scholarly journals 69Effect of smoking on treatment outcomes among newly diagnosed Tuberculosis patients in Shimla city India

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Anmol Gupta ◽  
Vineet Kumar
Keyword(s):  
Alcohol Use ◽  
Treatment Outcomes ◽  
Smokeless Tobacco ◽  
Smoking Status ◽  
World Health ◽  
P Value ◽  
Newly Diagnosed ◽  
Tuberculosis Patients ◽  
Harmful Alcohol ◽  
History Of

Abstract Background World health organization in 2015 had adopted “End TB Strategy” aimed at ending the global TB epidemic by 2035. Tobacco smoking has been reported to be associated with many aspects of TB disease, including increased vulnerability to being infected, recurrence with TB and related mortality. Methods A prospective cohort study was carried out among newly diagnosed tuberculosis patients of Shimla city which is the capital of Himachal Pradesh, a northern state of India. Data related to smoking status was collected using the standard questionnaire which was used for collection of data regarding tobacco use in Global Adult Tobacco Survey (GATS). Details of the participant’s final treatment outcomes after end of standardized treatment of 6 months was collected from the treatment records of the patients. Results 72 TB patients were included as study subjects. The prevalence of smoking came out to be 37.5%. In our analyses, the risk of unfavorable treatment outcomes was higher among smokers (p value 0.049), Smokeless tobacco users (p value 0.031) and those with history of harmful alcohol use (p value 0.002). Conclusions There is high prevalence of smoking among TB patients and risk factors associated with unfavorable treatment outcome are smoking, Smokeless tobacco and history of harmful alcohol use. Key messages Smoking and smokeless tobacco cessation programmes need to be targeted at Tuberculosis patients. Tuberculosis patients with alcohol related problems should be identified at the time of diagnosis and should be attached with de-addiction centre

scholarly journals Rifampicin-resistance Pattern of Mycobacterium Tuberculosis and Associated Risk Factors Among Presumptive Pulmonary and Extra Pulmonary Tuberculosis Patients at Madda Walabu University Goba Referral Hospital, Southeast Ethiopia

2021 ◽  
Author(s):  
Wakuman Taye Kelecha ◽  
Solomon Gebra-Sellasie Teklegiorgis ◽  
Mesay Mitiku Gemechu
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Close Contact ◽  
Previous History ◽  
Treatment Protocol ◽  
Resistance Pattern ◽  
P Value ◽  
Drug Resistant ◽  
Tuberculosis Patients ◽  
History Of ◽  
Extra Pulmonary

Abstract Background: Drug resistant M.tuberculosis is one of the serious public health trouble that intimidating progress made in tuberculosis cases and control in several countries. Early detection of drug-resistant tuberculosis is crucial for patient management and infection control. Methods: Hospital based cross-sectional study design was conducted from October 2020 to February 2021. Detection of Mycobacterium tuberculosis and resistance to Rifampicin pattern was determined by using GeneXpert MTB/RIF assay. Data were entered and analyzed by SPSS version 23.0. Bivariate and multivariate analyses were used to examine the relationship between dependent and independent variables. Less than 0.05 P-value was used to show significance.Results: A total of 301 presumptive tuberculosis patients were included in the study; of these, 46 (15.3%) of them were identified as having Mycobacterium tuberculosis, 2/46 (4.35%) were resistant to Rifampicin and 4/46 (14.8%) patients were TB/HIV co-infected. From the total of M. tuberculosis detected 40 (16.7%) were identified in pulmonary and 6 (9.8%) were in extra-pulmonary presumptive patients. Rifampicin-resistant M. tuberculosis was detected in 2 patients who had a history of taking Anti-tuberculosis drugs. Conclusion: Previous history of tuberculosis treatment and having close contact history with tuberculosis patients were found as important associated factors that enhance the prevalence of tuberculosis among presumptive tuberculosis patients. This indicates the mandate to make better and oversee the treatment protocol to control the burden of drug resistant M.tuberculosis.

scholarly journals Factors Related To Abortus Events In Mitra Medika Rsu Tanjung Mulia Medan In 2019

2020 ◽  
Vol 5 (3) ◽  
pp. 631
Author(s):  
Qori Armiza Septia
Keyword(s):  
Pregnant Women ◽  
Health Workers ◽  
Statistical Tests ◽  
World Health ◽  
Bivariate Analysis ◽  
P Value ◽  
Contraceptive Failure ◽  
Study Approach ◽  
History Of ◽  
Relationship Of

<p><em>Abortion is an important problem in public health because it affects maternal morbidity and mortality. Based on data from the World Health Organization (WHO) in 2016, around 830 women die from pregnancy-related complications worldwide every day. During 2010-2014, an estimated 56 million abortions occur each year worldwide. The aim is to find out factors related to the abortion at Mitra Medika Tanjung Mulia Medan Hospital in 2019.</em></p><pre><strong><em>         </em></strong><em>This research uses a Mix Methods research with a Sequential Explanatory strategy. The approach used in quantitative retrospectives and qualitative uses a case study approach. The population </em><em>in</em><em> this study were all pregnant women who experienced abortion recorded in the medical records of Mitra Medika Hospital Tanjung Mulia Medan as many as 73 respondents. The sample in a quantitative approach of 73 respondents with the technique of Total Population while for qualitative 2 pregnant women who have abortion, 2 husbands, 1 midwife. Data collection is carried out with primary, secondary and tertiary data. Data analysis was performed by univariate, bivariate analysis. Qualitative </em><em>data</em><em> analysis with data reduction, data presentation, and drawing conclusions.</em></pre><pre><em>         </em><em>Data obtained from the results of statistical tests show there is a relationship between age and abortion p value 0.005, there is a relationship of work with abortion p value 0.017, there is a relationship of parity with abortion p value 0.022, there is a relationship between historical abortion with abortion p value 0.001. And there is no correlation between contraceptive failure and abortion p value 0.297. Qualitatively based on in-depth interviews with informants that the cause of the occurrence of abortion is due to the age of the mother at risk, a history of previous abortion and fatigue at work. Another factor related to the incidence of abortion is husband's support.</em></pre><p><em>         The conclusion of this study is that there is a relationship between age, occupation, parity, history of abortion of pregnant women with abortion and there is no relationship between contraceptive failure of pregnant women with abortion in Mitra Medika Tanjung Mulia Hospital in 2019. It is expected that health workers can improve the quality of services in efforts to manage abortion and providing information about pre-conception preparation and health monitoring during pregnancy.</em><em></em></p>

Development of a Prognosis Nomogram of Treatment Outcomes for MDR-Tuberculosis in Guinea (Conakry): A retrospective cohort analysis

2019 ◽  
Author(s):  
Alhassane Diallo ◽  
Boubacar Djelo Diallo ◽  
Lansana Mady Camara ◽  
Mafouné Diallo ◽  
Souleymane Camara ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Treatment Outcomes ◽  
Retrospective Cohort ◽  
Clinical Symptoms ◽  
Absolute Risk ◽  
Cohort Analysis ◽  
World Health ◽  
Psychological State ◽  
P Value ◽  
Mdr Tb

Abstract Abstract Background: Despite the availability of the drug treatment for tuberculosis (TB) more than 75 years, mortality and drug resistance are increasing. Therefore, little data is available in Guinea. We aimed to develop and validate a prognosis nomogram of MDR-TB treatment outcomes. Methods:A retrospective cohort study was conducted among men and women, aged 18 years or older, with MDR-TB, from three major drug-resistance TB centres in Guinea. We used the logistic regression to analyse treatment outcomes. Prognostic factors with a p value less than 0.05 from a multivariate model were used to build nomogram and assessed their performance based on discriminative c-index, and calibration using the Hosmer-Lemeshow (H-L) test. To derive the optimal cut-off point score, the Youden’s index method was used. Results:Among 232 patients with MDR-TBenrolled and followed between June 07, 2016 and June 22, 2018, 218 were analyzed. All patients were resistant to rifampicin, which diagnosed by the Xpert MTB/RIF. The overall rate of success was 73%.Factors associated with successful treatment in drug-resistant TB patients were higher BMI more than 18.5 kg/m2(p = 0.0253; aOR = 2.94), good adherence to treatment (p = < 0.0001; aOR = 33.92), normal platelets count (p = 0.0053; OR = 1.004), and the absence of clinical symptoms such as chest pain (p = 0.0083; aOR = 3.19) and depression (p = 0.0308; aOR = 8.62). The discrimination (c-index= 0.848 [95% bootstrap CI, 0.780 – 0.916] in the derivation sample and 0.803 after correction for optimism) and calibration (H-LX2= 2.91 [p = 0.94]) were good. The optimal absolute risk threshold was 20%, corresponding to a sensibility of 95% and specificity of 58%. Conclusion:Treatment success outcomes was lower than those recommended by the World Health Organization (75%). We recommend to improve the MDR-TB patient monitoring during treatment, nutritional status, and considering the psychological state. Our prognosis nomogram needs to be validated in an external population before it can be used in clinical practice. Keywords:Nomogram, Multidrug-resistant, Tuberculosis, Guinea.

scholarly journals Psychological Distress and Its Correlates among Newly Diagnosed People Living with HIV in Northwest Ethiopia: Ordinal Logistic Regression Analyses

2021 ◽  
Vol 14 ◽  
pp. 117863372199459
Author(s):  
Nurilign Abebe Moges ◽  
Olubukola Adeponle Adesina ◽  
Micheal A Okunlola ◽  
Yemane Berhane ◽  
Joshua Odunayo Akinyemi
Keyword(s):  
Logistic Regression ◽  
Psychological Distress ◽  
Alcohol Use ◽  
Health Centers ◽  
People Living With Hiv ◽  
Newly Diagnosed ◽  
Regression Analyses ◽  
Sexually Transmitted ◽  
History Of ◽  
Living With Hiv

Background: Although there is a high burden of HIV in sub-Saharan Africa (SSA), studies on mental health issues among people living with HIV are scarce. The study addressed the transition to “test and treat” guidelines for HIV, which makes it unique regarding its evaluation of psychological distress amongst newly initiated people living with HIV in the test and treat era. Methods: We conducted a cross-sectional survey of 689 people newly diagnosed with HIV. Symptoms of psychological distress were measured using the Kessler-10 psychological distress assessment scale. Factors associated with psychological distress were captured using interviewer-administered questionnaires. Ordinal logistic regression analyses were employed to identify predictors of psychological distress. Results: The magnitude of psychological distress was 58.63% (95% CI = 55.2%-62.3%). The severity of the psychological distress of which, 17.42% had severe distress. Psychological distress was observed more among female patients (β = 0.47, AOR = 1.59, 95% CI = 1.12, 2.27), patients presented with opportunistic infections (β = 0.50, AOR = 1.65, 95% CI = 1.03, 2.66) and being non-working functional status (β = 0.99, AOR = 2.70, 95% CI = 1.64, 4.45). Moreover, patients who were malnourished (β = 0.46, AOR = 1.58, 95% CI = 1.09, 2.26), having good level of knowledge on HIV prevention (β = 0.59, 95% CI = 0.55, 0.39, 0.78), presented with sexually transmitted infection (β = 0.48, AOR = 1.61, 95% CI = 1.01, 2.58), history of alcohol use (β = 0.44, AOR = 1.55, 95% CI = 1.09, 2.21), perceived stigma (β = 0.08, AOR = 1.09 95% CI = 1.04, 1.15) and treated in health centers (β = 0.55, AOR = 1.74, 95% CI = 1.25, 2.41) had higher odds of psychological distress. Conclusion: The large majority of newly diagnosed HIV patients suffered from psychological distress. An increased vulnerability was observed among females, those with opportunistic and sexually transmitted infections, those having poor functional status and malnourished. Furthermore, HIV patients treated in health centers, those who had history of alcohol use and patients with high level of HIV related stigma are more negatively affected by the HIV diagnosis. Hence, all intervention strategies should target all the identified predictors.

scholarly journals Life"s simple 7 and the risk of stroke in Finnish men: a prospective cohort study

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
N Isiozor ◽  
SK Kunutsor ◽  
A Voutilainen ◽  
S Kurl ◽  
J Kauhanen ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischaemic Stroke ◽  
Lower Risk ◽  
Cardiovascular Health ◽  
Cox Regression ◽  
Smoking Status ◽  
Population Based ◽  
P Value ◽  
Cardiovascular Research ◽  
History Of

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): North Savo Regional Fund and Finnish Foundation for Cardiovascular Research Background Population-wide preventive measures constitute important approaches toward reducing stroke risk and its associated burden. We sought to examine the association between American Heart Association’s (AHA) Life’s Simple7 (LS7) score and the risk of stroke in men. Methods The study is based on the prospective population-based Kuopio Ischaemic Heart Disease cohort comprising men (42-60 years) without pre-existing history of stroke at baseline. LS7 was computed from AHA’s cardiovascular health metrics for 2520 men and includes data on diet, physical activity, body mass index, smoking status, blood pressures, total cholesterol and blood glucose. Participants were classified into three LS7 groups based on the number of ideal metrics: inadequate (0–2), average (3–4) and optimal (5–7). Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of LS7 scores for total and ischaemic stroke. Results During a median follow-up of 26years, 428 total and 362 ischaemic incident stroke events were recorded. The risk of both stroke outcomes decreased continuously with increasing LS7 scores across the range 2 to 6. Men with optimal LS7 had 48% (HR: 0.52; 95%CI: 0.32–0.86) lower risk of total stroke when compared with those with inadequate LS7. The association was similar for the risk of ischaemic stroke, with 50% (HR: 0.50; 95%CI: 0.29–0.87) lower risk among men with an optimal LS7 compared with those with inadequate LS7. Conclusion LS7 was strongly, inversely and linearly associated with risk of total and ischaemic strokes among a middle-aged male Caucasian population. Life’s Simple 7 and the risk of stroke Total Stroke Ischaemic Stroke LS7 score 0-2† (inadequate) 3-4 (average) 5-7 (optimal) 0-2† (inadequate) 3-4 (average) 5-7 (optimal) n/N 224/1109 187/1273 17/138 192/1109 156/1273 14/138 Model 1 HR (95%CI) 1 0.65 (0.53 - 0.79) 0.49 (0.30 - 0.81) 1 0.63 (0.51 - 0.78) 0.47 (0.27 - 0.82) p value* &lt;0.001 0.005 &lt;0.001 0.007 Model 2 HR (95%CI) 1 0,69 (0.56 - 0.84) 0.52 (0.32 - 0.86) 1 0.67 (0.54 - 0.84) 0.50 (0.29 - 0.87) p value* &lt;0.001 0.01 &lt;0.001 0.014 n/N, number of events/Total; HR, hazard ratio; CI, Confidence interval *p-values for the HRs &lt;0.05 are considered statistically significant †Reference category Model 1: adjusted for age, alcohol consumption and socioeconomic status Model 2: Model 1 plus history of coronary heart disease and history of type 2 diabetes mellitus

scholarly journals PREVALENCE AND RISK FACTORS OF DIABETES MELLITUS IN TUBERCULOSIS PATIENT AT PATRANG DISTRICT INDONESIA

2019 ◽  
Vol 7 (4) ◽  
pp. 79
Author(s):  
Hasri Yulia Sasmita ◽  
Irma Prasetyowati ◽  
Pudjo Wahjudi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Family History ◽  
Central Obesity ◽  
Smoking Status ◽  
Sampling Technique ◽  
Tuberculosis Patient ◽  
P Value ◽  
Cross Sectional ◽  
History Of

Tuberculosis (TB) is one of cause of death in infectious disease domain. The control of TB is complicated because the inclination of case numbers people with Diabetes Mellitus. Diabetes Mellitus (DM) is an important risk factor for TB development, with prove that more than ten percent of TB patient is DM patient. People with DM have risk three times more likely to suffer from TB than people without DM. The results of TB treatment with comorbid DM will be easier to be failed. Puskesmas Patrang have the highest bacteriologically confirmed BTA TB cases and DM cases in Jember during 2014 until 2016. The aim of this research is to know the DM prevalence in TB patients and to analyze the correlation between DM risk factors in TB patient to TB-DM incidence at Puskesmas Patrang Jember in 2017. The research uses observasional analytic with cross sectional approach. The sampling technique uses simple random sampling with 47 samples. The independent variables include respondent characteristics (age, sex, type of TB, medication category, and family history of DM), central obesity and smoking behavior. While the dependent variable is the DM status. The result shows that the prevelance of DM in TB patients at Puskesmas Patrang Jember regency is 23,4%. Factors associated with TB-DM are age (p-value = 0,012), family history of DM (p-value = 0,003), and smoking status (p-value = 0,035). Factors that do not associated with TB-DM are sex (p-value = 0,731), type of TB (p-value = 0,170), treatment category of TB (p-value = 0,560), central obesity (p-value = 0,435), the number of cigarette (p-value = 1,000) and smoking duration (p-value = 1,000). The most important factor of TB-DM is family history of DM that 10,850 times higher of getting TB-DM than patients without family history of DM.

scholarly journals HUBUNGAN STATUS GIZI DAN RIWAYAT PENYAKIT IBU DENGAN KEJADIAN BERAT BADAN LAHIR RENDAH DI RUMAH SAKIT MUHAMMADIYAH PALEMBANG TAHUN 2016

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Wulan Citra Sari Wulan Citra Sari
Keyword(s):  
Nutritional Status ◽  
Significant Relationship ◽  
Quantitative Research ◽  
Univariate Analysis ◽  
World Health ◽  
Bivariate Analysis ◽  
P Value ◽  
History Of Disease ◽  
History Of ◽  
Health Organization

ABSTRAK   Data World Health Organizationmenurut WHO (2010) diperkirakan 15% diseluruh kelahiran didunia dengan batasan 3,3%-3,8% dan lebih sering terjadi di negara berkembang atau ekonomi rendah.Tujuan Penelitian Diketahuinya hubungan status gizi dan riwayat penyakit ibu dengan kejadian BBLR di RumahSakit Muhammadiyah Palembang Tahun 2016. Populasi dalam penelitian ini adalah semua ibu bersalin 1881responden.Sampel pada penelitian ini adalah sebagian ibu bersalin 236 responden. Penelitian ini menggunakan desain penelitian kuantitatif dengan pendekatan Case Contro. di Rumah Sakit Muhammadiyah Palembang Tahun 2016. Analisa univariat Hasi penelitian ini yang BBLR pada kelompok kasus118  sedangkan yang tidak BBLR 118, dengan nilai OR 1:1 berdasarkan analisa bivariat didapat tidak ada hubungan yang bermakna antara status gizi dengan kejadian (p value=1,00) dan mengalami riwayat penyakit 117 dan tidak mengalami riwayat penyakit 119 menunjukan tidak ada hubungan yang bermakna antara riwayat penyakit dengan kejadian BBLR (p value=0,60). Hasil penelitian ini diharapkan dapat menjadi bahan masukan bagi rumah saki tmuhmmadiyah untuk lebih meningkatkan mutu dan upaya pelayanan di rumah sakit.       ABSTRACT   World Health Organization data according to WHO (2010) is estimated 15% in all births in the world with a limit of 3.3% -3.8% and is more common in developing countries or low economies. Research Objectives Knowing the relationship of nutritional status and history of maternal disease with LBW occurrence in Hospital Muhammadiyah Palembang 2016. Population in this research is all maternal mother 1881responden.Sampel in this research is partially mother of 236 respondents. This research uses quantitative research design with Case Contro approach. at the hospital  MuhammadiyahPalembang in 2016. Univariate analysis The result of this study is BBLR in the case group118, while those who are not BBLR 118, with OR 1: 1 score based on bivariate analysis, there is no significant relationship between nutritional status and occurrence (p value = 1, 00) and a history of disease 117 and no history of disease 119 showed no significant relationship between history of disease with the incidence of BBLR (p value = 0.60). The results of this study are expected to be input for Hospital muhammadiyah palembang  to further improve the quality and service efforts in hospitals.  

scholarly journals FACTORS THAT ARE RELATED TO THE EVENENCE OF THE PREMATURE RUPTURE OF MEMBRANES IN MATERNITY MOTHER IN SAYANG HOSPITAL, CIANJUR CITY

2019 ◽  
Vol 2 (2) ◽  
pp. 37-39
Author(s):  
Rahmawati .
Keyword(s):  
Health Workers ◽  
Statistical Test ◽  
World Health ◽  
P Value ◽  
Test Results ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
History Of ◽  
Health Organization ◽  
The Relationship

Premature rupture of membranes is rupture of membranes before there are signs of labor and after waiting for an hour before the start of labor. World Health Organization (WHO) in 2015 there were 303,000 women died during childbirth and as many as 20% caused by premature rupture of membranes. The incidence of maternity with premature rupture of membranes in Sayang Hospital Cianjur in 2016 was 1151 maternity with premature rupture of membranes from 6814 births while in 2017 there were 1272 births with premature rupture of 5887 births. This study aims to determine the relationship between premature rupture of membranes with age, parity, education, and history of premature rupture of membranes. Statistical test results obtained that there is a relationship between premature rupture of membranes with age with a P value = 0.008 OR value of 0.556. Statistical test results obtained that there is a relationship between premature rupture of membranes with parity with a P value = 0,000 OR value of 3.336. Statistical test results obtained that there is a relationship between premature rupture of membranes with education with a P value = 0.001 OR value of 2.431. Statistical test results obtained that there is no relationship between premature rupture of membranes with a history of premature rupture of membranes with a P value = 0.949 OR value of 2.431. It is recommended for health workers to increase their preventive efforts so that pregnant women get clear information about premature rupture of membranes and anticipate problems that can arise in labor

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