Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review

2018 ◽  
Vol 32 (11) ◽  
pp. 2164-2190 ◽  
Author(s):  
Jamshid Tabeshpour ◽  
Soghra Mehri ◽  
Fatemeh Shaebani Behbahani ◽  
Hossein Hosseinzadeh
Keyword(s):  
Vitis Vinifera ◽  
Biologically Active ◽  
Protective Effects ◽  
Comprehensive Review ◽  
Active Constituents

A Comprehensive Review on Pharmacological Properties of Abrus precatorius L.

2020 ◽  
Vol 10 (5) ◽  
pp. 543-549
Author(s):  
Vijay Chopra ◽  
Aishwarya Shriwastva ◽  
Gopal L. Khatik ◽  
Manish Vyas ◽  
Pramod Yadav ◽  
...  
Keyword(s):  
Chemotherapeutic Agent ◽  
Anthelmintic Activity ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Poisonous Plant ◽  
Comprehensive Review ◽  
Active Constituents ◽  
Abrus Precatorius ◽  
The Family ◽  
Different Parts

Background: Abrus precatorius L. (A. precatorius) is a valuable plant from the family Fabaceae which is a pea family. It is commonly known as Gunja or Jequirity, significantly found throughout India mainly Himalaya to Southern India and Ceylon. It is considered a poisonous plant due to the presence of abrin. Objective: A. precatorius has many pharmacological and biologically active constituents, such as alkaloids, glycosides and flavonoids situated in different parts of the plant. The objective of this review is to provide a retrospective study based on its anticancer potential. Results: Recent studies of A. precatorius are based on the isolation, characterization, and pharmacological evaluation of different secondary metabolites. These constituents possess significant cytotoxic properties against various cancer cell lines including breast, lung, liver, ovarian, prostate and leukaemia. A. precatorius is also reported to have anti-diabetic, anti-microbial, abortifacient, antioxidant, anthelmintic activity, antifertility, nephroprotective, and immunomodulatory activities. Conclusion: The present review summarizes the anticancer potential of A. precatorius and its constituents. However, extensive research is required to establish it as a potent chemotherapeutic agent.

scholarly journals Ethanol Extract of Maclura tricuspidata Fruit Protects SH-SY5Y Neuroblastoma Cells against H2O2-Induced Oxidative Damage via Inhibiting MAPK and NF-κB Signaling

2021 ◽  
Vol 22 (13) ◽  
pp. 6946
Author(s):  
Weishun Tian ◽  
Suyoung Heo ◽  
Dae-Woon Kim ◽  
In-Shik Kim ◽  
Dongchoon Ahn ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Oxidative Damage ◽  
Cell Damage ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Biologically Active ◽  
Mitogen Activated Protein Kinase ◽  
Protective Effects ◽  
Neuroprotective Effects

Free radical generation and oxidative stress push forward an immense influence on the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Maclura tricuspidata fruit (MT) contains many biologically active substances, including compounds with antioxidant properties. The current study aimed to investigate the neuroprotective effects of MT fruit on hydrogen peroxide (H2O2)-induced neurotoxicity in SH-SY5Y cells. SH-SY5Y cells were pretreated with MT, and cell damage was induced by H2O2. First, the chemical composition and free radical scavenging properties of MT were analyzed. MT attenuated oxidative stress-induced damage in cells based on the assessment of cell viability. The H2O2-induced toxicity caused by ROS production and lactate dehydrogenase (LDH) release was ameliorated by MT pretreatment. MT also promoted an increase in the expression of genes encoding the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). MT pretreatment was associated with an increase in the expression of neuronal genes downregulated by H2O2. Mechanistically, MT dramatically suppressed H2O2-induced Bcl-2 downregulation, Bax upregulation, apoptotic factor caspase-3 activation, Mitogen-activated protein kinase (MAPK) (JNK, ERK, and p38), and Nuclear factor-κB (NF-κB) activation, thereby preventing H2O2-induced neurotoxicity. These results indicate that MT has protective effects against H2O2-induced oxidative damage in SH-SY5Y cells and can be used to prevent and protect against neurodegeneration.

Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: A comprehensive review

2019 ◽  
Vol 123 ◽  
pp. 72-97 ◽  
Author(s):  
Muhammad A. Alsherbiny ◽  
Wessam H. Abd-Elsalam ◽  
Shymaa A. El badawy ◽  
Ehab Taher ◽  
Mohamed Fares ◽  
...  
Keyword(s):  
Protective Effects ◽  
Comprehensive Review ◽  
Radiation Induced

scholarly journals Influence of immunological nutrition on treatment of patients with oncological profile

2018 ◽  
Vol 1 (1) ◽  
pp. 19-24
Author(s):  
M. O. Katrichenko ◽  
I. I. Lisnyi
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Clinical Studies ◽  
Animal Studies ◽  
Immune Cell ◽  
Laboratory Data ◽  
Vital Role ◽  
Biologically Active ◽  
Protective Effects ◽  
Immunological Reactions

In the reviewed article, we consider epidemiological and laboratory data that confirm the protective effects of biologically active nutrients in our diet for various diseases. Along with various factors such as alcohol, smoking, nutrition plays a vital role in influencing the patient’s immune response by transforming cells or by preventing, or acceleration of malignancy. Many data suggest that immunoactive nutrients control inflammatory and precancerous reactions in immune cells. Immunoprophylaxis is usually associated with modulation of the immune response when inflamed, thereby improving clinical outcomes. Different nutrients, including glutamine, arginine, vitamins, minerals and long-chain fatty acids, are important components of immunological nutrition. Clinical studies associated with these substances show different results with minimal effect. However, some studies have shown that these nutrients may have immunomodulatory effects that can reduce the risk of developing cancer. Pre-clinical studies claim that most of these nutrients have a positive effect in the complex treatment of cancer patients. In this article, we will consider the effect of the above nutrients on the immune system in patients of oncologic profile. Recent evidences suggest that immunological nutrition plays an important role in the development of cancer and its progression. Data from animal studies have clearly shown that the use of immunomodulatory nutrients isolated from food, by launching a cascade of immunological reactions, can detect and eliminate the tumor. Although the technology has evolved to such an extent that we can study each individual cytokine or function of the immune cell, it is difficult to demonstrate the powerful role of the immune system in preventing or treating cancer due to the complexity of the tumor cell or heterogeneity in different patients' populations. However, the study sheds light on interactions in immune responses and cancer development, prevention and therapeutic strategies that involve modulation through biologically active agents.

Additional Biologically Active Constituents of the Chinese Tallow Tree (Sapium sebiferum)

1988 ◽  
Vol 51 (3) ◽  
pp. 619-620 ◽  
Author(s):  
Sheng-Quan Liu ◽  
John M. Pezzuto ◽  
A. Douglas Kinghorn ◽  
H. W. Scheld
Keyword(s):  
Biologically Active ◽  
Sapium Sebiferum ◽  
Chinese Tallow Tree ◽  
Chinese Tallow ◽  
Active Constituents ◽  
Tallow Tree

scholarly journals The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes.

1985 ◽  
Vol 33 (4) ◽  
pp. 1367-1374 ◽  
Author(s):  
HIROSHI KOHDA ◽  
WAKAKO TOKUMOTO ◽  
KIYOE SAKAMOTO ◽  
MICHIKO FUJII ◽  
YUKO HIRAI ◽  
...  
Keyword(s):  
Histamine Release ◽  
Ganoderma Lucidum ◽  
Biologically Active ◽  
Active Constituents

scholarly journals Metabolic Engineering of Yeast and Plants for the Production of the Biologically Active Hydroxystilbene, Resveratrol

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Philippe Jeandet ◽  
Bertrand Delaunois ◽  
Aziz Aziz ◽  
David Donnez ◽  
Yann Vasserot ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Stilbene Synthase ◽  
Molecular Engineering ◽  
Biologically Active ◽  
The Other ◽  
Alternative Mechanism ◽  
Comprehensive Review ◽  
Transgenic Lines ◽  
Key Enzyme ◽  
Recombinant Microorganisms

Resveratrol, a stilbenic compound deriving from the phenyalanine/polymalonate route, being stilbene synthase the last and key enzyme of this pathway, recently has become the focus of a number of studies in medicine and plant physiology. Increased demand for this molecule for nutraceutical, cosmetic and possibly pharmaceutic uses, makes its production a necessity. In this context, the use of biotechnology through recombinant microorganisms and plants is particularly promising. Interesting results can indeed arise from the potential of genetically modified microorganisms as an alternative mechanism for producing resveratrol. Strategies used to tailoring yeast as they do not possess the genes that encode for the resveratrol pathway, will be described. On the other hand, most interest has centered in recent years, onSTSgene transfer experiments from various origins to the genome of numerous plants. This work also presents a comprehensive review on plant molecular engineering with theSTSgene, resulting in disease resistance against microorganisms and the enhancement of the antioxidant activities of several fruits in transgenic lines.

Preliminary Phytochemical screening of Persicaria sagittata: Future prospective for kidney stone

2021 ◽  
pp. 4367-4370
Author(s):  
Ankita Sharma ◽  
Ishita Ishita ◽  
Inder Kumar ◽  
Kritika Verma ◽  
Bhumika Thakur ◽  
...  
Keyword(s):  
Uric Acid ◽  
Medicinal Plant ◽  
Kidney Stone ◽  
Methanolic Extract ◽  
Biologically Active ◽  
Phytochemical Screening ◽  
Secondary Product ◽  
Standard Methods ◽  
Active Constituents ◽  
Uric Acid Stones

Medicinal plants have bioactive compounds, which are used to treatments of various diseases. In the present study, Persicaria sagittata medicinal plant was used for the preliminary phytochemical screening. Methanol and petroleum ether were used as a solvent for obtaining the extraction of the plant. Both the extracts were further study for qualitative phytochemical screening using standard methods. Phytochemical screening shows that methanolic extract possesses the presence of tannins, flavonoids, and vitamin A as tannins and flavonoids are helpful for the uric acid stones. The study reveals that medicinal plant provides a basis of its use in medicine, improve to further drugs in the pharmaceutical area, and contains different biologically active constituents, and the secondary product is valuable of further analysis.

scholarly journals Dexmedetomidine: What’s New for Pediatrics? A Narrative Review

2020 ◽  
Vol 9 (9) ◽  
pp. 2724 ◽  
Author(s):  
Mohamed Mahmoud ◽  
Egidio Barbi ◽  
Keira P. Mason
Keyword(s):  
Clinical Practice ◽  
Animal Studies ◽  
Neurocognitive Function ◽  
Clinical Applications ◽  
Protective Effects ◽  
Comprehensive Review ◽  
Routes Of Administration ◽  
The Past ◽  
Growing Body ◽  
Alternative Routes

Over the past few years, despite the lack of approved pediatric labelling, dexmedetomidine’s (DEX) use has become more prevalent in pediatric clinical practice as well as in research trials. Its respiratory-sparing effects and bioavailability by various routes are only some of the valued features of DEX. In recent years the potential organ-protective effects of DEX, with the possibility for preserving neurocognitive function, has put it in the forefront of clinical and bench research. This comprehensive review focused on the pediatric literature but presents relevant, supporting adult and animal studies in order to detail the recent growing body of literature around the pharmacology, end-organ effects, organ-protective effects, alternative routes of administration, synergetic effects, and clinical applications, with considerations for the future.

scholarly journals Protective effects of proanthocyanidins of grape (Vitis vinifera L.) seeds on DNA damage induced by Doxorubicin in somatic cells of Drosophila melanogaster

2009 ◽  
Vol 47 (7) ◽  
pp. 1466-1472 ◽  
Author(s):  
Alexandre Azenha Alves de Rezende ◽  
Ulrich Graf ◽  
Zaira da Rosa Guterres ◽  
Warwick Estevam Kerr ◽  
Mário Antônio Spanó
Keyword(s):  
Dna Damage ◽  
Drosophila Melanogaster ◽  
Vitis Vinifera ◽  
Somatic Cells ◽  
Vitis Vinifera L ◽  
Protective Effects
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