Turning Expanded Poly(tetrafluoroethylene) Membranes into Potential Skin Wound Dressings by Grafting a Bioinert Epoxylated PEGMA Copolymer

2017 ◽  
Vol 3 (12) ◽  
pp. 3338-3350 ◽  
Author(s):  
Antoine Venault ◽  
Cheng-Sian Liou ◽  
Lu-Chen Yeh ◽  
Jheng-Fong Jhong ◽  
James Huang ◽  
...  
Keyword(s):  
Skin Wound ◽  
Wound Dressings

scholarly journals Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid

2021 ◽  
Vol 11 (18) ◽  
pp. 8591
Author(s):  
Jae Hyuk Choi ◽  
Donghee Son ◽  
Mikyung Shin
Keyword(s):  
Boronic Acid ◽  
Skin Wound ◽  
Body Fluids ◽  
The Body ◽  
Wound Dressings ◽  
Suture Materials ◽  
Wound Site ◽  
Long Term Stability ◽  
State Dependent

Adhesive hydrogels have been utilized as tissue sealants, hemostatic agents, and wound dressings, with the aim of replacing conventional sutures. To prevent immune response and serious inflammation from those hydrogels after sealing, natural biocompatible polysaccharides are widely used as a component of the hydrogels. However, the weak mechanical strength, insufficient adhesiveness, and rapid dissociation of the hydrogels necessitates additional suturing at the wound site. In this study, we report on a solid polysaccharide thread reversibly crosslinked with boronic acid-polyphenol complexation and its adhesive gelation for complete tissue sealing without additional suturing. The polysaccharide adhesive suture threads demonstrated long-term stability, which is useful when used for skin wound suturing. Specifically, their robust adhesion property occurred as soon as the threads were soaked, attaining a swollen hydrogel state, dependent on the presence of body fluids after suturing. Moreover, the pH of the body fluids affects the viscoelasticity and adhesiveness of the hydrogels in order to ensure a tight sealing. Therefore, we expect that these pH-responsive adhesive threads would be promising for the development of on-demand functional suture materials.

Preparation and antibacterial properties of an AgBr@SiO2/GelMA composite hydrogel

2022 ◽  
Author(s):  
Bo Li ◽  
Hong Li ◽  
Haocheng Yang ◽  
Yue Shu ◽  
Kejiang Li ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Uv Light ◽  
Antibacterial Properties ◽  
Silver Ions ◽  
Skin Wound ◽  
Wound Dressings ◽  
Sprague Dawley ◽  
Sio2 Microspheres ◽  
Modified Stöber Method

Abstract Pure gelatin hydrogels lack antibacterial function and have poor mechanical properties, which restrict their application in wound dressings. In this study, nanosized silver bromide-doped mesoporous silica (AgBr@SiO2) microspheres with hollow structures were prepared by a modified Stober method. The novel microspheres can not only release silver ions to treat bacteria but also release drugs to treat skin wound. Furthermore, AgBr@SiO2 microspheres were modified with propyl methacrylate, incorporated into methacrylated gelatin (GelMA), and crosslinked by UV light to prepare AgBr@SiO2/GelMA dressings consisting of composite hydrogels. The results showed that the AgBr@SiO2 microspheres could enhance the mechanical properties of the hydrogels. With the increase in the AgBr@SiO2 concentration from 0.5 to 1 mg/mL, the dressings demonstrated effective antimicrobial activity against both Staphylococcus aureus and Escherichia coli. Furthermore, full-thickness skin wounds in vivo wound healing studies with Sprague–Dawley rats were evaluated. When treated with AgBr@SiO2/GelMA containing 1 mg/mL AgBr@SiO2, only 15% of the wound area left on day 10. Histology results also showed the epidermal and dermal layers were better organized. These results suggest that AgBr@SiO2/GelMA-based dressing materials could be promising candidates for wound dressings.

scholarly journals Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation

2019 ◽  
Author(s):  
Chen-Chen Zhao ◽  
Lian Zhu ◽  
Zheng Wu ◽  
Rui Yang ◽  
Na Xu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Damage Model ◽  
Skin Wound ◽  
Scar Formation ◽  
Wound Dressings ◽  
Skin Damage ◽  
Skin Wound Healing ◽  
Accelerate Wound Healing ◽  
Peptide Hydrogels

Abstract Scar formation seriously affects the repair of damaged skin especially in adults and the excessive inflammation has been considered as the reason. The self-assembled peptide-hydrogels are ideal biomaterials for skin wound healing due to their similar nanostructure to natural extracellular matrix, hydration environment and serving as drug delivery systems. In our study, resveratrol, a polyphenol compound with anti-inflammatory effect, is loaded into peptide-hydrogel (Fmoc-FFGGRGD) to form a wound dressing (Pep/RES). Resveratrol is slowly released from the hydrogel in situ, and the release amount is controlled by the loading amount. The in vitro cell experiments demonstrate that the Pep/RES has no cytotoxicity and can inhibit the production of pro-inflammatory cytokines of macrophages. The Pep/RES hydrogels are used as wound dressings in rat skin damage model. The results suggest that the Pep/RES dressing can accelerate wound healing rate, exhibit well-organized collagen deposition, reduce inflammation and eventually prevent scar formation. The Pep/RES hydrogels supply a potential product to develop new skin wound dressings for the therapy of skin damage.

scholarly journals Polymeric hydrogels for burn wound care: Advanced skin wound dressings and regenerative templates

2014 ◽  
Vol 2 (4) ◽  
pp. 153 ◽  
Author(s):  
Marta Madaghiele ◽  
Alessandro Sannino ◽  
Luigi Ambrosio ◽  
Christian Demitri
Keyword(s):  
Wound Care ◽  
Skin Wound ◽  
Wound Dressings ◽  
Burn Wound ◽  
Polymeric Hydrogels

scholarly journals Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6123
Author(s):  
Fa-Wei Xu ◽  
Ying-Li Lv ◽  
Yu-Fan Zhong ◽  
Ya-Nan Xue ◽  
Yong Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Green Tea ◽  
Clinical Application ◽  
Epigallocatechin Gallate ◽  
Skin Wound ◽  
Wound Dressings ◽  
Skin Wound Healing ◽  
Comprehensive Review ◽  
Beneficial Effects ◽  
Underlying Mechanisms

Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

scholarly journals Degradable tough chitosan dressing for skin wound recovery

2020 ◽  
Vol 9 (1) ◽  
pp. 1576-1585
Author(s):  
Yan Kong ◽  
Xiaoxuan Tang ◽  
Yahong Zhao ◽  
Xiaoli Chen ◽  
Ke Yao ◽  
...  
Keyword(s):  
Water Absorption ◽  
Wound Dressing ◽  
Antibacterial Properties ◽  
High Water ◽  
Skin Wound ◽  
Wound Dressings ◽  
Wound Recovery ◽  
Recovery And Healing ◽  
Optimized Treatment ◽  
Better Than

Abstract The performance of wound dressing determines the effect of wound closure and recovery. Water absorption and bacteriostasis of wound dressings play an important role in wound recovery and healing. In this study, an optimized chitosan wound dressing-tough chitosan dressing (TCS) with high water absorption, high bacteriostasis, and degradability was developed. The chemical structure of chitosan remained stable during the process of optimized treatment, and an increase in mechanical properties was obtained for the dressing. After optimization, the water absorption and antibacterial properties of the chitosan dressing were greatly improved, which is significantly better than sodium alginate dressing. The authors believe that TCS dressing with high hygroscopicity and high bacteriostasis has great potential application value in the field of wound recovery and healing.

scholarly journals Graphene oxide-modified electrospun polyvinyl alcohol nanofibrous scaffolds with potential as skin wound dressings

RSC Advances ◽  
2017 ◽  
Vol 7 (46) ◽  
pp. 28826-28836 ◽  
Author(s):  
Qiang Zhang ◽  
Qiaoyue Du ◽  
Yanan Zhao ◽  
Feixiang Chen ◽  
Zijian Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Polyvinyl Alcohol ◽  
Potential Application ◽  
Skin Wound ◽  
Wound Dressings ◽  
Skin Tissue ◽  
Skin Tissue Engineering ◽  
Nanofibrous Scaffolds ◽  
Good Biocompatibility

Graphene oxide-modified electrospun polyvinyl alcohol nanofibrous scaffolds exhibit good biocompatibility and have potential application in skin tissue engineering.

Tough, Adhesive, Self-healable, and Antibacterial Plant-inspired Hydrogel Based on Pyrogallol-Borax Dynamic Cross-linking

2021 ◽  
Author(s):  
Chao Ma ◽  
Huiwen Pang ◽  
Hongguang Liu ◽  
Qian Yan ◽  
Jianzhang Li ◽  
...  
Keyword(s):  
Antibacterial Properties ◽  
Wearable Devices ◽  
Skin Wound ◽  
Wound Dressings ◽  
Cross Linking ◽  
Self Healing ◽  
Electronic Skin

Multifunctional hydrogels that integrate stretchability, adhesion, self-healing, and antibacterial properties may find use in a variety of fields including electronic skin, wound dressings, and wearable devices; however, traditional hydrogels often...

scholarly journals Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Peipei Feng ◽  
Yang Luo ◽  
Chunhai Ke ◽  
Haofeng Qiu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Wound Repair ◽  
Functional Materials ◽  
High Water ◽  
Skin Wound ◽  
Wound Dressings ◽  
Chemical Components ◽  
Intrinsic Nature ◽  
Repair Mechanisms ◽  
Other Substances ◽  
Polymeric Biomaterial

Skin wounds not only cause physical pain for patients but also are an economic burden for society. It is necessary to seek out an efficient approach to promote skin repair. Hydrogels are considered effective wound dressings. They possess many unique properties like biocompatibility, biodegradability, high water uptake and retention etc., so that they are promising candidate materials for wound healing. Chitosan is a polymeric biomaterial obtained by the deacetylation of chitin. With the properties of easy acquisition, antibacterial and hemostatic activity, and the ability to promote skin regeneration, hydrogel-like functional wound dressings (represented by chitosan and its derivatives) have received extensive attentions for their effectiveness and mechanisms in promoting skin wound repair. In this review, we extensively discussed the mechanisms with which chitosan-based functional materials promote hemostasis, anti-inflammation, proliferation of granulation in wound repair. We also provided the latest information about the applications of such materials in wound treatment. In addition, we summarized the methods to enhance the advantages and maintain the intrinsic nature of chitosan via incorporating other chemical components, active biomolecules and other substances into the hydrogels.

Sign in / Sign up

Export Citation Format

Share Document