Periodontal diseases in children

Author(s):  
P.A. Heasman ◽  
P.J. Waterhouse

Periodontal diseases comprise a group of infections that affect the supporting structures of the teeth: marginal and attached gingiva, periodontal ligament, cementum, and alveolar bone. Acute gingival diseases—primarily herpetic gingivostomatitis and necrotizing gingivitis—are ulcerative conditions that result from specific viral and bacterial infection. Chronic gingivitis, however, is a non-specific inflammatory lesion of the marginal gingiva which reflects the bacterial challenge to the host when dental plaque accumulates in the gingival crevice. The development of chronic gingivitis is enhanced when routine oral hygiene practices are impaired. Chronic gingivitis is reversible if effective plaque control measures are introduced. If left untreated, the condition invariably converts to chronic periodontitis, which is characterized by resorption of the supporting connective tissue attachment and apical migration of the junctional epithelia. Slowly progressing, chronic periodontitis affects most of the adult population to a greater or lesser extent, although the early stages of the disease are detected in adolescents. Children are also susceptible to aggressive periodontal diseases that involve the primary and permanent dentitions, and present in localized or generalized forms. These conditions, which are distinct clinical entities affecting otherwise healthy children, must be differentiated from the extensive periodontal destruction that is associated with certain systemic diseases, degenerative disorders, and congenital syndromes. Periodontal tissues are also susceptible to changes that are not, primarily, of an infectious nature. Factitious stomatitis is characterized by self-inflicted trauma to oral soft tissues and the gingiva are invariably involved. Drug-induced gingival enlargement is becoming increasingly prevalent with the widespread use of organ transplant procedures and long-term immunosuppressant therapy. Localized enlargement may occur as a gingival complication of orthodontic treatment. A classification of periodontal diseases in children is given in Table 12.1. Marginal gingival tissues around the primary dentition are more highly vascular and contain fewer connective tissue fibres than tissues around the permanent teeth. The epithelia are thinner with a lesser degree of keratinization, giving an appearance of increased redness that may be interpreted as mild inflammation. Furthermore, the localized hyperaemia that accompanies eruption of the primary dentition can persist, leading to swollen and rounded interproximal papillae and a depth of gingival sulcus exceeding 3mm.

2018 ◽  
Vol 66 (6) ◽  
pp. 467-475 ◽  
Author(s):  
Lívia S.F. e Ribeiro ◽  
Jean N. dos Santos ◽  
Clarissa A.G. Rocha ◽  
Patricia R. Cury

Mast cells (MCs) can influence the maturation of collagen fibers. This study evaluated the relationship between the distribution and degranulation of MCs and collagen maturation in human gingival tissue in chronic periodontitis. A total of 16 specimens of patients clinically diagnosed as periodontitis and 18 controls clinically diagnosed as healthy or gingivitis were included. Immunohistochemistry and Picrosirius staining were performed to identify MCs and assess collagen fibers, respectively. Chi-square, t test, and Pearson’s correlation test ( p<0.05) were used. In control specimens, there was a positive association between MCs in the connective tissue and the presence of immature collagen ( p=0.001); in periodontitis samples, this association was not confirmed ( p≥0.12). There was no significant relationship between periodontal diagnosis and collagen maturation or MC degranulation ( p≥0.35). MC density was significantly higher ( p=0.04) in periodontitis tissue (339.01 ± 188.94 MCs/mm2) than in control tissue (211.14 ± 131.13 MCs/mm2) in the area of connective tissue containing inflammatory infiltrate. There was a correlation between the number of MCs and probing depth ( r = 0.34, p=0.04). MCs are involved in the pathogenesis of periodontal diseases and might be associated with collagen maturation in periodontal tissue during the early stages of periodontal disease pathogenesis.


2021 ◽  
Vol 13 ◽  
pp. 22-31
Author(s):  
Shaswata Karmakar ◽  
Dipanjan Das ◽  
Baishakhi Modak ◽  
Madhurya Kedlaya ◽  
Anneysa Basu ◽  
...  

Oral carcinoma is a major public health concern worldwide due to its increasing mortality. Apart from alcohol consumption, tobacco and arecanut chewing, other risk factors for oral cancer include chronic infection and inflammation, poor nutritional status, chronic trauma to the oral soft tissues etc. Studies have also found that the risk of developing oral cancer may increase with periodontal diseases like periodontitis. Chronic periodontitis is a multifactorial, inflammatory disease of the periodontium primarily caused by the pathogenic microorganisms present in dental plaque biofilm, ultimately resulting in loss of the tooth. An induction of carcinoma by such chronic inflammatory disease appears possible since the involved inflammatory mediators and bacterial toxins in the disease have shown to have a potential for transformation into malignancy. Therefore, establishing a connection between chronic periodontitis and oral carcinoma would be of great interest. Moreover, it seems judicious to take measures to improve oral hygiene in order to minimize the cancer risks. This further intensifies the need for oral health education programs to educate individuals about the importance of maintaining a good oral hygiene for the prevention of other oral diseases as well as systemic conditions.


Author(s):  
Shaili Pradhan ◽  
Shweta Agrawal ◽  
Benju Shrestha

 Introduction: Periodontal diseases comprise a group of inflammatory diseases caused by bacteria that colonise the tooth surface and infect surrounding soft tissues, ultimately leading to tooth loss. Vitamin D, calcium, alkaline phosphatase, and parathyroid hormone have role in bone metabolism both in health or in disease. Objective: To compare serum Vitamin D, calcium, alkaline phosphatase, and parathyroid hormone levels in patients with generalised chronic periodontitis and healthy periodontium. Methods: A cross-sectional analytical study was done in 80 patients visiting Department of Dental Surgery from July to December 2019. Clinical parameters measured were plaque index, gingival index, clinical attachment level, and pocket depth in the healthy periodontium and generalised chronic periodontitis. Blood investigation for serum Vitamin D, calcium, alkaline phosphatase (ALP), and parathyroid hormone (PTH) level were done. Data was analysed in SPSS v.16. Results: Out of total 80 patients enrolled (mean age of 36.20±7.37 years), 40 (50%) patients had healthy periodontium and 40 (50%) had generalised chronic periodontitis. Mean levels of serum Vitamin D (P=0.006) and calcium (P=0.020) were significantly higher in chronic periodontitis patient compared to healthy controls while no significant intergroup differences were seen with respect to ALP (P=0.267) and PTH (P=0.351). Conclusion: No significant differences were found in the levels of ALP and PTH between generalised chronic periodontitis and healthy patients and higher levels of Vitamin D and calcium were seen in generalised chronic periodontitis patients as compared to healthy patients.


Author(s):  
Iskander I. Zaidullin ◽  
Denis O. Karimov ◽  
Lilija K. Karimova ◽  
Milyausha F. Kabirova ◽  
Rasima R. Galimova ◽  
...  

The susceptibility to the development and progression of inflammatory periodontal diseases, which depends on genetic and external factors (smoking, stress, oral hygiene), varies widely. In the development of these diseases, an important role is played not only by the presence of periodontal pathogenic microorganisms, but also by the presence of congenital or acquired immunodeficiency, immunoregulatory defects. The immune system plays a key role in the physiological and pathological processes of periodontal tissues. In this regard, IL17, produced by CD4+ Th cells, which has both Pro-inflammatory and protective activity, is of particular interest in the pathogenesis of periodontitis. The aim of study was to identify the relationship between polymorphic loci of the IL-17A (rs2275913) and MMP-1 (rs1799750) genes and clinical manifestations of chronic periodontitis in petrochemical workers. Dental examination was performed in 92 ethylene oxide production workers with chronic periodontitis and 74 patients with chronic periodontitis who did not come into contact with chemical factors (control group). Genotyping of polymorphisms rs2275913 of the IL17A gene and rs1799750 of the MMP1 gene was performed by allele-specific real-time polymerase chain reaction (PCR). Hygienic assessment of the degree of air pollution of the working area with harmful substances was carried out by gas chromatography according to the guidelines for the determination of harmful substances in the air № 5098-89, № 3119-84. When comparing the results of studies of both groups, there were no statistically significant differences in the frequency distributions of allelic variants and genotypes of the IL-17A and MMP-1 genes. The AA/AG genotypes of the IL-17A gene were associated with an increased risk of severe disease compared to the GG genotype in workers in the main group (OR=6.1; 95% CI 1.33-28.5; p=0.021) and in the control group (OR=7.26; 95% CI 1.34-39.25; p=0.016). Carriers of the A allele in the control group increased the risk of severe chronic periodontitis by 2.4 times compared to carriers of the G allele (OR=2.41; 95% CI 1.19-4.87; p=0.014). During the dental examination of employees of the ethylene oxide plant, the clinical course of periodontal diseases was more severe in comparison with the control group, and the number of patients with severe periodontitis was twice as high. It was found that the AA/AG genotypes of the IL-17A gene and the carrier of the A allele are associated with increased susceptibility to the development of severe chronic periodontitis. The association between the MMP-1 gene polymorphism and the risk of severe forms of chronic periodontitis has not been established. A risk factor for the development of inflammatory periodontal diseases in employees of the petrochemical complex is a complex of harmful production factors.


Symmetry ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1126
Author(s):  
Giovanna Iezzi ◽  
Francesca Di Lillo ◽  
Michele Furlani ◽  
Marco Degidi ◽  
Adriano Piattelli ◽  
...  

Symmetric and well-organized connective tissues around the longitudinal implant axis were hypothesized to decrease early bone resorption by reducing inflammatory cell infiltration. Previous studies that referred to the connective tissue around implant and abutments were based on two-dimensional investigations; however, only advanced three-dimensional characterizations could evidence the organization of connective tissue microarchitecture in the attempt of finding new strategies to reduce inflammatory cell infiltration. We retrieved three implants with a cone morse implant–abutment connection from patients; they were investigated by high-resolution X-ray phase-contrast microtomography, cross-linking the obtained information with histologic results. We observed transverse and longitudinal orientated collagen bundles intertwining with each other. In the longitudinal planes, it was observed that the closer the fiber bundles were to the implant, the more symmetric and regular their course was. The transverse bundles of collagen fibers were observed as semicircular, intersecting in the lamina propria of the mucosa and ending in the oral epithelium. No collagen fibers were found radial to the implant surface. This intertwining three-dimensional pattern seems to favor the stabilization of the soft tissues around the implants, preventing inflammatory cell apical migration and, consequently, preventing bone resorption and implant failure. This fact, according to the authors’ best knowledge, has never been reported in the literature and might be due to the physical forces acting on fibroblasts and on the collagen produced by the fibroblasts themselves, in areas close to the implant and to the symmetric geometry of the implant itself.


Author(s):  
Nurin Izyani Othman ◽  
Hanan Umaira Ismail ◽  
Norazlina Mohammad ◽  
Norzalina Ghazali ◽  
Muhammad Syafiq Alauddin

Abstract Objectives The aim of this study is to investigate the current knowledge and attitude of deep caries removal method among dental students in Malaysia. Materials and Methods A total of 303 students (n = 303) responded to the online questionnaire. The first part of questionnaire was to evaluate the demographic data of the respondents and focused on the technique and management approach used for deep caries lesion. The second part investigated the preferred treatment used for deep caries based on the designated clinical case, while the third part assessed the factors that affected the decision on deep caries management. Statistical Analysis Independent t-test was used to compare difference between the two groups. Results Seventy four percent of the students have the knowledge of the different methods of caries removal, while 25.8% were only familiar with complete caries removal. The preferred method for deep caries removal in permanent teeth was partial caries removal (53%). For primary dentition, 45.6% of the students prefer to perform pulpotomy as compared with other techniques. There was no significant difference in caries removal method for permanent teeth between undergraduate year of study (p > 0.05), which was partial caries removal at 52.7 and 53.5%, respectively. For primary dentition, the preferred caries removal method was pulpotomy for year 4 (39.8%) and year 5 (52%) students. The popular material to restore deep caries was resin composite (42%) followed by glass ionomer cement (23.3%). Conclusions This study showed that partial caries removal was the preferred method despite partial understanding on the identification of the clinical indicators of the technique.


2004 ◽  
Vol 15 (3) ◽  
pp. 165-175 ◽  
Author(s):  
P. C. Trackman ◽  
A. Kantarci

Gingival overgrowth occurs mainly as a result of certain anti-seizure, immunosuppressive, or antihypertensive drug therapies. Excess gingival tissues impede oral function and are disfiguring. Effective oral hygiene is compromised in the presence of gingival overgrowth, and it is now recognized that this may have negative implications for the systemic health of affected patients. Recent studies indicate that cytokine balances are abnormal in drug-induced forms of gingival overgrowth. Data supporting molecular and cellular characteristics that distinguish different forms of gingival overgrowth are summarized, and aspects of gingival fibroblast extracellular matrix metabolism that are unique to gingival tissues and cells are reviewed. Abnormal cytokine balances derived principally from lymphocytes and macrophages, and unique aspects of gingival extracellular matrix metabolism, are elements of a working model presented to facilitate our gaining a better understanding of mechanisms and of the tissue specificity of gingival overgrowth.


2005 ◽  
Vol 29 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Enrique Bimstein ◽  
Michael McIlwain ◽  
Joseph Katz ◽  
Greg Jerrell ◽  
Robert Primosch

The present case, of a child with an idiopathic immune deficiency and aggressive periodontitis in the primary dentition, serves as an example for the treatment considerations in these cases. Extraction of all the primary teeth proved to be the most adequate treatment. It allowed the child to eat properly and prevented unwanted infections that could endanger the life of the child. The newly erupted permanent teeth have been subjected to careful oral hygiene, clorhexidine topical applications, and have mild gingival inflammation and no attachment loss.


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