Confabulations about People and Their Limbs, Present or Absent

Author(s):  
William Hirstein

This article examines the neurobiological aspects of confabulations. It explains that confabulation is a false memory report and that to confabulate is to make unintentionally an ill-grounded, and hence probably false, claim that one should know is ill-grounded. Confabulation is caused by damage to some perceptual or mnemonic process in the posterior of the brain and damage to some prefrontal process that monitors and can manipulate and/or correct the output of that perceptual or mnemonic process. This article evaluates the application of this two-factor theory to the analysis of Capgras syndrome and anosognosia, the two oddest members of the family of confabulation syndromes.

1970 ◽  
Vol 6 (1) ◽  
Author(s):  
Muskinul Fuad

The education system in Indonesia emphasize on academic intelligence, whichincludes only two or three aspects, more than on the other aspects of intelligence. For thatreason, many children who are not good at academic intelligence, but have good potentials inother aspects of intelligence, do not develop optimally. They are often considered and labeledas "stupid children" by the existing system. This phenomenon is on the contrary to the theoryof multiple intelligences proposed by Howard Gardner, who argues that intelligence is theability to solve various problems in life and produce products or services that are useful invarious aspects of life.Human intelligence is a combination of various general and specific abilities. Thistheory is different from the concept of IQ (intelligence quotient) that involves only languageskills, mathematical, and spatial logics. According to Gardner, there are nine aspects ofintelligence and its potential indicators to be developed by each child born without a braindefect. What Gardner suggested can be considered as a starting point to a perspective thatevery child has a unique individual intelligence. Parents have to treat and educate theirchildren proportionally and equitably. This treatment will lead to a pattern of education that isfriendly to the brain and to the plurality of children’s potential.More than the above points, the notion that multiple intelligences do not just comefrom the brain needs to be followed. Humans actually have different immaterial (spiritual)aspects that do not refer to brain functions. The belief in spiritual aspects and its potentialsmeans that human beings have various capacities and they differ from physical capacities.This is what needs to be addressed from the perspective of education today. The philosophyand perspective on education of the educators, education stakeholders, and especially parents,are the first major issue to be addressed. With this step, every educational activity andcommunication within the family is expected to develop every aspect of children'sintelligence, especially the spiritual intelligence.


2018 ◽  
pp. 110-119

Primary Objectives: By extending the scope of knowledge of the primary care optometrist, the brain injury population will have expanded access to entry level neurooptometric care by optometric providers who have a basic understanding of their neurovisual problems, be able to provide some treatment and know when to refer to their colleagues who have advanced training in neuro-optometric rehabilitation.


Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 78
Author(s):  
Anne Bryden ◽  
Natalie Majors ◽  
Vinay Puri ◽  
Thomas Moriarty

This study examines an 11-year-old boy with a known history of a large previously asymptomatic arachnoid cyst (AC) presenting with acute onset of right facial droop, hemiplegia, and expressive aphasia. Shortly after arrival to the emergency department, the patient exhibited complete resolution of right-sided hemiplegia but developed headache and had persistent word-finding difficulties. Prior to symptom onset while in class at school, there was an absence of reported jerking movements, headache, photophobia, fever, or trauma. At the time of neurology consultation, the physical exam showed mildly delayed cognitive processing but was otherwise unremarkable. The patient underwent MRI scanning of the brain, which revealed left convexity subdural hematohygroma and perirolandic cortex edema resulting from ruptured left frontoparietal AC. He was evaluated by neurosurgery and managed expectantly. He recovered uneventfully and was discharged two days after presentation remaining asymptomatic on subsequent outpatient visits. The family express concerns regarding increased anxiety and mild memory loss since hospitalization.


Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 123
Author(s):  
Cigdem Yuce Kahraman ◽  
Ali Islek ◽  
Abdulgani Tatar ◽  
Özlem Özdemir ◽  
Adil Mardinglu ◽  
...  

Wilson disease (WD) (OMIM# 277900) is an autosomal recessive inherited disorder characterized by excess copper (Cu) storage in different human tissues, such as the brain, liver, and the corneas of the eyes. It is a rare disorder that occurs in approximately 1 in 30,000 individuals. The clinical presentations of WD are highly varied, primarily consisting of hepatic and neurological conditions. WD is caused by homozygous or compound heterozygous mutations in the ATP7B gene. The diagnosis of the disease is complicated because of its heterogeneous phenotypes. The molecular genetic analysis encourages early diagnosis, treatment, and the opportunity to screen individuals at risk in the family. In this paper, we reported a case with a novel, hotspot-located mutation in WD. We have suggested that this mutation in the ATP7B gene might contribute to liver findings, progressing to liver failure with a loss of function effect. Besides this, if patients have liver symptoms in childhood and/or are children of consanguineous parents, WD should be considered during the evaluation of the patients.


Development ◽  
1993 ◽  
Vol 119 (1) ◽  
pp. 247-261 ◽  
Author(s):  
B.A. Parr ◽  
M.J. Shea ◽  
G. Vassileva ◽  
A.P. McMahon

Mutation and expression studies have implicated the Wnt gene family in early developmental decision making in vertebrates and flies. In a detailed comparative analysis, we have used in situ hybridization of 8.0- to 9.5-day mouse embryos to characterize expression of all ten published Wnt genes in the central nervous system (CNS) and limb buds. Seven of the family members show restricted expression patterns in the brain. At least three genes (Wnt-3, Wnt-3a, and Wnt-7b) exhibit sharp boundaries of expression in the forebrain that may predict subdivisions of the region later in development. In the spinal cord, Wnt-1, Wnt-3, and Wnt-3a are expressed dorsally, Wnt-5a, Wnt-7a, and Wnt-7b more ventrally, and Wnt-4 both dorsally and in the floor plate. In the forelimb primordia, Wnt-3, Wnt-4, Wnt-6 and Wnt-7b are expressed fairly uniformly throughout the limb ectoderm. Wnt-5a RNA is distributed in a proximal to distal gradient through the limb mesenchyme and ectoderm. Along the limb's dorsal-ventral axis, Wnt-5a is expressed in the ventral ectoderm and Wnt-7a in the dorsal ectoderm. We discuss the significance of these patterns of restricted and partially overlapping domains of expression with respect to the putative function of Wnt signalling in early CNS and limb development.


Author(s):  
Siti Hajar Musa ◽  
Ahmad Fuad Shamsuddin ◽  
Emilia Abd Malek ◽  
Hamidon Basri ◽  
Mahiran Basri ◽  
...  

Meningitis is a disease caused by a bacterial infection in the brain. Streptococcus pneumonia is the most common causative agent for meningitis disease. Chloramphenicol used to be a drug used for the treatment of meningitis. Current medication in treating meningitis is using the family of cephalosporin drugs. However, due to the drug-resistant problem, this family of a drug is no longer efficient towards the meningitis bacteria. Thus, the use of chloramphenicol has caught back the attention in treating meningitis disease. Chloramphenicol is claimed to be toxic towards human cells since the higher dosage is needed per injection for every treatment. This is corresponding to the poor delivery method of this hydrophobic drug. Nanoemulsion is believed to be the best option in transporting chloramphenicol to the brain by the intravenous route. A good combination of oil mixed with a surfactant mixture led to the formation of formulation with small particle sizes with low PDI values. Optimization of nanoemulsion's composition using Response Surface Methodology (RSM) suggested that the best amount of oil, lecithin, and glycerol were 4%, 2.5%, and 2.25%, respectively. The optimized formulation was then modified due to the instability and insufficient osmolality value of the formulation. The physicochemical characteristics (particle size, PDI, zeta potential, osmolality, viscosity, and pH) of the formulation successfully fulfilled the requirement for parenteral application. Toxicity analysis showed that chloramphenicol encapsulated nanoemulsion system was much safer compared to the standard chloramphenicol. Storage of the chloramphenicol-loaded nanoemulsion at 4°C showed good stability for 3 months with no significant changes on the particle size.  


Part I. The Medulla Oblongata, And Its Variations Acoording To Diet And Feeding Habits In previous communications to this Society the relationship of the habits of feeding and diet to the form and pattern of the medulla oblongata has been described in the cyprinoids, clupeids, and gadoids (Evans, 1931, 1932, 1935). This research takes up a similar study of the brain of the Pleuronectidae. The expense has been borne by a grant from the Royal Society for which the author tenders his grateful thanks. It has seemed to be desirable to extend the observations to the fore- and mid-brain, as in some members of the family these present a very marked development. In order to elucidate some of the problems that arise I have also studied the brain of the eel, and some interesting conclusions have resulted. We find, as a result of examination by the naked eye and of serial sections, that we can divide the following species into four groups as follows: I. The sole, Solea vulgaris .


2021 ◽  
Vol 1 (1) ◽  
pp. 25-40
Author(s):  
Neriman Aral

From the moment the child is born, learning becomes meaningful and it is interpreted as a result of the experiences first in the family and then in school. However, it is sometimes not possible to talk about the fact that learning takes place in all children although the process has taken place in this direction. Sometimes the individual differences that exist in children and the inability to get the necessary support in structuring their learning experiences can be effective in the failure of learning, while sometimes the type of congenital difficulty can be effective. One of these types of difficulty is a specific learning difficulty. It is not always possible for children with specific learning difficulties to learn, even if they do not have any mental problems. In this case, many factors can be effective, especially the problems that children experience in their visual perception can become effective. Since visual perception is the processing of symbols received from the environment in the brain, the problem that may be experienced in this process can also make it difficult to learn this situation. In line with these considerations, it is aimed to focus on the importance of visual perception in specific learning difficulties.


2021 ◽  
Vol 1 ◽  
pp. 1350-1354
Author(s):  
Cahya Milla Rismawanti ◽  
Wiwiek Natalya ◽  
I Isytiaroh

AbstractStroke is a brain functional disorder characterized by nerve paralysis due to obstruction of blood flow to the brain. The frequent impact if a post-stroke client is not carried out with rehabilitation immediately will result in mobility disorder that can impede daily physical activity. One pratice in the rehabilitation process is to prevent disability in a client with post-stroke physical mobility disorder that is, by performing a Range Of Motion rope. The case study is intended to illustrate application of roma exercises to boost muscle strength. The method of writing the case study USES a descriptive design and case studies reported in narration. The instrumrnts used are observation sheets and structured observation sheets covering the assessment of muscle strength. The resulth of the case study have been after the six-meeting application of roma that the roma can increase muscle strength in subject. I the average muscle strength 3.31 to 3.50 and subject II average muscle strength 3.68 to 3,93. The conclusion of the case study increased muscle strength after the practice of roma. Suggestions for the family in order to train ROM for family members who had suffered stroke. Keywords: Stroke, muscle strength, ROM AbstrakStroke adalah penyakit nerulogis terbanyak yang dapat mengakibatkan disfungsi motorik dan sensorik.Dampak yang sering muncul jika klien pasca stroke tidak dilakukan rehabiltasi dengan segera maka akan mengalami gangguan mobilitas yang dapat menghambat aktivitas fisik sehari-hari. Saalah satu bentuk latihan dalam proses rehabilitasi untuk mencegah terjadinya kecacatan pada klien dengan gangguan mobilitas fisik pasca stroke yaitu dengan melakukan latihan Range Of Motion ROM. Studi kasus ini bertujuan untuk menggambarkan penerapan latihan ROM untuk meningkatkan kekuatan otot. Metode penulisan studi kasus ini menggunakan rancangan deskriptif dan hasil studi kasus dilaporkan dalam bentuk narasi. Instrumen yang digunakan yaitu lembar pengkajian dan lembar observasi terstruktur meliputi penilaian kekuatan otot. Hasil studi kasus setelah dilakukan penerapan ROM selama 6 pertemuan bahwa ROM dapat meningkatkan kekuatan otot pada Subyek I nilai rata-rata kekuatan otot 3,31 menjadi 3,50 dan Subyek II nilai rata-rata kekuatan otot 3,68 menjadi 3,93. Simpulan studi kasus ini terjadi peningkatan kekuatan otot setelah dilakukan latihan ROM. Saran bagi keluarga agar dapat melatih ROM pada anggota keluarga yang mengalmi stroke. Kata kunci: Stroke, kekuatan otot, ROM


2022 ◽  
Vol 5 (1) ◽  
pp. 01-04
Author(s):  
Aamir Jalal Al-Mosawi

Background: Cerebral palsy is a heterogeneous disorder that can cause a lifelong disability that is associated with a non-progressive damage in the brain. It is commonly caused by antenatal, perinatal, early postnatal and neonatal conditions. However, post-neonatal cases of acquired cerebral palsy have also been reported, and were commonly caused by infection. Patients and methods: The family of a girl from Qatar, who developed severe cerebral palsy caused by submersion injury, consulted us about the possible therapies for her condition. Clinical picture and brain imaging abnormalities are described, and the relevant literatures were reviewed with the aim of suggesting possible evidence-based therapies. Results: At the age of 23 months, a previously healthy girl developed anoxic encephalopathy after experiencing submersion injury. MRI showed evidence of significant hypoxic ischemic injury primarily affecting the deep grey matter, hippocami, mid-brain and the posterior cortex. EEG showed diffuse slowness of cerebral activity and diffuse attenuation of the background without no epileptic abnormalities suggesting diffuse encephalopathy resulting from diffuse cortical injury. At the about age of three and half years, her family consulted us about her condition as she was still showing no awareness to the environment, showing no significant spontaneous movements. She had poor head control. Unable to sit or stand alone, and had a flexed posture. She was on levetiracetam (Keppra), diazepam, and baclofen 30 mg daily. She was still having tracheotomy, and was fed through gastrostomy tube. Conclusion: In this paper, the rare occurrence of severe post-infantile cerebral palsy is described. Emphasis is made on the possibility of using evidence-based multi-factorial therapies in cerebral palsy.


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