Imaging-Based Multiscale Models of the Respiratory System That Account for Regional Heterogeneity in Health and Disease

2013 ◽  
Author(s):  
S. Kabilan ◽  
D. R. Einstein ◽  
R. E. Jacob ◽  
J. P. Carson ◽  
A. P. Kuprat ◽  
...  
Keyword(s):  
Differential Equations ◽  
Fluid Dynamic ◽  
Three Dimensional ◽  
Aerosol Deposition ◽  
Computational Techniques ◽  
Multiscale Models ◽  
Regional Heterogeneity ◽  
Disease States ◽  
Cfd Models ◽  
Health And Disease

Multiscale computational fluid dynamic (CFD) models are fast gaining importance in the field of respiratory systems modeling due to recent advancements in experimental and computational techniques. These models couple imaging-based, physiologically realistic, three-dimensional (3D) geometries to lower-dimensional ordinary differential equations (ODE) or partial differential equations (PDE) that represent the unseen lung. Local deviations from nominal heterogeneity and compliance in disease states such as emphysema and fibrosis have both important clinical and pathological implications. Hence, it is important to incorporate regional heterogeneity in the CFD models while modeling airflow characteristics, aerosol deposition, drug delivery, and risk assessment.

Uptake of Soluble Gases in the Entire Respiratory Systems of Rats and Humans Using Transient CFD/PBPK Models

2013 ◽  
Author(s):  
S. Kabilan ◽  
A. Kuprat ◽  
D. Einstein ◽  
J. Carson ◽  
R. Jacob ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Hydrogen Sulfide ◽  
Three Dimensional ◽  
Aerosol Deposition ◽  
Water Soluble ◽  
Computational Techniques ◽  
Nasal Airways ◽  
Cfd Models ◽  
Pbpk Models ◽  
Computational Fluid Dynamics Cfd

With the advancement of experimental and computational techniques, three-dimensional (3D) computational fluid dynamics (CFD) airflow models of the respiratory system have increasingly been used to evaluate aerosol deposition, gas exchange and airflow characteristics under various physiological and/or disease conditions. One specific application that is emerging in the field of toxicology is assessing the risk for exposure to highly reactive, water-soluble gases and vapors including formaldehyde, acetaldehyde, hydrogen sulfide, and acrolein by coupling CFD models of nasal airways of rats and humans to physiological based pharmacokinetic (PBPK) models.

Hypoxic Pulmonary Vasoconstriction and Chronic Lung Disease

2013 ◽  
Vol 12 (3) ◽  
pp. 135-144 ◽  
Author(s):  
Erik R. Swenson
Keyword(s):  
Pulmonary Hypertension ◽  
Lung Disease ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
World Health ◽  
Disease States ◽  
Pulmonary Vasoconstriction ◽  
Local Ventilation ◽  
Pulmonary Vascular Endothelium ◽  
Health And Disease ◽  
Health Organization

Hypoxic vasoconstriction in the lung is a unique and fundamental characteristic of the pulmonary circulation. It functions in health and disease states to better preserve ventilation-perfusion matching by diverting blood flow to better ventilated regions when local ventilation is compromised. As more areas of lung become hypoxic either with high altitude or global lung disease, then hypoxic pulmonary vasoconstriction (HPV) becomes less effective in ventilation-perfusion matching and can lead to pulmonary hypertension. HPV is intrinsic to the vascular smooth muscle and its mechanisms remain poorly understood. In addition, the pulmonary vascular endothelium, red cells, lung innervation, and numerous circulating vasoactive agents also affect the strength of HPV. This review will discuss the pathophysiology of HPV and address its role in pulmonary hypertension associated with World Health Organization Group 3 diseases. When sustained beyond many hours, HPV may initiate pulmonary vascular remodeling and lead to more fixed and less oxygen-responsive pulmonary hypertension if the hypoxic stimulus is maintained.

In Vitro Immunodetection of Prothymosin Alpha in Normal and Pathological Conditions

2020 ◽  
Vol 27 (29) ◽  
pp. 4840-4854 ◽  
Author(s):  
Chrysoula-Evangelia Karachaliou ◽  
Hubert Kalbacher ◽  
Wolfgang Voelter ◽  
Ourania E. Tsitsilonis ◽  
Evangelia Livaniou
Keyword(s):  
Mammalian Cells ◽  
Therapeutic Potential ◽  
Prothymosin Alpha ◽  
Disease States ◽  
Leading Role ◽  
Tissue Extracts ◽  
Biologic Response ◽  
Health And Disease ◽  
Almost All

Prothymosin alpha (ProTα) is a highly acidic polypeptide, ubiquitously expressed in almost all mammalian cells and tissues and consisting of 109 amino acids in humans. ProTα is known to act both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similar to molecules termed as “alarmins”. Antibodies and immunochemical techniques for ProTα have played a leading role in the investigation of the biological role of ProTα, several aspects of which still remain unknown and contributed to unraveling the diagnostic and therapeutic potential of the polypeptide. This review deals with the so far reported antibodies along with the related immunodetection methodology for ProTα (immunoassays as well as immunohistochemical, immunocytological, immunoblotting, and immunoprecipitation techniques) and its application to biological samples of interest (tissue extracts and sections, cells, cell lysates and cell culture supernatants, body fluids), in health and disease states. In this context, literature information is critically discussed, and some concluding remarks are presented.

scholarly journals Coupled Fluid–Solid Numerical Simulation for Flow Field Characteristics and Supporting Performance of Flexible Support Cylindrical Gas Film Seal

Aerospace ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 97
Author(s):  
Junfeng Sun ◽  
Meihong Liu ◽  
Zhen Xu ◽  
Taohong Liao ◽  
Xiangping Hu ◽  
...  
Keyword(s):  
Flow Field ◽  
Film Thickness ◽  
Fluid Dynamic ◽  
Structural Characteristics ◽  
Structural Parameters ◽  
Equivalent Stress ◽  
Three Dimensional ◽  
High Rotational Speed ◽  
Flexible Support ◽  
Flow Field Characteristics

A new type of cylindrical gas film seal (CGFS) with a flexible support is proposed according to the working characteristics of the fluid dynamic seal in high-rotational-speed fluid machinery, such as aero-engines and centrifuges. Compared with the CGFS without a flexible support, the CGFS with flexible support presents stronger radial floating characteristics since it absorbs vibration and reduces thermal deformation of the rotor system. Combined with the structural characteristics of a film seal, an analytical model of CGFS with a flexible wave foil is established. Based on the fluid-structure coupling analysis method, the three-dimensional flow field of a straight-groove CGFS model is simulated to study the effects of operating and structural parameters on the steady-state characteristics and the effects of gas film thickness, eccentricity, and the number of wave foils on the equivalent stress of the flexible support. Simulation results show that the film stiffness increases significantly when the depth of groove increases. When the gas film thickness increases, the average equivalent stress of the flexible support first decreases and then stabilizes. Furthermore, the number of wave foils affects the average foils thickness. Therefore, when selecting the number of wave foils, the support stiffness and buffer capacity should be considered simultaneously.

scholarly journals A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2428
Author(s):  
Małgorzata Guz ◽  
Witold Jeleniewicz ◽  
Anna Malm ◽  
Izabela Korona-Glowniak
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Current Knowledge ◽  
Vital Role ◽  
Disease States ◽  
Health And Disease ◽  
Dietary Components ◽  
Non Coding Rnas

A still growing interest between human nutrition in relation to health and disease states can be observed. Dietary components shape the composition of microbiota colonizing our gastrointestinal tract which play a vital role in maintaining human health. There is a strong evidence that diet, gut microbiota and their metabolites significantly influence our epigenome, particularly through the modulation of microRNAs. These group of small non-coding RNAs maintain cellular homeostasis, however any changes leading to impaired expression of miRNAs contribute to the development of different pathologies, including neoplastic diseases. Imbalance of intestinal microbiota due to diet is primary associated with the development of colorectal cancer as well as other types of cancers. In the present work we summarize current knowledge with particular emphasis on diet-microbiota-miRNAs axis and its relation to the development of colorectal cancer.

scholarly journals On the relations between some well-known methods and the projective Riccati equations

Open Physics ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 613-618
Author(s):  
Şamil Akçağıl
Keyword(s):  
Partial Differential Equations ◽  
Differential Equations ◽  
Evolution Equations ◽  
Nonlinear Evolution ◽  
Riccati Equations ◽  
Nonlinear Evolution Equations ◽  
Alternative Methods ◽  
Computational Techniques ◽  
Partial Differential ◽  
Traditional Methods

AbstractSolving nonlinear evolution equations is an important issue in the mathematical and physical sciences. Therefore, traditional methods, such as the method of characteristics, are used to solve nonlinear partial differential equations. A general method for determining analytical solutions for partial differential equations has not been found among traditional methods. Due to the development of symbolic computational techniques many alternative methods, such as hyperbolic tangent function methods, have been introduced in the last 50 years. Although all of them were introduced as a new method, some of them are similar to each other. In this study, we examine the following four important methods intensively used in the literature: the tanh–coth method, the modified Kudryashov method, the F-expansion method and the generalized Riccati equation mapping method. The similarities of these methods attracted our attention, and we give a link between the methods and a system of projective Riccati equations. It is possible to derive new solution methods for nonlinear evolution equations by using this connection.

The inlet flow structure of a conceptual open-nose supersonic drone

2021 ◽  
pp. 095441002098304
Author(s):  
Eiman B Saheby ◽  
Xing Shen ◽  
Anthony P Hays ◽  
Zhang Jun
Keyword(s):  
Flow Structure ◽  
Stokes Equations ◽  
Fluid Dynamic ◽  
Three Dimensional ◽  
Computational Fluid Dynamic Simulation ◽  
Navier Stokes ◽  
Ansys Fluent ◽  
Navier Stokes Equations ◽  
Aerodynamic Efficiency ◽  
Performance Effects

This study describes the aerodynamic efficiency of a forebody–inlet configuration and computational investigation of a drone system, capable of sustainable supersonic cruising at Mach 1.60. Because the whole drone configuration is formed around the induction system and the design is highly interrelated to the flow structure of forebody and inlet efficiency, analysis of this section and understanding its flow pattern is necessary before any progress in design phases. The compression surface is designed analytically using oblique shock patterns, which results in a low drag forebody. To study the concept, two inlet–forebody geometries are considered for Computational Fluid Dynamic simulation using ANSYS Fluent code. The supersonic and subsonic performance, effects of angle of attack, sideslip, and duct geometries on the propulsive efficiency of the concept are studied by solving the three-dimensional Navier–Stokes equations in structured cell domains. Comparing the results with the available data from other sources indicates that the aerodynamic efficiency of the concept is acceptable at supersonic and transonic regimes.

scholarly journals Comparison of Voxel‐Based and Mesh‐Based CFD Models for Aerosol Deposition on Complex Fibrous Filters

2021 ◽  
Vol 44 (6) ◽  
pp. 1153-1153
Author(s):  
Dennis Hoch ◽  
Mehdi Azimian ◽  
André Baumann ◽  
Jens Behringer ◽  
Jennifer Niessner
Keyword(s):  
Aerosol Deposition ◽  
Cfd Models ◽  
Fibrous Filters

scholarly journals Mathematical analysis of bio-convective micropolar nanofluid

2019 ◽  
Vol 6 (3) ◽  
pp. 233-242 ◽  
Author(s):  
Sohail Nadeem ◽  
Muhammad Naveed Khan ◽  
Noor Muhammad ◽  
Shafiq Ahmad
Keyword(s):  
Differential Equations ◽  
Microbial Fuel Cells ◽  
Shooting Method ◽  
Stretching Sheet ◽  
Volume Fraction ◽  
Three Dimensional ◽  
Convection Flow ◽  
Micropolar Nanofluid ◽  
Exponentially Stretching ◽  
Micro Organisms

Abstract The present investigation concentrates on three dimensional unsteady forced bio-convection flow of a viscous fluid. An incompressible flow of a micropolar nanofluid encloses micro-organisms past an exponentially stretching sheet with magnetic field is analyzed. By employing convenient transformation the partial differential equations are converted into the ordinary differential equations which are non-linear. By using shooting method to solved these equations numerically. The influence of the determining parameters on the velocity, temperature, micro-rotation, nanoparticle volume fraction, microorganism are incorporated. The skin friction, heat transfer rate, and the microorganism rate are analyzed. The results depicts that the value of the wall shear stress and Nusselt number are declined while an enhancement take place in the microorganism number. The slip parameters increases the velocity, thermal energy, and microorganism number consequentially. The present investigation are important in improving achievement of microbial fuel cells.

scholarly journals Fish larvae exploit edge vortices along their dorsal and ventral fin folds to propel themselves

2016 ◽  
Vol 13 (116) ◽  
pp. 20160068 ◽  
Author(s):  
Gen Li ◽  
Ulrike K. Müller ◽  
Johan L. van Leeuwen ◽  
Hao Liu
Keyword(s):  
Larval Fish ◽  
Fish Larvae ◽  
Fluid Dynamic ◽  
Three Dimensional ◽  
Reynolds Numbers ◽  
Bony Fish ◽  
The Body ◽  
Functional Explanation ◽  
Image Velocimetry ◽  
Median Fins

Larvae of bony fish swim in the intermediate Reynolds number ( Re ) regime, using body- and caudal-fin undulation to propel themselves. They share a median fin fold that transforms into separate median fins as they grow into juveniles. The fin fold was suggested to be an adaption for locomotion in the intermediate Reynolds regime, but its fluid-dynamic role is still enigmatic. Using three-dimensional fluid-dynamic computations, we quantified the swimming trajectory from body-shape changes during cyclic swimming of larval fish. We predicted unsteady vortices around the upper and lower edges of the fin fold, and identified similar vortices around real larvae with particle image velocimetry. We show that thrust contributions on the body peak adjacent to the upper and lower edges of the fin fold where large left–right pressure differences occur in concert with the periodical generation and shedding of edge vortices. The fin fold enhances effective flow separation and drag-based thrust. Along the body, net thrust is generated in multiple zones posterior to the centre of mass. Counterfactual simulations exploring the effect of having a fin fold across a range of Reynolds numbers show that the fin fold helps larvae achieve high swimming speeds, yet requires high power. We conclude that propulsion in larval fish partly relies on unsteady high-intensity vortices along the upper and lower edges of the fin fold, providing a functional explanation for the omnipresence of the fin fold in bony-fish larvae.

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