The Role of Calcium, Magnesium, and Zinc in Carcinogenesis

Author(s):  
Kazimierz S. Kasprzak ◽  
Michael P. Waalkes
Keyword(s):  
Author(s):  
Alan Kelly

The beginning of the story of food is what is termed food production. This might sound logically like the process of making food, such as a chef or food company might, but this term is rather generally used in food science to refer to the so-called primary production of food, from growth of crops to harvesting of fish and minding and milking of cows. Primary production is, for example, what farmers do, producing the food that is brought to the farm-gate, from where the processors take over. So the food chain runs, according to your preference for a snappy soundbite, from grass to glass (for milk), farm to fork, slurry to curry, or (taking the food chain to its logical conclusion, and including the role of the human gut charmingly but appropriately in the chain) from farm to flush. But where do these raw materials that are yielded by primary production actually come from? It is often said that all things found on earth can be divided into categories of animal, vegetable, and mineral. To these could perhaps be added two more categories, microbial and synthetic (man-made). Within these five groups can essentially be placed everything we know as food, so using this classification to consider where our food comes from seems like a good starting point for this book. Perhaps the simplest group to start with is minerals, which might intuitively seem an unlikely source of foodstuffs (do we eat metal or rock?), until we consider where salt comes from and how much of it we add to our food (in other words, probably too much). Our bodies, however, absolutely need for us to consume certain metals and other chemical elements to survive, beyond the sodium and chloride we get from salt, and so many extracted minerals find their way from deposits in the earth into food products. This is particularly important where their biological effects are a desirable outcome (such as in carefully formulated nutritional products). In addition, products such as milk contain minerals like calcium, magnesium, zinc, and more, because the infant or calf needs them to thrive.


1991 ◽  
Vol 3 (4) ◽  
pp. 447 ◽  
Author(s):  
RJ MacIsaac ◽  
JA Heath ◽  
CP Rodda ◽  
JM Moseley ◽  
AD Care ◽  
...  

The plasma Ca concentration of the fetus is maintained higher than maternal levels by active placental transport. Ca, Mg and PO4 accumulation by the fetus is mainly associated with skeletal growth. The fetal parathyroid glands are essential for maintenance of elevated plasma Ca, which is necessary for the stimulation of fetal osteoblasts and mineralization of cartilage and osteoid. Fetal thyroparathyroidectomy (TxPTx) results in a decreased activity of the placental Ca pump. The presence of a parathyroid hormone-related protein (PTHrP) has been demonstrated in fetal parathyroid glands and placental tissue. Extracts of fetal parathyroid glands and purified PTHrP, as well as recombinant PTHrP (1-84, 1-108 and 1-141), stimulate Ca and Mg but not PO4 transport across the placenta of TxPTx-ized fetuses perfused with autologous blood in the absence of the fetus. Parathyroid hormone (PTH) and the N-terminal region of PTHrP do not stimulate placental Ca and Mg transport. It is concluded that a mid-molecule region of this novel hormone may be required to stimulate placental Ca transfer and contribute to the regulation of fetal Ca homeostasis.


Author(s):  
Cathryn M Corns

The analysis of renal calculi is an oft-neglected corner of clinical biochemistry. This study compares results obtained by the conventional qualitative methods with results from quantitative and infrared methods and also investigates the role of x-ray diffraction analysis. Infrared spectroscopy, using a KBr disc technique, was found to be the single most useful method, being fast, simple to learn, using little sample, and in general permitting positive identification of most of the components found in renal calculi. A major advantage is that this method has approximately equal sensitivity for oxalate and phosphate, unlike the wet chemical methods. Infrared analysis is also useful in identifying the spurious materials sometimes submitted as renal calculi. X-ray diffraction analysis is not a technique that is routinely available, but it does provide information not given by other methods, eg, distinguishing Ca(COO)2·H2O from Ca(COO)2·2H2O. For complete analysis a combination of methods was adopted; carbonate is tested for using a microchemical technique, calcium, magnesium, and phosphate are quantitated by routine methods, and infrared analysis is used to detect oxalate and organic components. It must be emphasised that any method is only as good as the sample used, and different areas of the calculus must be analysed separately if useful results are to be obtained.


Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 4857
Author(s):  
Gilyana Kazakova ◽  
Tatiana Safronova ◽  
Daniil Golubchikov ◽  
Olga Shevtsova ◽  
Julietta V. Rau

Materials based on Mg2+-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play substantial roles in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. In this paper we provide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction. We consider the role of magnesium ions in angiogenesis, which is an important process associated with osteogenesis. Finally, we summarize the biological properties of calcium magnesium phosphates for regeneration of bone.


Cephalalgia ◽  
1994 ◽  
Vol 14 (1) ◽  
pp. 24-28 ◽  
Author(s):  
A Mauskop ◽  
BT Altura ◽  
RQ Cracco ◽  
BM Altura

The entity of chronic daily headache (CDH) is well documented, but is not included in the current classification. We divided patients with CDH into groups with and without migrainous features. This division resulted in clearly distinguishable syndromes of daily migrainous headaches (DMH) and daily tension-type headaches (DTH). Family history of headaches was more common in patients with DMH. Patients in both groups had a high incidence of caffeine or drug overuse. The clinical division into DMH and DTH was supported by our finding of a higher incidence of disturbed magnesium (Mg) metabolism in patients with DMH. Of 26 patients with DMH, 8 (30.8%) had low serum ionized, but not total, Mg levels, and 16 (61.5%) had high ionized calcium/magnesium ratios. The corresponding numbers for the 22 patients with DTH were 1 (4.5%) and 8 (30.4%). These new laboratory measurements offer possible biological markers for the diagnosis of different headache syndromes.


FEBS Journal ◽  
2014 ◽  
Vol 281 (11) ◽  
pp. 2638-2658 ◽  
Author(s):  
Juan Martínez-Oliván ◽  
Zuriñe Rozado-Aguirre ◽  
Xabier Arias-Moreno ◽  
Vladimir E. Angarica ◽  
Adrián Velázquez-Campoy ◽  
...  

1995 ◽  
Vol 75 (2) ◽  
pp. 343-346 ◽  
Author(s):  
J. R. Keiser ◽  
R. E. Mullen ◽  
P. N. Hinz

Inadequate seed Ca concentrations are associated with reduced seed quality of soybean [Glycine max (L.) Merr.]. Standard germination and sugar leakage tests were conducted to determine the effect of seed Ca content and exogenous Ca2+ or Mg2+ on seed quality and seed leakage. Soybean seeds containing different Ca levels were germinated in rolled towels that had been soaked in distilled water, 0.01 M Ca(NO3)2, or 0.01 M Mg(NO3)2. Sugar leakage was measured by soaking seed containing 1.10, 1.72 or 2.36 mg g−1 Ca in distilled water, 0.01 M Ca (NO3)2, 0.01 M Mg(NO3)2 or polyethylene glycol (PEG). An aliquot of the bathing solution was analyzed for sugar content after 6, 12 and 24 h of soaking, by using high-performance liquid chromatography. As seed Ca content decreased from 2.36 to 1.10 mg g−1, germination in distilled water decreased from 87 to 56%. Addition of either Ca(NO3)2 or Mg(NO3)2 to the medium resulted in increased germination of low-Ca seed, but Ca(NO3)2 was more effective in improving germination of low-Ca seed than Mg(NO3)2. Total sugar leakage was significantly greater in low-Ca seed than in high-Ca seed. Bathing solutions of Ca(NO3)2 or Mg(NO3)2 significantly decreased sugar leakage, compared with distilled water or PEG. These results suggest that the role of Ca in seed germination may involve membrane stabilization. They also indicate that the addition of Ca(NO3)2 or Mg(NO3)2 to the germination medium may improve germination of Ca-deficient seed. Key words: Soybean, germination, calcium, magnesium, sugar leakage, membrane integrity


1965 ◽  
Vol 45 (3) ◽  
pp. 147-156 ◽  
Author(s):  
L. D. Campbell ◽  
W. K. Roberts

The role of potassium in ovine nutrition was investigated by using 76 western range lambs in a 56-day feeding trial, a 56-day equalized feeding trial, and two 30-day balance trials. A semipurified ration (.046% potassium) was used and potassium was added as K2CO3. The level of potassium necessary to promote optimum feedlot performance was between 0.3 and 0.5% of the air-dry ration. A marked decrease in appetite was observed in lambs consuming a ration containing 0.1% potassium compared with one containing 0.5% potassium. Lambs receiving a ration containing 0.7% potassium gained significantly (P < 0.05) more body weight than lambs receiving a 0.3% potassium ration in the equalized feeding trial. Results of the balance studies suggested that the daily potassium maintenance requirement was less than 56.1 meq (63.6 mg/kg body weight). Low potassium intakes resulted in significantly (P < 0.05) lower serum levels of potassium and phosphorus with little change in serum sodium, calcium, magnesium, or chloride. Potassium depletion also resulted in a decrease in skeletal and heart muscle potassium and an increase in liver potassium. Apparent intestinal absorption of sodium was impaired by a relatively high dietary level of potassium (94.4 meq daily) while lower levels of potassium resulted in increased urinary sodium losses. Nitrogen balance was decreased when a low level of potassium (13.7 meq daily) was fed; however, potassium intake had no effect on apparent digestibilities of nitrogen, dry matter, or energy.


OSEANA ◽  
2018 ◽  
Vol 43 (3) ◽  
pp. 52-60
Author(s):  
Diah Anggraini Wulandari

THE BENEFITS AND ROLE OF SQUID FOR HEALTH. Squids are rich in protein with a protein content 15-20%. Squids containing macro and micro minerals such as sodium, potassium, phosphorus, calcium, magnesium and selenium, besides that squid also comprise essential amino acids such as tryptophan, threonine, methionine, lysine, leucine, isoleucine, valine, phenylalanine, and non-essential amino acids such as glutamic acid, aspartic acid, tyrosine, cysteine, serine, proline, glycine, arginine and histidine. Squid ink contain alkaloids that potential as anti-inflammatory, antihypertensive, anti-diabetic, anti-microbial and anti-malaria agents. The benefit of Squids in the food industry are an enhancer of flavor and an artificial leather constituent in the biomedical field.


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