PSVI-14 Characteristic of hybrid chicken derived from crossing of Ogye and white leghorn

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 231-231
Author(s):  
Hee-Jong Roh ◽  
Kim Jae-Hwan ◽  
Seung-Chang Kim ◽  
Daehyeok Jin ◽  
Ji-Hye Cha ◽  
...  
Keyword(s):  
Body Weight ◽  
P Value ◽  
White Leghorn ◽  
Internal Organs ◽  
Chicken Breed ◽  
Black Spots ◽  
Paternal Factors ◽  
Genetic Patterns ◽  
Body Weights

Abstract Ogye, an indigenous Korean chicken breed has entirely black external features and internal organs. White Leghron, an transboundary breed has white color features as opposed to Ogye. We make crossbreed (Ogye x White Leghorn) to investigate how the phenotype appeared in F1. In F0, 5 females and 1 male were selected for each parental type; 1) Ogye(♂) x White leghorn(♀), 2) White leghron(♂) x Ogye(♀). We A total of 321 individuals of F1 were made through artificial insemination. We measured body weights at birth, 8 weeks, 16 weeks, 24 weeks, and 32 weeks of age. In 1) type females, the average of body weight at each period was 39.04±0.32, 613.18±6.86, 1149.37±7.76, 1463.97±13.25, 1718.02±14.83 respectively. In 2 type females, that was 30.57±0.21, 543.19±7.54, 1069.63±12.92, 1410.06±10.80, 1527.53±13.73. The P-value values for each period were less than 0.05. In 1) type males, the average of body weight at each period was 39.18±0.34, 744.70±7.84, 1579.39±15.76, 2014.63±19.15, 2310.89±20.58. In 2 type females, that was 30.71±0.24, 683.75±9.51, 1419.79±15.76, 1800.00±18.88, 2064.79±19.68. The P-value values for each period were also less than 0.05. In the case of feather color, it was generally white, but black spots appeared only in females produced in type 1). Comb and beak color was generally also red, but black appeared only in in females produced in type 1). From these results, it can be estimated that paternal factors such as weight and appearance are greatly affected, and we plan to investigate the genetic patterns of each trait through F2 construction in the future.

Upgrading the indigenous poultry of Uganda IV. Egg production

1963 ◽  
Vol 60 (2) ◽  
pp. 225-227
Author(s):  
J. C. M. Trail
Keyword(s):  
Body Weight ◽  
Production Rate ◽  
Rhode Island ◽  
Food Consumption ◽  
Egg Production ◽  
White Leghorn ◽  
Egg Weight ◽  
Body Weights ◽  
The Cross ◽  
Egg Production Rate

Data on egg production, egg weight, food consumption, broodiness, mortality and body weights of the progeny of indigenous poultry of Uganda crossed with Light Sussex, White Leghorn, Rhode Island Red and Black Australorp breeds were collected collected over the 25-week period from 161 to 336 days of age and compared with the performances of indigenous poultry.In comparison with the indigenous birds, the cross-breeds had a 61% higher mean egg production rate, a 34% lower food consumption per pound of eggs produced, a 15% higher egg weight, a 30% reduction in mortality, a 23% increase in body weight and a decrease in broodiness.All the cross-breeds were superior in productive respects to the indigenous birds and the White Leghorn and Light Sussex breeds appeared to be the best for use in the upgrading of indigenous stock for highest egg production results.

scholarly journals Does curcumin or metformin attenuate oxidative stress and diabetic nephropathy in rats?

2018 ◽  
Vol 8 (1) ◽  
pp. 8-8 ◽  
Author(s):  
Soheila Asadi ◽  
Mohammad Taghi Goodarzi ◽  
Jamshid Karimi ◽  
Mohammad Hashemnia ◽  
Iraj Khodadadi
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Diabetic Nephropathy ◽  
Oxidative Status ◽  
P Value ◽  
Chow Diet ◽  
Therapeutic Effects ◽  
Urinary Creatinine ◽  
Antioxidant Agents

Background: Since the importance of oxidative stress in the development of diabetic nephropathy (DN) has previously been established, the therapeutic effects of various natural antioxidant agents or synthetic drugs have so far been investigated. Objectives: The aim of this study was to investigate the beneficial effects of curcumin (a natural polyphenol) and metformin (a common therapeutic medicine for type 2 diabetes) on oxidative status in kidney of type 1 diabetic rats. Materials and Methods: In this experimental study 60 male Wistar rats were divided into 10 groups. Type 1 diabetes was induced by streptozotocin. Rats received chow diet and treated with either normal saline in control (N) and diabetic control (D) groups or different doses of metformin (Met) (300 or 500 mg/kg body weight) or curcumin (Cur) (50 or 150 mg/kg body weight) in N+Met300, N+Met500, N+Cur50, N+Cur150, D+Met300, D+Met500, D+Cur50, and D+Cur150 groups. Urinary creatinine, urea, and protein were measured. Total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase were assessed in kidney tissues. Results: Both metformin and curcumin showed significant effects on urinary creatinine, urea, and protein levels (P value for all was <0.001). Unlike metformin, curcumin completely restored TAC and TOS (P<0.001), and MDA (P=0.012) in kidney tissues and significantly recovered the activities of SOD (P= 0.003), GPx (P< 0.001), and catalase (P=0.011). Conclusions: Curcumin was found more effective than metformin in attenuating oxidative status in DN.

scholarly journals Effects of thyroidectomy, T4, and DITPA replacement on brain blood vessel density in adult rats

2008 ◽  
Vol 294 (5) ◽  
pp. R1504-R1509 ◽  
Author(s):  
Evelyn Heymann Schlenker ◽  
Megan Hora ◽  
Yingheng Liu ◽  
Rebecca A. Redetzke ◽  
Eugene Morkin ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Vessel ◽  
Cardiac Function ◽  
Blood Vessels ◽  
Treated Group ◽  
P Value ◽  
Adult Rats ◽  
Adult Rat ◽  
Body Weights ◽  
And Function

In hypothyroid patients, altered microvascular structure and function may affect mood and cognitive function. We hypothesized that adult male hypothyroid rats will have significantly lower forebrain blood vessel densities (BVD) than euthyroid rats and that treatment with 3,5-diiothyroprionic acid (DITPA) (a thyroid hormone analog) or thyroxine (T4) will normalize BVDs. The euthyroid group received no thyroidectomy or treatment. The other three groups received thyroidectomies and pellets. The hypothyroid group received a placebo pellet, the DITPA group received an 80-mg DITPA-containing pellet, and the T4 group received a 5.2-mg T4 slow-release pellet for 6 wk. Body weights, cardiac function, and body temperatures were measured. A monoclonal antiplatelet endothelial cell adhesion antibody was used to visualize blood vessels. The euthyroid group averaged body weights of 548 ± 54 g, while the hypothyroid group averaged a body weight of 332 ± 19 g ( P value < 0.001). Relative to the euthyroid group, the DITPA-treated group was significantly lighter ( P value < 0.05), while the T4-treated group was comparable in body weight to the euthyroid group. The same trends were seen with body temperature and cardiac function with the largest difference between the euthyroid and hypothyroid groups. BVD in the euthyroid group was 147 ± 12 blood vessels/mm2 and in hypothyroid group 69 ± 5 blood vessels/mm2 ( P = 0.013) but similar among the euthyroid, DITPA, and T4 groups. These results show that hypothyroidism decreased BVD in adult rat forebrain regions. Moreover, DITPA and T4 were efficacious in preventing effects of hypothyroidism on cardiac function and BVD.

scholarly journals Growth and development of young game pheasants (<i>Phasianus colchicus</i>)

2011 ◽  
Vol 54 (1) ◽  
pp. 83-92 ◽  
Author(s):  
D. Kokoszyński ◽  
Z. Bernacki ◽  
A. Cisowska
Keyword(s):  
Body Weight ◽  
Small Intestine ◽  
Digestive Tract ◽  
Growth And Development ◽  
Lower Proportion ◽  
Phasianus Colchicus ◽  
Internal Organs ◽  
Commercial Feed ◽  
Body Weights ◽  
Ad Libitum

Abstract. Fifty game pheasants were kept to 8 weeks in confinement housing and later maintained outdoors in a partially roofed aviary. Pheasants received commercial feed mixtures ad libitum. Body weight and dimensions were determined every 4 weeks. Ten pheasants were selected for slaughter at the end of 18 and 20 weeks each. After slaughter, their heads, shanks, feathers, blood, inedible viscera and major internal organs were weighed and digestive tract separated and measured. The carcasses were dissected. Higher body weights and daily gains were found in males than in females on all test days during rearing to 20 weeks of age. Compared to females, males had significantly longer keel from 4 weeks, longer lower thighs and shanks from 8 weeks, and longer trunk with and without neck and greater chest circumference from 12 weeks of age. Older pheasants had a significantly lower proportion of feathers and blood, and higher content of inedible viscera, with significantly relatively shorter (cm 100 g b.w.−1) small intestine, caecum and rectum in males than in females. With advancing age, there was a decrease in the proportion of gizzard (significant) and liver, and in males a significant increase in the proportion of testicles.

L-Ascorbic Acid Addition to Chitosan Reduces Body Weight in Overweight Women

2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Fat Body ◽  
Body Weight Gain ◽  
Skinfold Thickness ◽  
The Body ◽  
Control Group ◽  
Percentage Body Fat ◽  
Overweight Women ◽  
Body Weights

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and Peptide YY

2020 ◽  
Vol 20 (8) ◽  
pp. 1262-1267
Author(s):  
Haojun Yang ◽  
Hanyang Liu ◽  
YuWen Jiao ◽  
Jun Qian
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Metabolic Diseases ◽  
Peptide Yy ◽  
The Body ◽  
Wild Type ◽  
L Cells ◽  
Body Weights ◽  
Gastrointestinal Bypass ◽  
G Protein Coupled

Background: G protein-coupled bile acid receptor (TGR5) is involved in a number of metabolic diseases. The aim of this study was to identify the role of TGR5 after Roux-en-Y gastric bypass (GBP). Methods: Wild type and TGR5 knockout mice (tgr5-/-) were fed a high-fat diet (HFD) to establish the obesity model. GBP was performed. The changes in body weight and food intake were measured. The levels of TGR5 and peptide YY (PYY) were evaluated by RT-PCR, Western blot, and ELISA. Moreover, the L-cells were separated from wild type and tgr5-/- mice. The levels of PYY in L-cells were evaluated by ELISA. Results: The body weights were significantly decreased after GBP in wild type mice (p<0.05), but not tgr5-/- mice (p>0.05). Food intake was reduced after GBP in wild type mice, but also not significantly affected in tgr5-/- mice (p>0.05). The levels of PYY were significantly increased after GBP compared with the sham group (p<0.05); however, in tgr5-/- mice the expression of PYY was not significantly affected (p>0.05). After INT-777 stimulation in L-cells obtained from murine intestines, the levels of PYY were significantly increased in L-cells tgr5+/+ (p<0.05). Conclusion: Our study suggests that GBP up-regulated the expression of TGR5 in murine intestines, and increased the levels of PYY, which further reduced food intake and decreased the body weight.

scholarly journals Genomic prediction for growth using a low-density SNP panel in dromedary camels

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Morteza Bitaraf Sani ◽  
Javad Zare Harofte ◽  
Mohammad Hossein Banabazi ◽  
Saeid Esmaeilkhanian ◽  
Ali Shafei Naderi ◽  
...  
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Sample Size ◽  
Genetic Improvement ◽  
Growth Traits ◽  
P Value ◽  
Dromedary Camels ◽  
Genome Wide ◽  
A Genome ◽  
Daily Gain

AbstractFor thousands of years, camels have produced meat, milk, and fiber in harsh desert conditions. For a sustainable development to provide protein resources from desert areas, it is necessary to pay attention to genetic improvement in camel breeding. By using genotyping-by-sequencing (GBS) method we produced over 14,500 genome wide markers to conduct a genome- wide association study (GWAS) for investigating the birth weight, daily gain, and body weight of 96 dromedaries in the Iranian central desert. A total of 99 SNPs were associated with birth weight, daily gain, and body weight (p-value < 0.002). Genomic breeding values (GEBVs) were estimated with the BGLR package using (i) all 14,522 SNPs and (ii) the 99 SNPs by GWAS. Twenty-eight SNPs were associated with birth weight, daily gain, and body weight (p-value < 0.001). Annotation of the genomic region (s) within ± 100 kb of the associated SNPs facilitated prediction of 36 candidate genes. The accuracy of GEBVs was more than 0.65 based on all 14,522 SNPs, but the regression coefficients for birth weight, daily gain, and body weight were 0.39, 0.20, and 0.23, respectively. Because of low sample size, the GEBVs were predicted using the associated SNPs from GWAS. The accuracy of GEBVs based on the 99 associated SNPs was 0.62, 0.82, and 0.57 for birth weight, daily gain, and body weight. This report is the first GWAS using GBS on dromedary camels and identifies markers associated with growth traits that could help to plan breeding program to genetic improvement. Further researches using larger sample size and collaboration of the camel farmers and more profound understanding will permit verification of the associated SNPs identified in this project. The preliminary results of study show that genomic selection could be the appropriate way to genetic improvement of body weight in dromedary camels, which is challenging due to a long generation interval, seasonal reproduction, and lack of records and pedigrees.

scholarly journals Efficacy of laparoscopic sleeve gastrectomy for patient with morbid obesity and type 1 diabetes mellitus: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hidetaka Ichikawa ◽  
Hirofumi Imoto ◽  
Naoki Tanaka ◽  
Hiroaki Musha ◽  
Shojiro Sawada ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Body Weight ◽  
Sleeve Gastrectomy ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Hba1c Level ◽  
Insulin Dose ◽  
Body Weight Loss

Abstract Background Bariatric surgery is effective for the treatment of patients with morbid obesity and type 2 diabetes mellitus (T2DM), for body weight loss and glycemic control. However, in Japan, there has been no previous report of the effectiveness bariatric surgery in a case of morbid obesity associated with acute onset type 1 diabetes mellitus (T1DM), in which pancreatic β-cells were destroyed and endogenous insulin was depleted. Case presentation A 36-year-old woman with morbid obesity and T1DM, diagnosed when she was 6 years, was admitted for bariatric surgery. At her first consultation, she had a body weight of 106.7 kg and a body mass index of 42.2 kg/m2. Her HbA1c level was 9.0%, with a required daily insulin dose of 75 units. She underwent laparoscopic sleeve gastrectomy. At 1 year after surgery, her body weight had decreased to 81.0 kg and her body mass index to 32.2 kg/m2. In addition, her daily required dose of insulin had decreased to 24 units, with an improvement in her HbA1c level to 7.7%. Conclusions Although further evidence needs to be accumulated, including long-term outcomes, laparoscopic sleeve gastrectomy may provide an effective treatment for patients with morbid obesity and T1DM for body weight loss, improvement in HbA1c level, and insulin dose reduction.

scholarly journals A deep-learning method using computed tomography scout images for estimating patient body weight

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shota Ichikawa ◽  
Misaki Hamada ◽  
Hiroyuki Sugimori
Keyword(s):  
Computed Tomography ◽  
Body Weight ◽  
Deep Learning ◽  
Contrast Medium ◽  
Model Performance ◽  
Ct Scanning ◽  
Drug Dosing ◽  
Body Weights ◽  
Dose Management ◽  
Medium Dose

AbstractBody weight is an indispensable parameter for determination of contrast medium dose, appropriate drug dosing, or management of radiation dose. However, we cannot always determine the accurate patient body weight at the time of computed tomography (CT) scanning, especially in emergency care. Time-efficient methods to estimate body weight with high accuracy before diagnostic CT scans currently do not exist. In this study, on the basis of 1831 chest and 519 abdominal CT scout images with the corresponding body weights, we developed and evaluated deep-learning models capable of automatically predicting body weight from CT scout images. In the model performance assessment, there were strong correlations between the actual and predicted body weights in both chest (ρ = 0.947, p < 0.001) and abdominal datasets (ρ = 0.869, p < 0.001). The mean absolute errors were 2.75 kg and 4.77 kg for the chest and abdominal datasets, respectively. Our proposed method with deep learning is useful for estimating body weights from CT scout images with clinically acceptable accuracy and potentially could be useful for determining the contrast medium dose and CT dose management in adult patients with unknown body weight.

scholarly journals CTNI-15. CLINICAL EFFICACY OF ONC201 IN NEWLY DIAGNOSED DIPG AND IN PREVIOUSLY IRRADIATED PEDIATRIC H3 K27M-MUTANT GLIOMAS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii45-ii45
Author(s):  
Sharon Gardner ◽  
Carl Koschmann ◽  
Rohinton S Tarapore ◽  
Jeffrey Allen ◽  
Wafik Zaky ◽  
...  
Keyword(s):  
Body Weight ◽  
Single Agent ◽  
Biologically Active ◽  
Pharmacokinetic Analysis ◽  
Low Grade ◽  
Newly Diagnosed ◽  
Liquid Formulation ◽  
Phase Ii Trials ◽  
Body Weights ◽  
Post Radiation

Abstract ONC201, an anti-cancer DRD2 antagonist and ClpP agonist, is in Phase II trials for adult H3 K27M-mutant diffuse midline gliomas. In adults, the recommended phase 2 dose (RP2D) of 625mg ONC201 once a week has been established as a biologically active dose that is well tolerated. Radiographic regressions with single agent ONC201 have been reported in adult recurrent H3 K27M-mutant glioma patients. This multi-arm, dose-escalation and dose-expansion trial determined the pediatric RP2D of ONC201 administered as an oral capsule (Arm A) or liquid formulation (Arm E) in post-radiation H3 K27M-mutant glioma (Arm A) or in newly diagnosed DIPG (Arm B) patients. Molecular assessments include intratumoral ONC201 concentrations (Arm C) and CSF H3 K27M DNA levels (Arm D). Enrollment as of April 30, 2020 is complete in Arm A (22) and Arm E (26) and continues in Arm B (18/24), Arm C (5/12), and Arm D (22/24). The RP2D of weekly 625mg ONC201 scaled by body weight was confirmed when administered as a capsule or a liquid formulation as a single agent or in combination with radiation without dose-limiting toxicity. The most frequent adverse events regardless of attribution to the drug were predominantly low grade: ONC201 capsule alone was headache (54.5%), nausea (36.4%), and fatigue (36.4%); ONC201 liquid formulation was vomiting (31.8%), headache (22.7%), VIth nerve disorder (22.7%); ONC201 capsules in combination with radiation (Arm B) was headache (47.1%), vomiting (52.9%), nausea (41.2%). Pharmacokinetic analysis in plasma of Arm A patients revealed T1/2: 8.4h; Tmax: 2.1h; Cmax: 2.3ug/mL; AUC0-tlast: 16.4ug/mL, with similar exposure across body weights. In conclusion, when scaled by body weight the ONC201 capsule or liquid formulation alone or in combination with radiation were associated with safety and pharmacokinetic profiles in pediatric H3 K27M-mutant diffuse midline glioma patients that are similar to the experience in adults.

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