble ◽  
Polypyridyl Complexes ◽  
Cervical Cancer Cells

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets

2020 ◽  
Vol 134 (12) ◽  
pp. 1403-1432 ◽  
Author(s):  
Manal Muin Fardoun ◽  
Dina Maaliki ◽  
Nabil Halabi ◽  
Rabah Iratni ◽  
Alessandra Bitto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fruits And Vegetables ◽  
Metabolic Diseases ◽  
Therapeutic Agents ◽  
Adipose Tissue Inflammation ◽  
Cellular Mechanisms ◽  
Tissue Inflammation ◽  
Cholesterol Levels ◽  
Naturally Occurring ◽  
Pro Inflammatory Cytokines

Abstract Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values.

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