Encapsulation of Bioactive Compound and Its Therapeutic Potential

2020 ◽  
pp. 687-714
Author(s):  
Lalduhsanga Pachuau ◽  
Laldinchhana ◽  
Probin Kumar Roy ◽  
James H. Zothantluanga ◽  
Supratim Ray ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Bioactive Compound

scholarly journals Bioactive Compound Studies of Lawsonia inermis L. (Henna) –Its Ethnomedicinal and Pharmacological Applications: A Review

2020 ◽  
Vol 06 (09) ◽  
pp. 187-200
Author(s):  
Leela K and Dr. Anita R J Singh
Keyword(s):  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Bioactive Compound ◽  
Stem Bark ◽  
Wide Distribution ◽  
Lawsonia Inermis ◽  
Ethnobotanical Survey ◽  
Medicinal Properties ◽  
Important Medicinal Plant

Plants play a wide role in our ecosystem due to their enormous medicinal properties and presence of diversified chemical constituents that are known to be highly beneficial to mankind to a large extent. The current review focusses on the detailed description, phytochemistry, bioactive components, ethnobotanical survey and the important pharmacological applications of the medicinal plant Lawsonia inermis L.It is commonly referred to as “Henna or Mehndi” and is a widely used plantknown for its coloring property and medicinal applications. It has wide distribution in both tropical as well as subtropical regions and has been extensively utilized by mankind for over 9,000 years. Its leaves, flowers, roots, seeds and stem bark are been utilized in the form of herbal medicine to treat a number of ailments such as diabetes, ulcer, rheumatoid arthritis, cardiac disease, leucorrhoea, leprosy, fever etc.. The plant has also been reported to possess antimicrobial, antioxidant, hepatoprotective, hypoglycemic, anticancer, anti-inflammatory, antiparasitic, anti-dermatophytic and tuberculostatic properties due to the presence of bioactive compounds such as alkaloids, terpenoids, phenols, tannins, quinones, flavanoids, coumarins, carbohydrates, proteins and fatty acids etc.. The need for medicinal plants are now been rapidly increasing due to their low toxic nature and high pharmacological properties hence the present review is compiled to give a detailed insight in to the therapeutic potential of the important medicinal plant Lawsonia inermis L.

A review of eugenol-based nanomedicine: Recent Advancements

2020 ◽  
Vol 16 ◽  
Author(s):  
Mohammed Asadullah Jahangir ◽  
Mohamad Taleuzzaman ◽  
Sarwar Beg ◽  
Surajpal Verma ◽  
Sadaf Jamal Gilani ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Chemical Properties ◽  
Aqueous Solubility ◽  
Bioactive Compound ◽  
Anti Cancer ◽  
Herbal Plants ◽  
Cancer Agent ◽  
Therapeutic Activities ◽  
Different Sources ◽  
Holy Basil

: Eugenol is a bioactive compound frequently available in many herbal plants. The different sources reported for eugenol are clove, cinnamon, holy basil, and pepper. There are several therapeutic activities reported for eugenol as antioxidant, antimicrobial, anesthetic, antiinflammatory, anti-carcinogenic, neuroprotective agent, anti-diabetic and anti-cancer agent. However, due to limited aqueous solubility they have poor bioavailability. Their therapeutic potential has been enhanced with the eugenol nano-formulations developed as liposome, nanoparticles, microemulsions and micelles. This article extensively reviews the chemical properties, pharmacological properties, andeugenol nano-formulations with their biological activity.

Investigation of Supramolecular Interaction of Quercetin with p-sulfonated Calix[4,8]arenes using Molecular Modeling and their In vitro Cytotoxic Response on Selected Cancer Cells

2021 ◽  
Author(s):  
Mehmet Oguz ◽  
Berna Dogan ◽  
Serdar Durdagi ◽  
Asif Ali Bhatti ◽  
Serdar Karakurt ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cancer Cells ◽  
Therapeutic Potential ◽  
Bioactive Compound ◽  
Supramolecular Interaction ◽  
Cytotoxic Response ◽  
Human Cancers

Though quercetin is an effective bioactive compound preventing the progress of several human cancers, its impact is reduced due to low bioavailability. The therapeutic potential of quercetin can be enhanced...

A review on chemistry, source and therapeutic potential of lambertianic acid

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Md Shahinozzaman ◽  
Moutushi Islam ◽  
Bristy Basak ◽  
Arifa Sultana ◽  
Rashiduzzaman Emran ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Bioactive Compound ◽  
Cancer Cell Proliferation ◽  
Neuroprotective Effects ◽  
Potential Health ◽  
Anticancer Properties ◽  
Toxicological Profile ◽  
Lambertianic Acid

Abstract Lambertianic acid (LA) is a diterpene bioactive compound mainly purified from different species of Pinus. It is an optical isomer of another natural compound daniellic acid and was firstly purified from Pinus lambertiana. LA can be synthesized in laboratory from podocarpic acid. It has been reported to have potential health benefits in attenuating obesity, allergies and different cancers including breast, liver, lung and prostate cancer. It exhibits anticancer properties through inhibiting cancer cell proliferation and survival, and inducing apoptosis, targeting major signalling components including AKT, AMPK, NFkB, COX-2, STAT3, etc. Most of the studies with LA were done using in vitro models, thus warranting future investigations with animal models to evaluate its pharmacological effects such as antidiabetic, anti-inflammatory and neuroprotective effects as well as to explore the underlying molecular mechanisms and toxicological profile. This review describes the chemistry, source, purification and therapeutic potentials of LA and it can therefore be a suitable guideline for any future study with LA.

scholarly journals Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yaxin Cheng ◽  
Yonghua Zhao ◽  
Ying Zheng
Keyword(s):  
Autoimmune Diseases ◽  
Therapeutic Potential ◽  
Low Cost ◽  
Chinese Herb ◽  
Bioactive Compound ◽  
Redox Balance ◽  
Research Progress ◽  
Severe Toxicity ◽  
Tripterygium Wilfordii Hook F

AbstractWith the increasing epidemiology of autoimmune disease worldwide, there is an urgent need for effective drugs with low cost in clinical treatment. Triptolide, the most potent bioactive compound from traditional Chinese herb Tripterygium Wilfordii Hook F, possesses immunosuppression and anti-inflammatory activity. It is a potential drug for the treatment of various autoimmune diseases, but its clinical application is still restricted due to severe toxicity. In this review, the pharmacodynamic effects and pharmacological mechanisms of triptolide in autoimmune diseases are summarized. Triptolide exerts therapeutic effect by regulating the function of immune cells and the expression of cytokines through inflammatory signaling pathways, as well as maintaining redox balance and gut microbiota homeostasis. Meanwhile, the research progress on toxicity of triptolide to liver, kidney, reproductive system, heart, spleen, lung and gastrointestinal tract has been systematically reviewed. In vivo experiments on different animals and clinical trials demonstrate the dose- and time- dependent toxicity of triptolide through different administration routes. Furthermore, we focus on the strategies to reduce toxicity of triptolide, including chemical structural modification, novel drug delivery systems, and combination pharmacotherapy. This review aims to reveal the potential therapeutic prospect and limitations of triptolide in treating autoimmune diseases, thus providing guiding suggestions for further study and promoting its clinical translation.

scholarly journals Antioxidant and Antisteatotic Activities of a New Fucoidan Extracted from Ferula hermonis Roots Harvested on Lebanese Mountains

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1161
Author(s):  
Zeinab El Rashed ◽  
Giulio Lupidi ◽  
Hussein Kanaan ◽  
Elena Grasselli ◽  
Laura Canesi ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Bioactive Compound ◽  
13C Nmr Spectroscopy ◽  
Antioxidant Property ◽  
Structural Features ◽  
Water Soluble ◽  
Cellular Models

Fucoidan is a fucose-rich sulfated polysaccharide with attractive therapeutic potential due to a variety of biological activities, including antioxidant action. Fucoidan is typically found in the cell wall of marine brown algae, but extra-algal sources have also been discovered. In the present work, for the first time we extracted a water soluble fucoidan fraction from the roots of the terrestrial shrub Ferula hermonis. This fucoidan fraction was termed FUFe, and contained fucose, glucose, sulfate, smaller amounts of monosaccharides such as galactose and mannose, and a minor quantity of proteins. FUFe structural features were investigated by FTIR, 1H NMR and 13C NMR spectroscopy. The antioxidant property of FUFe was measured by DPPH, ABTS and FRAP assays, which revealed a high radical scavenging capacity that was confirmed in in vitro cellular models. In hepatic and endothelial cells, 50 μg/mL FUFe could reduce ROS production induced by intracellular lipid accumulation. Moreover, in hepatic cells FUFe exhibited a significant antisteatotic action, being able to reduce intracellular triglyceride content and to regulate the expression of key genes of hepatic lipid metabolism. Altogether, our results candidate FUFe as a possible bioactive compound against fatty liver disease and related vascular damage.

Antioxidant Properties of Selected Malaysian Herbal Plant: A Review

2013 ◽  
Vol 832 ◽  
pp. 434-438
Author(s):  
Abu Samah Nadzirah ◽  
Mahmood Rusop ◽  
Abdullah Noriham
Keyword(s):  
Therapeutic Potential ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Bioactive Compound ◽  
Flowering Plants ◽  
Plant Resource ◽  
Cosmos Caudatus ◽  
The World ◽  
Herbal Plant ◽  
Diverse Plant

Malaysian is among the most diverse plant resource country in the world especially with its richesnest flora and fauna. It has about 12,000 species of flowering plants of which about 1,300 species were said to be medicinal plant and have been investigated for their therapeutic potential. Spies have been known to be a valuable source of bioactive compound which are being used to treat various diseases and improved health for a thousand years ago. The beneficial health effects of medicinal plants come from polyphenols group which is often attributed to their potent antioxidant activities. This paper reviews the antioxidant potential of selected plants from Malaysia as Persicaria hydropiper, Cosmos caudatus and Melicopeptelefolia based on reported from several researchers.

Lettuce: a promising leafy vegetable with functional properties

2017 ◽  
Vol 2 (2) ◽  
pp. 178 ◽  
Author(s):  
K. R. Anilakumar ◽  
S. N. Harsha ◽  
Mallesha . ◽  
R. K. Sharma
Keyword(s):  
Lactuca Sativa ◽  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Sesquiterpene Lactones ◽  
Bioactive Compound ◽  
Well Being ◽  
Biological Properties ◽  
The Body ◽  
Leafy Vegetable ◽  
Correct Operation

<em><span lang="EN-US">Lactuca sativa</span></em><span lang="EN-US"> (lettuce) belongs to Asteraceae family important leafy vegetable known for its medicinal properties. The lettuce is a food that should not lack in our meals, we should keep in mind that its low fat and carbohydrate contents and its high contents of water, it provides caloric power of only 13 Kcal /100gm are very appropriate for weight loss diets. It is rich in minerals, especially potassium that is very necessary to maintain appropriate levels of liquids in the body, together with calcium and phosphorus makes it especially for the correct well being of the bones. It contains selenium, an antioxidant that has a medicinal property in prevention of certain type of cancers, colon, prostrate and lungs. It contains many necessary amino acids for the formation of the proteins, alanine, and necessary for the construction of muscular and nervous tissues, glycine for the correct operation of immunological system. The most of therapeutic properties of this plant is due to sesquiterpene lactones- lactucin, lactucopicrin the most bioactive compound of <em>Lactuca sativa</em>. This review mainly focuses on the pharmacological action of the Lettuce and active constituents for the wide spectrum biological properties, such as anti-oxidant, anti-inflammatory, anti-microbial, analgesic, neuroprotective and sedative properties etc. Since Lettuce has medicinal therapeutic potential its usage in dietary supplementation can be exploited. Lettuce has also acquired a folk reputation. More clinical studies are needed to further asses the efficiency and safety in therapeutic application</span>

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