scholarly journals Overweight and obesity at age 19 after pre-natal famine exposure

2021 ◽  
Author(s):  
L. H. Lumey ◽  
Peter Ekamper ◽  
Govert Bijwaard ◽  
Gabriella Conti ◽  
Frans van Poppel
Keyword(s):  
Social Class ◽  
Prenatal Exposure ◽  
Rural Areas ◽  
Fertility Decline ◽  
Military Service ◽  
Later Life ◽  
Overweight And Obesity ◽  
Study Results ◽  
Famine Exposure ◽  
Prenatal Famine

Abstract Background Weight for height has been used in the past as an indicator of obesity to report that prenatal exposure to the Dutch famine of 1944–1945 determined subsequent obesity. Further evaluation is needed as unresolved questions remain about the possible impact of social class differences in fertility decline during the famine and because being overweight is now defined by a Body Mass Index (BMI: kg/m2) from 25 to <30 and obesity by a BMI of 30 or more. Methods We studied heights and weights of 371,100 men in the Netherlands born between 1943 and 1947 and examined for military service at age 19. This group includes men with and without prenatal exposure to the Dutch famine. Results There was a 1.3-fold increase in the risk of being overweight or obese in young adults at age 19 after prenatal famine exposure in early gestation. The increase was only seen in sons of manual workers born in the large cities of Western Netherlands and not among those born in smaller cities or rural areas in the West. Social class differentials in fertility decline during the famine did not bias study results. Conclusions The long-term adverse impact of prenatal famine on later life type 2 diabetes and mortality through age 63 is already showing at age 19 in this population as a significant increase in overweight risk.

scholarly journals A study on prevalence of overweight and obesity in school going adolescents and its association with socio-demographic factors in Lucknow district

2019 ◽  
Vol 6 (9) ◽  
pp. 3792
Author(s):  
Sudhanshu Mishra ◽  
Pratibha Gupta ◽  
Mrinal Ranjan Srivastava ◽  
Beena Sachan ◽  
Zeashan Haider Zaidi
Keyword(s):  
Public Health ◽  
Social Class ◽  
Sample Size ◽  
Rural Areas ◽  
Demographic Factors ◽  
Overweight And Obesity ◽  
Health Concern ◽  
Public Health Issue ◽  
Global Public Health ◽  
Socio Demographic Factors

Background: Overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. Obesity has become a global public health issue and is widely recognized as a key risk factor for coronary heart disease, hypertension, diabetes and many other health problems. The objectives of present study were to assess the prevalence of overweight and obesity and its association with socio-demographic factors amongst school-going adolescents in Lucknow district.Methods: This study was a school-based cross-sectional study and was carried out in urban and rural areas of Lucknow, from January 2018 to June 2018. Sample size was 620. A multi-stage random sampling technique has been used to select the required sample size. Data analysis was done using software MS Office excel and SPSS 18 for windows.Results: A total of 620 adolescents were studied. Majority (82.1%) of adolescents were found to be non-overweight/obese while 17.9% were found to be overweight/obese. Majority (66.7%) of students were overweight or obese, belonging to social class I while only 15.7% students were overweight or obese belonging to social class V.Conclusions: The results of our study show that overweight/obesity continues to be a public health concern in adolescents. The current study shows that adolescent overweight and obesity are increasing even in low socio-economic status. Emphasis should be placed on awareness program for obesity prevention among school students by strengthening lifestyle change.

Prenatal famine exposure, health in later life and promoter methylation of four candidate genes

2012 ◽  
Vol 3 (6) ◽  
pp. 450-457 ◽  
Author(s):  
M. V. Veenendaal ◽  
P. M. Costello ◽  
K. A. Lillycrop ◽  
S. R. de Rooij ◽  
J. A. van der Post ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Promoter Methylation ◽  
Peripheral Blood ◽  
Methylation Status ◽  
Later Life ◽  
Proximal Promoter ◽  
Promoter Regions ◽  
Increased Risk ◽  
Famine Exposure ◽  
Prenatal Famine

Poor nutrition during fetal development can permanently alter growth, cardiovascular physiology and metabolic function. Animal studies have shown that prenatal undernutrition followed by balanced postnatal nutrition alters deoxyribonucleic acid (DNA) methylation of gene promoter regions of candidate metabolic control genes in the liver. The aim of this study was to investigate whether methylation status of the proximal promoter regions of four candidate genes differed between individuals exposed to the Dutch famine in utero. In addition, we determined whether methylation status of these genes was associated with markers of metabolic and cardiovascular disease and adult lifestyle. Methylation status of the GR1-C (glucocorticoid receptor), PPARγ (peroxisome proliferator-activated receptor gamma), lipoprotein lipase and phosphatidylinositol 3 kinase p85 proximal promoters was investigated in DNA isolated from peripheral blood samples of 759 58-year-old subjects born around the time of the 1944–45 Dutch famine. We observed no differences in methylation levels of the promoters between exposed and unexposed men and women. Methylation status of PPARγ was associated with levels of high-density lipoprotein cholesterol and triglycerides as well as with exercise and smoking. Hypomethylation of the GR promoter was associated with adverse adult lifestyle factors, including higher body mass index, less exercise and more smoking. The previously reported increased risk of cardiovascular and metabolic disease after prenatal famine exposure was not associated with differences in methylation status across the promoter regions of these candidate genes measured in peripheral blood. The adult environment seems to affect GR and PPARγ promoter methylation.

Increased Risk of Affective Disorders in Males after Second Trimester Prenatal Exposure to the Dutch Hunger Winter of 1944–45

1995 ◽  
Vol 166 (5) ◽  
pp. 601-606 ◽  
Author(s):  
Alan S. Brown ◽  
Ezra S. Susser ◽  
Shang P. Lin ◽  
Richard Neugebauer ◽  
Jack M. Gorman
Keyword(s):  
Prenatal Exposure ◽  
Affective Disorders ◽  
Separate Analysis ◽  
Second Trimester ◽  
Birth Cohorts ◽  
Affective Psychosis ◽  
Affective Psychoses ◽  
Increased Risk ◽  
Famine Exposure ◽  
Prenatal Famine

BackgroundPrenatal and perinatal factors have been linked to affective disorders. We therefore undertook an exploratory study to determine whether prenatal exposure to severe famine was associated with an increased risk of affective disorders.MethodMonthly birth cohorts that were exposed and unexposed to the Dutch Hunger Winter of 1944–45 were identified. The cumulative incidences of affective psychoses and neurotic depression (ICD–9 criteria) were compared between exposed and unexposed cohorts during each trimester of gestation.ResultsThe relative risk (RR) of affective psychosis (broad and restricted definitions) among persons exposed to famine during the second trimester was significantly increased (broad: RR (95% confidence interval) = 1.62 (1.19, 2.20); restricted: 1.59 (1.14, 2.21)). Separate analysis by gender showed a significant association among males (broad: 2.26 (1.43, 3.57); restricted: 2.40 (1.49, 3.89)), but not females (broad: 1.28 (0.84, 1.94); restricted: 1.17 (0.73, 1.86)). The risk of neurotic depression was not increased after prenatal famine exposure.ConclusionsThese results suggest a possible relationship between prenatal famine during the second trimester and affective psychosis, lending plausibility to reports that have associated affective psychoses with prenatal exposures. Further studies of this relationship are warranted.

Effects of prenatal exposure to the 1983–1985 Ethiopian great famine on the metabolic syndrome in adults: a historical cohort study

2020 ◽  
Vol 124 (10) ◽  
pp. 1052-1060
Author(s):  
Getachew Arage ◽  
Tefera Belachew ◽  
Habtamu Hassen ◽  
Mubarek Abera ◽  
Fedilu Abdulhay ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Prenatal Exposure ◽  
Fasting Blood Glucose ◽  
International Diabetes Federation ◽  
Birth Date ◽  
Historical Cohort ◽  
The Metabolic Syndrome ◽  
Great Famine ◽  
Famine Exposure ◽  
Prenatal Famine

AbstractThe Ethiopian great famine was one of the severe forms of global famines ever documented in Africa as well as in the recent history of the world. Earlier famine studies, as natural experiments, had tested the association between prenatal famine exposure and the metabolic syndrome and reported heterogeneous findings. Hence, this study aimed at evaluating the effects of prenatal exposure to the 1983–1985 Ethiopian great famine on the metabolic syndrome in adults. Self-reported birth date and age of the study subjects were used to classify the status of famine exposure. The International Diabetes Federation criterion was used to assess the metabolic syndrome. Multivariable logistic regression models were fitted to examine relationship between prenatal famine exposure and the metabolic syndrome. The findings showed that, adjusted for covariates, adults who had prenatal exposure to famine were 2·94 times more likely to develop the metabolic syndrome compared with non-exposed groups (adjusted OR (AOR) 2·94, 95 % CI 1·66, 5·27). More specifically, famine exposure during prenatal life was associated with increased waist circumference (AOR 2·27 cm, 95 % CI 0·28, 4·26), diastolic blood pressure (AOR 2·47 mmHg, 95 % CI 0·84, 4·11), TAG (AOR 0·20 mmol/l, 95 % CI 0·10, 0·28) and fasting blood glucose (AOR 0·24 mmol/l, 95 % CI 0·04, 0·43) compared with the control groups. Higher proportion of the metabolic syndrome, risky anthropometric and dyslipidaemic parameters were observed among exposed groups. This finding adds further evidence on fetal origin of adult diseases hypothesis. The finding may imply that one potential means of preventing adulthood metabolic syndrome is to optimise maternal nutrition during pregnancy.

The Impact of Military Service Exposures and Psychological Resilience on the Mental Health Trajectories of Older Male Veterans

2020 ◽  
pp. 089826432097523
Author(s):  
Stephanie Ureña ◽  
Miles G. Taylor ◽  
Dawn C. Carr
Keyword(s):  
Mental Health ◽  
Depressive Symptom ◽  
Military Service ◽  
Later Life ◽  
Traumatic Experiences ◽  
Psychological Resilience ◽  
Previous Exposure ◽  
Negative Consequences ◽  
Symptom Trajectories ◽  
The Impact

Objectives: We examine the impact of exposure to the dead, dying, and wounded (DDW) during military service on the later-life depressive symptom trajectories of male United States veterans, using psychological resilience as an internal resource that potentially moderates negative consequences. Methods: The Health and Retirement Study (2006–2014) and linked Veteran Mail Survey were used to estimate latent growth curve models of depressive symptom trajectories, beginning at respondents’ first report of resilience. Results: Veterans with higher levels of resilience do not have increased depressive symptoms in later life, despite previous exposure to DDW. Those with lower levels of resilience and previous exposure to DDW experience poorer mental health in later life. Discussion: Psychological resilience is important for later-life mental health, particularly for veterans who endured potentially traumatic experiences. We discuss the importance acknowledging the role individual resources play in shaping adaptation to adverse life events and implications for mental health service needs.

scholarly journals Baseline risk factor prevalence among adolescents aged 15–17 years old: findings from National Non-communicable Disease Monitoring Survey (NNMS) of India

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e044066
Author(s):  
Prashant Mathur ◽  
Vaitheeswaran Kulothungan ◽  
Sravya Leburu ◽  
Anand Krishnan ◽  
Himanshu Kumar Chaturvedi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Rural Areas ◽  
Communicable Disease ◽  
National Level ◽  
Developed Countries ◽  
Overweight And Obesity ◽  
Baseline Risk ◽  
Attitudes And Practices ◽  
Non Communicable Disease

ObjectiveTo generate national estimates of key non-communicable disease (NCD) risk factors for adolescents (15–17 years) identified in the National NCD Monitoring Framework and, study the knowledge, attitudes and practices towards NCD risk behaviours among school-going adolescents.Design and settingA community-based, national, cross-sectional survey conducted during 2017–2018. The survey was coordinated by the Indian Council of Medical Research—National Centre for Disease Informatics and Research with 10 reputed implementing research institutes/organisations across India in urban and rural areas.ParticipantsA multistage sampling design was adopted covering ages between 15 and 69 years—adolescents (15–17 years) and adults (18–69 years). The sample included 12 000 households drawn from 600 primary sampling units. All available adolescents (15–17 years) from the selected households were included in the survey.Main outcome measuresKey NCD risk factors for adolescents (15–17 years)—current tobacco and alcohol use, dietary behaviours, insufficient physical activity, overweight and obesity.ResultsOverall, 1402 households and 1531 adolescents completed the survey. Prevalence of current daily use of tobacco was 3.1% (95% CI: 2.0% to 4.7%), 25.2% (95% CI: 22.2% to 28.5%) adolescents showed insufficient levels of physical activity, 6.2% (95% CI: 4.9% to 7.9%) were overweight and 1.8% (95% CI: 1.0% to 2.9%) were obese. Two-thirds reported being imparted health education on NCD risk factors in their schools/colleges.ConclusionThe survey provides baseline data on NCD-related key risk factors among 15–17 years in India. These national-level data fill information gaps for this age group and help assess India’s progress towards NCD targets set for 2025 comprehensively. Though the prevalence of select risk factors is much lower than in many developed countries, this study offers national evidence for revisiting and framing appropriate policies, strategies for prevention and control of NCDs in younger age groups.

scholarly journals Social Integration and Depression of Older Adults in Rural China: Do Family or Friendship Ties Make a Difference?

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 580-580
Author(s):  
Dan Zhang ◽  
Zhiyong Lin ◽  
Shuzhuo Li
Keyword(s):  
Older Adults ◽  
Social Integration ◽  
Rural Areas ◽  
Important Determinant ◽  
Rural China ◽  
Later Life ◽  
Social Contexts ◽  
Limited Data ◽  
Family Ties ◽  
Relevant Evidence

Abstract Despite increasing acknowledgement that social integration/isolation is an important determinant of health in later life, relevant evidence for older adults in less developed social contexts is still limited. Data derived from 2015 and 2018 waves of a longitudinal study of 976 older adults, aged 60 and older, living in rural areas of Anhui Province, China. We analyzed how the level of social integration/isolation (measured as family and friendship ties) impacted depressive symptoms of older adults. Our results showed that more than half of older adults in our sample were either isolated from family or friends. Further analysis demonstrated that older people who were isolated from friends were more depressed in comparison with those who were closely integrated into friendship ties, while no such association was found in relation to family ties. Assessments of social integration among older adults should account for both family and friendship ties.

scholarly journals Violence against Women - A Study Done in the One-Stop Crisis Centre (OCC) of Dhaka Medical College Hospital, Dhaka, Bangladesh

1970 ◽  
Vol 19 (2) ◽  
pp. 98-101 ◽  
Author(s):  
R Khanom ◽  
DK Saha ◽  
K Begum ◽  
J Nur ◽  
S Tanira
Keyword(s):  
Violence Against Women ◽  
Rural Areas ◽  
Medical College Hospital ◽  
Physical Assault ◽  
Community Based Interventions ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Study Results ◽  
One Stop

Objective: This study aims to describe main perpetrator of violence area and prevention of violence against women. Study design: A cross sectional study was carried out in One-stop Crisis Centre (OCC) of Dhaka Medical College Hospital, Dhaka, Bangladesh during the period of June 2006 to May 2007. Methods: 284 victims reported in OCC during the study period were selected as cases for the study and quantitative information was collected from them using cross sectional for the present study. Results: Study shows that most of the violence is done by husband (46.48%) and prevalence is more in rural areas (80.98%) in comparison to urban area (19.02%). Physical assault is the most common type of violence (50.35%), followed by sexual assault (36.63%) and burn (13.02%) Housewives are tortured more (67%). Conclusion: Proper implementation of existing rules and community based interventions for raising awareness about the domestic violence against women are recommended. Key words: Violence against women; assault; human rights; one-stop crisis centre (OCC); Bangladesh. DOI: 10.3329/jdmc.v19i2.7077J Dhaka Med Coll. 2010; 19(2) : 98-101

scholarly journals The Prevalence and Awareness of Cardiovascular Diseases Risk Factors among the Lebanese Population: A Prospective Study Comparing Urban to Rural Populations

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Iqbal Fahs ◽  
Zainab Khalife ◽  
Diana Malaeb ◽  
Mohammad Iskandarani ◽  
Pascale Salameh
Keyword(s):  
Risk Factors ◽  
Rural Areas ◽  
Overweight And Obesity ◽  
Undiagnosed Diabetes ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Undiagnosed Hypertension ◽  
Lebanese Population ◽  
Urban And Rural Areas ◽  
A Prospective Study

Introduction. CVDs are largely driven by modifiable risk factors. This study sought to determine the awareness and prevalence of the modifiable CVDs risk factors among the Lebanese population.Methods. In a cross-sectional survey, 1000 participants aged ≥ 45 years were randomly selected from pharmacies and interviewed. The data was analyzed with SPSS version 21.0 software.Results. Differences between urban and rural areas include alcohol consumption (2.8% versus 1.7%;p=0.0001), cardioprotective vegetable servings (6.1% versus 2.3%;p=0.016), sedentary hours per day (18.6% versus 15.1%;p=0.002), and hypertension (38.5% versus 25.4%;p=0.001). The prevalence of overweight and obesity (77.3% versus 75.2%;p=0.468), smoking (39.3% versus 43.3%;p=0.232), diabetes (25.4% versus 21.4%;p=0.173), and dyslipidemia (25 versus 21.2%) was reported. Measurements revealed 19.3% of undiagnosed hypertension (12.4% versus 22.4%,p=0.001), 61.7% of hypertension (59.8% versus 62.6%;p=0.203), and 7.9% of undiagnosed diabetes (6.6% versus 8.6%;p=0.323). The declared awareness of CVDs risk factors was highest for smoking (91.5% versus 89.7%;p=0.339) and lowest for diabetes (54.4 versus 55.7%;p=0.692).Conclusion. This study has shown a high prevalence of modifiable CVDs risk factors in the Lebanese population ≥ 45 years, among which hypertension is the most prominent.

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