Pediatric Lymphangiography: Imaging to Intervention

2019 ◽  
Vol 03 (03) ◽  
pp. 203-213
Author(s):  
Shimwoo Lee ◽  
Aarti P. Luhar ◽  
Edward Wolfgang Lee ◽  
Sanjay Sinha ◽  
Ravi N. Srinivasa
Keyword(s):  
Fluid Transport ◽  
Pediatric Patients ◽  
Lymphatic System ◽  
Pediatric Population ◽  
Immune Recognition ◽  
Significant Morbidity ◽  
Resonance Imaging ◽  
Lymphatic Malformations ◽  
Lymphatic Flow ◽  
Image Guided

AbstractThe lymphatic system plays a crucial role in fluid transport as well as facilitating immune recognition. Disruption of lymphatic flow can lead to significant morbidity and mortality in the pediatric population, manifesting as lymphatic malformations and lymphatic leaks. There has been rising interest in developing minimally invasive image-guided approaches to diagnose and treat lymphatic disorders in pediatric patients. Notably, magnetic resonance imaging of the lymphatic system has emerged as a promising diagnostic tool. Moreover, interventions such as sclerotherapy and thoracic duct embolization for treatment of lymphatic malformations and leaks have come forth as safe and effective alternatives to surgery. The aim of this article is to review various pediatric lymphatic disorders and discuss advances in image-guided diagnostic and therapeutic options for these entities.

scholarly journals Paranasal Mass in a Healthy Male Toddler

2021 ◽  
pp. 014556132110079
Author(s):  
Melonie Anne Phillips ◽  
Meredith Lind ◽  
Gerd McGwire ◽  
Diana Rodriguez ◽  
Suzanna Logan
Keyword(s):  
Differential Diagnosis ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Age Group ◽  
Significant Morbidity ◽  
Healthy Male ◽  
Neck Tumors ◽  
Complete Surgical Resection ◽  
Maxilla And Mandible ◽  
Benign Mass

Head and neck tumors are rare in pediatric patients but should be kept in the differential when a patient presents with a new swelling or mass. One of these tumors is a myxoma, which is an insidiously growing, benign mass originating from the mesenchyme. They most commonly arise in the myocardium but can also develop in facial structures, particularly in the maxilla and mandible. When arising in facial structures, ocular, respiratory, and digestive systems can be affected based on local invasion. Complete surgical resection is curative but can lead to significant morbidity as well. Here, we present a case of a 15-month-old toddler presenting with a paranasal mass, which was ultimately diagnosed as a maxillary myxoma. This tumor is very rare in the pediatric population, especially in the toddler age-group, reminding clinicians to broaden the differential diagnosis when a patient’s course is atypical.

scholarly journals Nodal and Pedal MR Lymphangiography of the Central Lymphatic System: Techniques and Applications

2020 ◽  
Vol 37 (03) ◽  
pp. 250-262 ◽  
Author(s):  
Claus Christian Pieper
Keyword(s):  
Interventional Radiology ◽  
Lymphatic System ◽  
Clinical Applications ◽  
Review Article ◽  
Flow Dynamics ◽  
Lymphatic Malformations ◽  
Lymphatic Flow ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Lymphatic Imaging

AbstractNovel lymphatic imaging and interventional techniques are increasingly used in the diagnostic workup and treatment of pathologies of the central lymphatic system and have opened a new field of interventional radiology. The mainstay of lymphatic imaging today is magnetic resonance lymphangiography (MRL). It provides information on the anatomy of the central lymphatic system, lymphatic flow, as well as lymphatic pathologies and therefore is a valuable tool for treatment planning. There are two techniques to perform contrast-enhanced MRL: nodal dynamic contrast-enhanced MRL (nodal DCE-MRL) and interstitial transpedal MRL (tMRL). Nodal DCE-MRL yields superior information on lymphatic flow dynamics and is therefore best suited for suspected lymphatic flow pathologies and lymphatic malformations. tMRL is a technically simpler alternative for central lymphatic visualization without the need for sonographically guided lymph node cannulation. This review article describes current MRL techniques with a focus on contrast-enhanced MRL, their specific advantages, and possible clinical applications in patients suffering from pathologies of the central lymphatic system.

Bone Bruise and Anterior Cruciate Ligament Tears: Presence, Distribution Pattern, and Associated Lesions in the Pediatric Population

2019 ◽  
Vol 47 (13) ◽  
pp. 3181-3186
Author(s):  
Vittorio Bordoni ◽  
Giorgio di Laura Frattura ◽  
Davide Previtali ◽  
Simone Tamborini ◽  
Christian Candrian ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Anterior Cruciate Ligament ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Cruciate Ligament ◽  
Bone Bruise ◽  
Resonance Imaging ◽  
Meniscal Lesions ◽  
Bone Bruises ◽  
Anterior Cruciate

Background: Bone bruise characteristics after anterior cruciate ligament (ACL) injury have been correlated with the level of joint derangement in adults. However, the literature lacks information about younger patients, whose higher ligamentous laxity may lead to different lesion patterns. Purpose: To investigate the prevalence, size, location, and role of bone bruise associated with ACL rupture in the pediatric population. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Knee magnetic resonance imaging scans (MRIs) of patients aged 8 to 16 years with ACL tears from 2010 to 2018 were selected from the institution database. Inclusion criteria were open or partially open physes, less than 90 days between trauma and MRI, and no history of injury or surgery. Presence, localization, and size of bone bruise were analyzed by 2 blinded researchers and scored with the Whole-Organ Magnetic Resonance Imaging Score (WORMS) bone bruise subscale. Ligamentous, cartilaginous, meniscal, and other lesions were documented. Results: Of the 78 pediatric patients selected from the database, 54 (69%) had bone bruise. The mean area of bone bruise was larger in males than in females (femur, 3.8 ± 2.8 vs 2.2 ± 1.4 cm2, respectively, P = .006; tibia, 2.6 ± 1.6 vs 1.5 ± 0.8 cm2, respectively, P = .007). The subregions most affected by bone bruise were the lateral posterior tibia and the lateral central femur (in 83% and 80% of the knees affected, respectively). A low correlation was found between age and bone bruise area (biggest areas r = 0.30, P = .03, and sum of areas r = 0.27, P = .04), but no correlation was found between age and WORMS (femur, r = −0.03, P = .85; tibia, r = −0.04, P = .76). The injuries most associated with bone bruise were 23 meniscal lesions (43%), 10 lesions of other ligaments (19.0%), 2 cartilage lesions (3.7%), and 2 patellar fractures (3.7%). Conclusion: The prevalence of bone bruises in pediatric patients with ACL tears is high, although it seems slightly lower than the prevalence documented in adults but with similar localization. The area and the distribution pattern of bone bruises are similar among different ages. The pediatric patients had a lower presence of cartilage and meniscal lesions compared with that reported in adults, which suggests a different effect of this trauma on the knee of pediatric patients.

Surgical Management of Pediatric Lymphedema: A Systematic Review

2019 ◽  
Vol 35 (06) ◽  
pp. 462-470 ◽  
Author(s):  
Aditi M. Kanth ◽  
Max Krevalin ◽  
Oluwaseun A. Adetayo ◽  
Ashit Patel
Keyword(s):  
Systematic Review ◽  
Surgical Treatment ◽  
Surgical Management ◽  
Conservative Management ◽  
Pediatric Patients ◽  
Lymphatic System ◽  
Pediatric Population ◽  
Small Population ◽  
Protein Rich ◽  
Genital Lymphedema

Background Lymphedema is a rare, progressive, and debilitating condition caused by failure of the lymphatic system to adequately drain the protein-rich fluid exiting the capillaries. Conservative management is often emphasized in pediatric patients, resulting in a paucity of literature describing surgical treatment in this population. Methods A systematic review was performed using PubMed, ScienceDirect, and Google Scholar to identify all studies describing surgical management of lymphedema in the pediatric population. Results Of the 343 relevant articles identified, 14 met the criteria for full review. Articles were divided into the following treatment categories: genital lymphedema, excisional procedures for extremity lymphedema, and physiologic procedures for extremity lymphedema. Outcomes for genital lymphedema were overall positive. For extremity lymphedema, excisional procedures yielded good results overall and included the majority of patients in this study. Physiologic procedures had mixed outcomes in the small population included in this study, but definitive conclusions cannot be drawn due to the paucity of existing data. Conclusion While conservative management of pediatric lymphedema is well described, the literature remains sparse regarding surgical treatment. Further studies are needed to evaluate efficacy and outcomes in all three categories in this population.

Hypoxemia without Respiratory Distress: Hereditary Hemorrhagic Telangiectasia in a Child

2020 ◽  
Author(s):  
Michael D. McCann ◽  
Claire Newlon ◽  
Conrad Krawiec
Keyword(s):  
Hereditary Hemorrhagic Telangiectasia ◽  
Arteriovenous Malformations ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Genetic Disorder ◽  
Significant Morbidity ◽  
Younger Patients ◽  
Life Threatening ◽  
Symptoms And Signs ◽  
Over Time

AbstractHereditary hemorrhagic telangiectasia (HHT) is an underrecognized genetic disorder of vascular development in pediatric patients. Its presentation can range from mild cutaneous findings to life-threatening hemorrhage from arteriovenous malformations. Clinical diagnosis can be challenging in the pediatric population as disease manifestations evolve over time and may be difficult to identify in younger patients. This case highlights how nonspecific symptoms and signs in the preanesthesia period can be misleading, potentially placing a patient with unrecognized HHT at risk for significant morbidity and mortality.

scholarly journals Contrast-Induced Vomiting in Pediatric Patients Under Propofol Sedation: A Case Series

2019 ◽  
Vol 24 (6) ◽  
pp. 534-537
Author(s):  
Shane C. Rainey ◽  
Nadia Shaikh ◽  
Keith A. Hanson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adverse Events ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Case Series ◽  
Resonance Imaging ◽  
Imaging Studies ◽  
Contrast Administration ◽  
Contrast Enhanced ◽  
Pediatric Sedation

Gadolinium-based compounds are frequently used in contrast-enhanced magnetic resonance imaging studies. Rarely, adverse events have been reported with administration of these compounds, of which the most common are nausea and vomiting. Although well established in the adult literature, these adverse effects are less well described in the pediatric population, who often need sedation to complete imaging studies. In this case series, we present 3 children who experienced vomiting shortly after contrast administration while under sedation with propofol, which is known to have antiemetic properties. Although all 3 children recovered without complication, this case series illustrates the serious potential consequences of vomiting while sedated, and providers should be aware of these possible adverse events as pediatric sedation becomes more common outside the operating room.

scholarly journals 1346. Implementation of a Multidisciplinary 48 Hour Antibiotic Timeout in a Pediatric Population

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S684-S684
Author(s):  
Victoria Konold ◽  
Palak Bhagat ◽  
Jennifer Pisano ◽  
Natasha N Pettit ◽  
Anish Choksi ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Pediatric Population ◽  
Intervention Group ◽  
Post Intervention ◽  
Days Of Therapy ◽  
New Antibiotics ◽  
Core Elements ◽  
Quasi Experimental ◽  
Empirical Antibiotics ◽  
The Impact

Abstract Background To meet the core elements required for antimicrobial stewardship programs, our institution implemented a pharmacy-led antibiotic timeout (ATO) process in 2017 and a multidisciplinary ATO process in 2019. An antibiotic timeout is a discussion and review of the need for ongoing empirical antibiotics 2-4 days after initiation. This study sought to evaluate both the multidisciplinary ATO and the pharmacy-led ATO in a pediatric population, compare the impact of each intervention on antibiotic days of therapy (DOT) to a pre-intervention group without an ATO, and to then compare the impact of the pharmacy-led ATO versus multidisciplinary ATO on antibiotic days of therapy (DOT). Methods This was a retrospective, pre-post, quasi-experimental study of pediatric patients comparing antibiotic DOT prior to ATO implementation (pre-ATO), during the pharmacy-led ATO (pharm-ATO), and during the multidisciplinary ATO (multi-ATO). The pre-ATO group was a patient sample from February-September 2016, prior to the initiation of a formal ATO. The pharmacy-led ATO was implemented from February-September 2018. This was followed by a multidisciplinary ATO led by pediatric residents and nurses from February-September 2019. Both the pharm-ATO and the multi-ATO were implemented as an active non-interruptive alert added to the electronic health record patient list. This alert triggered when new antibiotics had been administered to the patient for 48 hours, at which time, the responsible clinician would discuss the antibiotic and document their decision via the alert workspace. Pediatric patients receiving IV or PO antibiotics administered for at least 48 hours were included. The primary outcome was DOT. Secondary outcomes included length of stay (LOS) and mortality. Results 1284 unique antibiotic orders (n= 572 patients) were reviewed in the pre-ATO group, 868 (n= 323 patients) in the pharm-ATO and 949 (n= 305 patients) in the multi-ATO groups. Average DOT was not significantly different pre vs post intervention for either methodology (Table 1). Mortality was similar between groups, but LOS was longer for both intervention groups (Table 1). Impact of an ATO on DOT, Mortality and LOS Conclusion An ATO had no impact on average antibiotic DOT in a pediatric population, regardless of the ATO methodology. Disclosures All Authors: No reported disclosures

Evaluation of an Electronic Dosing Calculator to Reduce Pediatric Medication Errors

2019 ◽  
Vol 58 (4) ◽  
pp. 413-416
Author(s):  
Brian Murray ◽  
Matthew J. Streitz ◽  
Michael Hilliard ◽  
Joseph K. Maddry
Keyword(s):  
Patient Safety ◽  
Medication Errors ◽  
Prospective Cohort ◽  
Pediatric Patients ◽  
Cohort Analysis ◽  
Morbidity And Mortality ◽  
Patient Visit ◽  
Significant Morbidity ◽  
Potential Source ◽  
Medication Dosage

Introduction. Adverse medication events are a potential source of significant morbidity and mortality in pediatric patients, where dosages frequently rely on weight-based formulas. The most frequent occurrence of medication errors occurs during the ordering phase. Methods. Through a prospective cohort analysis, we followed medication errors through patient safety reports (PSRs) to determine if the use of a medication dosage calculator would reduce the number of PSRs per patient visits. Results. The number of PSRs for medication errors per patient visit occurring due to errors in ordering decreased from 10/28 417 to 1/17 940, a decrease by a factor of 6.31, with a χ2 value of 4.063, P = .0463. Conclusion. We conclude that the use of an electronic dosing calculator is able to reduce the number of medication errors, thereby reducing the potential for serious pediatric adverse medication events.

scholarly journals Image-guided Percutaneous Drainage in the Pediatric Population: A Primer for Radiologists

2011 ◽  
Vol 1 ◽  
pp. 31 ◽  
Author(s):  
Keerthi Arani ◽  
Kiran Nandalur ◽  
Christina M Tucker ◽  
David A Bloom
Keyword(s):  
Minimally Invasive ◽  
Patient Outcomes ◽  
Percutaneous Drainage ◽  
Pediatric Population ◽  
Infectious Complications ◽  
Image Guided ◽  
Pictorial Essay ◽  
Invasive Method ◽  
Patient Preparation ◽  
The Common

Image-guided percutaneous drainage is an excellent minimally invasive method for dealing with infectious complications in the pediatric population. A thorough understanding of drainage procedures in children can often lead to improved patient outcomes. Indications for percutaneous drainage will be reviewed, including abscesses related to appendicitis, post-surgical abscess formation, and abscesses related to Crohn's disease. This pictorial essay will help the radiologist better understand the common etiologies of abscesses in children that may require percutaneous drainage, the special considerations for catheter placement, patient preparation, and anesthesia or sedation issues unique to the pediatric population.

scholarly journals Investigating the Lymphatic System by Dual-Color Elemental Mass Spectrometry Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-8
Author(s):  
Ann-Christin Niehoff ◽  
Tim Klasen ◽  
Rebecca Schmidt ◽  
Daniel Palmes ◽  
Cornelius Faber ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Lymph Nodes ◽  
Contrast Agents ◽  
Inductively Coupled Plasma ◽  
Mass Spectrometry Imaging ◽  
Lymphatic System ◽  
Diagnostic Tools ◽  
Lymphatic Flow ◽  
Secondary Lymphedema ◽  
Inductively Coupled

Secondary lymphedema accompanied with strong restrictions in quality of life is still major side effects in cancer therapy. Therefore, dedicated diagnostic tools and further investigation of the lymphatic system are crucial to improve lymphedema therapy. In this pilot study, a method for quantitative analysis of the lymphatic system in a rat model by laser ablation (LA) with inductively coupled plasma mass spectrometry imaging (ICP-MSI) is presented. As a possible lymph marker, thulium(III)(1R,4R,7R,10R)-α,α′,α′′,α′′′-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (Tm-DOTMA) is introduced and compared to the clinically used magnetic resonance imaging contrast agent gadolinium(III)2,2′,2′′-(10-((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (Gd-DO3A-butrol). Gadobutrol functioned as standard contrast media in MRI lymphangiography to detect lymphatic flow qualitatively. Thus, Tm-DOTMA was investigated as lymphatic marker to detect lymphatic flow quantitatively. Both contrast agents were successfully used to visualize the lymphatic flow in successive lymph nodes in LA-ICP-MS due to lower limits of detection compared to MRI. Furthermore, the distribution of contrast agents by multicolored imaging showed accumulation in specific areas (sectors) of the lymph nodes after application of contrast agents in different areas.

Sign in / Sign up

Export Citation Format

Share Document