scholarly journals Bdellovibrio bacteriovorus: a potential ‘living antibiotic’ to control bacterial pathogens

Author(s):  
Francis M. Cavallo ◽  
Lorea Jordana ◽  
Alexander W. Friedrich ◽  
Corinna Glasner ◽  
Jan Maarten van Dijl
Fine Focus ◽  
2014 ◽  
Vol 1 (1) ◽  
pp. 51-61
Author(s):  
Elizabeth A. B. Emmert ◽  
Zachary M. Haupt ◽  
Katherine M. Pflaum ◽  
Jennifer L. Lasbury ◽  
Justin P. McGrath ◽  
...  

Bdellovibrio bacteriovorus is a naturally predatory bacterium that multiplies inside Gram negative prey bacteria. There is much interest in using Bdellovibrio as a living antibiotic to control infections by Gram negative pathogens. In recent years Caenorhabditis elegans has proven to be an attractive animal model of bacterial pathogenesis for a range of pathogens. We have used the C. elegans animal pathogenesis model to examine the ability of B. bacteriovorus to protect nematodes from four bacterial pathogens. In all cases, nematodes treated with B. bacteriovorus and the pathogen survived at a significantly higher level than nematodes treated with the pathogen alone. Treatment with B. bacteriovorus alone was nontoxic to the worms. We monitored the persistence of E. coli K-12 and E. coli OP50 in both B. bacteriovorus treated nematodes and control nematodes. E. coli K-12 levels were significantly lower in B. bacteriovorus treated nematodes than in control nematodes one day after Bdellovibrio exposure and E. coli K-12 was eliminated from the worm gut two days faster in B. bacteriovorus treated nematodes. E. coli OP50 also demonstrated significantly lower levels in B. bacteriovorus treated nematodes and faster elimination from the worm gut. The successful use of B. bacteriovorus as a therapeutic agent in C. elegans indicates that it may be useful as a living antibiotic in other animal systems.


Author(s):  
William B. McCombs ◽  
Cameron E. McCoy

Recent years have brought a reversal in the attitude of the medical profession toward the diagnosis of viral infections. Identification of bacterial pathogens was formerly thought to be faster than identification of viral pathogens. Viral identification was dismissed as being of academic interest or for confirming the presence of an epidemic, because the patient would recover or die before this could be accomplished. In the past 10 years, the goal of virologists has been to present the clinician with a viral identification in a matter of hours. This fast diagnosis has the potential for shortening the patient's hospital stay and preventing the administering of toxic and/or expensive antibiotics of no benefit to the patient.


Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Todd ◽  
DB Zich ◽  
AR Horswill ◽  
NB Cech

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Hussein A Kadhum ◽  
Thualfakar H Hasan2

The study involved the selection of two isolates from Bacillus subtilis to investigate their inhibitory activity against some bacterial pathogens. B sub-bacteria were found to have a broad spectrum against test bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. They were about 23-30 mm and less against Klebsiella sp. The sensitivity of some antibodies was tested on the test samples. The results showed that the inhibitory ability of bacterial growth in the test samples using B. subtilis extract was more effective than the antibiotics used.


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