Considering the Relationship Between Biological Aging and Cognitive Aging

2000 ◽  
Vol 6 (6) ◽  
pp. 736-737
Author(s):  
Judith Saxton
Keyword(s):  
Older People ◽  
Cognitive Aging ◽  
Aging Process ◽  
Close Association ◽  
Biological Aging ◽  
Biological Processes ◽  
Technological Changes ◽  
Neuropsychological Changes ◽  
The Relationship ◽  
Dementing Disorders

The psychological and neuropsychological changes of aging and dementia have been a topic of study for decades, if not centuries. It is only more recently, however, that technological changes have allowed the biological processes triggering the changes of aging to be uncovered. The overlap between these two sciences, namely, the relationship between cognitive aging and the study of biological aging, is an emerging area of research. The study of aging, however, is confounded by the close association between aging and the development of particular diseases. Older people are far more likely than young people to suffer from multiple illnesses. Furthermore, older people are far more vulnerable to specific types of diseases such as heart disease, cancer, and dementia. The relationship between the onset of the aging process and the development of dementing disorders such as Alzheimer's disease is of particular interest.

Considering the Relationship Between Biological Aging and Cognitive Aging

1999 ◽  
Vol 5 (7) ◽  
pp. 706-706
Author(s):  
Judith Saxton
Keyword(s):  
Older People ◽  
Cognitive Aging ◽  
Aging Process ◽  
Close Association ◽  
Biological Aging ◽  
Biological Processes ◽  
Technological Changes ◽  
Neuropsychological Changes ◽  
The Relationship ◽  
Dementing Disorders

The psychological and neuropsychological changes of aging and dementia have been a topic of study for decades, if not centuries. It is only more recently, however, that technological changes have allowed the biological processes triggering the changes of aging to be uncovered. The overlap between these two sciences, the relationship between cognitive aging and the study of biological aging, is an emerging area of research. The study of aging, however, is confounded by the close association between aging and the development of particular diseases. Older people are far more likely than young people to suffer from multiple illnesses. Furthermore, older people are far more vulnerable to specific types of diseases such as heart disease, cancer, and dementia. The relationship between the onset of the aging process and the development of dementing disorders such as Alzheimer's disease is of particular interest.

scholarly journals Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?

2020 ◽  
Vol 50 (6) ◽  
pp. 1504-1512
Author(s):  
Güler ÖZTÜRK ◽  
Kazime Gonca AKBULUT ◽  
Şevin GÜNEY
Keyword(s):  
Aging Process ◽  
Biological Process ◽  
The Elderly ◽  
The Body ◽  
Biological Processes ◽  
Therapeutic Approaches ◽  
Free Radical Reactions ◽  
Age Related ◽  
The Relationship ◽  
Age Related Changes

The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions.Melatoninrhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline is associated with several age-related diseases. Aging is closely associated with oxidative damage and mitochondrial dysfunction. Free radical reactions initiated by the mitochondria constitute the inherent aging process. Melatonin plays a pivotal role in preventing age-related oxidative stress. Coronavirus disease 2019 (COVID-19) fatality rates increase with chronic diseases and age, where melatonin levels decrease. For this reason, melatonin supplementation in elderly could be beneficial in COVID-19 treatment. Therefore, studies on the usage of melatonin in COVID-19 treatment are needed.

scholarly journals Socioeconomic Status, Biological Aging, and Memory in a Diverse National Sample of Older US Men and Women

2021 ◽  
Author(s):  
Justina F Avila ◽  
Indira Turney ◽  
Precious Esie ◽  
Jet M. J. Vonk ◽  
Vanessa Weir ◽  
...  
Keyword(s):  
Older Adults ◽  
Dna Methylation ◽  
Socioeconomic Status ◽  
Cognitive Aging ◽  
Memory Performance ◽  
National Sample ◽  
Biological Aging ◽  
White People ◽  
Men And Women ◽  
The Relationship

Importance: Exposure to socioeconomic disadvantage is associated with rapid cognitive aging. Biological aging, the progressive loss of system integrity that occurs as we age is proposed as a modifiable process mediating this health inequality. Objective: To test the hypothesis that socioeconomic disparities in cognitive aging in older adults is explained by accelerated biological aging. Design: Observational cohort study. Setting: U.S. Health and Retirement Study DNA-methylation sub-study. Participants: N=3,648 (49% male) adults aged 50-100 (M=70, SD=10) with DNA methylation data. Exposures: Socioeconomic status (SES) was measured from years of education and household wealth. The extent and pace of biological aging were quantified using three DNA-methylation measures: PhenoAge, GrimAge, and DunedinPoAm. Main Outcomes and Measures: Cognitive aging was measured from repeated longitudinal assessments of immediate and delayed word recall. Latent growth curve modeling estimated participants level of memory performance and rate of decline over 2-11 follow-up assessments spanning 2-20 years. Models were estimated to assess whether the relationship between SES and memory trajectories was mediated by biological aging. Results: Older adults with lower SES had lower memory performance, faster decline and exhibited accelerated biological aging (SES β=.33, 99% CI[.30-.36], biological-aging measure effect size associations ranged from .08 to .20). Accelerated biological aging was associated with decreased memory performance and faster memory decline (effect-size range .03 to .18). Higher SES was associated with slower biological aging for White and Black men and women, but not Latinx participants. The relationship between biological aging measures and memory was weaker for Black and Latinx participants compared with White people. In mediation analysis, biological aging accounted for 3-9% of the SES-memory gradient in White participants. There was no evidence of mediation in Black or Latinx participants. Conclusions and Relevance: Among a national sample of older adults, DNA-methylation measures of biological aging were associated with memory trajectories in White, but not Black or Latinx older adults. These results challenge the assumption that DNA-methylation biomarkers of aging that were developed in primarily White people can quantify aging processes affecting cognition in Black and Latinx older adults.

The Relationship Between Antioxidant Nutrient Intake and Cataracts in Older People

2006 ◽  
Vol 76 (6) ◽  
pp. 359-366 ◽  
Author(s):  
Rodríguez-Rodríguez ◽  
Ortega ◽  
López-Sobaler ◽  
Aparicio ◽  
Bermejo ◽  
...  
Keyword(s):  
Vitamin C ◽  
Older People ◽  
Dietary Intake ◽  
Protective Effect ◽  
Elderly People ◽  
Nutrient Intake ◽  
Institutionalized Elderly ◽  
Weighing Method ◽  
The Relationship

This study investigated the relationship between the intake of antioxidant nutrients and the suffering of cataracts in 177 institutionalized elderly people (61 men and 116 women) aged ≥ 65 years. Dietary intake was monitored for 7 consecutive days using a "precise individual weighing" method. Subjects, who during their earlier years were exposed by their work to sunlight, had a greater risk of suffering cataracts (OR = 3.2; Cl: 1.1–9.3, P < 0.05) than those who worked indoors. A relationship was found between increased vitamin C intake and a reduced prevalence of cataracts (i.e., when comparing those above P95 for vitamin C intake with those below P5; (OR = 0.08; Cl: 0.01–0.75, P 0.05). Among subjects with cataracts, 12.1% had vitamin C intakes of < 61 mg/day (P10) and only 2.2% had intakes of > 183 mg/day (P95) (p < 0.01). Subjects who consumed > 3290 μg/day (P95) of lutein were less likely to have cataracts (OR = 0.086; Cl: 0.007–1.084; p < 0.05) than those whose consumption was < 256 μg/day (P5). In men, high intakes of zeaxanthin seemed to provide a protective effect against the problem (OR = 0.96; Cl: 0.91–0.99; p < 0.05). The results suggest an association exists between exposure to sunlight and the development of cataracts, and that vitamin C, lutein, and zeaxanthin offer some protection against this disorder.

NEUROPSYCHOLOGICAL CHANGES IN PATIENTS WITH A CONSEQUENCE OF TRAUMATIC BRAIN INJURY

2020 ◽  
Vol 3 (1) ◽  
pp. 44-46
Author(s):  
Istatillo Shodjalilov ◽  
◽  
Saoda Igamova ◽  
Aziza Djurabekova
Keyword(s):  
Traumatic Brain Injury ◽  
Cognitive Impairment ◽  
Brain Injury ◽  
Neuropsychological Testing ◽  
Anxiety And Depression ◽  
Psychopathological Symptoms ◽  
Neuropsychological Changes ◽  
The Relationship

The incidence of cognitive impairment in TBI is high, depending on the severity. At the same time, psychopathological symptoms in the form of asthenia, increased anxiety and depression are encountered among patients with TBI. The work studied the relationship between cognitive and psychopathological symptoms in patients with TBI using neuropsychological testing on scales.

Oral health diseases among the older people: a general health perspective

2020 ◽  
Keyword(s):  
Public Health ◽  
Health Care ◽  
Oral Health ◽  
Older People ◽  
Health Professionals ◽  
General Health ◽  
Oral Health Care ◽  
Oral Diseases ◽  
Public Health Professionals ◽  
The Relationship

Background: The relationship between oral health and general health is gaining interest in geriatric research; however, a lack of studies dealing with this issue from a general perspective makes it somewhat inaccessible to non-clinical public health professionals. Purpose: The purpose of this review is to describe the relationship between oral health and general health of the elderly on the basis of literature review, and to give non-clinical medical professionals and public health professionals an overview of this discipline. Methods: This study was based on an in-depth review of the literature pertaining to the relationship between oral health and general health among the older people. The tools commonly used to evaluate dental health and the academic researches of male elderly people were also reviewed. And future research directions were summarized. Results: Dental caries, periodontal disease, edentulism, and xerostomia are common oral diseases among the older people. Dental caries and periodontal diseases are the leading causes of missing teeth and edentulism. Xerostomia, similar to dry mouth, is another common oral health disease in the older people. No clear correlation exists between the subjective feeling of dryness and an objective decrease of saliva. Rather, both conditions can be explained by changes in saliva. The General Oral Health Assessment Index (GOHAI) and the Oral Health Impact Profile (OHIP) are the main assessment tools used to examine oral health and quality of life in the older people. The GOHAI tends to be more sensitive to objective values pertaining to oral function. In addition, oral health studies in male elderly people are population-based cohort or cross-sectional studies, involving masticatory function, oral prevention, frailty problems, cardiovascular disease risk, and cognitive status. Conclusion: It is possible to reduce the incidence of certain oral diseases, even among individuals who take oral health care seriously. Oral health care should be based on the viewpoint of comprehensive treatment, including adequate nutrition, good life and psychology, and correct oral health care methods. In the future, researchers could combine the results of meta-analysis with the clinical experience of doctors to provide a more in-depth and broader discussion on oral health research topics concerning the older people.

HUBUNGAN KONDISI FISIK, PSIKOLOGIS, DAN SOSIAL LANJUT USIA DENGAN DISABILITAS FUNGSIONAL LANJUT USIA DI YOGYAKARTA

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Catur Hary Wibawa
Keyword(s):  
Older People ◽  
Physical Condition ◽  
Social Condition ◽  
Psychological Condition ◽  
High Category ◽  
Correlational Design ◽  
Functional Disabilities ◽  
Relationship Of ◽  
Spearman Test ◽  
The Relationship

Abstract This research aims to reveal 1. the condition of older people who lives in Plosokerep Shleter, 2. the psychological condition of older people in Plosokerep Shelter, 3. the social condition of older people in Plosokerep Shelter, 4. the relationship of physical condition experienced by older people with their functional disabilities in Plosokerep Shelter, 5. the relationship of psychological condition experienced by older people with their functional disabilities in Plosokerep Shleter, 6. to know the relatonship of social condition experienced by older people with their functional disabilities in Plosokerep Shelter. The research method used is explanatory-analytic correlational design, to examine the relationship of factors: Physical (X1 variable), Psychological (X2), and social (X3) with older people functional disabilities (Y variable) descriptive survey used explanatory-analytic correlational design. Data collection carried out through questionnaire. Research data analysis used descriptive statistic technique with Spearman test statistic. The result showed that: 1. some older people in Plosokerep shleter have high physical condition and the rest of them in the low physical condition category, 2. from the psychological condition some of older people are in high category, 3. Social condition experienced by older people who live in shelter are in high category, 4. The relationship of physical condition experienced by older people in the shelter with functional disabilities even though there is a correlation but not significant, 5. the relationship of psychological condition experienced by older people in shleter with functional disabilities even though there is a correlation but not significant, 6. the relationship of social condition experienced by older people in the shelter with functional disabilities even though there is a correlation but not significant, 7. the relationship of Physical, psychological and social condition together with functional disabilities even though there is a correlation but not significant.Keywords: physical, psychological, and social condition, functional disabilities, older people Abstrak Penelitian ini bertujuan untuk mengungkapkan: 1. Mengetahui kondisi fisik lanjut usia yang ada di shelter Plosokerep, 2. Mengetahui kondisi psikologis lanjut usia yang ada di shelter Plosokerep, 3. Mengetahui kondisi sosial lanjut usia yang ada di shelter Plosokerep, 4. Mengetahui hubungan kondisi fisik yang dialami lanjut usia dengan disabilitas fungsionalnya selama tinggal di shelter Plosokerep, 5. Mengetahui hubungan kondisi psikologis yang dialami lanjut usia dengan disabilitas fungsionalnya selama tinggal di shelter Plosokerep, 6. Mengetahui hubungan kondisi sosial yang dialami lanjut usia dengan disabilitas fungsionalnya selama tinggal di shelter Plosokerep.Metode penelitian yang digunakan adalah disain korelasional eksplanatori-analitis, yaitu untuk menguji hubungan antara faktor-faktor: fisik (variabel X1), psikologis (X2), dan sosial (X3) dengan disabilitas fungsional lanjut usia (variabel Y)survey deskriptif dengan menggunakan disain penelitian korelasional eksplanatori-analitis. Teknik pengumpulan data dilakukan melalui kuesioner. Analisis data penelitian menggunakan teknik Statistik deskriptif, dengan statistik uji Spearman.Hasil penelitian menunjukkan bahwa: 1. Sebagian lanjut usia di shelter pengungsian Plosokerep memiliki kondisi fisik kategori tinggi, dan sebagian lagi berada dalam kondisi fisik kategori rendah, 2. Dilihat dari kondisi psikologis, sebagian besar lanjut usia berada dalam kategori tinggi, 3. Kondisi sosial yang dialami lanjut usia selama berada di shelter pengungsian, sebagian besar juga berada dalam kategori tinggi, 4. Hubungan kondisi fisik yang dialami lanjut usia selama berada di shelter pengungsian dengan disabilitas fungsional, meskipun terdapat korelasi tetapi tidak signifikan, 5. Hubungan kondisi psikologis yang dialami lanjut usia selama berada di shelter pengungsian dengan disabilitas fungsional, meskipun terdapat korelasi tetapi tidak signifikan, 6. Hubungan kondisi sosial yang dialami lanjut usia selama berada di shelter pengungsian dengan disabilitas fungsional, meskipun terdapat korelasi tetapi tidak signifikan, 7. Hubungan kondisi fisik, psikologis, dan sosial secara bersama-sama dengan disabilitas fungsional, meskipun terdapat korelasi tetapi tidak signifikan.Kata kunci:  disabilitas fungsional, kondisi fisik, psikologis, dan sosial, lanjut usia

A FORECAST OF PRODUCTIVE LONGEVITY OF HOLSTEIN COWS BY INDIRECT SIGNS

2020 ◽  
Author(s):  
З.С. САНОВА
Keyword(s):  
Correlation Coefficient ◽  
Aging Process ◽  
Direct Relationship ◽  
Stability Index ◽  
Age At First Calving ◽  
Group I ◽  
Predicted Values ◽  
The Stability ◽  
Relationship Of ◽  
The Relationship

В статье представлены материалы о взаимосвязи продолжительности продуктивного использования коров с характеристикой устойчивости к деградации, с возрастом отела и удоем. В исследованной, разнородной по происхождению, группе животных для прогноза продуктивного периода коров, обусловленного устойчивостью к деградации и возрастом первого отела, пригодно уравнение регрессии, аргументами в котором являются индекс устойчивости, возраст первого отела в первой и второй степенях. Коэффициент корреляции межу предсказанными значениями продуктивного периода и его фактическими величинами в I группе составляет 0,502, во II - 0,604. При этом крайние варианты прогнозируются со статистическими ошибками 5 мес при оценке индекса устойчивости по 2 лактациям и 4,1 мес по 3, а средние варианты, соответственно, 1,6 и 1,51 мес. Индекс устойчивости к процессу старения является важной характеристикой биологических особенностей коров, определяющий их продуктивное долголетие. Его оценка по первым 2 и 3 лактациям имеет прямолинейную связь с продуктивным периодом (r=0,4109 и r=0,5270), соответственно. Зависимость продуктивного периода от возраста первого отела криволинейная — с увеличением возраста первого отела сокращается срок продуктивного использования, при возрасте первого отела более 1400 дней срок продуктивного использования колеблется от 1,33 до 1,41 лактации. Коэффициент корреляции между этими характеристиками коров составляет - 0,2164 в I и - 0,2620 во II группах. The article presents materials about the relationship of the duration of productive use of cows with the characteristic of resistance to degradation, with the age of calving and milk yield. In the studied group of animals, which is heterogeneous in origin, the regression equation is suitable for predicting the productive period of cows due to resistance to degradation and the age of the first calving, the arguments of which are the stability index, the age of the first calving in the first and second degrees. The correlation coefficient between the predicted values of the productive period and its actual values in group I is 0.502, in group II - 0.604. At the same time, the extreme variants are predicted with statistical errors of 5 months when evaluating the stability index for 2 lactations and 4.1 months for 3, and the average variants, respectively, are 1.6 and 1.51 months. The index of resistance to the aging process is an important characteristic of the biological characteristics of cows, which determines their productive longevity. Its estimate for the first 2 and 3 lactations has a direct relationship with the productive period (r=0.4109 and r=0.5270), respectively. The dependence of the productive period age at first calving curvilinear with increasing age at first calving reduces the time to productive use, while age at first calving of more than 1400 days, the period of productive use ranges from 1.33 to 1.41 lactation. The correlation coefficient between these characteristics of cows is-0.2164 in I and-0.2620 in II groups.

Sunlight exposure: the effects on the performance of paragliding fabric

2018 ◽  
Vol 69 (05) ◽  
pp. 381-389
Author(s):  
MENGÜÇ GAMZE SÜPÜREN ◽  
TEMEL EMRAH ◽  
BOZDOĞAN FARUK
Keyword(s):  
Mechanical Properties ◽  
Aging Process ◽  
Air Permeability ◽  
Sunlight Exposure ◽  
Test Results ◽  
Coating Materials ◽  
Strength Tests ◽  
Before And After ◽  
The Relationship ◽  
Dark Blue

This study was designed to explore the relationship between sunlight exposure and the mechanical properties of paragliding fabrics which have different colors, densities, yarn counts, and coating materials. This study exposed 5 different colors of paragliding fabrics (red, turquoise, dark blue, orange, and white) to intense sunlight for 150 hours during the summer from 9:00 a.m. to 3:00 p.m. for 5 days a week for 5 weeks. Before and after the UV radiation aging process, the air permeability, tensile strength, tear strength, and bursting strength tests were performed. Test results were also evaluated using statistical methods. According to the results, the fading of the turquoise fabric was found to be the highest among the studied fabrics. It was determined that there is a significant decrease in the mechanical properties of the fabrics after sunlight exposure. After aging, the fabrics become considerably weaker in the case of mechanical properties due to the degradation in both the dyestuff and macromolecular structure of the fiber

CASC15：A tumor-associated long non-coding RNA

2020 ◽  
Vol 26 ◽  
Author(s):  
Bei Wang ◽  
Wen Xu ◽  
Yuxuan Cai ◽  
Chong Guo ◽  
Gang Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Therapeutic Target ◽  
Cancer Colorectal ◽  
Tumor Development ◽  
Pathophysiological Mechanism ◽  
Biological Processes ◽  
Non Coding Rna ◽  
Cancer Côlon ◽  
The Relationship ◽  
Long Non Coding Rna

Background: CASC15, one of long non-coding RNA, is involved in the regulation of many tumor biological processes, and is expected to become a new biological therapeutic target. This paper aims to elucidate the pathophysiological function of CASC15 in various tumors. Methods: The relationship between CASC15 and tumors was analyzed by searching references, and summarizes the specific pathophysiological mechanism of CASC15. Results: LncRNA CASC15 is closely related to tumor development, and has been shown to be abnormally high expressed in all kinds of tumors, including breast cancer, cervical cancer, lung cancer, hepatocellular carcinoma, gastric cancer, bladder cancer, colon cancer, colorectal cancer, cardiac hypertrophy, intrahepatic cholangiocarcinoma, leukemia, melanoma, tongue squamous cell carcinoma, nasopharyngeal carcinoma. However, CASC15 has been found to be downexpressed abnormally in ovarian cancer, glioma and neuroblastoma. Besides, it is identified that CASC15 can affect the proliferation, invasion and apoptosis of tumors. Conclusion: LncRNA CASC15 has the potential to become a new therapeutic target or marker for a variety of tumors.

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