scholarly journals The effect of dispersal and preferential mating on the genetic control of mosquitoes

2020 ◽  
Author(s):  
Doran Khamis ◽  
Claire El Mouden ◽  
Klodeta Kura ◽  
Michael B. Bonsall
Keyword(s):  
Environmental Factors ◽  
Genetic Control ◽  
Mosquito Control ◽  
Economic Damage ◽  
Successful Implementation ◽  
Mathematical Framework ◽  
Lethal Gene ◽  
Control Technologies ◽  
The Impact ◽  
Gene Drives

AbstractMosquito-borne diseases cause significant social and economic damage across much of the globe. New biotechnologies that utilise manipulations of the mosquito genome have been developed to combat disease. The successful implementation of genetic mosquito control technologies may depend upon ecological, evolutionary and environmental factors, as well as the specifications of the chosen technology. Understanding the influence of these external factors will help inform how best to deploy a chosen technology to control vectors of infectious diseases. We use a continuous-time stochastic spatial network model of a mosquito life-cycle coupled to population genetics models to investigate the impact of releasing seven types of genetic control technology: a self-limiting lethal gene, two underdominance threshold gene drives, two homing gene drives and two Wolbachia systems. We apply the mathematical framework to understand control interventions of two archetypes of mosquito species: a short-range dispersing Aedes aegypti and comparatively longer-range dispersing Anopheles gambiae. We show that mosquito dispersal behaviour is an extremely important factor in determining the outcome of a release programme. Assortative mating – where the mating success of genetically modified males is lower than their wild counterparts – can facilitate the spatial containment of gene drives. The rapid evolution of strong mating preference can damage the efficacy of control efforts for all control technologies. We suggest that there cannot be a one-size-fits-all approach to regulation and implementation of vector control; there must be application-specific control plans that take account of understudied ecological, evolutionary and environmental factors.

scholarly journals Genetic Control of Mosquitoes: population suppression strategies

2012 ◽  
Vol 54 (5) ◽  
pp. 287-292 ◽  
Author(s):  
André Barretto Bruno Wilke ◽  
Mauro Toledo Marrelli
Keyword(s):  
Genetic Control ◽  
Mosquito Control ◽  
Public Health Problem ◽  
Mass Rearing ◽  
Control Measures ◽  
Reproductive Capacity ◽  
Lethal Gene ◽  
Control Methods ◽  
Species Specific ◽  
Population Suppression

Over the last two decades, morbidity and mortality from malaria and dengue fever among other pathogens are an increasing Public Health problem. The increase in the geographic distribution of vectors is accompanied by the emergence of viruses and diseases in new areas. There are insufficient specific therapeutic drugs available and there are no reliable vaccines for malaria or dengue, although some progress has been achieved, there is still a long way between its development and actual field use. Most mosquito control measures have failed to achieve their goals, mostly because of the mosquito's great reproductive capacity and genomic flexibility. Chemical control is increasingly restricted due to potential human toxicity, mortality in no target organisms, insecticide resistance, and other environmental impacts. Other strategies for mosquito control are desperately needed. The Sterile Insect Technique (SIT) is a species-specific and environmentally benign method for insect population suppression, it is based on mass rearing, radiation mediated sterilization, and release of a large number of male insects. Releasing of Insects carrying a dominant lethal gene (RIDL) offers a solution to many of the drawbacks of traditional SIT that have limited its application in mosquitoes while maintaining its environmentally friendly and species-specific utility. The self-limiting nature of sterile mosquitoes tends to make the issues related to field use of these somewhat less challenging than for self-spreading systems characteristic of population replacement strategies. They also are closer to field use, so might be appropriate to consider first. The prospect of genetic control methods against mosquito vectored human diseases is rapidly becoming a reality, many decisions will need to be made on a national, regional and international level regarding the biosafety, social, cultural and ethical aspects of the use and deployment of these vector control methods.

scholarly journals Ecological and economic assessment of public health in the Komi Republic

2021 ◽  
Vol 11 (3) ◽  
pp. 436-448
Author(s):  
T.E. Dmitrieva ◽  
◽  
V.F. Fomina ◽  
Keyword(s):  
Public Health ◽  
Environmental Factors ◽  
Respiratory Infections ◽  
Negative Impact ◽  
Musculoskeletal Diseases ◽  
Premature Mortality ◽  
Komi Republic ◽  
Morbidity And Mortality ◽  
Economic Damage ◽  
The Impact

The authors assess the economic damage caused by the morbidity and mortality of the working-age population and identify the negative impact of environmental factors on the state of health at the municipal level. To achieve this the authors studied morbidity and mortality of the population in the region and in the municipalities over the past five years according to the international classification of diseases. Via foreign and domestic methodology for assessing, they also analyzed the degree and the spatial structure of the impact of the environmental factors on public health. Of the two international approaches to measure lost labor income due to premature death and diseases — “costly” and “profitable” — the authors used the second approach, adapted to the domestic information base and the available algorithm for calculating economic damage. Preliminary estimates of the lost profit from morbidity and premature mortality in the Komi Republic have determined the value of the unproduced GRP by years of the period from the impact of all causes for 1.5% of its total volume. The main sources of lost profits due to premature mortality are cardiovascular diseases and cancer, and due to morbidity — musculoskeletal diseases and respiratory infections.

scholarly journals Combating mosquito-borne diseases using genetic control technologies

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Guan-Hong Wang ◽  
Stephanie Gamez ◽  
Robyn R. Raban ◽  
John M. Marshall ◽  
Luke Alphey ◽  
...  
Keyword(s):  
Disease Burden ◽  
Genome Engineering ◽  
Mosquito Control ◽  
Control Strategies ◽  
Current Control ◽  
Transmission Risk ◽  
Control Methods ◽  
Control Technologies ◽  
Health Burdens ◽  
Gene Drives

AbstractMosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.

Assessing the sustainability of the Siberian Federal District regions

2020 ◽  
Vol 18 (5) ◽  
pp. 891-908
Author(s):  
T.A. Smirnova
Keyword(s):  
Sustainable Development ◽  
Environmental Factors ◽  
Regional Development ◽  
Federal District ◽  
Integrated Approach ◽  
Siberian Federal District ◽  
The Sustainable Development ◽  
The Impact ◽  
Empirical Analyses

Subject. This article deals with the issues of functioning of the region as a system. Objectives. The article aims to identify the problems of the region's functioning as a system, develop methodological tools to monitor the sustainable development of the Siberian Federal District territories, and determine the the impact of socio-economic and environmental factors on the sustainable development of the region as a whole. Methods. For the study, I used the methods of theoretical, statistical, and empirical analyses taking into account an integrated approach. Results. The article reveals the impact of some individual components of regional development on the sustainability of the territorial system as a whole. Relevance. The results of the study can be used to analyze the sustainability of regions' development.

Directions of Accounting Environmental Factors for Forecasting Formation of Agroecosystems

2020 ◽  
pp. 31-35
Author(s):  
L.Z. Khalishkhova ◽  
◽  
A. Kh. Temrokova ◽  
I.R. Guchapsheva ◽  
K.A. Bogаtyreva ◽  
...  
Keyword(s):  
Sustainable Development ◽  
Comparative Analysis ◽  
Environmental Factors ◽  
Environmental Safety ◽  
Logical Analysis ◽  
Management Decisions ◽  
The Sustainable Development ◽  
The Impact

Ensuring the sustainable development of agroecosystems requires research into the justification of the impact of environmental factors on the formation of territorial agroecosystems and identifies ways to take them into account in order to justify management decisions and ensure environmental safety. The main goal of the research within the article is to identify the most significant environmental factors in predicting the formation of agroecosystems. Provisions are devoted to the study of the laws governing the functioning of agroecosystems in order to increase their stability. The methods of comparative analysis, generalization, abstraction, logical analysis are applied. A number of provisions are formulated regarding ways to account for the influence of factors on the formation of key elements of agroecosystems.

THE MAIN DIRECTIONS OF ECONOMIC SUPPORT OF THE REGIONAL SECURITY SYSTEM OF THE POPULATION

2020 ◽  
Vol 1 (11) ◽  
pp. 133-140
Author(s):  
E. V. DMITRIEVA ◽  
Keyword(s):  
Crisis Management ◽  
Security System ◽  
Regional Security ◽  
Economic Losses ◽  
Economic Damage ◽  
Economic Activities ◽  
The Sustainable Development ◽  
Economic Support ◽  
The Impact ◽  
Crisis Situations

The article considers topical issues of economic support for the development of the regional security system of the population against various risks. The dependence of the impact of the scale of crisis situations on economic activities in the constituent entities of the Russian Federation, which become a serious barrier to the sustainable development of the regions of the country, was investigated. The increasing importance of risks of economic losses from accidents and disasters at potentially dangerous facilities as a result of the complex influence of natural, manmade and fire factors has been established. An analysis was carried out and proposals were developed to implement the key tasks of the state in the field of ensuring the protection of the population and territories of the country from disasters in order to ensure the stability of the economy. The organizational structure, division of tasks and functions between officials, crisis management structures and responding units were analyzed, taking into account the reduction in current financial costs. On the basis of a study of the peculiarities of the regions of the country, recommendations were formed to fulfill the necessary tasks by the anti-crisis management bodies in the field of reducing economic damage on the basis of preventing crisis situations and ensuring fire safety. It is proposed to organize the practical application of a complex automated security system based on modern developments with the application of improving the qualities and efficiency of anti-crisis management processes in order to increase economic efficiency. Initial data were formed to reduce potential threats of a natural, man-made, fire and other nature in the regions using financial and economic mechanisms. It is proposed to implement a set of priority measures to further improve and increase the potential of economic support for the anti-crisis management system. The materials of the article can be used in planning the main directions of the development of the regional population security system and the implementation of socio-economic development programs.

scholarly journals Identifying key processes and sectors in the interaction between climate and socio-economic systems: a review toward integrating Earth–human systems

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Kaoru Tachiiri ◽  
Xuanming Su ◽  
Ken’ichi Matsumoto
Keyword(s):  
Ecosystem Services ◽  
Gross Domestic Product ◽  
Significant Influence ◽  
Ghg Emissions ◽  
Climate Impacts ◽  
Ecological Impacts ◽  
The Other ◽  
Economic Damage ◽  
Economic Systems ◽  
The Impact

AbstractFor the purpose of identifying the key processes and sectors involved in the interaction between Earth and socio-economic systems, we review existing studies on those processes/sectors through which the climate impacts socio-economic systems, which then in turn affect the climate. For each process/sector, we review the direct physical and ecological impacts and, if available, the impact on the economy and greenhouse gas (GHG) emissions. Based on this review, land sector is identified as the process with the most significant impact on GHG emissions, while labor productivity has the largest impact on the gross domestic product (GDP). On the other hand, the energy sector, due to the increase in the demand for cooling, will have increased GHG emissions. Water resources, sea level rise, natural disasters, ecosystem services, and diseases also show the potential to have a significant influence on GHG emissions and GDP, although for most of these, a large effect was reported only by a limited number of studies. As a result, more studies are required to verify their influence in terms of feedbacks to the climate. In addition, although the economic damage arising from migration and conflict is uncertain, they should be treated as potentially damaging processes.

scholarly journals GPS Coordinates for Modelling Correlated Herd Effects in Genomic Prediction Models Applied to Hanwoo Beef Cattle

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2050
Author(s):  
Beatriz Castro Dias Cuyabano ◽  
Gabriel Rovere ◽  
Dajeong Lim ◽  
Tae Hun Kim ◽  
Hak Kyo Lee ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Genomic Prediction ◽  
Prediction Models ◽  
Phenotypic Expression ◽  
Genetic Evaluation ◽  
Genomic Breeding ◽  
Breeding Values ◽  
Korean Cattle ◽  
Evaluation Programs ◽  
The Impact

It is widely known that the environment influences phenotypic expression and that its effects must be accounted for in genetic evaluation programs. The most used method to account for environmental effects is to add herd and contemporary group to the model. Although generally informative, the herd effect treats different farms as independent units. However, if two farms are located physically close to each other, they potentially share correlated environmental factors. We introduce a method to model herd effects that uses the physical distances between farms based on the Global Positioning System (GPS) coordinates as a proxy for the correlation matrix of these effects that aims to account for similarities and differences between farms due to environmental factors. A population of Hanwoo Korean cattle was used to evaluate the impact of modelling herd effects as correlated, in comparison to assuming the farms as completely independent units, on the variance components and genomic prediction. The main result was an increase in the reliabilities of the predicted genomic breeding values compared to reliabilities obtained with traditional models (across four traits evaluated, reliabilities of prediction presented increases that ranged from 0.05 ± 0.01 to 0.33 ± 0.03), suggesting that these models may overestimate heritabilities. Although little to no significant gain was obtained in phenotypic prediction, the increased reliability of the predicted genomic breeding values is of practical relevance for genetic evaluation programs.

scholarly journals Are Bacterio- and Phytoplankton Community Compositions Related in Lakes Differing in Their Cyanobacteria Contribution and Physico-Chemical Properties?

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 855
Author(s):  
Mikołaj Kokociński ◽  
Dariusz Dziga ◽  
Adam Antosiak ◽  
Janne Soininen
Keyword(s):  
Environmental Factors ◽  
Community Composition ◽  
Phytoplankton Community ◽  
Heterotrophic Bacteria ◽  
Bacterial Community Composition ◽  
Physical Factors ◽  
Research Attention ◽  
Phytoplankton Community Composition ◽  
The Impact ◽  
Bacteria Communities

Bacterioplankton community composition has become the center of research attention in recent years. Bacteria associated with toxic cyanobacteria blooms have attracted considerable interest. However, little is known about the environmental factors driving the bacteria community, including the impact of invasive cyanobacteria. Therefore, our aim has been to determine the relationships between heterotrophic bacteria and phytoplankton community composition across 24 Polish lakes with different contributions of cyanobacteria including the invasive species Raphidiopsis raciborskii. This analysis revealed that cyanobacteria were present in 16 lakes, while R. raciborskii occurred in 14 lakes. Our results show that bacteria communities differed between lakes dominated by cyanobacteria and lakes with minor contributions of cyanobacteria but did not differ between lakes with R. raciborskii and other lakes. Physical factors, including water and Secchi depth, were the major drivers of bacteria and phytoplankton community composition. However, in lakes dominated by cyanobacteria, bacterial community composition was also influenced by biotic factors such as the amount of R. raciborskii, chlorophyll-a and total phytoplankton biomass. Thus, our study provides novel evidence on the influence of environmental factors and R. raciborskii on lake bacteria communities.

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