Deep learning of the back-splicing code for circular RNA formation

2019 ◽  
Vol 35 (24) ◽  
pp. 5235-5242 ◽  
Author(s):  
Jun Wang ◽  
Liangjiang Wang
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Rna Splicing ◽  
Expression Patterns ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Superior Performance ◽  
Supplementary Information ◽  
Circular Rnas ◽  
Support Vector

Abstract Motivation Circular RNAs (circRNAs) are a new class of endogenous RNAs in animals and plants. During pre-RNA splicing, the 5′ and 3′ termini of exon(s) can be covalently ligated to form circRNAs through back-splicing (head-to-tail splicing). CircRNAs can be conserved across species, show tissue- and developmental stage-specific expression patterns, and may be associated with human disease. However, the mechanism of circRNA formation is still unclear although some sequence features have been shown to affect back-splicing. Results In this study, by applying the state-of-art machine learning techniques, we have developed the first deep learning model, DeepCirCode, to predict back-splicing for human circRNA formation. DeepCirCode utilizes a convolutional neural network (CNN) with nucleotide sequence as the input, and shows superior performance over conventional machine learning algorithms such as support vector machine and random forest. Relevant features learnt by DeepCirCode are represented as sequence motifs, some of which match human known motifs involved in RNA splicing, transcription or translation. Analysis of these motifs shows that their distribution in RNA sequences can be important for back-splicing. Moreover, some of the human motifs appear to be conserved in mouse and fruit fly. The findings provide new insight into the back-splicing code for circRNA formation. Availability and implementation All the datasets and source code for model construction are available at https://github.com/BioDataLearning/DeepCirCode. Supplementary information Supplementary data are available at Bioinformatics online.

scholarly journals Wheat Lodging Detection from UAS Imagery Using Machine Learning Algorithms

2020 ◽  
Vol 12 (11) ◽  
pp. 1838 ◽  
Author(s):  
Zhao Zhang ◽  
Paulo Flores ◽  
C. Igathinathane ◽  
Dayakar L. Naik ◽  
Ravi Kiran ◽  
...  
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Deep Learning ◽  
Standard Deviation ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Superior Performance ◽  
Support Vector ◽  
Unmanned Aerial Systems

The current mainstream approach of using manual measurements and visual inspections for crop lodging detection is inefficient, time-consuming, and subjective. An innovative method for wheat lodging detection that can overcome or alleviate these shortcomings would be welcomed. This study proposed a systematic approach for wheat lodging detection in research plots (372 experimental plots), which consisted of using unmanned aerial systems (UAS) for aerial imagery acquisition, manual field evaluation, and machine learning algorithms to detect the occurrence or not of lodging. UAS imagery was collected on three different dates (23 and 30 July 2019, and 8 August 2019) after lodging occurred. Traditional machine learning and deep learning were evaluated and compared in this study in terms of classification accuracy and standard deviation. For traditional machine learning, five types of features (i.e. gray level co-occurrence matrix, local binary pattern, Gabor, intensity, and Hu-moment) were extracted and fed into three traditional machine learning algorithms (i.e., random forest (RF), neural network, and support vector machine) for detecting lodged plots. For the datasets on each imagery collection date, the accuracies of the three algorithms were not significantly different from each other. For any of the three algorithms, accuracies on the first and last date datasets had the lowest and highest values, respectively. Incorporating standard deviation as a measurement of performance robustness, RF was determined as the most satisfactory. Regarding deep learning, three different convolutional neural networks (simple convolutional neural network, VGG-16, and GoogLeNet) were tested. For any of the single date datasets, GoogLeNet consistently had superior performance over the other two methods. Further comparisons between RF and GoogLeNet demonstrated that the detection accuracies of the two methods were not significantly different from each other (p > 0.05); hence, the choice of any of the two would not affect the final detection accuracies. However, considering the fact that the average accuracy of GoogLeNet (93%) was larger than RF (91%), it was recommended to use GoogLeNet for wheat lodging detection. This research demonstrated that UAS RGB imagery, coupled with the GoogLeNet machine learning algorithm, can be a novel, reliable, objective, simple, low-cost, and effective (accuracy > 90%) tool for wheat lodging detection.

scholarly journals A study of deep learning approaches for medication and adverse drug event extraction from clinical text

2019 ◽  
Vol 27 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Qiang Wei ◽  
Zongcheng Ji ◽  
Zhiheng Li ◽  
Jingcheng Du ◽  
Jingqi Wang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Learning Algorithms ◽  
Joint Model ◽  
Machine Learning Algorithms ◽  
Entity Recognition ◽  
Superior Performance ◽  
Drug Event ◽  
Support Vector ◽  
Learning Approaches

AbstractObjectiveThis article presents our approaches to extraction of medications and associated adverse drug events (ADEs) from clinical documents, which is the second track of the 2018 National NLP Clinical Challenges (n2c2) shared task.Materials and MethodsThe clinical corpus used in this study was from the MIMIC-III database and the organizers annotated 303 documents for training and 202 for testing. Our system consists of 2 components: a named entity recognition (NER) and a relation classification (RC) component. For each component, we implemented deep learning-based approaches (eg, BI-LSTM-CRF) and compared them with traditional machine learning approaches, namely, conditional random fields for NER and support vector machines for RC, respectively. In addition, we developed a deep learning-based joint model that recognizes ADEs and their relations to medications in 1 step using a sequence labeling approach. To further improve the performance, we also investigated different ensemble approaches to generating optimal performance by combining outputs from multiple approaches.ResultsOur best-performing systems achieved F1 scores of 93.45% for NER, 96.30% for RC, and 89.05% for end-to-end evaluation, which ranked #2, #1, and #1 among all participants, respectively. Additional evaluations show that the deep learning-based approaches did outperform traditional machine learning algorithms in both NER and RC. The joint model that simultaneously recognizes ADEs and their relations to medications also achieved the best performance on RC, indicating its promise for relation extraction.ConclusionIn this study, we developed deep learning approaches for extracting medications and their attributes such as ADEs, and demonstrated its superior performance compared with traditional machine learning algorithms, indicating its uses in broader NER and RC tasks in the medical domain.

scholarly journals Application of Deep Learning for Credit Card Approval: A Comparison with Two Machine Learning Techniques

2021 ◽  
Vol 11 (4) ◽  
pp. 286-290
Author(s):  
Md. Golam Kibria ◽  
◽  
Mehmet Sevkli
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Credit Card ◽  
Learning Algorithms ◽  
Learning Model ◽  
Machine Learning Algorithms ◽  
The Other ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Deep Learning Model

The increased credit card defaulters have forced the companies to think carefully before the approval of credit applications. Credit card companies usually use their judgment to determine whether a credit card should be issued to the customer satisfying certain criteria. Some machine learning algorithms have also been used to support the decision. The main objective of this paper is to build a deep learning model based on the UCI (University of California, Irvine) data sets, which can support the credit card approval decision. Secondly, the performance of the built model is compared with the other two traditional machine learning algorithms: logistic regression (LR) and support vector machine (SVM). Our results show that the overall performance of our deep learning model is slightly better than that of the other two models.

scholarly journals Automated Amharic News Categorization Using Deep Learning Models

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Demeke Endalie ◽  
Getamesay Haile
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Document Classification ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Language Resources ◽  
Data Set ◽  
Learning Techniques ◽  
Proposed Model

For decades, machine learning techniques have been used to process Amharic texts. The potential application of deep learning on Amharic document classification has not been exploited due to a lack of language resources. In this paper, we present a deep learning model for Amharic news document classification. The proposed model uses fastText to generate text vectors to represent semantic meaning of texts and solve the problem of traditional methods. The text vectors matrix is then fed into the embedding layer of a convolutional neural network (CNN), which automatically extracts features. We conduct experiments on a data set with six news categories, and our approach produced a classification accuracy of 93.79%. We compared our method to well-known machine learning algorithms such as support vector machine (SVM), multilayer perceptron (MLP), decision tree (DT), XGBoost (XGB), and random forest (RF) and achieved good results.

Using Machine Learning Algorithms on Prediction of Stock Price

2020 ◽  
Vol 12 (2) ◽  
pp. 84-99
Author(s):  
Li-Pang Chen
Keyword(s):  
Machine Learning ◽  
Stock Price ◽  
Short Term Memory ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Short Term ◽  
Learning Techniques ◽  
Historical Database ◽  
Long Short Term Memory

In this paper, we investigate analysis and prediction of the time-dependent data. We focus our attention on four different stocks are selected from Yahoo Finance historical database. To build up models and predict the future stock price, we consider three different machine learning techniques including Long Short-Term Memory (LSTM), Convolutional Neural Networks (CNN) and Support Vector Regression (SVR). By treating close price, open price, daily low, daily high, adjusted close price, and volume of trades as predictors in machine learning methods, it can be shown that the prediction accuracy is improved.

A Comparative Study of Different Machine Learning Algorithms for Disease Prediction

2017 ◽  
Vol 7 (7) ◽  
pp. 172
Author(s):  
Anantvir Singh Romana
Keyword(s):  
Machine Learning ◽  
Subsequent Treatment ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Disease Prediction ◽  
Classification Problems ◽  
Learning Techniques ◽  
Neural Network Classifiers ◽  
Diagnostic Detection

Accurate diagnostic detection of the disease in a patient is critical and may alter the subsequent treatment and increase the chances of survival rate. Machine learning techniques have been instrumental in disease detection and are currently being used in various classification problems due to their accurate prediction performance. Various techniques may provide different desired accuracies and it is therefore imperative to use the most suitable method which provides the best desired results. This research seeks to provide comparative analysis of Support Vector Machine, Naïve bayes, J48 Decision Tree and neural network classifiers breast cancer and diabetes datsets.

Efficient detection of hacker community based on twitter data using complex networks and machine learning algorithm

2021 ◽  
pp. 1-17
Author(s):  
Ahmed Al-Tarawneh ◽  
Ja’afer Al-Saraireh
Keyword(s):  
Machine Learning ◽  
Complex Networks ◽  
Nearest Neighbor ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
K Nearest Neighbor ◽  
Efficient Detection ◽  
Suggested Keywords

Twitter is one of the most popular platforms used to share and post ideas. Hackers and anonymous attackers use these platforms maliciously, and their behavior can be used to predict the risk of future attacks, by gathering and classifying hackers’ tweets using machine-learning techniques. Previous approaches for detecting infected tweets are based on human efforts or text analysis, thus they are limited to capturing the hidden text between tweet lines. The main aim of this research paper is to enhance the efficiency of hacker detection for the Twitter platform using the complex networks technique with adapted machine learning algorithms. This work presents a methodology that collects a list of users with their followers who are sharing their posts that have similar interests from a hackers’ community on Twitter. The list is built based on a set of suggested keywords that are the commonly used terms by hackers in their tweets. After that, a complex network is generated for all users to find relations among them in terms of network centrality, closeness, and betweenness. After extracting these values, a dataset of the most influential users in the hacker community is assembled. Subsequently, tweets belonging to users in the extracted dataset are gathered and classified into positive and negative classes. The output of this process is utilized with a machine learning process by applying different algorithms. This research build and investigate an accurate dataset containing real users who belong to a hackers’ community. Correctly, classified instances were measured for accuracy using the average values of K-nearest neighbor, Naive Bayes, Random Tree, and the support vector machine techniques, demonstrating about 90% and 88% accuracy for cross-validation and percentage split respectively. Consequently, the proposed network cyber Twitter model is able to detect hackers, and determine if tweets pose a risk to future institutions and individuals to provide early warning of possible attacks.

scholarly journals Accurate estimation of isoelectric point of protein and peptide based on amino acid sequences

2015 ◽  
Vol 32 (6) ◽  
pp. 821-827 ◽  
Author(s):  
Enrique Audain ◽  
Yassel Ramos ◽  
Henning Hermjakob ◽  
Darren R. Flower ◽  
Yasset Perez-Riverol
Keyword(s):  
Machine Learning ◽  
Isoelectric Point ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Basis Set ◽  
Superior Performance ◽  
Supplementary Information ◽  
Training Dataset ◽  
Accurate Estimation ◽  
Prediction Methods

Abstract Motivation: In any macromolecular polyprotic system—for example protein, DNA or RNA—the isoelectric point—commonly referred to as the pI—can be defined as the point of singularity in a titration curve, corresponding to the solution pH value at which the net overall surface charge—and thus the electrophoretic mobility—of the ampholyte sums to zero. Different modern analytical biochemistry and proteomics methods depend on the isoelectric point as a principal feature for protein and peptide characterization. Protein separation by isoelectric point is a critical part of 2-D gel electrophoresis, a key precursor of proteomics, where discrete spots can be digested in-gel, and proteins subsequently identified by analytical mass spectrometry. Peptide fractionation according to their pI is also widely used in current proteomics sample preparation procedures previous to the LC-MS/MS analysis. Therefore accurate theoretical prediction of pI would expedite such analysis. While such pI calculation is widely used, it remains largely untested, motivating our efforts to benchmark pI prediction methods. Results: Using data from the database PIP-DB and one publically available dataset as our reference gold standard, we have undertaken the benchmarking of pI calculation methods. We find that methods vary in their accuracy and are highly sensitive to the choice of basis set. The machine-learning algorithms, especially the SVM-based algorithm, showed a superior performance when studying peptide mixtures. In general, learning-based pI prediction methods (such as Cofactor, SVM and Branca) require a large training dataset and their resulting performance will strongly depend of the quality of that data. In contrast with Iterative methods, machine-learning algorithms have the advantage of being able to add new features to improve the accuracy of prediction. Contact: [email protected] Availability and Implementation: The software and data are freely available at https://github.com/ypriverol/pIR. Supplementary information: Supplementary data are available at Bioinformatics online.

scholarly journals Implementation of IoT Framework with Data Analysis Using Deep Learning Methods for Occupancy Prediction in a Building

2021 ◽  
Vol 13 (3) ◽  
pp. 67
Author(s):  
Eric Hitimana ◽  
Gaurav Bajpai ◽  
Richard Musabe ◽  
Louis Sibomana ◽  
Jayavel Kayalvizhi
Keyword(s):  
Machine Learning ◽  
Time Series ◽  
Deep Learning ◽  
Time Series Data ◽  
Multivariate Time Series ◽  
Machine Learning Algorithms ◽  
Series Data ◽  
Support Vector ◽  
Human Beings ◽  
Feed Forward Network

Many countries worldwide face challenges in controlling building incidence prevention measures for fire disasters. The most critical issues are the localization, identification, detection of the room occupant. Internet of Things (IoT) along with machine learning proved the increase of the smartness of the building by providing real-time data acquisition using sensors and actuators for prediction mechanisms. This paper proposes the implementation of an IoT framework to capture indoor environmental parameters for occupancy multivariate time-series data. The application of the Long Short Term Memory (LSTM) Deep Learning algorithm is used to infer the knowledge of the presence of human beings. An experiment is conducted in an office room using multivariate time-series as predictors in the regression forecasting problem. The results obtained demonstrate that with the developed system it is possible to obtain, process, and store environmental information. The information collected was applied to the LSTM algorithm and compared with other machine learning algorithms. The compared algorithms are Support Vector Machine, Naïve Bayes Network, and Multilayer Perceptron Feed-Forward Network. The outcomes based on the parametric calibrations demonstrate that LSTM performs better in the context of the proposed application.

A Comparative Study of Alzheimer Detection Techniques

2021 ◽  
Vol 9 (8) ◽  
pp. 2877-2883
Author(s):  
Adwait Patil
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Learning ◽  
Comparative Study ◽  
Fuzzy System ◽  
Early Stage ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Detection Techniques

Abstract: Alzheimer’s disease is one of the neurodegenerative disorders. It initially starts with innocuous symptoms but gradually becomes severe. This disease is so dangerous because there is no treatment, the disease is detected but typically at a later stage. So it is important to detect Alzheimer at an early stage to counter the disease and for a probable recovery for the patient. There are various approaches currently used to detect symptoms of Alzheimer’s disease (AD) at an early stage. The fuzzy system approach is not widely used as it heavily depends on expert knowledge but is quite efficient in detecting AD as it provides a mathematical foundation for interpreting the human cognitive processes. Another more accurate and widely accepted approach is the machine learning detection of AD stages which uses machine learning algorithms like Support Vector Machines (SVMs) , Decision Tree , Random Forests to detect the stage depending on the data provided. The final approach is the Deep Learning approach using multi-modal data that combines image , genetic data and patient data using deep models and then uses the concatenated data to detect the AD stage more efficiently; this method is obscure as it requires huge volumes of data. This paper elaborates on all the three approaches and provides a comparative study about them and which method is more efficient for AD detection. Keywords: Alzheimer’s Disease (AD), Fuzzy System , Machine Learning , Deep Learning , Multimodal data

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