scholarly journals GdxFe3-xO4 nanoparticles with silane shell as potential theranostic agent for cancer treatment

2022 ◽  
Vol 2155 (1) ◽  
pp. 012006
Author(s):  
Alexandr V. Zibert ◽  
Lana I. Lissovskaya ◽  
Ilya V. Korolkov ◽  
Maxim V. Zdorovets
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Ftir Spectroscopy ◽  
Biomedical Applications ◽  
Mri Imaging ◽  
Shell Nanoparticles ◽  
Theranostic Agent ◽  
Theranostic Agents

Abstract In this study of GdxFe3-xO4 compound core silane shell nanoparticles method is represented.Samples were analyzed with SEM, EDA and FTIR spectroscopy. Further attaching of carborane compounds is discussed. Products can be used in biomedical applications for MRI imaging and drug delivery for NCT, so can be considered as potential theranostic agents for cancer treatment.

scholarly journals Pharmaceutical aspects of green synthesized silver nanoparticles: A boon to cancer treatment

2020 ◽  
Vol 20 ◽  
Author(s):  
Vijay Mishra ◽  
Pallavi Nayak ◽  
Manvendra Singh ◽  
Murtaza M. Tambuwala ◽  
Alaa A. Aljabali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Cancer Treatment ◽  
Biomedical Applications ◽  
Drug Loading ◽  
Relevant Literature ◽  
Formulation Development ◽  
Green Approach ◽  
Current Scenario ◽  
Tissue Restoration

Background: Silver nanoparticles (AgNPs) are one of the most investigated nanostructures in recent years, which gives more challenging and promising qualities in different biomedical applications. The AgNPs synthesized by the green approach provide potential healthcare benefits over chemical approaches, including improvement of tissue restoration, drug delivery, diagnosis, environmentally friendly and a boon to cancer treatment. Objective: In the current scenario, the development of safe and effective drug delivery systems is the utmost concern of formulation development scientists as well as clinicians. Methods: Google, Web of Science, PubMed, portals have been searched for potentially relevant literature to get latest developments and updated information related to different aspects of green synthesized AgNPs along with their biomedical applications especially in the treatment of different types of cancers. Results: The present review highlights the latest published research regarding the different green approaches for the synthesis of AgNPs, their characterization techniques as well as various biomedical applications, particularly in cancer treatment. In this context, environment friendly AgNPs are proving themselves as better candidates in terms of size, drug loading and release efficiency, targeting efficiency, minimal drug-associated side effects, pharmacokinetic profiling, and biocompatibility issues. Conclusion: With continuous efforts by multidisciplinary team approaches, nanotechnology-based AgNPs will shed new light on diagnostics and therapeutics in various disease treatments. However, the toxicity issues of AgNPs needs the greatest attention as unanticipated toxic effects must be ruled out for their diversified applications.

Pharmaceutical Applications of Carbon Nanotube-Mediated Drug Delivery Systems

2012 ◽  
Vol 5 (2) ◽  
pp. 1685-1696 ◽  
Author(s):  
Pradeep Kumar S ◽  
Prathibha D ◽  
Gowri Shankar N L ◽  
Parthibarajan R ◽  
Mastyagiri L ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Width Ratio ◽  
Wide Range

Carbon nanotubes, which are elongated fullerenes, resemble graphite sheets wrapped into cylinders with a high length-to-width ratio (few nm in diameter and up to 1 mm in length). Carbon nanotubes are molecular-scale tubes of graphitic carbon with outstanding properties. Carbon nanotubes have drawn great interest and attraction in the field of novel drug delivery system. Nanomedicines can target, diagnose, monitor and treat cancerous cell also. The small nanoscale dimension and astonishing properties make them a distinctive carrier with a wide range of promising applications. These cylindrical carbon molecules have novel properties that make them potentially useful in many applications in nanotechnology. The various nano-size carrier systems are available for biotechnological applications including the drug delivery. Carbon nanotubes are typically used for bioactive delivery due to their some unique outstanding properties. Carbon nanotubes drug delivery system opens up new potential and possibilities over nanoparticles, dendrimers, liposomes etc. for biomedical applications and new drug delivery. In last few years, Carbon nanotubes (CNTs) have shown unexpected advantages in the field of cancer treatment and drug delivery systems. Present review article discuss in brief about the methods of synthesis, with purification as well as sorting techniques for giving different grades to different types of CNTs and biomedical applications. These show very good adsorption properties which helps in the detection of various chemicals, toxic agents etc. Research done using CNTs for cancer treatment is also discussed in brief.  

scholarly journals ParamagneticGd2O3Nanoparticle-Based Targeting Theranostic Agent for C6 Rat Glioma Cell

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Seong-Pyo Hong ◽  
Seong Hee Kang ◽  
Do Kyung Kim ◽  
Bo Sun Kang
Keyword(s):  
Mtt Assay ◽  
Glioma Cell ◽  
Laser Scanning ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
C6 Cells ◽  
Mri Imaging ◽  
Rat Glioma ◽  
Theranostic Agent ◽  
Theranostic Agents

This study aimed to synthesize theranostic agent targeting C6 rat glioma cell, which was based on the dextran coated paramagnetic gadolinium oxide nanoparticles (D-PGONs) conjugated with folic acid (FA) or paclitaxel (PTX). The D-PGONs were synthesized by thein situcoprecipitation method, and the average value of the size distribution was 2.9 nm. FTIR spectroscopy was fulfilled to confirm the conjugations of FA or PTX with D-PGONs. The bioprotective effects of dextran coating and chemotherapeutic effect of PTX in the C6 glioma cell were evaluated by the MTT assay. The differences in uptakes between the synthesized theranostic agents into C6 cells were observed by confocal laser scanning microscopy. In addition, the magnetic contrast enhancement with different concentration of the synthesized agent was compared by theT1-weighted MRI imaging. It was experimentally shown that the synthesized theranostic agent targets C6 cells due to the ligand-receptor-mediated endocytosis and provides enhancement in MR contrast depending on the concentration due to the paramagnetic property of gadolinium nanoparticle. In addition, it was shown by the results of MTT assay that the synthesized nanocomposites were more effective in reducing cell viability than bare gadolinium nanoparticles. In conclusion, it was shown that FA and PTX conjugated D-PGONs could be used as the theranostic agent with paramagnetism and chemotherapeutic property.

Overview of polyethylene glycol-based materials with a special focus on core-shell particles for drug delivery application

2021 ◽  
Vol 27 ◽  
Author(s):  
Nasrullah Shah ◽  
Manzoor Hussain ◽  
Touseef Rehan ◽  
Abbas Khan ◽  
Zubair Ullah Khan
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Water Soluble ◽  
Core Shell ◽  
Special Focus ◽  
Tissue Engineering Scaffolds ◽  
Shell Nanoparticles ◽  
Composites Materials ◽  
Shell Particles ◽  
Core Shell Nanoparticles

: Polyethylene glycols (PEG) are water-soluble nonionic polymeric molecules. PEG and PEG-based materials are used for various important applications such as solvents, adhesives, adsorbents, drug delivery agents, tissue engineering scaffolds, etc. The coating of nanoparticles with PEG forms core-shell nanoparticles. The PEG-based core-shell nanoparticles are synthesized for the development of high-quality drug delivery systems. In the present review, we first explained the basics and various applications of PEGs and PEG-based composites materials and then concentrated on the PEG-based core-shell nanoparticles for biomedical applications specifically their use in drug delivery.

Nanotechnology Assisted Chemotherapy for Targeted Cancer Treatment: Recent Advances and Clinical Perspectives

2020 ◽  
Vol 20 (27) ◽  
pp. 2442-2458
Author(s):  
Huan-Rong Lan ◽  
Zhi-Qiang Wu ◽  
Li-Hua Zhang ◽  
Ke-Tao Jin ◽  
Shi-Bing Wang
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Chemotherapeutic Agents ◽  
Clinical Settings ◽  
Effective Parameters ◽  
Design And Synthesis ◽  
Recent Advances ◽  
Theranostic Agents ◽  
Reduced Toxicity ◽  
Encapsulation Methods

Nanotechnology has recently provided exciting platforms in the field of anticancer research with promising potentials for improving drug delivery efficacy and treatment outcomes. Nanoparticles (NPs) possess different advantages over the micro and bulk therapeutic agents, including their capability to carry high payloads of drugs, with prolonged half-life, reduced toxicity of the drugs, and increased targeting efficiency. The wide variety of nanovectors, coupled with different conjugation and encapsulation methods available for different theranostic agents provide promising opportunities to fine-tune the pharmacological properties of these agents for more effective cancer treatment methods. This review discusses applications of NPs-assisted chemotherapy in preclinical and clinical settings and recent advances in design and synthesis of different nanocarriers for chemotherapeutic agents. Moreover, physicochemical properties of different nanocarriers, their impacts on different tumor targeting strategies and effective parameters for efficient targeted drug delivery are discussed. Finally, the current approved NPs-assisted chemotherapeutic agents for clinical applications and under different phases of clinical trials are discussed.

scholarly journals Polydopamine Modified Superparamagnetic Iron Oxide Nanoparticles as Multifunctional Nanocarrier for Targeted Prostate Cancer Treatment

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 138 ◽  
Author(s):  
Nimisha Singh ◽  
Fadoua Sallem ◽  
Celine Mirjolet ◽  
Thomas Nury ◽  
Suban Kumar Sahoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photoelectron Spectroscopy ◽  
Targeted Delivery ◽  
Easy Access ◽  
Shell Nanoparticles ◽  
Vis Spectroscopy

Polydopamine (pDA)-modified iron oxide core-shell nanoparticles (IONPs) are developed and designed as nanovectors of drugs. Reactive quinone of pDA enhances the binding efficiency of various biomolecules for targeted delivery. Glutathione disulfide (GSSG), an abundant thiol species in the cytoplasm, was immobilized on the pDA-IONP surface. It serves as a cellular trigger to release the drug from the nanoparticles providing an efficient platform for the drug delivery system. Additionally, GSSG on the surface was further modified to form S-nitrosoglutathione that can act as nitric oxide (NO) donors. These NPs were fully characterized using a transmission electronic microscopy (TEM), thermogravimetric analysis (TGA), dynamic light scattering (DLS), zeta potential, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) and UV-vis spectroscopies. Doxorubicin (DOX) and docetaxel (DTX) are two anticancer drugs, which were loaded onto nanoparticles with respective loading efficiencies of 243 and 223 µmol/g of IONPs, calculated using TGA measurements. DOX release study, using UV-vis spectroscopy, showed a pH responsive behavior, making the elaborated nanocarrier a potential drug delivery system. (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl) -2H-tetrazolium (MTS) and apoptosis assays were performed on PC3 cell lines to evaluate the efficiency of the developed nanocarriers. These nanoparticles thus can prove their worth in cancer treatment on account of their easy access to the site and release of drug in response to changes to internal parameters such as pH, chemicals, etc.

scholarly journals Biomedical Applications of Hyaluronic Acid-Based Nanomaterials in Hyperthermic Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 306 ◽  
Author(s):  
Subin Kim ◽  
Myeong ju Moon ◽  
Suchithra Poilil Surendran ◽  
Yong Yeon Jeong
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Biomedical Applications ◽  
Treatment Approach ◽  
Critical Role ◽  
Sulfated Polysaccharide

Hyaluronic acid (HA) is a non-sulfated polysaccharide polymer with the properties of biodegradability, biocompatibility, and non-toxicity. Additionally, HA specifically binds to certain receptors that are over-expressed in cancer cells. To maximize the effect of drug delivery and cancer treatment, diverse types of nanomaterials have been developed. HA-based nanomaterials, including micelles, polymersomes, hydrogels, and nanoparticles, play a critical role in efficient drug delivery and cancer treatment. Hyperthermic cancer treatment using HA-based nanomaterials has attracted attention as an efficient cancer treatment approach. In this paper, the biomedical applications of HA-based nanomaterials in hyperthermic cancer treatment and combined therapies are summarized. HA-based nanomaterials may become a representative platform in hyperthermic cancer treatment.

scholarly journals Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1888
Author(s):  
Lu Tang ◽  
Shun He ◽  
Yue Yin ◽  
Hening Liu ◽  
Jingyi Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Tumor Development ◽  
Cell Types ◽  
Physicochemical Characteristics ◽  
Delivery Systems ◽  
Specific Tumor ◽  
Different Cell Types

Cell-based drug delivery systems have shown tremendous advantages in cancer treatment due to their distinctive properties. For instance, delivery of therapeutics using tumor-tropic cells like neutrophils, lymphocytes and mesenchymal stem cells can achieve specific tumor targeting due to the “Trojan Horse” effect. Other circulatory cells like erythrocytes and platelets can greatly improve the circulation time of nanoparticles due to their innate long circulation property. Adipocytes, especially cancer-associated adipocytes, play key roles in tumor development and metabolism, therefore, adipocytes are regarded as promising bio-derived nanoplatforms for anticancer targeted drug delivery. Nanomaterials are important participants in cell-based drug delivery because of their unique physicochemical characteristics. Therefore, the integration of various nanomaterials with different cell types will endow the constructed delivery systems with many attractive properties due to the merits of both. In this review, a number of strategies based on nanomaterial-involved cell-mediated drug delivery systems for cancer treatment will be summarized. This review discusses how nanomaterials can be a benefit to cell-based therapies and how cell-derived carriers overcome the limitations of nanomaterials, which highlights recent advancements and specific biomedical applications based on nanomaterial-mediated, cell-based drug delivery systems.

Nanotheranostic agents for neurodegenerative diseases

2020 ◽  
Vol 4 (6) ◽  
pp. 645-675
Author(s):  
Parasuraman Padmanabhan ◽  
Mathangi Palanivel ◽  
Ajay Kumar ◽  
Domokos Máthé ◽  
George K. Radda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Cell Types ◽  
Specific Cell ◽  
Ageing Population ◽  
Target Tissue ◽  
Therapeutic Approaches ◽  
Surface Receptors ◽  
Theranostic Agents ◽  
Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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