scholarly journals WHY CRIMINAL CULPABILITY SHOULD FOLLOW THE CRITICAL PATH: REFRAMING THE THEORY OF ‘EFFECTIVE CONTROL’

2009 ◽  
Vol 40 ◽  
pp. 3-73 ◽  
Author(s):  
Michael A. Newton ◽  
Casey Kuhlman
Author(s):  
V. J. Wright ◽  
R. E. Seymour ◽  
N. D. Norris

The C.E.G.B. operates 230 power stations of various ages and output capacities representing a total capital investment of some £2400 million. The steam conditions, sizes of generating units, and complexity of the installed plant reflect the stage of technical development at the time of their construction. These factors influence the cost of production at individual stations as also do the nature and cost of fuel. The economic level of maintenance at each station is thus dependent upon a number of factors and must generally be established locally. This places an obligation on the maintenance engineer to collect and consider economic, in addition to technical, data. Also, service experience must be fed back to the design engineer so that future plant designs may be improved. Unless a simple and effective control system is employed paper work can become an intolerable burden. Power station maintenance can be broadly divided between: (1) work which can only be carried out while a generating unit is shut down; (2) work which can be carried out with the main plant on load. The first category has received the greatest attention, since the cost of keeping a modern generator out of service can be substantial. Planning of this work is based on Critical Path Analysis techniques which are now well known and widely practised. However, the day-to-day maintenance of a large variety of auxiliary plant also presents a heavy planning burden upon the maintenance department. The basic minimum requirements for the effective local control of this work have been examined, while the most economic methods of: (a) co-ordinating maintenance in a number of stations in the best national interest, and (b) ensuring that service experience is fed back to design engineers are also receiving attention.


2020 ◽  
Vol 3 (2) ◽  
pp. 74-91
Author(s):  
Wasito Wasito ◽  
Ahmad Yani Syaikhudin

The process of planning and project control during the execution of the construction project work is an important part of the project. Because time is limited by the project management work schedules are determined so that the leaders involved in the project should be able to anticipate changes in conditions. The failure of a project can be caused by poor planning and control are less effective, so that the project activity is not efficient. Doing so may result in delay time, declining quality, and the rising cost of implementation. Conversely, careful planning and effective control will bring the project to success.Critical path method (CPM) is one option that is right for project management to control the project completion time effective and efficient. In order to reduce the impact of delays and cost overruns of the project budget can be done with three alternative acceleration process control; (I) Addition of labor, (ii) Overtime, (iii) Subcontract. Acceleration duration is done on the works is in the critical path.


Author(s):  
H.M. Mazzone ◽  
G. Wray ◽  
R. Zerillo

The fungal pathogen of the Dutch elm disease (DED), Ceratocystis ulmi (Buisman) C. Moreau, has eluded effective control since its introduction in the United States more than sixty years ago. Our studies on DED include establishing biological control agents against C. ulmi. In this report we describe the inhibitory action of the antibiotic polymyxin B on the causal agent of DED.In screening a number of antibiotics against C. ulmi, we observed that filter paper discs containing 300 units (U) of polymyxin B (Difco Laboratories) per disc, produced zones of inhibition to the fungus grown on potato dextrose agar or Sabouraud agar plates (100mm x 15mm), Fig. 1a. Total inhibition of fungal growth on a plate occurred when agar overlays containing fungus and antibiotic (polymyxin B sulfate, ICN Pharmaceuticals, Inc.) were poured on the underlying agar growth medium. The agar overlays consisted of the following: 4.5 ml of 0.7% agar, 0.5 ml of fungus (control plate); 4.0 ml of 0.7% agar, 0.5 ml of fungus, 0.5 ml of polymyxin B sulfate (77,700 U). Fig. 1, b and c, compares a control plate and polymyxin plate after seven days.


Author(s):  
Betty Ruth Jones ◽  
Steve Chi-Tang Pan

INTRODUCTION: Schistosomiasis has been described as “one of the most devastating diseases of mankind, second only to malaria in its deleterious effects on the social and economic development of populations in many warm areas of the world.” The disease is worldwide and is probably spreading faster and becoming more intense than the overall research efforts designed to provide the basis for countering it. Moreover, there are indications that the development of water resources and the demands for increasing cultivation and food in developing countries may prevent adequate control of the disease and thus the number of infections are increasing.Our knowledge of the basic biology of the parasites causing the disease is far from adequate. Such knowledge is essential if we are to develop a rational approach to the effective control of human schistosomiasis. The miracidium is the first infective stage in the complex life cycle of schistosomes. The future of the entire life cycle depends on the capacity and ability of this organism to locate and enter a suitable snail host for further development, Little is known about the nervous system of the miracidium of Schistosoma mansoni and of other trematodes. Studies indicate that miracidia contain a well developed and complex nervous system that may aid the larvae in locating and entering a susceptible snail host (Wilson, 1970; Brooker, 1972; Chernin, 1974; Pan, 1980; Mehlhorn, 1988; and Jones, 1987-1988).


2019 ◽  
Vol 7 (1) ◽  
pp. 256-259
Author(s):  
P.Balasowandari ◽  
Dr. V.Anusuya

2019 ◽  
Vol 2 (5) ◽  
Author(s):  
Tong Wang

The compaction quality of the subgrade is directly related to the service life of the road. Effective control of the subgrade construction process is the key to ensuring the compaction quality of the subgrade. Therefore, real-time, comprehensive, rapid and accurate prediction of construction compaction quality through informatization detection method is an important guarantee for speeding up construction progress and ensuring subgrade compaction quality. Based on the function of the system, this paper puts forward the principle of system development and the development mode used in system development, and displays the development system in real-time to achieve the whole process control of subgrade construction quality.


Author(s):  
Totska Olesia ◽  
Glovatsky Anastasia

The purpose of the article is to plan a project of an electric vehicle technicalassistance point. the methodology of the study is to use the critical path method.the scientific novelty of the obtained results is that the article describes the practicalaspects of project planning of the creation of an electric vehicle technical assistancepoint. In particular, the tasks of the project are described, labor, material and financialresources necessary for its realization are specified. conclusions. The implementationof the developed project will effectively manage the content, time and resources ofthe project of the creation of an electric vehicle technical assistance point.


Author(s):  
Tazia Irfan ◽  
Mainul Haque ◽  
Sayeeda Rahman ◽  
Russell Kabir ◽  
Nuzhat Rahman ◽  
...  

Breast cancer remains one of the major causes of death in women, and endocrine treatment is currently one of the mainstay of treatment in patients with estrogen receptor positive breast cancer. Endocrine therapy either slows down or stops the growth of hormone-sensitive tumors by blocking the body’s capability to yield hormones or by interfering with hormone action. In this paper, we intended to review various approaches of endocrine treatments for breast cancer highlighting successes and limitations. There are three settings where endocrine treatment of breast cancer can be used: neoadjuvant, adjuvant, or metastatic. Several strategies have also been developed to treat hormone-sensitive breast cancer which include ovarian ablation, blocking estrogen production, and stopping estrogen effects. Selective estrogen-receptor modulators (SERMs) (e.g. tamoxifen and raloxifene), aromatase inhibitors (AIs) (e.g. anastrozole, letrozole and exemestane), gonadotropin-releasing hormone agonists (GnRH) (e.g. goserelin), and selective estrogen receptor downregulators (SERDs) (e.g. fulvestrant) are currently used drugs to treat breast cancer. Tamoxifen is probably the first targeted therapy widely used in breast cancer treatment which is considered to be very effective as first line endocrine treatment in previously untreated patients and also can be used after other endocrine therapy and chemotherapy. AIs inhibit the action of enzyme aromatase which ultimately decrease the production of estrogen to stimulate the growth of ER+ breast cancer cells. GnRH agonists suppress ovarian function, inducing artificial menopause in premenopausal women. Endocrine treatments are cheap, well-tolerated and have a fixed single daily dose for all ages, heights and weights of patients. Endocrine treatments are not nearly as toxic as chemotherapy and frequent hospitalization can be avoided. New drugs in preliminary trials demonstrated the potential for improvement of the efficacy of endocrine therapy including overcoming resistance. However, the overall goals for breast cancer including endocrine therapy should focus on effective control of cancer, design personalized medical therapeutic approach, increase survival time and quality of life, and improve supportive and palliative care for end-stage disease.


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