Maternal fish and shellfish consumption and preterm birth: A retrospective study in urban China

2021 ◽  
pp. 1-31
Author(s):  
Li Wang ◽  
Zhongxia Fu ◽  
Wei Deng ◽  
Shengdong Zhu ◽  
Chuan Zhang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Preterm Birth ◽  
Protective Role ◽  
Urban China ◽  
Spontaneous Preterm Birth ◽  
Maternal Complications ◽  
Mortality And Morbidity ◽  
Logistic Regression Models ◽  
Total Fish ◽  
Fish And Shellfish

Abstract Preterm birth is the leading cause of perinatal mortality and morbidity. Some prospective cohort studies suggested that fish and shellfish consumption may affect the incidence of preterm birth. However, conflicting evidence exists on the relationship between fish and shellfish consumption and preterm birth. This retrospective study was conducted in Lanzhou, China, between 2010 and 2012. A total of 10,179 women were interviewed after delivery to collect information on their past intake of fish and shellfish using food frequency questionnaire. Clinical data including birth outcomes and maternal complications were extracted from medical records of the participants. Logistic regression models were used to estimate odds ratios and 95% confidence intervals to examine the association between fish and shellfish consumption and preterm birth and its clinical subtypes. Fish and shellfish consumption was associated with reduced risk of preterm birth (OR=0.65, 95%CI:0.56-0.77). Increasing frequency of fish and shellfish consumption, compared with no fish and shellfish consumption, were associated with decreasing odds of preterm birth: for ≤ 1 time/ week, OR = 0.74 (95% CI: 0.63-0.89); for ≥2 times a week, OR = 0.57 (95% CI:0.48-0.68). The P for trend was 0.023. Besides, increasing weekly total amount of fish and shellfish consumption, compared with no fish and shellfish consumption, were also associated with decreasing odds of preterm birth: for <350 g/week, OR = 0.67 (95% CI: 0.57-0.78); for ≥350 g/week, OR = 0.57 (95% CI:0.43-0.74). The P for trend was 0.011. Significant trend effect was also seen between fish and shellfish consumption and very preterm birth (P for trend =0.001) and spontaneous preterm birth (P for trend =0.003). Interaction was observed between total fish and shellfish consumption with maternal age (P for interaction=0.041) and pre-pregnancy BMI underweight (P for interaction=0.012). Maternal fish and shellfish consumption was associated with lower incidence of preterm birth. The findings support for the protective role of fish and shellfish consumption in preventing preterm birth and recommend for the national guideline of ≥350 g/week of fish and shellfish consumption among pregnant women.

scholarly journals Use of the Pessary in the Prevention of Preterm Delivery

2019 ◽  
Vol 41 (01) ◽  
pp. 053-058
Author(s):  
Thayane Corrêa ◽  
Ester Amorim ◽  
Jade Tomazelli ◽  
Mário Corrêa
Keyword(s):  
Preterm Birth ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Preterm Births ◽  
Spontaneous Preterm Birth ◽  
Mortality And Morbidity ◽  
Pooled Data ◽  
Cervical Pessary ◽  
Significant Difference ◽  
Preventive Method

Objective The gestational complication most associated with perinatal mortality and morbidity is spontaneous preterm birth with gestational age < 37 weeks. Therefore, it is necessary to identify its risk factors and attempt its prevention. The benefits of the pessary in prematurity are under investigation. Our objective was to analyze the use of the pessary in the prevention of preterm births in published studies, and to compare its efficacy with other methods. Methods Randomized clinical trials published between 2010 and 2018 were selected from electronic databases. Studies on multiple gestations were excluded. Results Two studies were in favor of the pessary as a preventive method, one study was contrary to the method and another two showed no statistically significant difference. The meta-analysis showed no statistical difference with the use of a cervical pessary in the reduction of births < 37 (odds ratio [OR]: 0.63; confidence interval [95% CI]: 0.38–1.06) and < 34 weeks (OR: 0.74; 95% CI: 0.35–1.57) Conclusion The pooled data available to date seems to show a lack of efficacy of the cervical pessary in the prevention of preterm birth, although the heterogeneity of the studies made comparisons more difficult.

scholarly journals Association of Antenatal Depression with Clinical Subtypes of Preterm Birth

2018 ◽  
Vol 36 (06) ◽  
pp. 567-573 ◽  
Author(s):  
Kartik Venkatesh ◽  
Kelly Ferguson ◽  
Nicole Smith ◽  
David Cantonwine ◽  
Thomas McElrath
Keyword(s):  
Preterm Birth ◽  
Multinomial Logistic Regression ◽  
Treatment Options ◽  
Secondary Analysis ◽  
Antenatal Depression ◽  
Spontaneous Preterm Birth ◽  
Logistic Regression Models ◽  
History Of ◽  
Antidepressant Use ◽  
Nested Case Control

Objective To estimate the association between antenatal depression and spontaneous preterm birth (SPTB) relative to medically indicated preterm birth (MPTB). Study Design This was a secondary analysis of a nested case–control study of preterm birth (PTB). The exposure was a clinical diagnosis of antenatal depression. The outcome was PTB at <37 weeks classified as SPTB (spontaneous labor, preterm premature rupture of membranes, placental abruption, and cervical shortening); and MPTB (preeclampsia and intrauterine growth restriction). Multinomial logistic regression models compared women without PTB versus MPTB and SPTB, adjusting for age, race, parity, tobacco use, insurance status, and prepregnancy body mass index, and history of PTB for SPTB. Results Among 443 pregnant women, 15.6% had an SPTB and 8.6% had an MPTB, and 16% were diagnosed with antenatal depression. Women with an SPTB were three times more likely to have antenatal depression compared with women without an SPTB (adjusted odds ratio [AOR]: 2.81; 95% confidence interval [CI]: 1.40–5.63). No significant association was identified between antenatal depression and MPTB (AOR: 1.77; 95% CI: 0.67–4.62). The association between antenatal depression and SPTB did not change after adjusting the aforementioned model for a history of PTB and antidepressant use. Conclusion Antenatal depression may differentially affect the risk of PTB through an increase in the odds of SPTB. These results have implications for future studies on prevention and treatment options for depression and PTB.

scholarly journals Fetomaternal outcome in women with hemolysis, elevated liver enzymes and low platelet count syndrome: a retrospective study

2020 ◽  
Vol 9 (9) ◽  
pp. 3798
Author(s):  
M. B. Divya ◽  
Nishi Roshini Kondakasseril ◽  
Mekkattukunnel Andrews Andrews
Keyword(s):  
Platelet Count ◽  
Retrospective Study ◽  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Fetal Mortality ◽  
Variant Form ◽  
Maternal Complications ◽  
Mortality And Morbidity ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count

Background: HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome which is a variant form of severe preeclampsia is an important cause of maternal and fetal mortality and morbidity. The importance lies in the early diagnosis and timely intervention for better fetal and maternal outcome. The objective of this study was to assess the maternal and fetal outcome in pregnancies complicated with HELLP syndrome.Methods: This is a retrospective study analyzing fetomaternal outcome in 63 women diagnosed with HELLP syndrome in the department of obstetrics and gynecology, Government Medical College, Thrissur from 1st January 2014 to 31st December 2016. Details were collected from data records library.Results: Among 7,566 deliveries, 63 women (0.83%) had HELLP syndrome. Mean age was 29.5 years. 47.6% (n=30) women developed HELLP syndrome at gestational age less than 34 weeks. Maternal complications were abruption (27.78%), acute kidney injury (16.67%), DIC (16.67%), sepsis (11.11%) and postpartum hemorrhage (11.11%). In this study, HELLP syndrome lead to one maternal death (1.58%). The perinatal mortality was 25.75%.Conclusions: HELLP syndrome is an alarming complication, which brings high maternal and perinatal morbidity and mortality.

scholarly journals Maternal and foetal outcome in preterm births in a rural tertiary care centre: a retrospective study

2021 ◽  
Vol 11 (1) ◽  
pp. 50
Author(s):  
Deeksha Rao M. ◽  
Vasantha Kumar S.
Keyword(s):  
Retrospective Study ◽  
Preterm Birth ◽  
Tertiary Care ◽  
Preterm Births ◽  
Morbidity And Mortality ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Mortality And Morbidity ◽  
Medical Disorders ◽  
Nicu Admission

Background: Preterm birth (PTB) is one of the main causes of perinatal mortality and morbidity. It can also result in long term health consequences for both mother and the newborn. The objective was to assess maternal and fetal morbidity and mortality in PTBs.Methods: A retrospective study was done in the department of obstetrics and gynecology in a tertiary care hospital during January 2020 and June 2020. Ninety-three women with records of preterm births were analyzed for maternal and fetal outcomes. coGuide statistical software was used for data analysis.Results: 48.39% of the women were between 20 to 24 years of age. The majority (50.54%) were primigravida. The main causes for PTB among the study participants were medical disorders (39.78%), PPROM (29.03%), spontaneous labor without any underlying cause (18.28%). 51.61% had a vaginal delivery, 88.17% had a live birth. The majority of 52 (55.91%) neonates had birth weights between 1.51 to 2.5 kg. Fifty-nine neonates (63.44%) needed NICU admission. The reason for NICU admission in majority 25 (26.88%) was respiratory distress.Conclusions: Timely, early diagnosis and treatment of medical disorders among antenatal women can aid in reducing the occurrence of preterm births and their associated morbidity and mortality. Medical disorders and premature preterm rupture of membrane remain the main causes of preterm birth. 

Early- and Late-Respiratory Outcome in Very Low Birth Weight with or without Intrauterine Inflammation

2020 ◽  
Vol 37 (S 02) ◽  
pp. S76-S83
Author(s):  
Simona Perniciaro ◽  
Jvan Casarin ◽  
Luana Nosetti ◽  
Chiara Binda ◽  
Silvia Salvatore ◽  
...  
Keyword(s):  
Risk Factor ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Spontaneous Preterm Birth ◽  
Mortality And Morbidity ◽  
Respiratory Outcome

Abstract• IUI is a risk factor for spontaneous preterm birth and contributes to prematurity-associated mortality and morbidity.• HCA greatly affected Apgar’s score and lung management of VLBWI at birth and later on with increased incidence of BPD.• HCA + FUN did not significantly impact on respiratory outcome.

Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention

2019 ◽  
Vol 20 (5) ◽  
pp. 354-365 ◽  
Author(s):  
Víctor M. Muñoz-Pérez ◽  
Mario I. Ortiz ◽  
Raquel Cariño-Cortés ◽  
Eduardo Fernández-Martínez ◽  
Leticia Rocha-Zavaleta ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Medicinal Plants ◽  
Low Income ◽  
Experimental Studies ◽  
Neonatal Outcomes ◽  
New Drugs ◽  
Alternative Strategies ◽  
Mortality And Morbidity ◽  
Therapeutic Benefits ◽  
Gynecology And Obstetrics

Background:Worldwide, the progress in reducing neonatal mortality has been very slow. The rate of preterm birth has increased over the last 20 years in low-income and middle-income countries. Its association with increased mortality and morbidity is based on experimental studies and neonatal outcomes from countries with socioeconomic differences, which have considered implementing alternative healthcare strategies to prevent and reduce preterm births.Methods:Currently, there is no widely effective strategy to prevent preterm birth. Pharmacological therapies are directed at inhibiting myometrial contractions to prolong parturition. Some drugs, medicinal plants and microorganisms possess myorelaxant, anti-inflammatory and immunomodulatory properties that have proved useful in preventing preterm birth associated with inflammation and infection.Results:This review focuses on the existing literature regarding the use of different drugs, medicinal plants, and microorganisms that show promising benefits for the prevention of preterm birth associated with inflammation and infection. New alternative strategies involving the use of PDE-4 inhibitors, medicinal plants and probiotics could have a great impact on improving prenatal and neonatal outcomes and give babies the best start in life, ensuring lifelong health benefits.Conclusion:Despite promising results from well-documented cases, only a small number of these alternative strategies have been studied in clinical trials. The development of new drugs and the use of medicinal plants and probiotics for the treatment and/or prevention of preterm birth is an area of growing interest due to their potential therapeutic benefits in the field of gynecology and obstetrics.

Interleukin-6 and Malondialdehyde in Women with Preterm Birth

2019 ◽  
Vol 15 (2) ◽  
pp. 207-212
Author(s):  
Vinita Verma ◽  
Hina Oza ◽  
Riddhi Thaker ◽  
Sunil Kumar
Keyword(s):  
Oxidative Stress ◽  
Preterm Birth ◽  
Interleukin 6 ◽  
Critical Role ◽  
Serum Levels ◽  
Maternal Serum ◽  
Full Term ◽  
Mortality And Morbidity ◽  
Term Birth ◽  
Weak Negative Correlation

Background: Preterm Birth (PTB) is one of the main causes of neonatal death and infant mortality and morbidity. The pro-inflammatory cytokine interleukin-6 (IL-6) is a major proinflammatory mediator of the host response to infection and malondialdehyde (MDA) is a marker of oxidative stress. Objective : To evaluate potential associations between IL-6 and MDA levels in women with preterm birth. Method: A total of 150 women (66 with full-term and 84 with PTB) were enrolled in this case-control study. Predesigned performas were filled through questionnaire interviews to collect data on personal, demographic, occupational, lifestyle and reproductive history. Blood samples were collected within 36 hours of delivery. Serum concentrations of IL-6 and MDA were determined in mothers with full-term and preterm birth. Results: The mean age was marginally higher; whereas BMI was slightly lower in cases (PTB) as compared to controls (full-term) subjects. Serum IL-6 and MDA levels were significantly higher in subjects with PTB than full-term birth. The data were further analyzed with respect to underweight, normal and overweight/obese BMI. In all the BMI categories, the levels of IL-6 and MDA were higher in PTB cases. Among the PTB categories, the levels of IL-6 and MDA were highest in moderate to late preterm birth. A significant positive correlation was found between IL-6 and MDA levels. There was a weak negative correlation between either IL-6 or MDA and the number of gestational weeks. Conclusion : Elevated maternal serum levels of Interleukin-6 and Malondialdehyde in preterm as compared to full-term birth might suggest that inflammation and oxidative stress play a critical role in PTB.

scholarly journals Spontaneous Preterm Birth: Is Prevention with Aspirin Possible?

2021 ◽  
Author(s):  
Richard Berger ◽  
Ioannis Kyvernitakis ◽  
Holger Maul
Keyword(s):  
Preterm Birth ◽  
Low Dose ◽  
Randomized Study ◽  
Preterm Births ◽  
Spontaneous Preterm Birth ◽  
Dose Aspirin ◽  
Nulliparous Women ◽  
Low Dose Aspirin ◽  
Secondary Analyses ◽  
Double Blinded

Abstract Background The rate of preterm births in Germany is 8.6%, which is very high compared to other European countries. As preterm birth contributes significantly to perinatal morbidity and mortality rates, the existing prevention strategies need to be optimized and expanded further. About ⅔ of all women with preterm birth have preterm labor or premature rupture of membranes. They are bracketed together under the term “spontaneous preterm birth” as opposed to iatrogenic preterm birth, for example as a consequence of preeclampsia or fetal growth retardation. Recent studies suggest that low-dose aspirin does not just reduce the rate of iatrogenic preterm births but can also further reduce the rate of spontaneous preterm births. This review article presents the current state of knowledge. Method A selective literature search up until April 2020 was done in PubMed, using the terms “randomized trial”, “randomized study”, “spontaneous preterm birth”, and “aspirin”. Results Secondary analyses of prospective randomized studies on the prevention of preeclampsia with low-dose aspirin show that this intervention also significantly reduced the rate of spontaneous preterm births in both high-risk and low-risk patient populations. The results of the ASPIRIN trial, a prospective, randomized, double-blinded multicenter study carried out in six developing countries, also point in this direction, with the figures showing that the daily administration of 81 mg aspirin starting before 14 weeks of gestation lowered the preterm birth rate of nulliparous women without prior medical conditions by around 11% (11.6 vs. 13.1%; RR 0.89; 95% CI: 0.81 – 0.98, p = 0.012). Conclusion Further studies on this issue are urgently needed. If these confirm the currently available results, then it would be worth discussing whether general aspirin prophylaxis for all pregnant women starting at the latest in 12 weeks of gestation is indicated.

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