scholarly journals Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?

2021 ◽  
Author(s):  
Sophie E. Carter ◽  
Richard Draijer ◽  
Claire E. Stewart ◽  
Andy D. Moss ◽  
Dick H. J. Thijssen ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Low Frequency ◽  
Serum Markers ◽  
Necrosis Factor Alpha ◽  
Paired Samples ◽  
Markers Of Inflammation ◽  
Cerebrovascular Function ◽  
Carbon Dioxide Reactivity ◽  
Mood And Cognition ◽  
Induced Changes

Abstract Purpose Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced changes are related to impaired mood and cognition. Methods Twenty-five healthy desk workers (18 male, 28.3 ± 7.5 years, BMI: 24.2 ± 3.3 kg∙m−2) were recruited. During laboratory visit one, participants were familiarised with cognitive performance tests measuring executive function, attention and working memory. During laboratory visit two, participants completed 6 h of continuous, uninterrupted sitting. At baseline and after 6 h, serum markers of inflammation, middle cerebral artery blood flow velocity (MCAv), cerebrovascular carbon dioxide reactivity (CVR), dynamic cerebral autoregulation (CA), cognitive performance and mood (positive and negative affect, alert, contented and calm) were assessed. Data were analysed using paired-samples t tests and correlation analyses. Results Following sitting, C-reactive protein (∆-1.0 µg/ml) and tissue plasminogen activator (∆-360.4 pg/ml) decreased (p < 0.05), MCAv reduced (∆-2.9 cm∙s−1, p = 0.012) and normalised gain increased in the very low frequency range, indicating impaired CA (∆ + 0.22%·mmHg−1, p = 0.016). Positive affect (∆-4.6, p < 0.001), and alert (∆-10.6 p = 0.002) and contented (∆-7.4, p = 0.006) mood states also decreased following sitting. No significant changes in interleukin-6, tumour necrosis factor-alpha, von Willebrand factor, CVR or cognitive performance were observed (p > 0.05). The observed changes in inflammation and cerebrovascular function were not related to changes in mood (p > 0.05). Conclusion Alterations in inflammation or cerebrovascular function following six hours of prolonged, uninterrupted sitting are not related to the observed reductions in mood, indicating other mechanisms underlie the relationship between acute sitting and mood disturbances.

Circulating progenitor cells in patients with atrial fibrillation and their relation with serum markers of inflammation and angiogenesis

2010 ◽  
Vol 104 (08) ◽  
pp. 327-334 ◽  
Author(s):  
Andrew Blann ◽  
Timothy Watson ◽  
Eduard Shantsila ◽  
Gregory Lip
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Progenitor Cells ◽  
Cell Population ◽  
Fas Ligand ◽  
Serum Markers ◽  
Endothelial Damage ◽  
Stepwise Multiple Regression ◽  
Soluble Fas ◽  
Markers Of Inflammation

Summary The pathophysiological inter-relationships and underlying ‘drivers’ of a prothrombotic state in atrial fibrillation (AF) are complex but may include endothelial abnormalities. Circulating progenitor cells (CPCs) have been recently described as a cell population that may promote repair of endothelial damage. We hypothesised abnormalities in this cell population, alongside abnormal markers of endothelial damage/dysfunction (von Willebrand factor, soluble E-selectin), apoptosis (soluble Fas, soluble Fas ligand), angiogenesis (vascular endothelial growth factor) and inflammation (interleukin-6) in 135 consecutive AF patients (14 with lone AF), who were compared to 33 ‘disease controls’ and 13 healthy controls. We also explored whether restoration of sinus rhythm would alter these indices. No significant differences in research indices were observed between AF and disease controls, apart from soluble Fas levels (p<0.001). Median CPC levels in lone AF were higher compared to ‘non-lone AF’ (that is, AF patients with co-morbidities) [p<0.001], apparently because of difference in age and presence of co-morbidities. There was an increase in CPC counts (p=0.007), but in not other markers following DC cardioversion. CPCs increased significantly in the 17 patients who were successfully cardioverted into sinus rhythm (p=0.003). In a stepwise multiple regression analysis, age (p=0.014), hyperlipidaemia (p=0.001) and use of statins (but not AF) was predictive of CPC counts (p=0.014). In conclusion, AF is unlikely to be independently associated with abnormalities in CPCs. Successful cardioversion is associated with a modest but significant increase in CPCs.

Exercise intensity and markers of inflammation during and after (neo-) adjuvant cancer treatment

2021 ◽  
Vol 28 (3) ◽  
pp. 191-201
Author(s):  
Tim Schauer ◽  
Anne-Sophie Mazzoni ◽  
Anna Henriksson ◽  
Ingrid Demmelmaier ◽  
Sveinung Berntsen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Exercise Intensity ◽  
Interleukin 1 ◽  
Secondary Analysis ◽  
Post Treatment ◽  
Moderate Intensity ◽  
Post Intervention ◽  
Necrosis Factor Alpha ◽  
Markers Of Inflammation

Exercise training has been hypothesized to lower the inflammatory burden for patients with cancer, but the role of exercise intensity is unknown. To this end, we compared the effects of high-intensity (HI) and low-to-moderate intensity (LMI) exercise on markers of inflammation in patients with curable breast, prostate and colorectal cancer undergoing primary adjuvant cancer treatment in a secondary analysis of the Phys-Can randomized trial (NCT02473003). Sub-group analyses focused on patients with breast cancer undergoing chemotherapy. Patients performed 6 months of combined aerobic and resistance exercise on either HI or LMI during and after primary adjuvant cancer treatment. Plasma taken at baseline, immediately post-treatment and post-intervention was analyzed for levels of interleukin 1 beta (IL1B), IL6, IL8, IL10, tumor-necrosis factor alpha (TNFA) and C-reactive protein (CRP). Intention-to-treat analyses of 394 participants revealed no significant between-group differences. Regardless of exercise intensity, significant increases of IL6, IL8, IL10 and TNFA post-treatment followed by significant declines, except for IL8, until post-intervention were observed with no difference for CRP or IL1B. Subgroup analyses of 154 patients with breast cancer undergoing chemotherapy revealed that CRP (estimated mean difference (95% CI): 0.59 (0.33; 1.06); P  = 0.101) and TNFA (EMD (95% CI): 0.88 (0.77; 1); P  = 0.053) increased less with HI exercise post-treatment compared to LMI. Exploratory cytokine co-regulation analysis revealed no difference between the groups. In patients with breast cancer undergoing chemotherapy, HI exercise resulted in a lesser increase of CRP and TNFA immediately post-treatment compared to LMI, potentially protecting against chemotherapy-related inflammation.

Exposure to industrial noise: impacts on cognitive performance

2021 ◽  
Vol 263 (4) ◽  
pp. 2590-2600
Author(s):  
Luiz Henrique Mesa Casa Pereira ◽  
Björn Knöfel ◽  
Jan Troge ◽  
Welf-Guntram Drossel ◽  
Marcel Klein ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Noise Analysis ◽  
Low Frequency ◽  
Cumulative Effect ◽  
Noise Sources ◽  
Industrial Noise ◽  
Sound Levels ◽  
Office Environments ◽  
High Sound ◽  
High Frequency Content

Research on the relation between exposure to noise and cognitive performance inside industrial environments is not as broad as on office environments. For a better understanding of the specific industrial noise problems, participants performed arithmetic tests inside a hemi anechoic room while they were exposed to sounds of five typical industrial noise sources. The subjects also classified how annoying they perceived the noise signals. The effect of noise on the arithmetic test's performance was larger on accuracy than on velocity, which was verified using a Student t-test. Spectral-temporal characteristics - especially high frequency content and strong low frequency modulation - appear to relate better with lower performance on the test than high sound levels. Subjects that evaluated noise as more annoying performed worse in a final arithmetic test (under silence) after being exposed to the noises, indicating a possible cumulative effect of noise on performance. The findings provide a better insight in the cognitive behavior of people who are exposed to industrial noise. Hence, the study will proceed with the specific noise analysis of single industrial workplaces.

scholarly journals Evaluation of Antioxidant and Anti-Inflammatory Activity of Anthocyanin-Rich Water-Soluble Aronia Dry Extracts

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4055 ◽  
Author(s):  
Mariusz Banach ◽  
Magdalena Wiloch ◽  
Katarzyna Zawada ◽  
Wojciech Cyplik ◽  
Wojciech Kujawski
Keyword(s):  
Lipid Peroxidation ◽  
Interleukin 1 ◽  
Radical Scavenging ◽  
Water Soluble ◽  
Anthocyanin Content ◽  
Necrosis Factor Alpha ◽  
Paramagnetic Resonance ◽  
Markers Of Inflammation ◽  
Radical Scavenging Properties

Aronia fruits contain many valuable components that are beneficial to human health. However, fruits are characterized by significant variations in chemical composition dependent on the growing conditions and harvesting period. Therefore, there is a need to formulate the extracts with a precisely defined content of health-promoting substances. Aronia dry extracts (ADE) were prepared from frozen pomace applying water extraction, followed by purification and spray-drying. Subsequently, the content of anthocyanins, phenolic acids, and polyphenols was determined. The high-quality chokeberry pomace enabled obtaining extracts with anthocyanin content much higher than the typical market standards. Moreover, it was found that the antioxidant capacity of aronia extracts exceeded those found in other fruit preparations. Antioxidant and free-radical scavenging properties were evaluated using a 2,2′-diphenyl-1-picrylhydrazyl using Electron Paramagnetic Resonance (EPR) spectroscopy (DPPH-EPR) test and Oxygen Radical Absorbance Capacity (ORAC) assay. The inhibition of lipid peroxidation and the level of inflammatory markers have been also investigated using lipopolysaccharide (LPS)-stimulated RAW 264 cells. It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and malondialdehyde (MDA)) in in vitro conditions. Additionally, it was confirmed that ADE at all analyzed concentrations did not show any cytotoxic effect as demonstrated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.

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