scholarly journals Identification of the phase composition of solid microparticles in the nasal mucosa of patients with chronic hypertrophic rhinitis using Raman microspectroscopy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kristina Čabanová ◽  
Oldřich Motyka ◽  
Hana Bielniková ◽  
Lenka Čábalová ◽  
Petr Handlos ◽  
...  
Keyword(s):  
Nasal Mucosa ◽  
Living Organism ◽  
Raman Microspectroscopy ◽  
Solid Particles ◽  
Submicron Particles ◽  
Control Group ◽  
Direct Identification ◽  
Chronic Hypertrophic Rhinitis ◽  
The Individual ◽  
Reference Samples

AbstractSolid particles, predominantly in micron and submicron sizes, have repeatedly been observed as a threat to a human health unique compared to the other textures of the same materials. In this work, the hypothesis the solid metal-based particles play a role in the pathogenesis of chronic hypertrophic rhinitis was investigated in patients who had not responded positively to medication. In the group of 40 randomly selected patients indicated for surgical mucotomy, the presence of solid micro- and submicron particles present in their nasal mucosa was assessed. For comparison, a set of 13 reference samples from patients without diagnosed chronic hypertrophic rhinitis was evaluated. The analysis was performed using Raman microspectroscopy. The advantage of this method is the direct identification of compounds. The main detected compounds in the mucosa samples of patients with chronic hypertrophic rhinitis were TiO2, carbon-based compounds, CaCO3, Ca(Fe, Mg, Mn)(CO3)2 MgCO3, Fe2O3, BaSO4, FeCO3 and compounds of Al and Si, all of which may pose a health risk to a living organism. In the reference samples, only TiO2 and amorphous carbon were found. In the control group mucosa, a significantly lower presence of most of the assessed compounds was found despite the longer time they had to accumulate them due to their higher mean age. Identification and characterisation of such chemicals compounds in a living organism could contribute to the overall picture of the health of the individual and lead to a better understanding of the possible causes not only in the chronic hypertrophic rhinitis, but also in other mucosal and idiopathic diseases.

Dose-Response Study of Formaldehyde on Nasal Mucosa Swelling. A Study on Residents with Nasal Distress at Home

1994 ◽  
Vol 8 (3) ◽  
pp. 143-146 ◽  
Author(s):  
Jan E. Falk ◽  
Jan E. Juto ◽  
Göran Stridh ◽  
Gunnar Bylin
Keyword(s):  
Nasal Mucosa ◽  
World Health ◽  
Control Group ◽  
Great Effort ◽  
Indoor Climate ◽  
Sick Building ◽  
Health Organization ◽  
The Individual ◽  
Dose Response Study ◽  
The Impact

Despite great effort, it has been difficult to demonstrate in an objective way any impact of sick building environment on affected individuals. The aim of this study was to learn whether or not it is possible with rhinostereometry to register changes in the nasal mucosa swelling at exposure to formaldehyde in concentrations 0–0.174 mg/m3. Seven persons, non-allergic, otherwise healthy, and with a history of nasal distress in their homes, participated in the study. Six healthy persons, without nose problems, were controls. Each person was exposed to formaldehyde in different concentrations during two hours in a climate chamber. Increased swelling was recorded al the two highest concentrations (0.073 and 0.174 mg/m3) in the symptomatic group. The control group did not show any mucosal swelling. It was possible to demonstrate an increased mucosal swelling that must be attributed to exposure to formaldehyde. This was possible at formaldehyde concentrations close to the (0.125 mg/m3) upper limit for indoor climate recommended by the World Health Organization (WHO). The study model can be considered useful for further investigations of the impact on the individual from other airborne irritants connected to sick building environments.

scholarly journals Primary dementia care based on the individual needs of the patient: study protocol of the cluster randomized controlled trial, DemStepCare

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Isabella Bablok ◽  
◽  
Harald Binder ◽  
Dominikus Stelzer ◽  
Klaus Kaier ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Dementia Care ◽  
Cluster Randomized Controlled Trial ◽  
Control Group ◽  
Care Model ◽  
Randomized Controlled ◽  
Individual Needs ◽  
Cluster Randomized ◽  
The Individual

Abstract Background Most people with dementia (PwD) are cared for at home, with general practitioners (GPs) playing a key part in the treatment. However, primary dementia care suffers from a number of shortcomings: Often, diagnoses are made too late and therapies by GPs do not follow the guidelines. In cases of acute crises, PwD are too often admitted to hospital with adverse effects on the further course of the disease. The aim of this study is to implement and evaluate a new GP-based, complex dementia care model, DemStepCare. DemStepCare aims to ensure demand-oriented, stepped care for PwD and their caregivers. Methods/design In a cluster randomized controlled trial, the care of PwD receiving a complex intervention, where the GP is supported by a multi-professional team, is compared to (slightly expanded) usual care. GPs are clustered by GP practice, with 120 GP practices participating in total. GP practices are randomized to an intervention or a control group. 800 PwD are to be included per group. Recruitment takes place in Rhineland-Palatinate, Germany. In addition, a second control group with at least 800 PwD will be formed using aggregated routine data from German health insurance companies. The intervention comprises the training of GPs, case management including repeated risk assessment of the patients’ care situation, the demand-oriented service of an outpatient clinic, an electronic case record, external medication analyses and a link to regional support services. The primary aims of the intervention are to positively influence the quality of life for PwD, to reduce the caregivers’ burden, and to reduce the days spent in hospital. Secondary endpoints address medication adequacy and GPs’ attitudes and sensitivity towards dementia, among others. Discussion The GP-based dementia care model DemStepCare is intended to combine a number of promising interventions to provide a complex, stepped intervention that follows the individual needs of PwD and their caregivers. Its effectiveness and feasibility will be assessed in a formative and a summative evaluation. Trial registration German Register of Clinical Trials (Deutsches Register Klinischer Studien, DRKS), DRKS00023560. Registered 13 November 2020 - Retrospectively registered. HTML&TRIAL_ID=DRKS00023560.

scholarly journals Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandra Brunner ◽  
Márta Medvecz ◽  
Nóra Makra ◽  
Miklós Sárdy ◽  
Kinga Komka ◽  
...  
Keyword(s):  
Lichen Sclerosus ◽  
Gardnerella Vaginalis ◽  
Control Group ◽  
Vaginal Microbiome ◽  
Microbiome Composition ◽  
Streptococcus Anginosus ◽  
Menopausal Women ◽  
Post Menopausal ◽  
The Individual ◽  
Level Production

AbstractHuman beta defensins (hBDs) may play an important role in the progression of lichen sclerosus (LS), due to their ability to induce excessive stimulation of extracellular matrix synthesis and fibroblast activation. The genetic ability of the individual to produce defensins, the presence of microbes influencing defensin production, and the sensitivity of microbes to defensins together regulate the formation of an ever-changing balance between defensin levels and microbiome composition. We investigated the potential differences in postmenopausal vaginal microbiome composition and vaginal hBD levels in LS patients compared to non-LS controls. LS patients exhibited significantly lower levels of hBD1 (p = 0.0003), and significantly higher levels of hBD2 (p = 0.0359) and hBD3 (p = 0.0002), compared to the control group. The microbiome of the LS patients was dominated by possibly harmful bacteria including Lactobacillus iners, Streptococcus anginosus or Gardnerella vaginalis known to initiate direct or indirect damage by increasing defensin level production. Our observations highlight that correcting the composition of the microbiome may be applicable in supplementary LS therapy by targeting the restoration of the beneficial flora that does not increase hBD2-3 production.

scholarly journals Proteome Profiling of PMJ2-R and Primary Peritoneal Macrophages

2021 ◽  
Vol 22 (12) ◽  
pp. 6323
Author(s):  
Alexander L. Rusanov ◽  
Peter M. Kozhin ◽  
Olga V. Tikhonova ◽  
Victor G. Zgoda ◽  
Dmitry S. Loginov ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Living Organism ◽  
Peritoneal Macrophages ◽  
In Vitro Models ◽  
Individual Characteristics ◽  
Essential Proteins ◽  
Comparative Proteomic Analysis ◽  
Immortalized Cell ◽  
The Individual

In vitro models are often used for studying macrophage functions, including the process of phagocytosis. The application of primary macrophages has limitations associated with the individual characteristics of animals, which can lead to insufficient standardization and higher variability of the obtained results. Immortalized cell lines do not have these disadvantages, but their responses to various signals can differ from those of the living organism. In the present study, a comparative proteomic analysis of immortalized PMJ2-R cell line and primary peritoneal macrophages isolated from C57BL/6 mice was performed. A total of 4005 proteins were identified, of which 797 were quantified. Obtained results indicate significant differences in the abundances of many proteins, including essential proteins associated with the process of phagocytosis, such as Elmo1, Gsn, Hspa8, Itgb1, Ncf2, Rac2, Rack1, Sirpa, Sod1, C3, and Msr1. These findings indicate that outcomes of studies utilizing PMJ2-R cells as a model of peritoneal macrophages should be carefully validated. All MS data are deposited in ProteomeXchange with the identifier PXD022133.

Acquiring variable commands at home and abroad: Examining optatives and imperatives in L1 and L2 Spanish

2020 ◽  
Vol 13 (1) ◽  
pp. 79-113
Author(s):  
Farrah Neumann ◽  
Matthew Kanwit
Keyword(s):  
Second Language ◽  
Second Language Acquisition ◽  
Study Abroad ◽  
Language Teaching ◽  
Applied Linguistics ◽  
Future Research ◽  
Control Group ◽  
Before And After ◽  
The Individual ◽  
At Home

AbstractSince many linguistic structures are variable (i. e. conveyed by multiple forms), building a second-language grammar critically involves developing sociolinguistic competence (Canale and Swain. 1980. Theoretical bases of communicative approaches to second language teaching and testing. Applied Linguistics 1(1). 1–47), including knowledge of contexts in which to use one form over another (Bayley and Langman. 2004. Variation in the group and the individual: Evidence from second language acquisition. International Review of Applied Linguistics in Language Teaching 42(4). 303–318). Consequently, researchers interested in such competence have increasingly analyzed the study-abroad context to gauge learners’ ability to approximate local norms following a stay abroad, due to the quality and quantity of input to which learners may gain access (Lafford. 2006. The effects of study abroad vs. classroom contexts on Spanish SLA: Old assumptions, new insights and future research directions. In Carol Klee & Timothy Face (eds.), Selected proceedings of the 7th conference on the acquisition of Spanish and Portuguese as first and second languages, 1–25. Somerville, MA: Cascadilla Proceedings Project). Nevertheless, the present study is the first to examine native or learner variation between imperative (e. g. ven ‘come’) and optative Spanish commands (e. g. que vengas ‘come’). We first performed a corpus analysis to determine the linguistic factors to manipulate in a contextualized task, which elicited commands from learners before and after four weeks abroad in Alcalá de Henares, Spain. Their overall rates of selection and predictive factors were compared to local native speakers (NSs) and a control group of at-home learners.Results revealed that the abroad learners more closely approached NS rates of selection following the stay abroad. Nonetheless, for both learner groups conditioning by independent variables only partially approximated the NS system, which was more complex than previously suggested.

Evaluation of Functionality in Families with Depressed Patient by Using the FFS - Poster Prezentation

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
T. Maria-Silvia
Keyword(s):  
Major Depression ◽  
Depressive Disorder ◽  
Positive Affect ◽  
Psychiatric Patients ◽  
Normal Families ◽  
Control Group ◽  
World Population ◽  
Dsm Iv ◽  
The Individual ◽  
Family Functionality

Depression is a disorder of representation and regulation of mood and emotion; it affects 5% of world population, in a year. Unlike normal loss and sadness feelings, major depression is persistant and it interferes significantly with thoughts, behaviour, emotions, activity and health of the individual. If untreated, depression can lead to suicide. Using family therapy in treating psychiatric patients is a must due to the significance that a family holds in individual and society life.Objective:Assesing family functionality in families with a member diagnosed according to DSM IV TR with depressive disorder; depression intensity was assesed with HDRS.Methods:A sample of 3o families (71 members); FFS assesses the most important and consistent five functioning areas: positive affect, comunication, conflicts, worries and rituals.Results:Values obtained in each of the 40 questions of the scale can give information on variables affecting the increase or decrease in subscales values. Positive affect 35,07, communication 37, conflicts 15,11, worries 40,77, rituals 45,03. The reuslts were compared to those obtained by assessin normal families from a control group of 132 families (323 members).Conclusions:Differences were noticed. Values obtained in our study represent the standard of functioning of families with a depressed member.

AESTHETIC AND ART EDUCATION AS A SOCIOCULTURAL PHENOMENON

2020 ◽  
Vol 1 (2) ◽  
pp. 6-17
Author(s):  
S. I. Kolbysheva ◽  
Keyword(s):  
Art Education ◽  
Informal Education ◽  
Social Role ◽  
Leisure Activities ◽  
Living Organism ◽  
Cultural Value ◽  
The Social ◽  
Human Creativity ◽  
Classical Culture ◽  
The Individual

The article analyzes the phenomenon of aesthetic and art education in the context of postnon- classical culture, which most fully reflects the peculiarities of the worldview orientations and values of a modern man, and is a kind of reference point for determining the scientific and theoretical basis for the development of this phenomenon at the present time. The article reveals the reasons for strengthening the social role of aesthetic and art education, which connects it with the values of the family, leisure activities and informal education. Aesthetic and art education is considered as a “living” organism that is in constant motion, able to respond to sociocultural changes, and in its rhizomaticity does not ignore the heterogeneity of the surrounding world; as an integral component of education in general, which is found in the community of key tasks focused on “human creativity” in the context of value and meaning categories of culture. It is justified the shift from information and knowledge pedagogy to pedagogy of meaning, actualizing the importance of processes of self-identification, harmonizing the relationship between man and the world, itself based on the parity of dialogical forms of cognition; the transfer of dynamics of artistic and creative activities to the internal world of the individual and the updating on this basis of strategies of irrational thinking. In conclusion, the author is concerned about the level of humanitarian culture in the society and studies aesthetic and art education as an effective mechanism for its development, as a general cultural value internalized by society.

Effect of short-term mental stress on time- domain indices of heart rate variability in obese individuals – A case- control study

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 274-277
Author(s):  
Priya S.A. ◽  
R. Rajalakshmi
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Neuronal Activity ◽  
Time Domain ◽  
Mental Stress ◽  
Mental Arithmetic ◽  
High Body Mass Index ◽  
Control Group ◽  
Stress Task ◽  
The Individual

  Introduction and Aim: Mental stress may impact dramatically on dynamic autonomic control on heart. Many studies have demonstrated association of high body mass index (BMI) with greater risk for cardiovascular disease with disturbance in autonomic neuronal activity. Analysis of Heart rate variability (HRV)during acute mental stress assesses the autonomic status of the individual. Hence, we aimed to study the effect of acute mental stress on time domain measures in obese adults.   Materials and Methods:Sixty male volunteers of 30 each in study group (obese individuals) and control group (non-obese individuals) were recruited for the study. A basal recording of ECG in lead II was done on all the individuals. Then they underwent mental arithmetic stress task for 5 minutes during which again ECG was recorded. The change in time domain measures of HRV during rest and stress task was analyzed and compared between both the groups.   Results: Analysis of time domain measures of HRV revealed a statistically significant increase (p ? 0.001) in mean heart rate in both obese and non-obese individuals, while rMSSD(root mean square differences of successive RR interval) and SDNN (standard deviation of all NN intervals) showed a statistically significant (p? 0.001) decrease in obese individuals and non-obese individuals did not show any statistically significant change during the mental stress task.   Conclusion: In response to acute mental stress there was increased heart rate in both the groups. But the autonomic neuronal activity differed by way of sympathetic dominance in non-obese individuals and parasympathetic withdrawal in obese individuals.  

scholarly journals Team Resilience Training in the Workplace: E-Learning Adaptation, Measurement Model, and Two Pilot Studies (Preprint)

2017 ◽  
Author(s):  
Joel B Bennett ◽  
Michael Neeper ◽  
Brittany D Linde ◽  
Gale M Lucas ◽  
Lindsay Simone
Keyword(s):  
Intervention Group ◽  
Measurement Model ◽  
Control Group ◽  
Pilot Studies ◽  
Working Model ◽  
Team Resilience ◽  
Two Samples ◽  
Program Efficacy ◽  
E Learning ◽  
The Individual

BACKGROUND The majority of resilience interventions focus on the individual. Workplace resilience is a growing field of research. Given the ever-increasing interconnectedness in businesses, teamwork is a guarantee. There is also growing recognition that resilience functions at the team level. OBJECTIVE The objective of our work was to address three shortcomings in the study of workplace resilience interventions: lack of interventions focusing on group-level or team resilience, the need for brief interventions, and the need for more theoretical precision in intervention studies. METHODS The authors took an established evidence-based program (Team Resilience) and modified it based on these needs. A working model for brief intervention evaluation distinguishes outcomes that are proximal (perceptions that the program improved resilience) and distal (dispositional resilience). A total of 7 hypotheses tested the model and program efficacy. RESULTS Two samples (n=118 and n=181) of engineering firms received the Web-based training and provided immediate reactions in a posttest-only design. The second sample also included a control condition (n=201). The findings support the model and program efficacy. For example, workplace resilience was greater in the intervention group than in the control group. Other findings suggest social dissemination effects, equal outcomes for employees at different stress levels, and greater benefit for females. CONCLUSIONS This preliminary research provides evidence for the capabilities of e-learning modules to effectively promote workplace resilience and a working model of team resilience.

scholarly journals Effect of the Leisure Activities on the Level of Psychological stress among the elderly during the Coronavirus Outbreak

2021 ◽  
Vol 9 (1) ◽  
pp. 70-78
Author(s):  
Ayed Zureigat ◽  
Osama Abdel Fattah
Keyword(s):  
Psychological Stress ◽  
Healthy Aging ◽  
Leisure Activities ◽  
The Elderly ◽  
Control Group ◽  
Face To Face ◽  
Quasi Experimental ◽  
Physical Abilities ◽  
The Individual ◽  
Experimental Group

Background: It is well known that advancing age is accompanied by many negative feelings due to the feeling of loneliness and psychological emptiness, which leads to the individual feeling that society does not need him due to his weak physical abilities and thus this, will negatively affect healthy aging. Objective: The study aimed to investigate the effect of the leisure activities on the psychological stress among the elderly during Coronavirus (COVID-19) Outbreak. Design: To achieve this, we used the quasi-experimental approach on a sample consisting of 54, with the average age of (65.4±2.3) years. Divided into two groups 27 as a control group and 27 as the experimental group and this sample was purposively selected. Because of the home quarantine and to reduce face-to-face interaction, we used a questionnaire to measure the psychological stress level by using the Google form. The study tool consisted of 7 paragraphs associated with depression and 6 paragraphs associated with anxiety, finally 6 paragraphs associated with aggression. Before applying the experiment, the psychological stress was measured among the study sample, and then the leisure activities program was sent to the experimental group by the WhatsApp application. The researchers used means, standard deviations, paired and independent sample t-test by using SPSS version 24 with a confidence level of 95% (p<0.05). Results: The results of the study have shown that the level of the psychological stress among both groups came with a high average in the pre-measurement, as well as the anxiety domain that were the most affected in a positive way through leisure activities practicing. Additionally, there were statistically significant differences between the pre and post measurement among experiment group and favor of the post measurement. Conclusion: the leisure activities practicing among the elderly have contributed positively to reducing the level of psychological stress represented by depression, anxiety.

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