Adequacy of nutrition and body weight in patients with early stage dementia: The cognition and aging study

2019 ◽  
Vol 38 (5) ◽  
pp. 2187-2194 ◽  
Author(s):  
Hua-Tsen Hsiao ◽  
Jun-Jun Lee ◽  
Hsiu-Hui Chen ◽  
Ming-Kung Wu ◽  
Chi-Wei Huang ◽  
...  
Keyword(s):  
Body Weight ◽  
Early Stage ◽  
Aging Study ◽  
Cognition And Aging

scholarly journals Systematic evaluation of CdSe/ZnS Quantum Dots toxicity on the reproduction and offspring health in male BALB/c mice

2020 ◽  
Author(s):  
Li Li ◽  
Xiaotan Lin ◽  
Tingting Chen ◽  
Kan Liu ◽  
Zhiwen Yang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Body Weight ◽  
Early Stage ◽  
Sperm Quality ◽  
Systematic Evaluation ◽  
High Dose ◽  
Male Mice ◽  
Organ Index ◽  
Acrosome Integrity ◽  
Offspring Health

Abstract Background: Increased applications of quantum dots (QDs) in biomedical field have aroused attention for their potential toxicological effects. Although many studies have been carried out on the toxicity of QDs, their effects on reproductive and development are still unclear. In this study, we systematically evaluated the male reproductive toxicity and developmental toxicity of CdSe/ZnS QDs in BALB/c mice.Results: The male mice were injected intravenously with CdSe/ZnS QDs at the dosage of 2.5 mg/kg BW or 25 mg/kg BW, respectively, and the survival status, biodistribution of QDs in testes, serum sex hormone levels, histopathology, sperm motility and acrosome integrity was measured on Day 1, 7, 14, 28 and 42 after injection. On Day 35 after treatment, male mice were housed with non-exposed female mice, and then offspring number, body weight, organ index and histopathology of major organs, blood routine and biochemical tests of offspring were measured to evaluate the fertility and offspring health. The results showed that CdSe/ZnS QDs could rapidly distribute in the testis, and the fluorescence of QDs could still be detected on Day 42 post-injection. QDs had no adverse effect on the structure of testis and epididymis, but high-dose QDs could induce apoptosis of Leydig cells in testis at an early stage. No significant differences in survival of state, body weight organ index of testis and epididymis, sex hormones levels, sperm quality, sperm acrosome integrity and fertility of male mice were observed in QDs exposed groups. However, the development of offspring was obviously influenced, which was mainly manifested in the slow growth of offspring, changes of organ index of main organs, and the abnormality of liver and kidney function parameters.Conclusion: Our findings revealed that CdSe/ZnS QDs were able to cross the blood-testis barrier (BTB), produce no discernible toxic effects on the male reproductive system, but could affect the healthy growth of future generations to some extent. In view of the broad application prospect of QDs in biomedical fields, our findings might provide insight into the biological safety evaluation of the reproductive health of QDs.

scholarly journals Interrelation between body weights of sire, dam and their lambs at early stage of growth

2020 ◽  
Vol 36 (2) ◽  
pp. 205-214
Author(s):  
Violeta Caro-Petrovic ◽  
Milan Petrovic ◽  
Dragana Ruzic-Muslic ◽  
Nevena Maksimovic ◽  
Irina Sycheva ◽  
...  
Keyword(s):  
Body Weight ◽  
Early Stage ◽  
Descriptive Statistics ◽  
Coefficient Of Determination ◽  
Measures Of Association ◽  
Paired Sample ◽  
Body Weights ◽  
Sample Test ◽  
Highly Correlated

Records of female lambs and their parents of the Mis sheep breed have used. All animals are approximately have weaned at 90 days of age. Descriptive statistics, paired sample test, paired differences, measures of association, correlations and regression of body weights between female lambs and their parents have done. A complementary least body weights at 30 days and weaning between dams and lambs but utmost weight at 30 days, the lambs were higher while at weaning, the dams had higher weight. It can observe that the averages on body weights the rams were the highest, followed by lambs and the lowest the dams? body weights. The coefficient of determination of R2 varies from low to high, indicating that the lamb's body weight has more influenced by other factors that we have not considered. There were significant correlations between lamb body weight at birth and sire/dam body weight at birth. The results showed highly significant correlations of lamb's body weight at 30 days with dams but with sires, positive and very low. There had positive but no significant correlation between lamb body weight at weaning and sire body weight at weaning. Lamb body weight at weaning and dam body weight at weaning are highly correlated.

Effects of the Avian Leukosis Virus on the Weight of Immune Organs and Other Important Organs and Body Weight of Chicks at Different Growth Stages

2021 ◽  
Author(s):  
Z.H. Guo ◽  
X. Li ◽  
Y.F. Huang ◽  
X. Lan
Keyword(s):  
Body Weight ◽  
Early Stage ◽  
Economic Loss ◽  
Avian Leukosis Virus ◽  
Bursa Of Fabricius ◽  
Growth Stages ◽  
Loss Of Function ◽  
Irreversible Damage ◽  
Immune Organs ◽  
Different Growth Stages

Background: The avian leukosis virus (ALV-J) is a retrovirus causing irreversible damage and loss of function in tissues and organs in a chicken body, especially in those related to the immune system, thus resulting in considerable economic loss. Methods: We measured the changes in the weights of immune organs, such as the spleen, bursa of Fabricius, thymus, heart and liver and body weight at days 3, 5, 7, 14, 21, 28 and 42 after ALV-J infection and analysed the differences between the corresponding tissues and normal groups at each time. Result: The unique weight change in pspleen tissues indicates that the organ plays an important role in fighting ALV-J infection in the early stage. Moreover, the phenotypic inhibition of ALV-J in the tissues and organs started to appear 28 days after infection.

Decreased Renal Function Induced by High-Fat Diet in Wistar Rat: The Role of Plasma Angiotensin Converting Enzyme 2 (ACE2)

2019 ◽  
Vol 12 (3) ◽  
pp. 1279-1287
Author(s):  
Ridwan Ridwan ◽  
Rosdiana Natzir ◽  
Haerani Rasyid ◽  
Ilhamjaya Patellongi ◽  
Mochammad Hatta ◽  
...  
Keyword(s):  
Renal Function ◽  
Body Weight ◽  
Body Fat ◽  
High Fat Diet ◽  
Early Stage ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Angiotensin Converting Enzyme 2 ◽  
Obesity Index

Researches on the effects of High Fat Diet (HFD) on decreased renal function with cystatin C (cysC) serum levels biomarker are few and show different findings. Renin Angiotensin System (RAS) plays a key role in controlling renal function and one of the integral components of the RAS is Angiotensin Converting Enzyme 2 (ACE2). Research on the relationship between plasma ACE2 levels with serum cysC levels in animals induced by HFD has not been done. We hypothesize that administration of HFD can cause a decline in early stage renal function through the role of ACE2. 30 male wistar rats aged 10-12 weeks (body weight between 170-220 grams) were randomly divided into 5 groups (6 rats/group): baseline, normal diet for 8 weeks (ND8), ND for 16 weeks (ND16), HFD for 8 weeks (HFD8) and HFD for 16 weeks (HFD16). Body weight and naso-anal length were measured to get the index value of obesity and body fat percentage. Obesity index measured are lee index, rohrer index and TM index. Blood samples obtained by intracardiac for examination of plasma ACE2 levels and serum cysC levels. After 8 and 16 weeks, HFD increases body weight, obesity index and body fat percentage. HFD also increases plasma ACE2 levels and serum cysC levels. Body weight, obesity index and body fat percentage have a positive correlation with plasma ACE2 levels. Plasma ACE2 levels were positively correlated with serum cysC levels. HFD causes a decrease of early stage renal function as evidenced by the increase in serum cysC levels. Plasma ACE2 levels play a role in the pathogenesis of the decline in early stage renal function induced by HFD.

scholarly journals Resting Heart Rate as a Predictor of Body Weight Gain in the Early Stage of Hypertension

Obesity ◽  
2011 ◽  
Vol 19 (3) ◽  
pp. 618-623 ◽  
Author(s):  
Paolo Palatini ◽  
Lucio Mos ◽  
Massimo Santonastaso ◽  
Nello Zanatta ◽  
Paolo Mormino ◽  
...  
Keyword(s):  
Heart Rate ◽  
Body Weight ◽  
Weight Gain ◽  
Early Stage ◽  
Body Weight Gain ◽  
Resting Heart Rate

scholarly journals SHORT COMMUNICATION Performance of local fowls fed plantain peels meal

2020 ◽  
Vol 40 (1) ◽  
pp. 79-82
Author(s):  
C. T. Ezeokeke
Keyword(s):  
Body Weight ◽  
Early Stage ◽  
Body Weight Gain ◽  
Control Diet ◽  
Average Weight ◽  
Test Diet ◽  
Feed Conversion ◽  
Communication Performance ◽  
Randomized Design ◽  
And Control

Experiment was carried out to determine performance of day old local fowls, fed supplemented plantain peels meal (PPM). The birds were arranged in completely randomized design having six birds per replicate and two treatments comprising one test diet and one control diet. At starter phase, all the parameters (body weight, body weight gain, feed intake and feed conversion ratio) measured were not significant (p>0.05). The birds on the test diet had average initial weight, 42.00g while that of the control had average weight, 43.75g and at 5 weeks of age average weights of 133.30g and 134.54g (p>0.05) ,respectively. At the finisher phase, all the parameters measured were not significant (p>0.5). The prices per kg of feed for the test and control diets were N93.05 and N95.05, respectively. Therefore, PPM inclusion fed at early stage of life of the birds enhanced performance at a lower cost.

scholarly journals Genome-wide Association Analysis of Adaptation to Oxygen Stress in Nile Tilapia (Oreochromis Niloticus)

2020 ◽  
Author(s):  
Xiaofei Yu ◽  
Hendrik-Jan Megens ◽  
Samuel B. Mengistu ◽  
John W.M. Bastiaansen ◽  
Han A. Mulder ◽  
...  
Keyword(s):  
Body Weight ◽  
Growth Stage ◽  
Early Stage ◽  
Nervous System Development ◽  
Genome Wide Association ◽  
Environment Interaction ◽  
Genome Wide ◽  
Hypoxic Environment ◽  
A Genome ◽  
Vegf Signalling

Abstract Background: Tilapia is one of the most abundant species in aquaculture. Hypoxia is known to depress growth rate, but the genetic mechanism by which this occurs is unknown. In this study, two groups consisting of 3140 fish that were raised in either aerated (normoxia) or non-aerated pond (nocturnal hypoxia). During grow out, fish were sampled five times to determine individual body weight (BW) gains. We applied a genome-wide association study to identify SNPs and genes associated with the hypoxic and normoxic environments in the 17th generation of a Genetically Improved Farmed tilapia population. Results: In the hypoxic environment, 36 SNPs associated with at least one of the five body weight measurements (BW1 till BW5), of which six, located between 19.48 Mb and 21.04 Mb on Linkage group (LG) 8, were significant for body weight in the early growth stage (BW1 to BW2). Further significant associations were found for BW in the later growth stage (BW3 to BW5), located on LG1 and LG8. Analysis of genes within the candidate genomic region suggested that MAPK and VEGF signalling were significantly involved in the later growth stage under the hypoxic environment. Well-known hypoxia-regulated genes such as igf1rb, rora, efna3 and aurk were also associated with growth in the later stage in the hypoxic environment. Conversely, 13 linkage groups containing 29 unique significant and suggestive SNPs were found across the whole growth period under the normoxic environment. A meta-analysis showed that 33 SNPs were significantly associated with BW across the two environments, indicating a shared effect independent of hypoxic or normoxic environment. Functional pathways involved in nervous system development and organ growth in the early stage, and oocyte maturation in the later stage.Conclusions: There are clear genotype-growth associations in both normoxic and hypoxic environments, although genome architecture involved changed over the growing period, indicating a transition in metabolism along the way. The involvement of pathways important in hypoxia especially at the later growth stage indicates a genotype-by-environment interaction, in which MAPK and VEGF signalling are important components.

scholarly journals Efficacy of dapagliflozin versus sitagliptin on cardiometabolic risk factors in Japanese patients with type 2 diabetes: a prospective, randomized study (DIVERSITY-CVR)

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Ayako Fuchigami ◽  
Fumika Shigiyama ◽  
Toru Kitazawa ◽  
Yosuke Okada ◽  
Takamasa Ichijo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Body Weight ◽  
Primary Endpoint ◽  
Hba1c Level ◽  
Cardiometabolic Risk ◽  
Early Stage ◽  
Body Weight Loss ◽  
Cardiometabolic Risk Factors

Abstract Background Few prospective studies have compared the cardiovascular benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase 4 (DPP-4) inhibitors. We aimed to clarify the efficacy of dapagliflozin versus sitagliptin for modulating cardiometabolic risk factors including high glycated hemoglobin (HbA1c) levels, hypoglycemia, and body weight. Methods This prospective, randomized, open-label, blinded-endpoint, parallel-group trial enrolled 340 Japanese patients with early-stage type 2 diabetes receiving metformin alone or no glucose-lowering agents, who were randomized to receive dapagliflozin or sitagliptin for 24 weeks. The primary endpoint was the proportion of patients who achieved the composite endpoint of HbA1c level maintenance < 7.0% (53 mmol/mol), avoidance of hypoglycemia (maintenance of sensor glucose ≥ 3.0 mmol/L or ≥ 54 mg/dL), and ≥ 3.0% body weight loss from baseline. Secondary endpoints included components of the primary endpoint, other metabolic indices, and glucose variability indices measured using flash glucose monitoring. Results Clinical characteristics of patients were age, 58.1 ± 12.2 years; known duration of diabetes, 5.8 ± 6.1 years; body weight, 74.7 ± 14.2 kg; body mass index, 27.9 ± 4.1 kg/m2; and HbA1c level, 7.8 ± 0.8% at baseline. The achievement ratio of primary endpoint was significantly higher in the dapagliflozin group than in the sitagliptin group (24.4% vs. 13.8%, P < 0.05). While the rates of HbA1c level maintenance < 7.0% (53 mmol/mol) and avoidance of hypoglycemia were comparable between the groups (49.4 vs. 50.0% and 88.7 vs. 92.3% for dapagliflozin vs. sitagliptin, respectively), body weight loss of ≥ 3.0% was significantly achieved in the dapagliflozin group (54.4 vs. 19.6%, P < 0.001). Moreover, dapagliflozin was superior to sitagliptin regarding several secondary endpoints that modulate cardiometabolic risk, namely reducing fasting plasma glucose, insulin, uric acid, increasing high-density lipoprotein cholesterol, and suppressing the increase in serum creatinine and the decrease in estimated glomerular filtration rate. On the other hand, sitagliptin was superior to dapagliflozin in suppressing glucose variability. Conclusions Compared to sitagliptin, dapagliflozin was significantly more effective at improving cardiometabolic risk factors, suggesting that SGLT2 inhibitors might be more suitable than DPP-4 inhibitors for preventing cardiovascular events in patients with early-stage but inadequately controlled type 2 diabetes. Trial registration Trial number, UMIN000028014; registered on June 30, 2017

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