scholarly journals Estimation of genetic parameters for superovulatory response traits in Japanese Black cows

2021 ◽  
Author(s):  
A Zoda ◽  
M Urakawa ◽  
Y Oono ◽  
S Ogawa ◽  
M Satoh
Keyword(s):  
Genetic Improvement ◽  
Genetic Parameters ◽  
Genetic Correlations ◽  
Rank Correlation ◽  
Japanese Black Cattle ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Estimation Of Genetic Parameters ◽  
Response Traits ◽  
Donor Cows

Abstract The aim of this study was to estimate genetic parameters for superovulatory response traits in order to explore the possibility of genetic improvement in Japanese Black cows. 19 155 records of the total number of embryos and oocytes (TNE) and the number of good embryos (NGE) collected from 1532 donor cows between 2008 and 2018 were analyzed. A two-trait repeatability animal model analysis was performed for both. Because records of TNE and NGE did not follow a normal distribution, the records were analyzed following no, logarithmic, or Anscombe transformation. Without transformation, the heritability estimates were 0.26 for TNE and 0.17 for NGE. With logarithmic transformation, they were 0.22 for TNE and 0.18 for NGE. With Anscombe transformation, they were 0.26 for TNE and 0.18 for NGE. All analyses gave similar genetic correlations between TNE and NGE, ranging from 0.60 to 0.71. Spearman’s rank correlation coefficient between breeding values of cows with more than 10 records was ≥0.95 with both transformations. Thus, the genetic improvement of TNE and NGE of donor cows could be possible in Japanese Black cattle.

scholarly journals Deregulation of lncRNA HIST1H2AG-6 and AIM1-3 in peripheral blood mononuclear cells is associated with newly diagnosed type 2 diabetes

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Hui Jiang ◽  
Peian Lou ◽  
Xiaoluo Chen ◽  
Chenguang Wu ◽  
Shihe Shao
Keyword(s):  
Roc Curve ◽  
Multivariate Logistic Regression Analysis ◽  
Rank Correlation ◽  
Differentially Expressed ◽  
Healthy Controls ◽  
Biological Functions ◽  
Multivariate Logistic Regression ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient

Abstract Background Type 2 diabetes mellitus (T2DM) is mainly affected by genetic and environmental factors; however, the correlation of long noncoding RNAs (lncRNAs) with T2DM remains largely unknown. Methods Microarray analysis was performed to identify the differentially expressed lncRNAs and messenger RNAs (mRNAs) in patients with T2DM and healthy controls, and the expression of two candidate lncRNAs (lnc-HIST1H2AG-6 and lnc-AIM1-3) were further validated using quantitative real-time polymerase chain reaction (qRT-PCR). Spearman’s rank correlation coefficient was used to measure the degree of association between the two candidate lncRNAs and differentially expressed mRNAs. Furthermore, the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway and GO (Gene Ontology) enrichment analysis were used to reveal the biological functions of the two candidate lncRNAs. Additionally, multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were performed. Results The microarray analysis revealed that there were 55 lncRNAs and 36 mRNAs differentially expressed in patients with T2DM compared with healthy controls. Notably, lnc-HIST1H2AG-6 was significantly upregulated and lnc-AIM1-3 was significantly downregulated in patients with T2DM, which was validated in a large-scale qRT-PCR examination (90 controls and 100 patients with T2DM). Spearman’s rank correlation coefficient revealed that both lncRNAs were correlated with 36 differentially expressed mRNAs. Furthermore, functional enrichment (KEGG and GO) analysis demonstrated that the two lncRNA-related mRNAs might be involved in multiple biological functions, including cell programmed death, negative regulation of insulin receptor signal, and starch and sucrose metabolism. Multivariate logistic regression analysis revealed that lnc-HIST1H2AG-6 and lnc-AIM1-3 were significantly correlated with T2DM (OR = 5.791 and 0.071, respectively, both P = 0.000). Furthermore, the ROC curve showed that the expression of lnc-HIST1H2AG-6 and lnc-AIM1-3 might be used to differentiate patients with T2DM from healthy controls (area under the ROC curve = 0.664 and 0.769, respectively). Conclusion The profiles of lncRNA and mRNA were significantly changed in patients with T2DM. The expression levels of lnc-HIST1H2AG-6 and lnc-AIM1-3 genes were significantly correlated with some features of T2DM, which may be used to distinguish patients with T2DM from healthy controls and may serve as potential novel biomarkers for diagnosis in the future.

scholarly journals Association between Endoscopic Milk-White Mucosa, Epithelial Intracellular Lipid Droplets, and Histological Grade of Superficial Non-Ampullary Duodenal Epithelial Tumors

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 769
Author(s):  
Yuko Hara ◽  
Kenichi Goda ◽  
Shinichi Hirooka ◽  
Takehiro Mitsuishi ◽  
Masahiro Ikegami ◽  
...  
Keyword(s):  
Lipid Droplets ◽  
Histological Grade ◽  
Rank Correlation ◽  
Intraepithelial Neoplasia ◽  
Low Grade ◽  
Intracellular Lipid ◽  
En Bloc ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Positive Rate

We previously reported that superficial non-ampullary duodenal tumors (SNADETs) commonly had a whitish mucosal surface, named milk-white mucosa (MWM). The aim of this study was to evaluate the association of MWM with epithelial intracellular lipid droplets (immunohistochemically stained by adipose differentiation-related protein (ADRP)) and histological tumor grades. We reviewed endoscopic images and the histopathology of SNADETs resected en bloc endoscopically. We analyzed the correlation between the positive rates of endoscopic MWM in preoperative endoscopy and resected specimens, and ADRP-positive rates in the resected specimens. Associations between the MWM-positive rates and tumor grades, high-grade intraepithelial neoplasia (HGIN)/intramucosal carcinoma (IC), and low-grade intraepithelial neoplasia (LGIN) were analyzed. All the 92 SNADETs analyzed were <20 mm and histologically classified into 39 HGIN/IC and 53 LGIN. Spearman’s rank correlation coefficient showed a significant correlation between MWM-positive and ADRP-positive rates (p < 0.001). MWM-positive rates were significantly lower in the HGIN/IC than in the LGIN in preoperative endoscopy (p < 0.001) and resected specimens (p = 0.02). Our results suggest that endoscopic MWM is closely associated with epithelial intracellular lipid droplets and that the MWM-positive rate may be a predictor of histological grade in small SNADETs.

scholarly journals Correlation between nasopharyngoscopy and cephalometry in the diagnosis of hyperplasia of the pharyngeal tonsils

2012 ◽  
Vol 16 (02) ◽  
pp. 209-216 ◽  
Author(s):  
Luana Berwig ◽  
Ana da Silva ◽  
Eliane Corrêa ◽  
Eliane Serpa ◽  
Rodrigo Ritzel
Keyword(s):  
Quantitative Study ◽  
Fiber Optic ◽  
Rank Correlation ◽  
Accurate Diagnosis ◽  
Cross Sectional ◽  
Significance Level ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Tonsil Hyperplasia ◽  
Pharyngeal Tonsil

Summary Introduction: Hyperplasia of the pharyngeal tonsil is one of the main causes of mouth breathing, and accurate diagnosis of this alteration is important for proper therapeutic planning. Therefore, studies have been conducted in order to provide information regarding the procedures that can be used for the diagnosis of pharyngeal obstruction. Objective: To verify the correlation between nasopharyngoscopy and cephalometric examinations in the diagnosis of pharyngeal tonsil hyperplasia. Method: This was a cross-sectional, clinical, experimental, and quantitative study. Fifty-five children took part in this study, 30 girls and 25 boys, aged between 7 and 11 years. The children underwent nasofibropharyngoscopic and cephalometric evaluation to determine the grade of nasopharyngeal obstruction. The Spearman's rank correlation coefficient at the 5% significance level was used to verify the correlation between these exams. Results: In the nasopharyngoscopy evaluation, most children showed grade 2 and 3 hyperplasia of the pharyngeal tonsil, which was followed by grade 1. In the cephalometry assessment, most children showed grade 1 hyperplasia of the pharyngeal tonsil, which was followed by grade 2. A statistically significant regular positive correlation was observed between the exams. Conclusion: It was concluded that the evaluation of the pharyngeal tonsil hyperplasia could be carried out by fiber optic nasopharyngoscopy and cephalometry, as these examinations were regularly correlated. However, it was found that cephalometry tended to underestimate the size of the pharyngeal tonsil relative to nasopharyngoscopy.

Dentists’ knowledge of fluoride cariostatic mechanisms

2018 ◽  
Vol 23 (3) ◽  
Author(s):  
Urszula Kaczmarek ◽  
Wojciech Kowalczyk ◽  
Dariusz Gozdowski ◽  
Dorota Olczak-Kowalczyk
Keyword(s):  
Rank Correlation ◽  
Bone Fragility ◽  
Caries Prevention ◽  
Water Fluoridation ◽  
Chi Square ◽  
Significance Level ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Chi Square Test ◽  
Almost All

Introduction. The use of age- and risk-adjusted caries prevention requires up-to-date knowledge on the cariostatic effects of fluoride, as well as the methods and safety of fluoride prophylaxis. Aim. The aim of the study was to assess dentists’ knowledge of the safety and mechanism of anticaries effects of fluoride. Material and methods. An anonymous questionnaire was conducted among 212 dentists participating in dental training. The questions included in the questionnaire related to knowledge about water fluoridation, fluoride cariostatic mechanisms and the safety of fluoride prophylaxis. The chi-square test and the Spearman’s rank correlation coefficient were used for statistical analysis. A significance level of 0.05 was used. Results. Incorrect knowledge about water fluoridation was demonstrated by 26.9% of respondents in the country and 16.0% of respondents in Europe. Most respondents (80.7%) reported higher efficacy of exogenous vs endogenous anticaries approaches, and more than half of respondents (59.0%) considered the processes of remineralisation and demineralisation as the most important anticaries activity. Almost all respondents (95.7%) agreed that the use of fluoride for caries prevention is controversial, mainly due to its dose-dependent therapeutic or toxic effects (85.4%). According to about 20% of respondents, cariostatic fluoride doses have adverse effects on the general health, mainly in the form of bone fragility (10.4%). Conclusions. Lack of correct knowledge about the dominant cariostatic effects of fluoride may result in the choice of an inappropriate preventive method or avoiding local application of fluoride preparations for fear of adverse systemic effects, which may in turn lead to increased caries prevalence in a given population.

scholarly journals Evaluation Method for Green Ecological Airports in China Based on Combination Weighting

2018 ◽  
Vol 30 (4) ◽  
pp. 419-428
Author(s):  
Danwen Bao ◽  
Xiaoling Zhang ◽  
Jiayu Gu
Keyword(s):  
Evaluation Method ◽  
Rank Correlation ◽  
Resource Conservation ◽  
Evaluation Index System ◽  
Weighting Method ◽  
Environmental Friendliness ◽  
International Airport ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
The Status

To scientifically and accurately evaluate the status of the development of green airports in China, evaluation methods of green, ecological airports are established in this paper. To address the shortcomings in subjective and objective weighting methods, we propose a combination weighting method based on Spearman’s rank correlation coefficient and evaluation grades based on interval approximation. At the same time, by taking into account resource conservation, environmental friendliness, operation efficiency, and people-oriented service, we propose an evaluation index system and an interval number for each index. Lastly, the theory is applied to five large airports in different regions of China. Analysis of the evaluation results shows that Shanghai Pudong International Airport (PVG) and Guangzhou Baiyun International Airport (CAN) have the highest scores for the resource conservation and environmental friendliness indexes, thus indicating that the development of a green ecological airport is closely related to its passenger transportation scale and economic strength. All considered airports showed the need for upgrading public  service facilities and constructing intelligent equipment. The method proposed in this paper is reasonable  and reliable; therefore, it can provide guidance for the evaluation and construction of green, ecological  airports.

scholarly journals The relationship between the effectiveness of performing technical elements and indicators of static and dynamic balance in young acrobats 6-7 years old

2021 ◽  
Vol 7 (4) ◽  
pp. 58-68
Author(s):  
T. Chernykh ◽  
V. Mulyk ◽  
K. Mulyk ◽  
А. Skaliy ◽  
А. Ostrowski ◽  
...  
Keyword(s):  
Correlation Coefficient ◽  
Dynamic Equilibrium ◽  
Dynamic Balance ◽  
Rank Correlation ◽  
Young Athletes ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Initial Stage ◽  
Equilibrium Test ◽  
The Relationship

Purpose: to determine the relationship between the performance of basic elements and indicators of static and dynamic balance in the training process of young acrobats 6-7 years. Material and methods. The study involved 16 young acrobats at the stage of initial training (age 6-7 years). All parents of the participants gave written consent for the participation of children in the study. The study involved testing the technique of performing basic elements of sports acrobatics and assessing the static and dynamic balance of young athletes. The relationship between (swallow, shoulder blade, forward squat, wheel (sideways overturning), bridges) and static and dynamic equilibrium tests was determined. Spearman's rank correlation coefficient method was used as a method of statistical analysis. Results. It is established that the largest relationship between the performance of basic elements and static balance in the basic exercises of young acrobats have: Romberg's test with the elements "Swallow", "Stand on the shoulders", "Bridge"; Biryuk test with elements "Swallow", "Wheel", "Bridge"; balance "Swallow" with elements "Swallow", "Wheel"; static equilibrium test with the elements "Swallow", "Rack on the shoulders", "Rolling forward with a squat", "Wheel". Reliable values ​​of the correlation coefficient were established between the tests of dynamic balance and the basic elements of sports acrobatics in young athletes 6-7 years, namely: "Swallow", "Flip forward with a squat", "Wheel" and "Bridge". The analysis of special tests of static and dynamic balance in mastering the basic elements of acrobatics at the first stage of long-term training makes it possible to use them to determine the level of coordination capabilities of young athletes and further improve the use of acrobatic exercises. Conclusions. A reliable relationship between the performance of basic exercises and indicators of static and dynamic balance in young acrobats at the initial stage of training. It is shown that the level of static and dynamic balance is of great importance for the assimilation and improvement of basic elements of technology by young acrobats 6-7 years. Static and dynamic balance tests can be used to individually build training programs and young acrobats. It is shown that sports acrobatics is a significant means of developing the balance of children 6-7 years.

scholarly journals Role of Chest X-Ray in Coronavirus Disease and Correlation of Radiological Features with Clinical Outcomes in Indian Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Satyanand Sathi ◽  
Richa Tiwari ◽  
Savita Verma ◽  
Anil Kumar Garg ◽  
Virendra Singh Saini ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Hospital Stay ◽  
Rank Correlation ◽  
X Rays ◽  
X Ray ◽  
Radiological Features ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Discharged Patients ◽  
Chest X Ray

Recent literature has reported that radiological features of coronavirus disease (COVID-19) patients are influenced by computed tomography. This study aimed to assess the characteristic chest X-ray features of COVID-19 and correlate them with clinical outcomes of patients. This retrospective study included 120 COVID-19 patients. Baseline chest X-rays and serial chest X-rays were reviewed. A severity index in the form of maximum radiological assessment of lung edema (RALE) score was calculated for each lung, and scores of both the lungs were summed to obtain a final score. The mean ± standard deviation (SD) and frequency (%) were determined, and an unpaired t test, Spearman’s rank correlation coefficient, and logistic regression analyses were performed for statistical analyses. Among 120 COVID-19 patients, 74 (61.67%) and 46 (38.33%) were males and females, respectively; 64 patients (53.33%) had ground-glass opacities (GGO), 55 (45.83%) had consolidation, and 38 (31.67%) had reticular-nodular opacities, with lower zone distribution (50%) and peripheral distribution (41.67%). Baseline chest X-ray showed a sensitivity of 63.3% in diagnosing typical findings of SARS-CoV-2 pneumonia. The maximum RALE score was 2.13 ± 1.9 in hospitalized patients and 0.57 ± 0.77 in discharged patients ( p value <0.0001). Spearman’s rank correlation coefficient between maximum RALE score and clinical outcome parameters was as follows: age, 0.721 ( p value <0.00001); >10 days of hospital stay, 0.5478 ( p value <0.05); ≤10 days of hospital stay, 0.5384 ( p value <0.0001); discharged patients, 0.5433 ( p value <0.0001); and death, 0.6182 ( p value = 0.0568). The logistic regression analysis revealed that maximum RALE scores (0.0932 [0.024–0.367]), (10.730 [2.727–42.206]), (1.258 [0.990–1.598]), and (0.794 [0.625–1.009]) predicted discharge, death, >10 days of hospital stay, and ≤10 days of hospital stay, respectively. The study findings suggested that the RALE score can quantify the extent of COVID-19 and can predict the prognosis of patients.

scholarly journals The association between parameters of oral mucosal immunity and 25-hydroxyvitamin D in patients with rampant caries

2022 ◽  
Vol 20 (4) ◽  
pp. 32-38
Author(s):  
A. S. Putneva ◽  
T. M. Karavaeva ◽  
M. V. Maksimenya ◽  
P. P. Tereshkov ◽  
M. N. Mishchenko ◽  
...  
Keyword(s):  
Plasma Level ◽  
Correlation Coefficient ◽  
Rank Correlation ◽  
Control Group ◽  
Hydroxyvitamin D ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
25 Hydroxyvitamin D ◽  
Tgf Β1 ◽  
Rampant Caries

Aim. To determine the saliva level of immunoregulatory proteins in patients with rampant caries and 25-hydroxyvitamin D (25(OH)D) deficiency and evaluate the association of their concentration with 25(OH)D plasma level.Materials and methods. The study was performed in two groups. The experimental group included 15 patients aged 20–22 years with rampant caries and the 25(OH)D plasma level of < 20 ng / ml. The control group encompassed 15 healthy age-matched volunteers with the 25(OH)D plasma level of 20–100 ng / ml. The concentrations of B7.2 (CD86), free active TGF-β1, CTLA-4, PD-1, Tim-3, LAG-3, IGFBP-4, and ICAM-1 were assessed using flow cytometry. The levels of LL-37 and secretory immunoglobulin A (sIgA) were measured using ELISA. The Spearman’s rank correlation coefficient was used to reveal a correlation between the indicated proteins and the 25(OH)D plasma level.Results. A decrease in B7.2 (CD86), PD-1, Tim-3, sIgA, and LL-37 and elevation of IGFBP-4 and ICAM-1 saliva levels were detected in patients with rampant caries and 25-hydroxyvitamin D deficiency. A positive Spearman’s rank correlation coefficient was revealed between plasma 25(OH)D and saliva levels of free active TGF-β1, CTLA4, B7.2 (CD86), LL-37, and sIgA. A negative correlation was revealed between 25(OH)Dand ICAM-1.Conclusion. 25(OH)D deficiency in patients with rampant caries is associated with decreased levels of B7.2 (CD86), PD-1, Tim-3, sIgA, and LL-37 and elevated levels of IGFBP-4 and ICAM-1 in the saliva. 

scholarly journals Estimation of Genetic Parameters for Body Weight and Some Colour Traits in the Seventh-generation Index Selected Nigeria Heavy Local Chicken Ecotype

2021 ◽  
Author(s):  
I.J. Ohagenyi ◽  
F.C. Iregbu ◽  
V.C. Udeh
Keyword(s):  
Body Weight ◽  
Genetic Parameters ◽  
Genetic Correlations ◽  
The Body ◽  
Pedigree Selection ◽  
Egg Colour ◽  
Local Chicken ◽  
Range Test ◽  
Estimation Of Genetic Parameters ◽  
Selection Of

Background: This study was conducted to estimate the genetic parameters of body weight and some colour traits in seventh generation (G7) index selected Nigerian Heavy Local Chicken Ecotype (NHLCE) progenies at point of lay to 12 weeks. Methods: 5 sires and 12 hens were used to generate the progenies used for the experiment. Traits measured included weekly body weight, egg colour, beak colour and feather colour. Data collected were subjected to one way analysis of variance in a Paternal half sib analysis using Animal model of SAS (2003). Four weeks body weight measurements, egg colour, beak colour and feather colour for 5 sires ranged from 1.29±0.05 1.54±0.07; 2.55±0.02 to 4.00±0.02; 2.45±0.02 to 4.83±0.02 and 1.73±0.02 to 4.58±0.04 respectively. Result: The new Duncan’s multiple range test shows that sire families are similar (p greater than 0.05) in the body weight and beak colour, but significantly differed (p greater than 0.05) in the egg colour and feather colour. The heritability estimates of mature body weight for week 3 was medium, while estimates of heritability for weekly mature body weight for weeks 1, 2 and 4, egg colour, beak colour and feather colour of NHLCE were low heritability. Low h2 of traits suggest that progeny and pedigree selection could be employed for improvement of the egg colour, beak colour and feather colour of NHLCE. The study showed positive genetic correlations between beak colour and egg colour, negative genetic correlations between beak and feather colour. This means that no decision can be taken in isolation as the selection of one trait will have consequences on other traits.

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