Serum Irisin Concentrations in Severely Inflamed Patients

AbstractIrisin is a recently discovered exercise-induced myokine that has been attributed the role of favoring white-to-brown adipose tissue trans-differentiation. We confirmed in a population-based cohort that irisin serum concentrations are independently correlated with the habitual level of physical activity, but we also observed an independent correlation with serum concentrations of high-sensitivity C-reactive protein (hs-CRP), thus suggesting that inflammation may influence irisin production. In order to investigate the association between irisin and inflammation, we measured serum irisin concentrations in a group of inflamed inpatients. We hypothesized that if an association between irisin and inflammation exists, severely inflamed patients, even though physically inactive, might also exhibit high serum irisin levels. We recruited 40 consecutive markedly inflamed inpatients on the basis of serum CRP levels. Their irisin serum concentrations (Phoenix Europe, Germany) were compared with those obtained in the population-based cohort of the ABCD_2 study (Alimentazione, Benessere Cardiovascolare e Diabete) (ISRCTN15840340). The inflamed patients exhibited higher serum irisin concentrations (median: 6.77 ng/ml; 95% CI for the median: 5.97–7.23) than those observed in the ABCD cohort (median: 5.21 ng/ml; 95% CI for the median: 5.08–5.30; p <0.001). Irisin concentrations were significantly correlated with age (r=−0.44; p <0.001), creatinine (r=−0.35; p <0.05), and fibrinogen (r=0.40; p <0.05) concentrations. No association was observed between irisin, interleukine-6 and tumor necrosis factor alpha. This study confirms the association between inflammation and irisin concentrations. Further studies are needed to understand the mechanisms underlying this association and its possible clinical implications.

Download Full-text

Non-Hepatic Alkaline Phosphatase, hs-CRP and Progression of Vertebral Fracture in Patients with Rheumatoid Arthritis: A Population-Based Longitudinal Study

Journal of Clinical Medicine ◽

10.3390/jcm7110439 ◽

2018 ◽

Vol 7 (11) ◽

pp. 439 ◽

Cited By ~ 6

Author(s):

Jih-Chen Yeh ◽

Chang-Chin Wu ◽

Cheuk-Sing Choy ◽

Shu-Wei Chang ◽

Jian-Chiun Liou ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Alkaline Phosphatase ◽

Cox Regression ◽

High Sensitivity ◽

Population Based ◽

Reactive Protein ◽

Prognostic Assessment ◽

Product Term ◽

Hs Crp ◽

Stratified Analysis

Background: Interactions and early warning effects of non-hepatic alkaline phosphatase (NHALP) and high-sensitivity C-reactive protein (hs-CRP) on the progression of vertebral fractures (VFs) in patients with rheumatoid arthritis (RA) remain unclear. We aim to explore whether serum concentrations of NHALP and hs-CRP could serve as a promising dual biomarker for prognostic assessment of VF progression. Methods: Unadjusted and adjusted hazard ratios (aHRs) of VF progression were calculated for different categories of serum NHALP and hs-CRP using the Cox regression model in RA patients. The modification effect between serum NHALP and hs-CRP on VF progression was determined using an interaction product term. Results: During 4489 person-years of follow-up, higher NHALP (>125 U/L) and hs-CRP (>3.0 mg/L) were robustly associated with incremental risks of VF progression in RA patients (aHR: 2.2 (95% confidence intervals (CIs): 1.2–3.9) and 2.0 (95% CI: 1.3–3.3) compared to the lowest HR category, respectively). The interaction between NHALP and hs-CRP on VF progression was statistically significant (p < 0.05). In the stratified analysis, patients with combined highest NHALP and hs-CRP had the greatest risk of VF progression (aHR: 4.9 (95% CI: 2.5–9.6)) compared to the lowest HR group (NHALP < 90 U/L and hs-CRP < 1 mg/L). Conclusions: In light of underdiagnoses of VFs and misleading diagnosis by single test, NHALP and hs-CRP could serve as compensatory biomarkers to predict subclinical VF progression in RA patients.

Download Full-text

KORELASI KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN DENGAN KADAR LOW DENSITY LIPOPROTEIN PADA PENYANDANG OBES

Human Care Journal ◽

10.32883/hcj.v5i3.717 ◽

2020 ◽

Vol 5 (3) ◽

pp. 676

Author(s):

Rama Dhanivita Djamin

Keyword(s):

Interleukin 1 ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Sensitivity ◽

Low Grade ◽

Low Density ◽

C Reactive Protein ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

Hs Crp

Obesitas terjadi karena akumulasi lemak berlebih di dalam tubuh. Akumulasi lemak menimbulkan low grade inflammation pada jaringan adiposa, menyebabkan peningkatan sitokin inflamasi seperti tumor necrosis factor-alpha, interleukin-1 beta, dan interleukin-6 (IL-6). Peningkatan sekresi IL-6 merangsang hepar meningkatkan produksi protein fase akut. High sensitivity C-reactive protein (hs-CRP) sebagai penanda inflamasi merupakan protein fase akut. Low density lipoprotein (LDL-kolesterol) adalah lipoprotein yang paling banyak mengandung kolesterol. Peningkatan kadar hs-CRP dan kadar LDL-kolesterol pada obesitas diidentifikasi sebagai faktor risiko aterosklerosis. Penelitian ini bertujuan menganalisis hubungan hs-CRP dengan LDL-kolesterol pada penyandang obes, merupakan penelitian analitik rancangan potong lintang dilakukan September 2018 sampai Agustus 2019. Kadar hs-CRP diperiksa dengan metode enzyme linked immunoassay (ELISA), sedangkan kadar LDL-kolesterol dengan metode kalkulasi (rumus Friedewald). Uji korelasi Spearman digunakan untuk menganalisi data, jika didapatkan nilai p<0,05 korelasi dinyatakan bermakna. Subjek penelitian berjumlah 26 penyandang obes terdiri dari 6 laki-laki (23,1%) dan 20 perempuan (76,9%). Rerata umur subjek penelitian adalah 36,46(7,68) tahun. Rerata kadar hs-CRP dan kadar LDL-kolesterol adalah 5,08(1,28) mg/L dan 154,69(45,8) mg/dL. Analisis korelasi menunjukkan korelasi positif lemah dan tidak bermakna secara statistik antara kadar hs-CRP dengan kadar LDL-kolesterol (r= 0,333, p=0,096). Simpulan: Terdapat korelasi positif lemah antara kadar hs-CRP dengan kadar LDL-kolesterol pada penyandang obes.Kata kunci: Obesitas, High Sensitivity C-Reactive, Low Density Lipoprotein

Download Full-text

Baseline High-Sensitivity C-Reactive Protein Predicts Macrovascular and Microvascular Complications of Type 2 Diabetes: A Population-Based Study

Annals of Nutrition and Metabolism ◽

10.1159/000488537 ◽

2018 ◽

Vol 72 (4) ◽

pp. 287-295 ◽

Cited By ~ 12

Author(s):

Zahra Aryan ◽

Alireza Ghajar ◽

Sara Faghihi-Kashani ◽

Mohsen Afarideh ◽

Manouchehr Nakhjavani ◽

...

Keyword(s):

Kidney Disease ◽

Diabetic Kidney Disease ◽

Microvascular Complications ◽

High Sensitivity ◽

Population Based ◽

End Points ◽

Diabetic Kidney ◽

Reactive Protein ◽

Hs Crp ◽

Traditional Risk Factors

Background/Aims: This prospective study is aimed at examining the predictive value of high-sensitivity C-reactive protein (hs-CRP) for coronary heart disease (CHD) events and microvascular complications of type 2 diabetes mellitus (T2DM). Methods: A population-based study (NCT02958579) was conducted on 1,301 participants with T2DM (mean follow-up of 7.5 years). Risk assessment for vascular events was done at baseline, and serum hs-CRP was measured. End points of this study include CHD events, diabetic retinopathy, neuropathy, and diabetic kidney disease. Individuals with unavailable data or hs-CRP >20 mg/L were excluded. The discrimination and reclassification improvement of study end points were tested after addition of hs-CRP to traditional risk factors. Results: Median serum hs-CRP was 2.00 ranging from 0.1 to 17 mg/L. Hazards ratio of each SD increment in baseline hs-CRP was 1.028 (1.024–1.032) for CHD, 1.025 (1.021–1.029) for diabetic neuropathy, 1.037 (1.030–1.043) for diabetic retinopathy, and 1.035 (1.027–1.043) for diabetic kidney disease. The addition of hs-CRP to traditional risk factors of vascular complications of T2DM improved discrimination of all end points (p < 0.001). Net reclassification improvement ranged from 8% for diabetic neuropathy to 31% for diabetic kidney disease (p < 0.05). Conclusion: Baseline hs-CRP predicts both of CHD events and microvascular complications of patients with T2D.

Download Full-text

A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS)

Public Health Nutrition ◽

10.1017/s1368980013002565 ◽

2013 ◽

Vol 17 (8) ◽

pp. 1825-1833 ◽

Cited By ~ 279

Author(s):

Nitin Shivappa ◽

Susan E Steck ◽

Thomas G Hurley ◽

James R Hussey ◽

Yunsheng Ma ◽

...

Keyword(s):

Seasonal Variation ◽

High Sensitivity ◽

Population Based ◽

Blood Cholesterol ◽

Dietary Inflammatory Index ◽

C Reactive Protein ◽

Dietary Recall ◽

Inflammatory Index ◽

Reactive Protein ◽

Hs Crp

AbstractObjectiveTo perform construct validation of the population-based Dietary Inflammatory Index (DII) using dietary data from two different dietary assessments and serum high-sensitivity C-reactive protein (hs-CRP) as the construct validator.DesignUsing data derived from (i) three 24 h dietary recalls (24HR) at baseline and at the end of each subsequent quarter (i.e. up to fifteen over a year) and (ii) a 7 d dietary recall (7DDR) measured at baseline and then quarterly, regression analyses were conducted to test the effect of the DII score on serum hs-CRP as dichotomous (≤3 mg/l, >3 mg/l), while controlling for important potential confounders.SettingExisting data from the Seasonal Variation of Blood Cholesterol Study (SEASONS), a longitudinal observational study of healthy participants recruited in Worcester, MA, USA and participants were followed for 1 year.SubjectsParticipants who had at least one hs-CRP measurement over her/his 1-year participation (n495 for 24HR,n559 for 7DDR).ResultsHigher DII scores were associated with values of hs-CRP >3 mg/l (OR = 1·08; 95 % CI 1·01, 1·16,P= 0·035 for the 24HR; and OR = 1·10; 95 % CI 1·02, 1·19,P= 0·015 for the 7DDR).ConclusionsThe population-based DII was associated with interval changes in hs-CRP using both the 24HR and 7DDR. The success of this first-of-a-kind attempt at relating individuals’ intakes of inflammation-modulating foods using this refined DII, and the finding that there is virtually no drop-off in predictive capability using a structured questionnaire in comparison to the 24HR standard, sets the stage for use of the DII in a wide variety of other epidemiological and clinical studies.

Download Full-text

Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome

Mediators of Inflammation ◽

10.1155/2007/93573 ◽

2007 ◽

Vol 2007 ◽

pp. 1-8 ◽

Cited By ~ 17

Author(s):

Juha Saltevo ◽

Mauno Vanhala ◽

Hannu Kautiainen ◽

Esko Kumpusalo ◽

Markku Laakso

Keyword(s):

Metabolic Syndrome ◽

Receptor Antagonist ◽

Interleukin 1 ◽

High Sensitivity ◽

Population Based ◽

C Reactive Protein ◽

Reactive Protein ◽

Interleukin 1 Receptor Antagonist ◽

The Metabolic Syndrome ◽

Hs Crp

This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to subjects with MetS. If MetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.

Download Full-text

Relation between glucose levels, high-sensitivity C-reactive protein (hs-CRP), body mass index (BMI) and serum and dietary retinol in elderly in population-based study

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2011.06.005 ◽

2012 ◽

Vol 54 (3) ◽

pp. 462-468 ◽

Cited By ~ 6

Author(s):

Rafaella C.P. Luna ◽

Christiane C.C. do Nascimento ◽

Luiza S.R. Asciutti ◽

Sylvia do C.C. Franceschini ◽

Rosália Gouveia Filizola ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

High Sensitivity ◽

Population Based ◽

C Reactive Protein ◽

Population Based Study ◽

Glucose Levels ◽

Reactive Protein ◽

Hs Crp

Download Full-text

Head-out immersion in hot water does not increase serum CXCL1 in healthy men

Trends in Immunotherapy ◽

10.24294/ti.v3.i1.37 ◽

2019 ◽

Vol 3 (1) ◽

pp. 19

Author(s):

Yuta Sakurai ◽

Yasunori Umemoto ◽

Takashi Kawasaki ◽

Daisuke Kojima ◽

Tokio Kinoshita ◽

...

Keyword(s):

Water Immersion ◽

Venous Blood ◽

High Sensitivity ◽

Hot Water ◽

Serum Concentrations ◽

Healthy Men ◽

Reactive Protein ◽

Tnf Α ◽

Exercise Induced ◽

Necrosis Factor

Exercise-induced production of interleukin (IL)-6 results in the expression of chemokine CXC-motif ligand 1 (CXCL1) in mice. Recent studies described the increase in serum IL-6 levels during immersion of subjects in hot water. The present study investigated the effects of a 20-min head-out water immersion in 42 °C water (hot-HOI) on serum concentrations of CXCL1 in eight healthy men. Venous blood samples were taken at rest, immediately after hot-HOI, as well as 1, 2, 3, and 4 h after hot-HOI for measurements of serum concentrations of CXCL1, IL-6, tumor necrosis factor (TNF)-α, high-sensitivity C-reactive protein (hsCRP), while assessing counts of blood cells (CBC) and monitoring core temperature (Tcore). Tcore and serum IL-6 increased during hot-HOI and remained high until 4 h after hot-HOI. However, serum CXCL1, TNF-α, hsCRP, and CBC remained constant throughout the experiment. In conclusion, the results from our study demonstrated that 20-min hot-HOI increased serum IL-6, but not CXCL1 in healthy man.

Download Full-text

Moderate Vitamin D Deficiency and Inflammation Related Markers in Overweight/Obese Schoolchildren

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000197 ◽

2014 ◽

Vol 84 (1-2) ◽

pp. 98-107 ◽

Cited By ~ 8

Author(s):

Elena Rodríguez-Rodríguez ◽

Aránzazu Aparicio ◽

Pedro Andrés ◽

Rosa M. Ortega

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

High Sensitivity ◽

High Serum ◽

Obese Children ◽

Reactive Protein ◽

Tnf Α ◽

Obese Subjects ◽

Hs Crp ◽

Necrosis Factor

Objective: Obesity has been associated with vitamin D deficiency and increased oxidative stress, which can lead to the dysregulation of adipokines and inflammation. The aim of the present work was to examine the association of vitamin D status [25(OH)D] on inflammatory related markers in overweight/obese children. Subjects/Methods: A total of 137 Spanish schoolchildren between 9 and 12 years of age (31.4 % with overweight/obesity) were studied. Being overweight was defined as BMI ≥ 85th percentile and obesity as BMI ≥ 97th percentile using the reference tables of Hernández. Serum 25(OH)D concentrations were measured by chemiluminescent assay. Plasma tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were measured by immunoenzyme assay. Serum adiponectin was determined using an ELISA kit. Serum high-sensitivity C-reactive protein (hs-PCR) was tested by immunonephelometry. Results: IL-6 concentrations were higher in the overweight/obese children with deficient serum 25(OH)D (< 20 ng/mL) than in those in this group but whose serum 25(OH)D concentrations were adequate (≥ 20 ng/mL). Serum 25(OH)D was inversely associated with IL-6 concentrations in the overweight/obese subjects taking into account different covariates; thus, for every 1 ng/mL rise in the former, the latter fell by 0.160 pg/mL (β = - 0.160 ± 0.068; R2 = 0.131; p = 0.023). The obese subjects with concentrations of ≥ 25 ng/mL had lower hs-CRP values compared to those with concentrations of < 25 ng/mL (0.053 ± 0.035 vs. 0.356 ± 0.613 mg/dL; p = 0.035). Conclusion: Low serum 25(OH)D was significantly associated high serum IL-6 in overweight/obese children, and with increased hs-CRP in obese children.

Download Full-text

Migraine and vascular disease biomarkers: A population-based case-control study

Cephalalgia ◽

10.1177/0333102417698936 ◽

2017 ◽

Vol 38 (3) ◽

pp. 511-518 ◽

Cited By ~ 11

Author(s):

Gretchen E Tietjen ◽

Jagdish Khubchandani ◽

Nabeel Herial ◽

Inge H Palm-Meinders ◽

Hille Koppen ◽

...

Keyword(s):

Vascular Disease ◽

Plasma Concentrations ◽

High Sensitivity ◽

Endothelial Activation ◽

Population Based ◽

Disease Biomarkers ◽

Reactive Protein ◽

Factor Ii ◽

Hs Crp ◽

Epidemiologic Risk

Background The underpinnings of the migraine-stroke association remain uncertain, but endothelial activation is a potential mechanism. We evaluated the association of migraine and vascular disease biomarkers in a community-based population. Methods Participants (300 women, 117 men) were recruited as a part of the Dutch CAMERA 1 (Cerebral Abnormalities in Migraine, an Epidemiologic Risk Analysis) study. Participants were aged 30–60 (mean 48) years, 155 migraine had with aura (MA), 128 migraine without aura (MO), and 134 were controls with no severe headaches. Plasma concentrations of fibrinogen, Factor II, D-dimer, high sensitivity C-reactive protein (hs-CRP), and von Willebrand factor antigen were compared between groups, also stratifying by sex. Results Fibrinogen and hs-CRP were elevated in migraineurs compared to controls. In logistic regression analyses, MO and MA had increased likelihood of elevated fibrinogen, and MA had increased likelihood of elevated Factor II and hs-CRP. Fibrinogen and Factor II were associated with MA in women but not men. In the migraine subgroup, the total number of years of aura, but not headache, predicted elevated hs-CRP, and the average number of aura, but not headache, attacks predicted all biomarkers but Factor II. Conclusions Elevated vascular biomarkers were associated with migraine, particularly MA, as well as with years of aura and number of aura attacks.

Download Full-text

Correlation Between High Sensitivity C-Reactive Protein Level and Executive Function Disorders in Elderly Patients

Journal of Computational and Theoretical Nanoscience ◽

10.1166/jctn.2020.9145 ◽

2020 ◽

Vol 17 (7) ◽

pp. 3113-3116

Author(s):

Dyah Anetta Afri Rukmi ◽

Joseph Eko Wahono Rahardjo

Keyword(s):

Executive Function ◽

Elderly Patients ◽

Complete Blood Count ◽

High Sensitivity ◽

High Serum ◽

Control Group ◽

Case Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high-sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the frontal-subcortical circuit. To determine the correlation between high serum concentration of hs-CRP and executive function disorder in elderly patients. Thirty six elderly patients was examined by using a case control study. The subjects were enrolled from the out-patient at Neurology Department Dr. Soetomo General Hospital, Surabaya, Indonesia. The time period was 4 months (April to July 2015). Executive function was measured with the Trail Making Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis. Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%) subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0, 538-58, 860). These data suggested that high levels of hs-CRP was not associated with executive function in elderly patients.

Download Full-text