The Effect of Varied Dietary Grains on Plasma Lipid Profiles, Gut Transit Time, and Aorta Histopathology in Experimental Rats

2007 ◽  
Vol 77 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Kim ◽  
Kim ◽  
Lee ◽  
Kim ◽  
Lee
Keyword(s):  
Transit Time ◽  
Aortic Wall ◽  
Brown Rice ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Black Rice ◽  
White Rice

This study was designed to investigate the influence of natural brown and black rice consumption on plasma lipid parameters, transit time, and thickness of the aortic wall in rats fed different combinations of grains. Fifty male rats were divided into five groups and raised for eight weeks with diets containing white rice (WR), white rice and brown rice (WRBR), white rice and black rice (WRBL), brown rice and black rice (BRBL), or wheat flour (WH). Gut transit time was the shortest in the BRBL group, and was longer in the order of WRBL, WRBR, WR, and WH group. Plasma lipid profiles differed significantly according to the grain combination. The BRBL group had the lowest levels of triglyceride (TG), total cholesterol (T-C), and low-density lipoprotein cholesterol (LDL-C), and the highest plasma high-density lipoprotein cholesterol (HDL-C) concentration among all groups. The aortic wall thickness hatro for body weight was lower in rats in order of BRBL, WRBR, WH, WRBL, and WR group. In conclusion, black rice and brown rice have anti-atherogenic effects by decreasing plasma lipide profiles and attenuating the thickness of the aortic wall.

Cardioprotective Effects of Diet with Different Grains on Lipid Profiles and Antioxidative System in Obesity-Induced Rats

2012 ◽  
Vol 82 (2) ◽  
pp. 85-93 ◽  
Author(s):  
Y. Kim ◽  
H. Shin ◽  
S. Lee
Keyword(s):  
Aortic Wall ◽  
Plasma Lipids ◽  
Antioxidant Activities ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Thiobarbituric Acid ◽  
Lipid Profiles ◽  
Dietary Lipids ◽  
Male Rats

In the present study, the nutritional quality of four grains including adlay (AD), buckwheat (BW), glutinous barley (GB), and white rice (WR) were evaluated in terms of plasma lipid parameters, gut transit time, and thickness of the aortic wall in rats. The rats were then raised for 4 weeks on the high-fat diet based on the American Institute of Nutrition-93 (AIN-93 G) diets containing 1 % cholesterol and 20 % dietary lipids. Forty male rats were divided into 4 groups and raised for 4 weeks with a diet containing one of the following grains: WR, AD, BW, or WB. The level of thiobarbituric acid-reactive substances (TBARS) in liver was shown to be higher in rats by the order of those fed WR, AD, GB, and BW. This indicates that other grains decreased oxidative stress in vivo more than WR. The superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase levels in the AD, BW, and GB groups were significantly higher than those in the WR group (p < 0.05). Plasma lipid profiles differed significantly according to grain combination, and decreased aortic wall thickness was consistent with the finding of decreased plasma low-density lipoprotein cholesterol (LDL-C) (p < 0.05) and increased high-density lipoprotein (HDL-C) in rats fed AD, BW, and GB (p < 0.001). The antioxidant and hypolipidemic capacities of grains are quite high, especially those of adlay, buckwheat, and glutinous barley. In conclusion, this study has demonstrated that the whole grains had a cardioprotective effect. This effect was related to several mechanisms that corresponded to lowering plasma lipids, decreasing TBARS, and increasing antioxidant activities.

scholarly journals Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats

2015 ◽  
Vol 8 (3) ◽  
pp. 151-154 ◽  
Author(s):  
Saeed Samarghandian ◽  
Mohsen Azimi-Nezhad ◽  
Mahmoud M. Shabestari ◽  
Farahzad Jabbari Azad ◽  
Tahereh Farkhondeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Chronic Exposure ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Serum Triglycerides ◽  
Stress Indices ◽  
And Oxidative Stress

Abstract Cadmium (Cd) is an environmental toxic metal implicated in lipid abnormalities. The present study was designed to elucidate the possible association between chronic exposure to Cd concentration and alterations in plasma lipid, lipoprotein, and oxidative stress indices in rats. Sixteen male rats were assigned to 2 groups of 8 rats each (test and control). The Cd-exposed group obtained drinking water containing cadmium chloride (CdCl2) in the concentration of 2.0 mg Cd/L in drinking water for 3 months. At the end of the experimental period, blood samples were obtained to determine the changes of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), malondialdehyde (MDA) and also serum Cd contents. The results of the present study indicated that Cd administration significantly increased the serum levels of TG, TC, LDL-C, MDA and Cd with reduction in the HDL-C and GSH levels. In conclusion, evidence is presented that chronic exposure to low Cd concentration can adversely affect the lipid and lipoprotein profile via lipid peroxidation.

scholarly journals Effects of summer shield supplementation on growth performance, nutrient utilisation, and plasma lipid profiles in broiler chickens 

2014 ◽  
Vol 59 (No. 11) ◽  
pp. 536-542 ◽  
Author(s):  
AA Saleh ◽  
D. Ijiri ◽  
A. Ohtsuka
Keyword(s):  
Growth Performance ◽  
Broiler Chickens ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Basal Diet ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Dry Matter Content ◽  
Positive Effects ◽  
Nutrient Utilisation

This study was conducted to evaluate the effects of herb mixture (summer shield) supplementation on growth performance, nutrient utilisation, and plasma lipid profiles in broiler chickens. Thirty-six male chicks at 15&nbsp;days of age were divided into three groups with three replicates of four birds. The control group of chicks was fed a basal diet and the remaining two groups of chicks were fed the basal diet supplemented with summer shield at a concentration of 1 g/kg or 2 g/kg, respectively, until 37 days of age. Although feed intake was not different among the three groups, both body weight gain and breast muscle weight were increased in chicks fed a summer shield-supplemented diet. Summer shield supplementation decreased abdominal fat weight and consequently feed efficiency was improved. Both protein and fat utilisation was improved in chickens fed a summer shield-supplemented diet although dry matter content was not influenced. In addition, summer shield supplementation improved plasma lipid profiles, i.e., total cholesterol, triglyceride, and low-density lipoprotein cholesterol were decreased, whereas high-density lipoprotein cholesterol was increased. Furthermore, summer shield supplementation increased total protein, albumin, and globulin levels in plasma, while neither glutamate oxaloacetate transaminase nor glutamate pyruvate transaminase were affected. These results suggest that summer shield supplementation has positive effects on growth performance, nutrient utilisation, and plasma lipid profiles in broiler chickens.

scholarly journals Saturated fat in the diet of Spanish children: relationship with anthropometric, alimentary, nutritional and lipid profiles

2006 ◽  
Vol 9 (4) ◽  
pp. 429-435 ◽  
Author(s):  
MA Royo-Bordonada ◽  
C Garcés ◽  
L Gorgojo ◽  
JM Martín-Moreno ◽  
MA Lasunción ◽  
...  
Keyword(s):  
Diet Quality ◽  
Plasma Lipid ◽  
Saturated Fat ◽  
Density Lipoprotein ◽  
Healthy Eating Index ◽  
Lipid Profiles ◽  
Apolipoprotein A1 ◽  
Lipoprotein Cholesterol ◽  
Fat Intake ◽  
Saturated Fat Intake

AbstractObjectiveTo compare the anthropometric, alimentary, nutritional and lipid profiles and global diet quality of Spanish children according to saturated fat intake.DesignThis was a cross-sectional study. Food data were collected using a food-frequency questionnaire.Subjects and methodsThe sample included 1112 children of both sexes, aged between 6 and 7 years, selected by means of random cluster sampling in schools. The plasma lipid profile included measurements of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, apolipoprotein A1 (apoA1) and apolipoprotein B (apoB). Global diet quality was evaluated by the Dietary Variety Index (DVI) and the Healthy Eating Index (HEI).ResultsEnergy intake, DVI and HEI of children from the lower quartile of saturated fat intake (LL) were higher (P < 001) than in the remaining children (UL). However, there were no significant differences in average height or weight between groups. The UL children had lower intakes of meat, fish, vegetables, fruits and olive oil and a higher intake of dairy products (P < 0.001). The intakes of fibre, vitamins C, D, B6, E and folic acid were higher in the LL children, who had lower intakes of vitamin A and calcium. The ratios LDL-C/HDL-C and apoB/apoA1 were lower (P = 0.04) in the LL children (1.87 and 0.52, respectively) than in the UL children (2.02 and 0.54, respectively).ConclusionsThe growth rate of children does not seem to be affected by the level of saturated fat intake. Furthermore, at the levels of intake observed in this study, diets with less saturated fat are associated with better alimentary, nutritional and plasma lipid profiles.

Passive Smoking Alters Lipid Profiles in Adolescents

PEDIATRICS ◽  
1991 ◽  
Vol 88 (2) ◽  
pp. 259-264 ◽  
Author(s):  
Joseph Feldman ◽  
I. Ronald Shenker ◽  
Michael Nussbaum ◽  
Marc S. Jacobson ◽  
Ruth A. Etzel ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Passive Smoking ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Increased Risk ◽  
Plasma Cotinine

Although cigarette smoking is associated with elevation of plasma lipid levels and changes in lipoprotein distribution, it is not known whether passive smoking is associated with an alteration in lipid profiles. The relation between plasma cotinine, a marker of exposure to tobacco smoke, and lipid profiles was studied in healthy adolescents from a suburban New York high school district who were undergoing preparticipation sports physicals. Forty-four percent of the adolescents reported that one or both parents currently smoked. Eleven percent of the adolescents had plasma cotinine concentrations ≥2.5 ng/mL, the level considered indicative of exposure. Adolescents with two smoking parents had significantly higher plasma cotinine concentrations after adjustment for other factors than adolescents whose parents did not smoke. Plasma cotinine concentration ≥2.5 ng/mL was associated with an 8.9% greater ratio of total cholesterol to high-density lipoprotein cholesterol (P &lt; .003) and a 6.8% lower high-density lipoprotein cholesterol (P &lt; .03). These results suggest that passive smoking, like active smoking, leads to alterations in lipid profiles predictive of an increased risk of atherosclerosis.

scholarly journals The effect of dietary fatty acid composition on the hepatic fatty acid content and plasma lipid profile in rats

2015 ◽  
Vol 84 (2) ◽  
pp. 197-207
Author(s):  
Tomáš Komprda ◽  
Veronika Rozíková ◽  
Barbora Němcová ◽  
Branislav Ruttkay-Nedecký
Keyword(s):  
Fatty Acid ◽  
Acid Content ◽  
Fatty Acid Content ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Dietary Lipids ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Feed Mixture ◽  
Hepatic Fatty Acid

The objective of the present study was to evaluate in a model organism the effect of different dietary lipids on plasma concentration of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triacylglycerols (TAG). One hundred adult male rats (Wistar Albino) were divided into 10 groups with 10 animals each and fed for 7 weeks either basic feed mixture (control diet, C) or basic feed mixture with 5% of palm oil (P), safflower oil (SF), salmon oil (S), fish oil (F), Schizochytrium microalga oil (A), and 20% of beef tallow (T; four groups), respectively. The T-groups were fed for another 7 weeks T-, SF-, F- and A-diet, respectively. At the end of both the first and the second 7-week fattening period, plasma lipid concentration and hepatic fatty acid content was determined. Both A and F diets fed for 7 weeks decreased (P < 0.05) plasma TC (0.98 mmol∙l-1) compared to control (1.19 mmol∙l-1). The highest (P < 0.05) plasma TC was established in rats fed for 7 weeks the SF-diet following the previous 7-week T-treatment (2.15 mmol∙l-1). A-diet had the most positive (decreasing) effect on TAG concentrations (0.68–0.86 mmol∙l-1 compared to 1.22 and 2.88 mmol∙l-1 found in the C and T diets, respectively; P < 0.05). Both plasma TC and TAG were in a negative relationship (P < 0.01) with the hepatic eicosapentaenoic acid and docosahexaenoic acid (DHA) contents, respectively. It was concluded that dietary Schizochytrium microalga oil (with high DHA content) may have the potential for decreasing the risk of cardiovascular diseases.

scholarly journals Effect of Eight Weeks of Resistance Training and Consumption of Tribulus Terrestris on Androgenic Receptor-1, Fas Ligand Gene Expression, and Lipid Profiles in Rats Exposed to Stanozolol

2020 ◽  
Vol 8 (1) ◽  
pp. 27-34
Author(s):  
Mohammad Derakhshandeh ◽  
Farzaneh Taghian ◽  
Khosro Jalali Dehkordi ◽  
Seyed Ali Hosseini
Keyword(s):  
Gene Expression ◽  
Androgen Receptor ◽  
Resistance Training ◽  
Fas Ligand ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Tribulus Terrestris ◽  
Fasl Gene

Background: Protective effect of medicinal plants on the heart has been reported, but the effect of resistance training (RT) and Tribulus terrestris (TT) on the heart exposed to anabolic-androgenic steroids (AAS) abuse is still unknown. Objectives: The present study aimed to investigate the effect of RT and TT on androgen receptor-1 (ar-1), Fas ligand (fasl) gene expression and lipid profiles in rats exposed to stanozolol (S). Methods: Thirty-five male rats were selected and divided into 7 groups as follows: (1) sham (normal saline/Sh), (2) stanozolol (S), (3) S+100 mg/kg TT (S+TT100), (4) S+ 50 mg/kg TT (S+TT50), (5) S+RT+TT, (6) S+RT+TT100, and (7) S+RT+TT50. Over a course of eight-week period, groups 3, 4, 6, and 7 received 50 and 100 mg/kg/d doses of TT peritoneally and groups 5-7 performed three sessions of increasing RT per week. Results: RT decreased plasma cholesterol and low-density lipoprotein cholesterol (LDL-C) levels, as well as ar-1 and fasl gene expression in S-exposed rats (P<0.05). TT50, TT100, SRTT100, and SRTT50 reduced ar-1 and fasl gene expressions (P<0.05). TT50 reduced triglyceride (TG), cholesterol and increased high-density lipoprotein-cholesterol (HDL-C) (P≤0.01), and TT100 decreased LDL-C levels (P<0.05). Additionally, SRTT100 reduced TG, cholesterol, and LDL-C levels and increased HDL-C level (P<0.05), and SRTT50 decreased cholesterol level and increased HDL-C level in S-exposed rats (P<0.05). Conclusion: RT and consumption of TT appear to have protective effects on the improvement of apoptosisdependent androgen receptor-1 and lipid profile in S-exposed rats.

scholarly journals Plasma Lipid Profile of Moderate and Severe Hypertensive Patients

2020 ◽  
Vol 1 (4) ◽  
Author(s):  
Ibikunle Akinlua ◽  
Akinwumi T. Ogundajo ◽  
Olufisayo G. Oyebanji ◽  
Babajide O. Arobasalu
Keyword(s):  
Cardiovascular Diseases ◽  
Plasma Level ◽  
Lipid Profile ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
University Teaching ◽  
Lipoprotein Cholesterol ◽  
Hypertensive Patients ◽  
Control Subjects ◽  
Mild Hypertensive

Hypertension is the most prevalent and treatable risk factors for cardiovascular diseases and a major cause of morbidity and mortality worldwide. Elevated levels of lipid in the blood also known as hyperlipideamia or dyslipidemia have been implicated in the development of atherosclerosis and most cardiovascular diseases including hypertension. This study was designed to evaluate the plasma level of lipid profile in mild and severe hypertensive patients with a view to provide information on the link between these parameters and the development and severity of hypertension. Blood samples were collected from 120 freshly diagnosed hypertensive patients consisting of 60 mild and 60 severe hypertensive patients at Wesley Guide Hospital of Obafemi Awolowo University teaching Hospital Ilesa Osun state and 60 relatively healthy subjects as control. Plasma level of lipid profile [namely High density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc), triglycerides (TG), total cholesterol (TC)] in the blood sample of both patients and control subjects were analyzed using standard methods. The results obtained were subjected to statistical analysis (p<0.05).The results of lipid profile in mild and severe hypertensive patients was compared to the control subjects. The results in mild hypertensive patients were also compared with the severe ones. There was a significant increase (P<0.05) in the plasma level of TC and LDLc in both mild and severe hypertensive patients when compared with the control subjects. Similarly a significant increase (p<0.05) was recorded in the plasma level of the both TC and LDLc in severe hypertensive patients when compared with mild hypertensive patients. However, the plasma level of HDLc in moderate and severe hypertensive patients was slightly lowered but not significant (p<0.05) while plasma TG level was not significantly different when compared with the control subjects. This study reveals a progressive increase in the plasma level of TC and LDLc from mild to severe hypertensive patients which could be a pointer to the fact that abnormalities in lipid metabolism might plays a significant role in the development and severity of hypertension.

scholarly journals Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243538
Author(s):  
Endalamaw Tesfa ◽  
Endalkachew Nibret ◽  
Abaineh Munshea
Keyword(s):  
Pregnant Women ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipid Profiles ◽  
Maternal Serum ◽  
Lipoprotein Cholesterol ◽  
Low Density Lipoprotein Cholesterol ◽  
Standardized Mean Difference

Introduction Some studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women. Methods Four electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI. Results In this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39). Conclusions In this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.

Influence of Melatonin and Linseed Oil on the State of Lipid Metabolism at Desynchronosis in Rats

2021 ◽  
pp. 58-68
Author(s):  
Irina S. Sobolevskaya ◽  
◽  
Oleg D. Myadelets ◽  
Natalʼya N. Yarotskaya
Keyword(s):  
Lipid Metabolism ◽  
Linseed Oil ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Male Rats ◽  
Serum Concentrations ◽  
Rat Serum ◽  
Lighting Conditions

The purpose of this study was to substantiate the possibility of correcting lipid metabolism changes at dark deprivation using linseed oil, melatonin, and their combination. Materials and methods. The experiment involved 130 white outbred male rats with a body weight of 170–220 g. The animals were divided into 5 groups: rats under standard fixed lighting conditions (12 hours light/12 hours dark); rats under modelled dark deprivation with round-the-clock lighting (24 hours light); rats under modelled dark deprivation with round-the-clock lighting (24 hours light) receiving intragastric injections of linseed oil, melatonin or their combination from day 1 of the experiment. Serum concentrations of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total phospholipids (TPL) and atherogenic index (AI) were determined. Results. Long-term dark deprivation led to dyslipoproteinemia, which consists in an increase in serum concentrations of TC by a factor of 1.33 (p = 0.0009), TG by a factor of 1.62 (p = 0.013), LDL-C by a factor of 1.2 (p = 0.026) and TPL by a factor of 1.15 (p = 0.0082). The severity of changes in TC, TG, LDL-C, HDL-C and TPL concentrations varied depending on the duration of the experiment. During the use of linseed oil, melatonin or their combination under dark deprivation, the severity of disorders caused by desynchronosis decreased and lipid metabolism in rat serum normalized, especially at the initial stages of the research. Conclusion. Changes in lipid metabolism due to desynchronosis in rats injected with the substances under study were significantly smaller compared with animals that did not receive them. The most pronounced effects of administering these substances were observed in the group of rats treated with linseed oil and melatonin at the same time.

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