Precision Nutrition Assessment of Risk for Metabolic Syndrome in Active Duty Service Members

Abstract Objectives Precision nutrition leverages the specificity of molecular and phenotypic differences in personalizing diet and lifestyle interventions.Objective for this phase of the study: 1) examine the effectiveness of gene-based nutrition counseling on behavior change measured by weight, body mass index (BMI), blood glucose, lipids, 25-hydroxyvitamin (OH) D, %body fat (BF), waist circumference, and blood pressure. Methods In this prospective multisite RCT, a baseline genomic profile from 70 diet-responsive genes/80 variants, is augmented by biomarkers specific to metabolic syndrome (MetS) risk for each subject. Treatment group (TG) receives gene-based nutrition counseling for six weekly sessions; Control group (CG) receives evidence-based nutrition content in pamphlets directed at preventing metabolic syndrome. A digital app provides real-time health data capture with continuous feedback and is validated by in-person interviews. Primary outcome is weight loss at 12 weeks. Results Army NW cohort has enrolled 90 subjects to date; 49 are assigned to the TG. Sample demographics: males (70%), mean age 32 yrs, 58% married, 75% Caucasian, non-Hispanic, and 78% report some college education. In females, mean BMI 28.3, %BF 34.2, waist circumference 32.2 in; males mean BMI 30.1, %BF 29, waist circumference 40 in. For MetS components, 27/90 subjects show no abnormal components yet 41/90 have 2 or 3 alterations. Elevations noted as follows: fasting blood glucose in 47%, blood pressure in 38%, and waist circumference in 30%. High variant presence is noteworthy for genes with a role in obesity and hypertension. In 71% of subjects baseline 25(OH) D ≤ 30 ng/mL. Preliminary results for primary outcome of weight loss at 12 weeks reveal no change in TG (n = 21), an average loss of 5 lbs in CG (n = 21) within groups, and a significant difference between groups; TG 197.4 (39.3) vs CG 192.6 (40.3), p < .001. Conclusions Digital health integration, along with genomic data and family history, can reveal early signals of risk in a young, generally healthy, military population. Health promotion efforts must drive behavior change at both the individual and population level. Funding Sources The TriService Nursing Research Program

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The Metabolic Syndrome: Comparison of Newly Proposed IDF, Modified ATP III and WHO Criteria and their Agreements

Cardiovascular Journal ◽

10.3329/cardio.v6i1.16110 ◽

2013 ◽

Vol 6 (1) ◽

pp. 17-22 ◽

Cited By ~ 2

Author(s):

AKM Mainuddin ◽

KN Choudhury ◽

KR Ahmed ◽

S Akter ◽

N Islam ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Waist Circumference ◽

Fasting Blood Glucose ◽

T Test ◽

Anthropometric Measurement ◽

Who Criteria ◽

Significant Difference

Background: Metabolic syndrome (MS) results from clustering of cardiovascular risk factors occurring in association with insulin resistance and obesity. With the increasing prevalence of obesity worldwide, MS is of keen interest in research. The disorder is defined in various ways, but one consolidated definition is needed to make studies comparable worldwide. The study was to determine the risk factors of metabolic syndrome in Bangladesh and comparison of newly proposed definition of International Diabetes Federation (IDF), modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the World Health Organization (WHO) criteria and their agreements. Materials and Methods: This was a cross sectional hospital based study. We randomly selected 229 participants. After obtaining informed written consent data collectors collected data by interview, clinical examination, anthropometric measurement and investigations. We calculated independent sample t-test means between to distinguish which risk factors were present in participants with and without MS, using SPSS v17. Results: The percentage of risk factors of MS among subjects according to different criteria was 72% of Modified ATP-III, 69% of IDF and 39% of WHO definition .In Modified NCEP ATP III when did independent sample t-test mean of BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, high density lipoprotein and triglyceride were present statistically significant difference between without MS and with MS (p<0.05). According to WHO criteria BMI, waist circumference, fasting blood glucose were statistically significant (p<0.05) and similarly fasting blood glucose & triglyceride were statistically significant difference between without MS and with MS (p<0.05) according to IDF criteria.ATP III and WHO criteria showed good agreement (k 0.56) compared to ATP III with IDF (k 0.31) and WHO with IDF (k 0.11) criteria. Conclusion: Metabolic syndrome is highly prevalent in Bangladesh. We detected the highest proportion of participants with MS using the ATP III definition, which emphasizes the predominant focus on the modified waist circumference for Asian participants. However, MS prevalence following WHO criteria in those with impaired glucose regulation is comparable with ATP III definition. Follow up study needed to examine the significance of MS following all definitions for the assessment of risk for diabetes and or cardiovascular disease. Cardiovascular Journal Volume 6, No. 1, 2013, Page 17-22 DOI: http://dx.doi.org/10.3329/cardio.v6i1.16110

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A telephone-supported cardiovascular lifestyle programme (CLIP) for lipid reduction and weight loss in general practice patients: a randomised controlled pilot trial

Public Health Nutrition ◽

10.1017/s1368980013000220 ◽

2013 ◽

Vol 17 (3) ◽

pp. 640-647 ◽

Cited By ~ 7

Author(s):

Keren Louise Stuart ◽

Belinda Wyld ◽

Kathryn Bastiaans ◽

Nigel Stocks ◽

Grant Brinkworth ◽

...

Keyword(s):

Blood Pressure ◽

Weight Loss ◽

General Practice ◽

General Practitioner ◽

Primary Prevention ◽

Waist Circumference ◽

Total Cholesterol ◽

Pilot Trial ◽

Control Group ◽

Call Centre

AbstractObjectiveTo evaluate a primary prevention care model using telephone support delivered through an existing health call centre to general practitioner-referred patients at risk of developing CVD, using objective measures of CVD risk reduction and weight loss.DesignParticipants were randomised into two groups: (i) those receiving a telephone-supported comprehensive lifestyle intervention programme (CLIP: written structured diet and exercise advice, plus seven telephone sessions with the Heart Foundation Health Information Service); and (ii) those receiving usual care from their general practitioner (control: written general lifestyle advice). Fasting plasma lipids, blood pressure, weight, waist circumference and height were assessed on general practice premises by a practice nurse at Weeks 0 and 12.SettingTwo general practices in Adelaide, South Australia.SubjectsForty-nine men and women aged 48·0 (sd5·88) years identified by their general practitioner as being at future risk of CVD (BMI = 33·13 (sd5·39) kg/m2; LDL cholesterol (LDL-C) = 2·66 (sd0·92) mmol/l).ResultsCLIP participants demonstrated significantly greater reductions in LDL-C (estimated mean (EM)= 1·98 (se0·17) mmol/l) and total cholesterol (EM = 3·61 (se0·21) mmol/l) at Week 12 when compared with the control group (EM = 3·23 (se0·18) mmol/l and EM = 4·77 (se0·22) mmol/l, respectively). There were no significant treatment effects for systolic blood pressure (F(1,45) = 0·28,P= 0·60), diastolic blood pressure (F(1,43) = 0·52,P= 0·47), weight (F(1,42) = 3·63,P= 0·063) or waist circumference (F(1,43) = 0·32,P= 0·577).ConclusionsIn general practice patients, delivering CLIP through an existing telephone health service is effective in achieving reductions in LDL-C and total cholesterol. While CLIP may have potential for wider implementation to support primary prevention of CVD, longer-term cost-effectiveness data are warranted.

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Prevalence of Metabolic Syndrome and Related Factors in Patients with Non-alcoholic Fatty Liver

Jundishapur Journal of Chronic Disease Care ◽

10.5812/jjcdc.114541 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Mehrnoosh Zakerkish ◽

Abolghasem Assarzadeh ◽

Seyed Saeed Seyedian ◽

Alireza Jahanshahi

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Fatty Liver ◽

Significant Relationship ◽

Common Symptom ◽

Related Factors ◽

Alcoholic Fatty Liver ◽

Number Of Patients ◽

Significant Difference

Objectives: This study was designed to investigate the prevalence of metabolic syndrome in patients diagnosed with non-alcoholic fatty liver disease (NAFLD) referring to the gastrointestinal and endocrinology clinics of Golestan and Imam Khomeini Hospitals, Ahvaz. Methods: The current cross-sectional study was performed on patients with NAFLD referring to the gastroenterology and endocrinology clinics of Golestan and Emam Khomeini hospitals, Ahvaz in the second half of 2020. Demographic information included age, gender, lumbar posture (while standing and the waist be in the upper edge of the iliac crest at the end of a normal exhalation using a non-elastic meter), grading fatty liver evidenced by ultrasound, and blood pressure and laboratory parameters, including triglyceride (TG), fasting blood sugar (FBS), and high-density lipoprotein (HDL) was recorded in the checklist. Data analysis was performed using SPSS 26.0 software. Results: This study was performed on 130 patients with an average age of 46.22 ± 14.27 years. Patients comprised 42 men (32.8%) and 88 women (67.2/%). Also, 63.84% of the patients with NAFLD had metabolic syndrome, and 56.2, 69.6, and 81.8% with grades 1, 2, and 3 of fatty liver, respectively had metabolic syndrome. There was a significant difference in terms of mean height and weight in both gender. There was a significant relationship between age and FBS, so that the levels of FBS increased statistically significantly with age (P < 0.05). Gender had a statistically significant relationship with HDL and waist circumference (P = 0.038). There was no statistically significant relationship between blood pressure, TG, HDL, FBS, and waist circumference, and different grades of fatty liver (P > 0.05). Conclusions: The current study showed a significant number of patients with NAFLD had metabolic syndrome, so that the most common symptom of metabolic syndrome was low HDL levels, followed by high FBS levels, blood pressure, and TG levels and waist circumference size. Nevertheless, it was not probable to assess whether NAFLD precedes the progress of metabolic syndrome.

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HUBUNGAN KUALITAS TIDUR DENGAN 5 INDIKATOR SINDROMA METABOLIK PADA PERAWAT DI RUMAH SAKIT UMUM PUSAT HAJI ADAM MALIK MEDAN

VISIKES: Jurnal Kesehatan Masyarakat ◽

10.33633/visikes.v20i2.5076 ◽

2021 ◽

Vol 20 (2) ◽

Author(s):

Simon Simon

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Sleep Quality ◽

Fasting Blood Glucose ◽

Hdl Cholesterol ◽

T Test ◽

Human Beings ◽

Glucose Content ◽

Significant Difference

ABSTRACTHigh death rate caused by non-transmitted diseases in the world is begun with metabolic syndrome in human beings such the increase in IMT (Body Mass Index) to be obesity, the increase in blood pressure to be hypertension, the increase in blood glucose to be diabetes mellitus, and abnormality of triglycerides, and HDL cholesterol. Many factors which trigger the indicator abnormality, and of them is bad sleep quality. The research used cross sectional design by analyzing the correlation between sleep quality and 5 metabolic syndrome indicator in female nurses in the operation room of Adam Malik Medan hospital. Sleep quality was measured by using questionnaire of Pittsburg Sleep Quality Index (PSQI), body height and weight were measured to get IMT value, blood pressure was measured by using tensimeter, blood glucose and blood lipid were measured by getting the respondent’s vena blood samples. The data were processed and analysis with independent t-test.The result with independent t-test showed that there was significant difference in IMT (sig=0,003), systolic blood pressure (sig=0,028), and fasting blood glucose content (sig=0,00). However, there was no significant difference in trigliyceride content (sig=0,519), HDL cholesterol content (sig=0,300),). The conclusion was that sleep quality was correlated with three metabolic syndrome indicators: IMT, blood pressure, and blood glucose content, but there was no correlation with trigliyceride and HDL cholesterol.Keywords: Sleep Quality, Metabolic Syndrome , T-Test,

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Abstract P111: A Cluster Randomized Controlled Trial to Examine the Effects of Tai Chi and Walking Exercises on Weight Loss, Metabolic Syndrome Parameters, and Bone Mineral Density

Circulation ◽

10.1161/circ.131.suppl_1.p111 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Yao Jie Xie ◽

Stanley Sai-chuen Hui ◽

Timothy Chi-yui Kwok ◽

Jean Woo

Keyword(s):

Bone Mineral Density ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Weight Loss ◽

Body Weight ◽

Waist Circumference ◽

Lean Mass ◽

Tai Chi ◽

Density Lipoprotein ◽

Mineral Density

Introduction: Tai Chi and walking are both moderate-intensity physical activity (PA) that can be easily practiced in daily life. The purpose of this study was to better understand that after practicing these two types of PAs in a relative short term and keeping the stable dietary intake in this period, how much body weight would be reduced and what extent the metabolic syndrome parameters would be improved; and if a significant weight loss was observed, whether this exercise-induced weight loss had adverse effect on bone mineral density (BMD). Methods: Three-hundred seventy-four healthy and physically inactive adults (45.8±5.3 years) from 9 geographic areas in Hong Kong were randomized to 12 weeks training (45 minutes per day, 5 days per week) of Tai Chi (n=124) or self-paced walking (n=121), or control group (n=129) at area level. Body weight, fat and lean mass, waist circumference, blood pressure and regional BMD, as well as the fasting blood samples were obtained at the beginning and end of trial. Fasting blood glucose (FBG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides were analyzed. Results: On average, Tai Chi and walking groups lost 0.50 and 0.76 kg of body weight, 0.47 and 0.59 kg of fat mass, respectively (all p<0.001). No significant changes were observed for lean mass and BMD. Two intervention groups had significant improvements in waist circumference and FBG. The between-group difference of waist circumference and FBG was -3.7 cm and -0.18 mmol/L for Tai Chi vs. control; and -4.1 cm and -0.22 mmol/L for walking vs. control (all p<0.001). No significant differences were observed regarding blood pressure, total cholesterol, HDL-C, LDL-C and triglycerides compared to control (all p>0.05). The effects on all outcomes between Tai Chi and walking were similar (all p>0.05). Among intervention groups, change in lean mass, not fat mass or total weight loss, was significantly correlated to the change in BMD. Conclusions: 12-week Tai Chi and walking exercises can produce moderate weight loss and improve the waist circumference and FBG in middle-aged Hong Kong Chinese people, with no additional effects on BMD.

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The Relationship between Risk Factors for Metabolic Syndrome and Bone Mineral Density in Menopausal Korean Women

Iranian Journal of Public Health ◽

10.18502/ijph.v48i6.2899 ◽

2020 ◽

Author(s):

Seok-Hee KIM ◽

Jooyoung KIM

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Bone Mineral ◽

Korean Women ◽

Mineral Density ◽

Significant Difference ◽

The Relationship

Background: The risk factors of metabolic syndrome (MetS) in menopausal women are potential causes of osteoporosis. However, there is no consensus on this. We aimed to determine the relationship between risk factors of MetS and bone mineral density (BMD) in menopausal Korean women. Methods: We enrolled 205 menopausal Korean women who visited a health promotion center in Seoul in 2015 and divided them into the following two groups according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria with modified waist-circumference criteria: the non-MetS group (Group 1, n=90) and the MetS group (Group 2, n=115). Anthropometric parameters and clinical parameters, including blood pressure, blood lipid profile (cholesterol, triglycerides), and fasting blood sugar levels were recorded for all participants. BMD at the lumbar spine was determined using dual-energy X-ray absorptiometry (DEXA). The relationship between the risk factors of MetS and bone mineral density was analyzed by statistical methods. Results: There was no significant difference in risk factors of MetS between the groups. In correlation tests, waist circumference showed a significant association with body surface area (BSA) (r = -0.242, P < 0.001). Diastolic blood pressure was correlated with BSA (r = 0.186, P < 0.01) and bone mineral content (BMC) (r = 0.161, P < 0.05). However, multiple regression analysis showed no significant relationship between MetS risk factors and BMD. Conclusion: The risk factors of MetS did not affect BMD in menopausal Korean women. Follow-up studies with a larger study population are necessary size to allow the investigation of other research variables.

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The Effects of Combined Fruit-Infused Water (Apple, Pineapple, Strawberry, Cucumber) on Blood Pressure and Fasting Blood Glucose in Patients with Metabolic Syndrome

Amerta Nutrition ◽

10.20473/amnt.v5i4.2021.313-319 ◽

2021 ◽

Vol 5 (4) ◽

pp. 313

Author(s):

Astri Purwanti ◽

Sugiarto Sugiarto ◽

Dono Indarto

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Radical Reaction ◽

Control Group ◽

Chi Square ◽

Control Group Design ◽

Before And After ◽

Randomized Control

ABSTRACTBackground: Fruit-infused water (FIW) contains antioxidants and potassium as a antihyperglycemic and antihypertension via inhibition or break the chain of radical reaction but has not been proven in patients with MS.Purpose: To evaluate the effects of FIW on blood pressure and fasting blood glucose (FBG) in patients with MS.Method: This is a Randomized-Control Trial with pre-posttest control group design. 24 patients of Cakranegara Health Center who fulfilled the criteria were randomly divided into control (given counseling only) and treatment (counseling + FIW consists of apple, cucumber, pineapple and strawberry in 250 ml water for 14 days) groups. Blood pressure and FBG were measured before and after intervention. Chi Square was used for descriptive analyze, whereas T-test, Mann Whitney and Wilcoxon was used for differences in means.Result: In the treatment group (n=11), systolic and diastolic mean levels were decreased by 5,4 mmHg (p=0,140) and 0,9 mmHg (p=0,792) respectively. However, FBG levels were increased by 9,2 mg/dL (p=0.929). There were no differences on systolic (p=0,448), diastolic (p=0,835) and FBG (p=0,599) between two groups.Conclusion: FIW consumption are unable to improve blood pressure and FBG levels on metabolic syndrome. Keywords: Fruit-Infused Water, Blood Pressure, Fasting Blood Sugar Level, Metabolic Syndrome

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Konsumsi lemak total, lemak jenuh, dan kolesterol sebagai faktor risiko sindroma metabolik pada masyarakat perkotaan di Denpasar

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.17751 ◽

2011 ◽

Vol 7 (3) ◽

pp. 107

Author(s):

Ni Komang Wiardani ◽

Pande Putu Sri Sugiani ◽

Ni Made Yuni Gumala

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Fatty Acid ◽

Blood Glucose ◽

Waist Circumference ◽

Total Cholesterol ◽

Blood Sugar ◽

Saturated Fatty Acid ◽

Fat Intake ◽

Fat Consumption

Background: Metabolic syndrome is a health problem with its prevalence increasing in the worldwide. It is characterized by a group metabolic factor including abdominal obesity, dyslipidemia, elevated blood pressure and insulin resistance. Metabolic syndrome affected by changes in lifestyle and unhealthy dietary patterns with high cholesterol, saturated fatty acid and trans fatty acid.Objective: The study conducted to know relationship between fat consumption with metabolic syndrome among adult people in Denpasar city.Method: The case control study designed was applied. The cases were adult people who had metabolic syndrome, and the control was healthy people from the case-neighboring household. Total subject were 130, taken by consecutive sampling: 65 cases and 65 controls. The subject identity, fat intake, waist circumference, blood pressure and fasting blood sugar were collected. The food frequency questionnaire (FFQ) was used to measure fat consumption and blood glucose test meter for measuring fasting blood sugar. Mantel Haenzel statistic analysis were used to test the association of fat intake with metabolic syndrome.Result: The study showed that means of syndrome metabolic component in case higher than control (p<0.05). Waist circumference in case was 97.23 cm, blood pressure was 141.4/93.3 mmHg, fasting blood glucose was 132 mg/dl. There were significant difference between intake fat total, cholesterol, saturated fatty acid (SAFA) and frequency of intake in case and control (p<0.05). Intake fat on cases were fat total 85.5% >25% energy total/day, SAFA 90.8% >10%, cholesterol 55.4% >300 mg/day. Odd Ratio Mantel Haenzel analysis showed that fat consumption (fat total, cholesterol and frequency consumption of fat were risk factor to metabolic syndrome (OR >1)).Conclusion: There was significant relations between fat consumption (fat total cholesterol, SAFA, frequency of fat consumption) with metabolic syndrome among adult people for Denpasar City.

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Physiological and Therapeutic Outcomes of Intermittent Fasting versus Calorie-Restriction Diet in Patients suffering from Metabolic Syndrome

MCAST Journal of Applied Research & Practice ◽

10.5604/01.3001.0013.2067 ◽

2019 ◽

Vol 3 (1) ◽

pp. 4-19

Author(s):

Doreen Susanne Micallef

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Weight Loss ◽

Blood Glucose ◽

Calorie Restriction ◽

Fasting Blood Glucose ◽

Hdl Cholesterol ◽

Intermittent Fasting ◽

Retrospective Case ◽

Restriction Diet

The main objective of this study was to determine whether an intermittent fasting diet in combination with a CR diet results in better outcomes on risk factors associated with metabolic syndrome (such as lowering of triglycerides, fasting blood glucose, and blood pressure decrease in abdominal obesity and an increase in HDL-cholesterol and related weight loss for both male and female patients) than with a conventional CR diet alone. A 12-week retrospective case-control study was carried out and involved 78 females and 22 males who exhibited or were receiving medications for three or more conditions related to metabolic syndrome and who completed the study out of 120 participants at baseline. These were randomly assigned to either a conventional calorie-restriction diet or to an intermittent-fasting diet. Relevant baseline parameters were measured during the first encounter and were then repeated after twelve weeks. Professional contact was maintained on a fortnightly basis for both groups. Subjects randomly assigned to the intermittent fasting diet lost more weight than subjects on a conventional calorie-restriction diet after 12 weeks (mean ± SD, 5.7 ± 3.2 kg vs 11.4 ± 6.4 kg; p < 0.001). There were also statistically significant decreases in waist circumference (10.1 ± 7.2 cm vs 4.5 ± 3.3 cm; p < 0.001), serum triglycerides (0.31 ± 0.29 mmol/l vs 0.16 ± 0.16 mmol/l; p = 0.002), and systolic blood pressure (11.1 ± 8.2 mm Hg vs 5.2 ± 4.8 mm Hg; p < 0.001) and an increase in HDL-cholesterol (0.25 ± 0.16 vs 0.14 ± 0.15 mmol/l; p = 0.001). However, no statistically significant changes in diastolic blood pressure and fasting blood glucose were recorded. The intermittent fasting diet gave better weight loss outcomes (6.67% vs 12.35%) than did the conventional calorie restriction diet when compared to the baseline weight after the conclusion of the 12-week programme. The intermittent fasting diet was also associated with statistically significant improvements in four out of the six parameters measured and associated with metabolic syndrome. Longer-term studies are required to determine whether these outcomes will be maintained over longer periods of time assuming that there is compliance by the participants.

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Early-onset Male Androgenetic Alopecia and Metabolic Syndrome: Are They Associated?

International Journal of Recent Surgical and Medical Sciences ◽

10.5005/jp-journals-10053-0002 ◽

2016 ◽

Vol 02 (01) ◽

pp. 005-009

Author(s):

Sampada Thakare ◽

Adarshlata Singh

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Early Onset ◽

Tertiary Care ◽

Androgenetic Alopecia ◽

Control Group ◽

P Value ◽

Case Group ◽

Large Sample Size

Abstract Aims and objectives: To study the pattern of early-onset male androgenetic alopecia (AGA) and its association with metabolic syndrome (MetS). Study design: A case–control study was conducted in the tertiary care center, Department of Dermatology, from year 2012 to 2014. Materials and methods: A total number of 100 patients, 50 male patients with early-onset AGA cases and 50 age-matched controls, were enrolled. The Norwood–Hamilton classification was used to assess the grade of AGA. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Blood pressure, blood glucose, and lipid parameters along with waist circumference were assessed in all the study participants. Statistical analysis was done by using descriptive and inferential statistics using chi-square test and Z test for difference between two means. The statistical software used in the analysis was Statistical Package for the Social Sciences 17.0 and Graph Pad Prism 5.0, and the results with (p < 0.05) were considered significant. Results: Most common grades of early-onset male AGA were 38% with grade IV, 26% with grade IIIv (vertex), and 16% with grade III. 50% of the case group with early-onset male AGA and 10% of control group patients had MetS (p < 0.05). As compared with controls, patients with early-onset AGA had a statistically significant mean value for fasting blood sugar level (p-value 0.001), triglyceride level (p-value 0.013), waist circumference (p-value 0.004), systolic blood pressure (p-value 0.006), and diastolic blood pressure (p-value 0.010) respectively. There was no significant association between early-onset male AGA and serum levels of HDL, LDL, VLDL, and cholesterol (p > 0.05). Conclusion: It is inferred from this study that the most common grade of early-onset male AGA was grades IV and III vertex. There also was association of early-onset male AGA with MetS. More prospective studies are required with a large sample size to justify the association between early-onset male AGA and MetS.

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