Partial sequence characterization and ontogenetic expression of genes involved in lipid metabolism in the tropical gar ( Atractosteus tropicus )

2018 ◽  
Vol 50 (1) ◽  
pp. 162-172 ◽  
Author(s):  
Luis D. Jiménez‐Martínez ◽  
Carlos A. Álvarez‐González ◽  
Erick De la Cruz‐Hernández ◽  
Dariel Tovar‐Ramírez ◽  
Mario A. Galaviz ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Partial Sequence ◽  
Sequence Characterization ◽  
Expression Of Genes ◽  
Tropical Gar ◽  
Atractosteus Tropicus

scholarly journals Foam Cells as Therapeutic Targets in Atherosclerosis with a Focus on the Regulatory Roles of Non-Coding RNAs

2021 ◽  
Vol 22 (5) ◽  
pp. 2529
Author(s):  
Amin Javadifar ◽  
Sahar Rastgoo ◽  
Maciej Banach ◽  
Tannaz Jamialahmadi ◽  
Thomas P. Johnston ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Foam Cell ◽  
Cell Formation ◽  
Foam Cells ◽  
Foam Cell Formation ◽  
Special Focus ◽  
Lipid Uptake ◽  
Therapeutic Goals ◽  
Expression Of Genes

Atherosclerosis is a major cause of human cardiovascular disease, which is the leading cause of mortality around the world. Various physiological and pathological processes are involved, including chronic inflammation, dysregulation of lipid metabolism, development of an environment characterized by oxidative stress and improper immune responses. Accordingly, the expansion of novel targets for the treatment of atherosclerosis is necessary. In this study, we focus on the role of foam cells in the development of atherosclerosis. The specific therapeutic goals associated with each stage in the formation of foam cells and the development of atherosclerosis will be considered. Processing and metabolism of cholesterol in the macrophage is one of the main steps in foam cell formation. Cholesterol processing involves lipid uptake, cholesterol esterification and cholesterol efflux, which ultimately leads to cholesterol equilibrium in the macrophage. Recently, many preclinical studies have appeared concerning the role of non-encoding RNAs in the formation of atherosclerotic lesions. Non-encoding RNAs, especially microRNAs, are considered regulators of lipid metabolism by affecting the expression of genes involved in the uptake (e.g., CD36 and LOX1) esterification (ACAT1) and efflux (ABCA1, ABCG1) of cholesterol. They are also able to regulate inflammatory pathways, produce cytokines and mediate foam cell apoptosis. We have reviewed important preclinical evidence of their therapeutic targeting in atherosclerosis, with a special focus on foam cell formation.

scholarly journals Western and Heart Healthy Dietary Patterns Differentially Affect the Expression of Genes Associated with Lipid Metabolism, Interferon Signaling and Inflammation in the Jejunum of Ossabaw Pigs

2020 ◽  
pp. 108577
Author(s):  
Shumao Ye ◽  
Nirupa R. Matthan ◽  
Stefania Lamon-Fava ◽  
Gloria Solano Aguilar ◽  
Jerrold R. Turner ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Dietary Patterns ◽  
Interferon Signaling ◽  
Expression Of Genes

scholarly journals Abnormal Expression of Genes Involved in Inflammation, Lipid Metabolism, and Wnt Signaling in the Adipose Tissue of Polycystic Ovary Syndrome

2012 ◽  
Vol 97 (5) ◽  
pp. E765-E770 ◽  
Author(s):  
Gregorio Chazenbalk ◽  
Yen-Hao Chen ◽  
Saleh Heneidi ◽  
Jung-Min Lee ◽  
Marita Pall ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Wnt Signaling ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Abnormal Expression ◽  
Expression Of Genes

Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acids and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer's disease zebrafish model

2021 ◽  
Author(s):  
Junli Feng ◽  
Gongshuai Song ◽  
Yuanyuan Wu ◽  
Xi Chen ◽  
Jie Pang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Lipid Metabolism ◽  
Human Health ◽  
Swimming Performance ◽  
Cognitive Impairments ◽  
Zebrafish Model ◽  
Expression Of Genes ◽  
Health Studies ◽  
Underlying Mechanisms

Plasmalogens (PLs) are critical to human health. Studies have reported a link between downregulation of PLs levels and cognitive impairments in patients with Alzheimer´s disease (AD). however, the underlying mechanisms...

scholarly journals The role of cinnamon as a modulator of the expression of genes related to antioxidant activity and lipid metabolism of laying quails

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0189619 ◽  
Author(s):  
Marisa Silva Bastos ◽  
Ana Paula Del Vesco ◽  
Thaís Pacheco Santana ◽  
Thailine Santana Santos ◽  
Gregório Murilo de Oliveira Junior ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Lipid Metabolism ◽  
Expression Of Genes

Partial characterization of digestive proteases in tropical gar Atractosteus tropicus juveniles

2013 ◽  
Author(s):  
R. Guerrero-Zárate ◽  
C. A. Alvarez-González ◽  
M. A. Olvera-Novoa ◽  
N. Perales-García ◽  
C. A. Frías-Quintana ◽  
...  
Keyword(s):  
Partial Characterization ◽  
Digestive Proteases ◽  
Tropical Gar ◽  
Atractosteus Tropicus

The complete mitochondrial DNA of the tropical gar (Atractosteus tropicus)

2014 ◽  
Vol 27 (1) ◽  
pp. 557-558 ◽  
Author(s):  
Miguel A. Del Río-Portilla ◽  
Carmen E. Vargas-Peralta ◽  
Fabiola Lafarga-De La Cruz ◽  
Lenin Arias-Rodriguez ◽  
Rigoberto Delgado-Vega ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Tropical Gar ◽  
Atractosteus Tropicus

scholarly journals SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy

2018 ◽  
Vol 18 (6) ◽  
pp. 484-493 ◽  
Author(s):  
Xiang Cheng ◽  
Jianying Li ◽  
Deliang Guo
Keyword(s):  
Lipid Metabolism ◽  
Cancer Therapy ◽  
Transcriptional Activation ◽  
Molecular Mechanisms ◽  
Regulatory Element ◽  
Lipid Synthesis ◽  
Feedback Regulation ◽  
Negative Feedback Regulation ◽  
Expression Of Genes ◽  
New Findings

Lipid metabolism reprogramming emerges as a new hallmark of malignancies. Sterol regulatory element-binding proteins (SREBPs), which are central players in lipid metabolism, are endoplasmic reticulum (ER)-bound transcription factors that control the expression of genes important for lipid synthesis and uptake. Their transcriptional activation requires binding to SREBP cleavageactivating protein (SCAP) to translocate their inactive precursors from the ER to the Golgi to undergo cleavage and subsequent nucleus translocation of their NH2-terminal forms. Recent studies have revealed that SREBPs are markedly upregulated in human cancers, providing the mechanistic link between lipid metabolism alterations and malignancies. Pharmacological or genetic inhibition of SCAP or SREBPs significantly suppresses tumor growth in various cancer models, demonstrating that SCAP/SREBPs could serve as promising metabolic targets for cancer therapy. In this review, we will summarize recent progress in our understanding of the underlying molecular mechanisms regulating SCAP/SREBPs and lipid metabolism in malignancies, discuss new findings about SREBP trafficking, which requires SCAP N-glycosylation, and introduce a newly identified microRNA-29-mediated negative feedback regulation of the SCAP/SREBP pathway. Moreover, we will review recently developed inhibitors targeting the SCAP/SREBP pathway for cancer treatment.

scholarly journals Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovine Parthenogenetic Embryos Revealed by Fluorescent Staining and RNA-seq

2020 ◽  
Vol 21 (18) ◽  
pp. 6488
Author(s):  
Arkadiusz Kajdasz ◽  
Ewelina Warzych ◽  
Natalia Derebecka ◽  
Zofia E. Madeja ◽  
Dorota Lechniak ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lipid Metabolism ◽  
Inner Cell Mass ◽  
Mammalian Species ◽  
Cell Mass ◽  
Blastocyst Stage ◽  
Preimplantation Embryos ◽  
Rna Seq ◽  
Expression Of Genes ◽  
Bovine Blastocyst

Compared to other mammalian species, porcine oocytes and embryos are characterized by large amounts of lipids stored mainly in the form of droplets in the cytoplasm. The amount and the morphology of lipid droplets (LD) change throughout the preimplantation development, however, relatively little is known about expression of genes involved in lipid metabolism of early embryos. We compared porcine and bovine blastocyst stage embryos as well as dissected inner cell mass (ICM) and trophoblast (TE) cell populations with regard to lipid droplet storage and expression of genes functionally annotated to selected lipid gene ontology terms using RNA-seq. Comparing the number and the volume occupied by LD between bovine and porcine blastocysts, we have found significant differences both at the level of single embryo and a single blastomere. Aside from different lipid content, we found that embryos regulate the lipid metabolism differentially at the gene expression level. Out of 125 genes, we found 73 to be differentially expressed between entire porcine and bovine blastocyst, and 36 and 51 to be divergent between ICM and TE cell lines. We noticed significant involvement of cholesterol and ganglioside metabolism in preimplantation embryos, as well as a possible shift towards glucose, rather than pyruvate dependence in bovine embryos. A number of genes like DGAT1, CD36 or NR1H3 may serve as lipid associated markers indicating distinct regulatory mechanisms, while upregulated PLIN2, APOA1, SOAT1 indicate significant function during blastocyst formation and cell differentiation in both models.

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