Periconceptional seafood intake and pregnancy complications

AbstractObjectiveTo investigate associations of maternal periconceptional shellfish, lean fish and fatty fish intake with risk of pregnancy complications.DesignIn this prospective cohort study, we collected information on intake of seafood subtypes using FFQ. We categorized seafood intake into frequencies of <0·2 servings/month, 0·2 servings/month–<0·5 servings/week, 0·5–1·0 servings/week and >1 servings/week. We ascertained gestational hypertension, pre-eclampsia, gestational diabetes and preterm birth diagnoses from medical records. Using generalized linear models with a log link, the Poisson family and robust standard errors, we estimated risk ratios and 95 % confidence intervals across seafood intake categories.SettingThe Omega study, a study of risk factors for pregnancy complications among women recruited from prenatal clinics in Washington State, USA, 1996–2008.SubjectsThe current study included 3279 participants from the Omega study.ResultsMedian (interquartile range) shellfish, lean fish and fatty fish intake was 0·3 (0–0·9), 0·5 (0–1·0) and 0·5 (0·1–1·0) servings/week, respectively. Lean fish intake of >1 servings/week (v. <0·2 servings/month) was associated with a 1·55-fold higher risk of preterm birth (95 % CI 1·04, 2·30) and was not associated with the other pregnancy complications. Higher intake of seafood (total or other subtypes) was not associated with pregnancy complications (separately or combined).ConclusionsHigher intake of lean fish, but not fatty fish or shellfish, was associated with a higher risk of preterm birth; these findings may have significance for preterm birth prevention. Studies of mechanisms and potential contributing factors (including seafood preparation and nutrient/contaminant content) are warranted.

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Dietary Data in the Malmö Offspring Study–Reproducibility, Method Comparison and Validation against Objective Biomarkers

Nutrients ◽

10.3390/nu13051579 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1579

Author(s):

Sophie Hellstrand ◽

Filip Ottosson ◽

Einar Smith ◽

Louise Brunkwall ◽

Stina Ramne ◽

...

Keyword(s):

Fruits And Vegetables ◽

Method Comparison ◽

Principal Component ◽

Fish Intake ◽

Dietary Intakes ◽

Food Groups ◽

Food Record ◽

Fatty Fish ◽

Lean Fish ◽

Β Carotene

Irregular dietary intakes impairs estimations from food records. Biomarkers and method combinations can be used to improve estimates. Our aim was to examine reproducibility from two assessment methods, compare them, and validate intakes against objective biomarkers. We used the Malmö Offspring Study (55% women, 18–71 y) with data from a 4-day food record (4DFR) and a short food frequency questionnaire (SFFQ) to compare (1) repeated intakes (n = 180), (2) intakes from 4DFR and SFFQ (n = 1601), and (3) intakes of fatty fish, fruits and vegetables, and citrus with plasma biomarkers (n = 1433) (3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid [CMPF], β-carotene and proline betaine). We also combined 4DFR and SFFQ estimates using principal component analysis (PCA). Moderate correlations were seen between repeated intakes (4DFR median ρ = 0.41, SFFQ median ρ = 0.59) although lower for specific 4DFR-items, especially fatty/lean fish (ρ ≤ 0.08). Between-method correlations (median ρ = 0.33) were higher for intakes of overall food groups compared to specific foods. PCA scores for citrus (proline betaine ρ = 0.53) and fruits and vegetables (β-carotene: ρ = 0.39) showed the highest biomarker correlations, whereas fatty fish intake from the SFFQ per se showed the highest correlation with CMPF (ρ = 0.46). To conclude, the reproducibility of SFFQ data was superior to 4DFR data regarding irregularly consumed foods. Method combination could slightly improve fruit and vegetable estimates, whereas SFFQ data gave most valid fatty fish intake.

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Exploration of biomarkers for total fish intake in pregnant Norwegian women

Public Health Nutrition ◽

10.1017/s1368980009005904 ◽

2009 ◽

Vol 13 (1) ◽

pp. 54-62 ◽

Cited By ~ 54

Author(s):

Anne Lise Brantsæter ◽

Margaretha Haugen ◽

Yngvar Thomassen ◽

Dag G Ellingsen ◽

Trond A Ydersbond ◽

...

Keyword(s):

Multivariate Analyses ◽

Arsenic Concentration ◽

Positive Association ◽

Fish Intake ◽

Food Groups ◽

Food Diary ◽

Fatty Fish ◽

Lean Fish ◽

Mother And Child ◽

Total Fish

AbstractObjectiveFew biomarkers for dietary intake of various food groups have been established. The aim of the present study was to explore whether selenium (Se), iodine, mercury (Hg) or arsenic may serve as a biomarker for total fish and seafood intake in addition to the traditionally usedn-3 fatty acids EPA and DHA.DesignIntake of fish and seafood estimated by an FFQ was compared with intake assessed by a 4 d weighed food diary and with biomarkers in blood and urine.SettingValidation study in the Norwegian Mother and Child Cohort Study (MoBa).SubjectsOne hundred and nineteen women.ResultsTotal fish/seafood intake (median 39 g/d) calculated with the MoBa FFQ was comparable to intake calculated by the food diary (median 30 g/d,rS= 0·37,P< 0·001). Erythrocyte DHA and blood Hg, Se and arsenic concentrations were positively correlated with intake of fish and seafood, but the association for DHA was weakened by the widespread use of supplements. The main finding was the consistent positive association between the intake of fish/seafood and blood arsenic concentration. In multivariate analyses, blood arsenic was associated with blood Hg and fish and seafood intake. In these models, arsenic turned out to be the best indicator of intake of fish and seafood, both totally and in subgroups of fish/seafood intake.ConclusionsWhile DHA reflected the intake of fatty fish andn-3 PUFA supplements, blood arsenic concentration also reflected the intake of lean fish and seafood. Blood arsenic appears to be a useful biomarker for total fish and seafood intake.

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High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: a randomised trial

British Journal Of Nutrition ◽

10.1017/s0007114517001234 ◽

2017 ◽

Vol 117 (10) ◽

pp. 1368-1378 ◽

Cited By ~ 15

Author(s):

Anita Helland ◽

Marianne Bratlie ◽

Ingrid V. Hagen ◽

Svein A. Mjøs ◽

Steinar Sørnes ◽

...

Keyword(s):

Ex Vivo ◽

Randomised Trial ◽

Postprandial Glucose ◽

Fish Intake ◽

Glucose Regulation ◽

Control Group ◽

Fatty Fish ◽

Obese Adults ◽

High Intake ◽

Lean Fish

AbstractThe prevalence of type 2 diabetes (T2D) is low in populations with a high fish intake; however prospective studies with fish intake have shown positive, negative or no association between fish intake and the risk for T2D. The aim of this study was to investigate the effects of high intake of lean or fatty fish on glucose tolerance, leucocyte membrane fatty acid composition and leucocyte function in overweight/obese adults. In this randomised clinical trial, sixty-eight healthy overweight/obese participants consumed 750 g/week of either lean or fatty fish as dinners, or were instructed to continue their normal eating habits but to avoid fish intake (control group), for 8 weeks. Energy and macronutrient intake and physical activity were not changed within the groups during the study period. High intake of fatty fish, but not of lean fish, significantly improved glucose regulation 120 min postprandially (P=0·012), but did not affect fasting glucose concentration. A smaller increase in fasting to 120 min postprandial insulin C-peptide concentration was seen after fatty fish intake (P=0·012). Lean fish increased the DHA content in leucocyte membranes (P=0·010), and fatty fish increased the total content of n-3 PUFA (P=0·00016) and reduced the content of n-6 PUFA (P=0·00057) in leucocyte membranes. Lean and fatty fish intake did not affect phagocytosis of bacteria ex vivo. The findings suggest that high intake of fatty fish, but not of lean fish, beneficially affected postprandial glucose regulation in overweight/obese adults, and may therefore prevent or delay the development of T2D in this population.

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High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial

British Journal Of Nutrition ◽

10.1017/s0007114516002555 ◽

2016 ◽

Vol 116 (4) ◽

pp. 648-657 ◽

Cited By ~ 23

Author(s):

Ingrid V. Hagen ◽

Anita Helland ◽

Marianne Bratlie ◽

Karl A. Brokstad ◽

Grethe Rosenlund ◽

...

Keyword(s):

Risk Factors ◽

Hdl Cholesterol ◽

Normal Weight ◽

Fish Intake ◽

Serum Concentrations ◽

Fatty Fish ◽

High Intake ◽

Potential Health ◽

Lean Meat ◽

Lean Fish

AbstractThe aim of the present study was to examine whether high intake of lean or fatty fish (cod and farmed salmon, respectively) by healthy, normal-weight adults would affect risk factors of type 2 diabetes and CVD when compared with lean meat (chicken). More knowledge is needed concerning the potential health effects of high fish intake (>300 g/week) in normal-weight adults. In this randomised clinical trial, thirty-eight young, healthy, normal-weight participants consumed 750 g/week of lean or fatty fish or lean meat (as control) for 4 weeks at dinner according to provided recipes to ensure similar ways of preparations and choices of side dishes between the groups. Energy and macronutrient intakes at baseline and end point were similar in all groups, and there were no changes in energy and macronutrient intakes within any of the groups during the course of the study. High intake of fatty fish, but not lean fish, significantly reduced TAG and increased HDL-cholesterol concentrations in fasting serum when compared with lean meat intake. When compared with lean fish intake, fatty fish intake increased serum HDL-cholesterol. No differences were observed between lean fish, fatty fish and lean meat groups regarding fasting and postprandial glucose regulation. These findings suggest that high intake of fatty fish, but not of lean fish, could beneficially affect serum concentrations of TAG and HDL-cholesterol, which are CVD risk factors, in healthy, normal-weight adults, when compared with high intake of lean meat.

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Lean Fish Intake Decreases the Risk of Type 2 Diabetes Mellitus in Norwegian Women (P18-036-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz039.p18-036-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Jannike Øyen ◽

Lise Madsen ◽

Anne Lise Brantsæter ◽

Svetlana Ondrasova Skurtveit ◽

Grace Margrethe Egeland

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cohort Study ◽

Fish Intake ◽

Fatty Fish ◽

Supplement Use ◽

Lean Fish ◽

Mother And Child

Abstract Objectives The potential impact of seafood consumption and long chain n-3 polyunsaturated fatty acids (LCn-3PUFA) supplement use on the development of insulin resistance and type 2 diabetes mellitus (T2DM) is not yet fully clarified. The aim of this large cohort study was to investigate the associations between prenatal intake of total seafood, lean fish, fatty fish and LCn-3PUFA supplement use and the risk of T2DM in women after pregnancy. Methods The study subjects (n = 60 831, median age 31 years) participates in the ongoing population-based Norwegian Mother and Child Cohort study (MoBa) initiated and maintained by the Norwegian Institute of Public Health. Recruitment lasted from 1999 through 2009. The MoBa database is linked to the Medical Birth Registry of Norway. For the current study we also obtained permission to link the data to the Norwegian Prescription Database for ascertainment of medications dispensed for diabetes (ATC code A10) 90 days or more after delivery. Dietary intake was obtained by a validated 255-item semi-quantitative food frequency questionnaire (FFQ) and assessed habitual diet during the first four to five months of pregnancy. Results During a median (IQR) follow up time of 7.5 (6.5, 8.5) years, T2DM was identified for 711 (1.2%) of the participants. Adjusted linear Cox regression analyses estimated a decreased risk of T2DM with increased lean fish intake as g/1000 kcal intake (HR 0.98, 95% CI 0.97, 0.99, P = 0.010). Modeling intake as quintiles, a decreased risk of T2DM was seen among those in quintiles two to five compared to the first quintile of energy adjusted lean fish intake (P for trend across quintiles = 0.002). No associations between total seafood, fatty fish, or LCn-3PUFA supplement use and pharmacologically treated T2DM were identified in adjusted models. Conclusions Intake of lean fish was associated with decreased risk of T2DM. Funding Sources The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NINDS (grant no.1 UO1 NS 047537–01 and grant no.2 UO1 NS 047537-06A1).

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Fatty fish intake is associated with decreased occurrence of multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458513509508 ◽

2013 ◽

Vol 20 (6) ◽

pp. 726-732 ◽

Cited By ~ 49

Author(s):

Maria Bäärnhielm ◽

Tomas Olsson ◽

Lars Alfredsson

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Population Based ◽

Fish Intake ◽

Dietary Vitamin ◽

Fatty Fish ◽

Swedish Population ◽

Lean Fish ◽

Vitamin D Levels ◽

Incident Cases

Background: High vitamin D levels have been associated with a decreased risk of developing multiple sclerosis (MS). The most important source of dietary vitamin D is fatty fish. Objective: The objective of this paper is to investigate the association between fish consumption and the risk of MS, including the interaction between fish intake and ultraviolet radiation (UVR) exposure habits. Methods: This study is based on the project Epidemiological Investigation of MS (EIMS), which is a Swedish population-based case-control study. The analysis included 1879 incident cases of MS and 4135 controls. Subjects who reported high fatty fish intake were compared regarding occurrence of MS with those who reported low intake by calculating odds ratio (OR) with 95% confidence interval (CI). Results: Frequent fatty fish intake was associated with decreased occurrence of MS (adjusted OR 0.82 (95% CI 0.68-0.98). There was no significant association between intake of lean fish and MS. Conclusion: Fatty fish intake might decrease the risk for MS. A hypothetical explanation is that intake of fatty fish may compensate for vitamin D deficiency that is associated with increased MS risk.

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Pregnancy Complications and Risk of Cardiovascular Disease Later in Life: A Nationwide Cohort Study

Journal of the American Heart Association ◽

10.1161/jaha.121.023079 ◽

2022 ◽

Author(s):

Elin Täufer Cederlöf ◽

Maria Lundgren ◽

Bertil Lindahl ◽

Christina Christersson

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

Preterm Birth ◽

Cardiovascular Mortality ◽

Pregnancy Complications ◽

Gestational Hypertension ◽

Medical Birth Register ◽

Swedish Medical ◽

Artery Disease ◽

Cox Proportional Hazard Regression

Background The aim of this study was to investigate the associations between pregnancy complications and cardiovascular mortality and hospitalizations of cardiovascular disease (CVD) after adjustment for major confounding. Methods and Results In a nationwide register‐based cohort study, women with singleton births between 1973 and 2014 were included from the Swedish Medical Birth Register. Outcomes of mortality and hospitalizations of CVD were collected from the Cause of Death Register and the National Inpatient Register. The cohort was followed from the date of the first delivery until death or end of follow‐up, whichever occurred first. The pregnancy complications studied were preeclampsia or eclampsia, gestational hypertension, gestational diabetes, preterm birth, small for gestational age, and stillbirth. Among the 2 134 239 women (mean age at first pregnancy, 27.0 [SD, 5.1] and mean parity 1.96 [SD, 0.9]), 19.1% (N=407 597) had 1 of the studied pregnancy complications. All pregnancy complications were associated with all‐cause and cardiovascular mortality and hospitalization for CVD (ischemic heart disease, ischemic stroke, and peripheral artery disease) after adjustment for major confounding in a Cox proportional hazard regression model. The adjusted hazard ratio for cardiovascular mortality was 1.84 (95% CI, 1.38–2.44) for preterm birth and 3.14 (95% CI, 1.81–5.44) for stillbirth. Conclusions In this large cohort study, pregnancy complications were associated with all‐cause mortality, cardiovascular mortality, and hospitalizations for CVD, also after adjusting for confounding, including overweight, smoking, and comorbidities. The study highlights that less established pregnancy complications such as preterm birth and stillbirth are also associated with cardiovascular mortality and CVD.

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Consumption of fish and risk of colon cancer in the Norwegian Women and Cancer (NOWAC) study

British Journal Of Nutrition ◽

10.1017/s0007114507721487 ◽

2007 ◽

Vol 98 (3) ◽

pp. 576-582 ◽

Cited By ~ 20

Author(s):

Dagrun Engeset ◽

Vegard Andersen ◽

Anette Hjartåker ◽

Eiliv Lund

Keyword(s):

Colon Cancer ◽

Relative Risk ◽

Fish Consumption ◽

Fish Intake ◽

Fatty Fish ◽

Northern Norway ◽

The Third ◽

Lean Fish ◽

Colon Cancer Risk

Recent studies have shown a decreased risk of colon cancer with consumption of fish. However, most studies on fish consumption do not distinguish between lean and fatty fish, or between poached and fried fish. The aim of this study was to investigate any association between fish consumption and colon cancer in The Norwegian Women and Cancer (NOWAC) study. We focused mainly on lean fish, which was further divided into poached and fried fish. A total of 63 914 women were included in the analysis, 254 of whom were found to have colon cancer during follow-up. Since fish consumption was one of the main topics of interest in the NOWAC study, there is a predominance of women from northern Norway due to higher fish intake in this area; hence the study is not representative of the whole of Norway. The participants completed a semi-quantitative FFQ between 1996 and 1999, and were followed-up for incidence of colon cancer until 2004. No association between fish consumption and risk of colon cancer was seen, except for the third tertile of poached lean fish consumption (relative risk (RR) 1·46, 95 % CI 1·04, 2·06). This association disappeared when excluding women with less than 1 year of follow-up. In conclusion, the present study does not support the hypothesis of a protective effect of fish against colon cancer risk.

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Association of fish consumption and dietary intake of marine n-3 PUFA with myocardial infarction in a prospective Danish cohort study

British Journal Of Nutrition ◽

10.1017/s000711451600180x ◽

2016 ◽

Vol 116 (1) ◽

pp. 167-177 ◽

Cited By ~ 9

Author(s):

Anders Gammelmark ◽

Michael S. Nielsen ◽

Christian S. Bork ◽

Søren Lundbye-Christensen ◽

Anne Tjønneland ◽

...

Keyword(s):

Myocardial Infarction ◽

Cohort Study ◽

Relative Risk ◽

Dietary Intake ◽

Fish Consumption ◽

Fish Intake ◽

Fatty Fish ◽

High Intake ◽

Lean Fish ◽

Danish Cohort

AbstractSeveral studies have investigated the potential benefits of marine n-3 PUFA in CVD, generally suggesting a lower risk of CHD. However, recent trials have questioned these results. This study investigated the association of fish consumption with dietary intake of marine n-3 PUFA with incident myocardial infarction (MI). In a Danish cohort study, 57 053 subjects between 50 and 64 years of age were enrolled from 1993 to 1997. From national registries, we identified all cases of incident MI. Dietary fish consumption was assessed using a semi-quantitative food questionnaire, including twenty-six questions regarding fish intake. In addition, we calculated the intake of total and individual marine n-3 PUFA. During a median follow-up of 17·0 years, we identified 3089 cases of incident MI. For both men and women, a high intake of fatty fish was inversely related to incident MI. Thus, when comparing the highest and the lowest quintile of fatty fish intake, we found a 12 % lower relative risk of MI in men (hazard ratio (HR) 0·88; 95 % CI 0·77, 1·00) and a 22 % lower relative risk in women (HR 0·78; 95 % CI 0·63, 0·96) after adjustments. For women, similar associations were observed for individual and total marine n-3 PUFA. In contrast, intake of lean fish was not associated with MI. In conclusion, incident MI was inversely related to a high intake of fatty fish, but not lean fish. However, test for trends across quintiles was not statistically significant. In general, this study supports the view that consumption of fatty fish may protect against MI.

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Endometriosis and Risk of Adverse Pregnancy Outcome: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm10040667 ◽

2021 ◽

Vol 10 (4) ◽

pp. 667

Author(s):

Kjerstine Breintoft ◽

Regitze Pinnerup ◽

Tine Brink Henriksen ◽

Dorte Rytter ◽

Niels Uldbjerg ◽

...

Keyword(s):

Preterm Birth ◽

Cesarean Section ◽

Placental Abruption ◽

Gestational Hypertension ◽

Adverse Pregnancy Outcome ◽

Placenta Previa ◽

Meta Analysis ◽

Increased Risk ◽

Spontaneous Hemoperitoneum ◽

In Pregnancy

Background: This systematic review and meta-analysis summarizes the evidence for the association between endometriosis and adverse pregnancy outcome, including gestational hypertension, pre-eclampsia, low birth weight, and small for gestational age, preterm birth, placenta previa, placental abruption, cesarean section, stillbirth, postpartum hemorrhage, spontaneous hemoperitoneum in pregnancy, and spontaneous bowel perforation in pregnancy. Methods: We performed the literature review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), by searches in PubMed and EMBASE, until 1 November 2020 (PROSPERO ID CRD42020213999). We included peer-reviewed observational cohort studies and case-control studies and scored them according to the Newcastle–Ottawa Scale, to assess the risk of bias and confounding. Results: 39 studies were included. Women with endometriosis had an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth, compared to women without endometriosis. These results remained unchanged in sub-analyses, including studies on spontaneous pregnancies only. Spontaneous hemoperitoneum in pregnancy and bowel perforation seemed to be associated with endometriosis; however, the studies were few and did not meet the inclusion criteria. Conclusions: The literature shows that endometriosis is associated with an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth.

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