scholarly journals Corticosteroid Guidance for Pregnancy during COVID-19 Pandemic

2020 ◽  
Vol 37 (08) ◽  
pp. 809-812 ◽  
Author(s):  
Jennifer Jury McIntosh
Keyword(s):  
The Novel ◽  
Risks And Benefits ◽  
Key Points ◽  
Maternal Risks ◽  
Rapid Adjustment ◽  
Novel Coronavirus

The novel coronavirus disease 2019 (COVID-19) pandemic is causing a necessary, rapid adjustment within the field of obstetrics. Corticosteroid use is a mainstay of therapy for those women delivering prematurely. Unfortunately, corticosteroid use has been associated with worse outcomes in COVID-19 positive patients. Given this information, it is necessary that obstetricians adjust practice to carefully weigh the fetal benefits with maternal risks. Therefore, our institution has examined the risks and benefits and altered our corticosteroid recommendations. Key Points

scholarly journals The Teaching Design and Application of Online - Offline Hybrid Curriculum under the Influence of the Novel Coronavirus Pneumonia Epidemic

2021 ◽  
Vol 245 ◽  
pp. 03065
Author(s):  
Wenjia Xie ◽  
Kun Han ◽  
Xiaoli Zhang ◽  
Xinwei Gao ◽  
Meimei He
Keyword(s):  
The Novel ◽  
Hybrid Courses ◽  
Course Content ◽  
Teaching Objectives ◽  
Key Points ◽  
Hybrid Teaching ◽  
Teaching Design ◽  
Key Issues ◽  
Hybrid Curriculum ◽  
Novel Coronavirus

This paper analyzes the differences between online and offline courses in teaching organization, course content and practice, as well as the differences between hybrid teaching and hybrid courses in concept and emphasis. This paper puts forward the basic principles and requirements of hybrid courses teaching design, and discusses the key points and application scenarios of hybrid courses teaching design from three aspects: teaching objectives, teaching elements and teaching activities. And the key issues that need to be figured out are explained.

scholarly journals Beyond the First Wave: Consequences of COVID-19 on High-Risk Infants and Families

2020 ◽  
Vol 37 (12) ◽  
pp. 1283-1288
Author(s):  
Monica E. Lemmon ◽  
Ira Chapman ◽  
William Malcolm ◽  
Kelli Kelley ◽  
Richard J. Shaw ◽  
...  
Keyword(s):  
High Risk ◽  
Care Delivery ◽  
The Novel ◽  
High Risk Infant ◽  
Infant Outcomes ◽  
Developmental Care ◽  
Key Points ◽  
Centered Care ◽  
High Risk Infants ◽  
Novel Coronavirus

The novel coronavirus disease 2019 (COVID-19) pandemic is affecting care for high-risk newborns in ways that will likely be sustained beyond the initial pandemic response. These novel challenges present an urgent imperative to understand how COVID-19 impacts parent, family, and infant outcomes. We highlight three areas that warrant targeted attention: (1) inpatient care: visitation policies, developmental care, and communication practices; (2) outpatient care: high-risk infant follow-up and early intervention programs; and (3) parent psychosocial distress: mental health, social support, and financial toxicity. Changes to care delivery in these areas provide an opportunity to identify and implement novel strategies to provide family-centered care during COVID-19 and beyond. Key Points

scholarly journals Increasing the Signal-to-Noise Ratio: COVID-19 Clinical Synopsis for Outpatient Providers

2020 ◽  
Vol 11 ◽  
pp. 215013272092295
Author(s):  
Zach Sartor ◽  
Burritt Hess
Keyword(s):  
Signal To Noise Ratio ◽  
Review Article ◽  
Medical Community ◽  
Ambulatory Setting ◽  
The Novel ◽  
Medical Providers ◽  
Signal To Noise ◽  
Key Points ◽  
Novel Coronavirus ◽  
Relevant Material

The novel coronavirus (SARS-CoV-2), which is the cause of coronavirus disease (COVID-19 formally 2019-nCoV), has received widespread attention from the medical community. Despite the rapid publication of research on the virus and the disease it causes, there is a lack of concise and relevant material to help busy medical providers navigate recognition and management of the disease in the ambulatory setting. This review article aims to bridge this gap by briefly reviewing the key points of the evaluation and treatment of patients with COVID-19 in the ambulatory clinic environment.

scholarly journals Bronchial Asthma in Children Amidst the Novel Coronavirus Infection

Doctor Ru ◽  
2020 ◽  
Vol 19 (10) ◽  
pp. 42-47
Author(s):  
E.G. Furman ◽  
◽  
E.A. Khuzina ◽  
M.N. Repetskaya ◽  
◽  
...  
Keyword(s):  
Gene Expression ◽  
Bronchial Asthma ◽  
School Children ◽  
The Novel ◽  
Key Points ◽  
Inhibit Gene Expression ◽  
Coronavirus Infection ◽  
Asthma In Children ◽  
Novel Coronavirus ◽  
Keywords Bronchial Asthma

Objective of the Review: to present current information on monitoring and therapy of bronchial asthma (BA) in children amidst the novel coronavirus infection COVID-19. Key Points. There is no evidence that controlled BA increases the risk of SARS-CoV-2 infection or leads to more severe COVID-19. Inhaled glucocorticosteroids (IGCS) to manage BA inhibit gene expression of major SARS-CoV-2 target receptors. Anti-inflammatory BA therapy, primarily IGCS, should not be discontinued until BA is controlled, thus mitigating the risk of unfavourable course of COVID-19. Nebuliser therapy at home remains the preferred treatment in pre-school children with BA. Conclusion. Amidst the novel coronavirus infection COVID-19, children with BA should receive individualised therapy depending on disease severity and rate of disease control. Keywords: bronchial asthma, children, novel coronavirus infection COVID-19.

scholarly journals Поражение пищеварительного тракта как проявление COVID-19 у ребенка 4 лет

Doctor Ru ◽  
2021 ◽  
Vol 20 (3) ◽  
pp. 56-59
Author(s):  
I.M. Osmanov ◽  
◽  
O.N. Solodovnikova ◽  
S.N. Borzakova ◽  
T.V. Sbrodova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Bacterial Infections ◽  
Clinical Manifestations ◽  
Enteric Infection ◽  
The Novel ◽  
Key Points ◽  
Enteric Infections ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Objective of the Paper: To represent a case of the novel coronavirus infection COVID-19 in a 4-year-old child with isolated bowel damage. Key Points. COVID-19 impacts several systems and organs. Usually, children have mild or asymptomatic disease. Clinical manifestations of COVID-19 in children can be damage not only of respiratory tract, but also of GIT, requiring differential diagnosis of enteric infections (both viral and bacterial). Prompt diagnosis of COVID-19 is essential for antiepidemic measures and suppression an infectious process. The case shows challenges faced by clinicians when diagnosing COVID-19 in patients with isolated GIT damages without catarrhal signs. Course of the disease in this patient was characterised by a number of features indicative of a bacterial enteric infection: abdominal pain, diarrhoea, increased CRP, colitis syndrome in stool test, warranting differential diagnosis of acute enteric bacterial infections. Negative bacterial culture, detection of SARS-CoV2 RNA in oropharynx and nasopharynx mucous, fast stool normalisation and dyspeptic events arrest allowed diagnosing that the diarrhoea was associated with COVID-19. One month of metabolic and probiotic therapy normalised stool, arrested abdominal pain, and improved exercise tolerance. Conclusion. GIT damage in paediatric COVID-19 patients is essential and unexplored. COVID-19 should be added to differential diagnosis in case of clinical manifestations of an acute enteric infection. Keywords: children, novel coronavirus infection, COVID-19, GIT.

scholarly journals Considerations for Obstetric Care during the COVID-19 Pandemic

2020 ◽  
Vol 37 (08) ◽  
pp. 773-779 ◽  
Author(s):  
Sarah K. Dotters-Katz ◽  
Brenna L. Hughes
Keyword(s):  
Severe Disease ◽  
Herd Immunity ◽  
Obstetric Care ◽  
The Novel ◽  
Intensive Care Admission ◽  
Care Workers ◽  
Increased Risk ◽  
Key Points ◽  
High Risk Populations ◽  
Novel Coronavirus

The novel coronavirus disease 2019 (COVID-19) is a growing pandemic that is impacting daily life across the globe. Though disease is often mild, in high-risk populations, severe disease often leads to intubation, intensive care admission (ICU) admission, and in many cases death. The implications for pregnancy remain largely unknown. Early data suggest that COVID-19 may not pose increased risk in the pregnant population. Vertical transmission has not been confirmed. Because no treatment, no vaccine and no herd immunity exist, social distancing is the best mechanism available to protect patients and health care workers from infection. This review will discuss what is known about the virus as it relates to pregnancy and then consider management considerations based on these data. Key Points

scholarly journals Research on Emergency Management of Pharmaceutical Care  in Designated Hospital for Patients with COVID-19

2020 ◽  
Author(s):  
Xiu-lan Liu ◽  
Yi Liu ◽  
Qiu Lin ◽  
Luo Pan ◽  
Jin Jingjin ◽  
...  
Keyword(s):  
Support System ◽  
Severe Pneumonia ◽  
The Novel ◽  
Drug Management ◽  
Pharmaceutical Management ◽  
Key Points ◽  
Consultation Team ◽  
Set Up ◽  
Novel Coronavirus ◽  
And Control

Abstract Background: The novel coronavirus pneumonia (COVID-19) was entered into the critical period of epidemic prevention. Our hospital was designated as a hospital for severe pneumonia in Wuhan. Timely and effective pharmaceutical emergency support system is of great significance for the epidemic prevention and control of COVID-19. Method:In order to ensure COVID-19 patients' medication needs and ensure the safety treatment, we focus on the key points and difficult problems in the practice of pharmaceutical management during the period of COVID-19, and then formulate appropriate pharmaceutical emergency support system combined with clinical practice. Results:The pharmaceutical department quickly launched the emergency mechanism, formulated the key drug catalog for COVID-19, purchased some treatment drugs, reformed the emergency pharmacy process, established the donated drug management system, established the pharmacist consultation team, set up the "cloud pharmacy" for patients with chronic diseases other than COVID-19, and strengthened pharmacist protection management. Conclusion:During the period of COVID-19, the pharmaceutical administration is a professional, comprehensive, complex and systematic emergency project to ensure the drug supply and safety administration.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

SARS-COV2 virus and Coronavirus disease (COVID-19)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 977-982
Author(s):  
Mohamed J. Saadh ◽  
Bashar Haj Rashid M ◽  
Roa’a Matar ◽  
Sajeda Riyad Aldibs ◽  
Hala Sbaih ◽  
...  
Keyword(s):  
Close Contact ◽  
Antiviral Agents ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Fatal Disease ◽  
Mild Disease ◽  
Life Threatening ◽  
Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

Coronavirus: Towards controlling of the pandemic - Indian scenario

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 462-468
Author(s):  
Latika kothari ◽  
Sanskruti Wadatkar ◽  
Roshni Taori ◽  
Pavan Bajaj ◽  
Diksha Agrawal
Keyword(s):  
Control Measures ◽  
The Novel ◽  
Medical Treatments ◽  
Health Crisis ◽  
The Public ◽  
Infection Control Measures ◽  
The Social ◽  
Asking Questions ◽  
The Government ◽  
Novel Coronavirus

Coronavirus disease 2019 (COVID-19) is a communicable infection caused by the novel coronavirus resulting in severe acute respiratory syndrome coronavirus 2 (SARS-CoV). It was recognized to be a health crisis for the general population of international concern on 30th January 2020 and conceded as a pandemic on 11th March 2020. India is taking various measures to fight this invisible enemy by adopting different strategies and policies. To stop the COVID-19 from spreading, the Home Affairs Ministry and the health ministry, of India, has issued the nCoV 19 guidelines on travel. Screening for COVID-19 by asking questions about any symptoms, recent travel history, and exposure. India has been trying to get testing kits available. The government of India has enforced various laws like the social distancing, Janata curfew, strict lockdowns, screening door to door to control the spread of novel coronavirus. In this pandemic, innovative medical treatments are being explored, and a proper vaccine is being hunted to deal with the situation. Infection control measures are necessary to prevent the virus from further spreading and to help control the current situation. Thus, this review illustrates and explains the criteria provided by the government of India to the awareness of the public to prevent the spread of COVID-19.

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