Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicentre study (iFAME-Fertility)

ObjectivesThe impact of inflammatory arthritis (IA) on male fertility remains unexplored. Our objective was to evaluate the impact of IA on several male fertility outcomes; fertility rate (number of biological children per man), family planning, childlessness and fertility problems.MethodsWe performed a multicentre cross-sectional study (iFAME-Fertility). Men with IA 40 years or older who indicated that their family size was complete were invited to participate. Participants completed a questionnaire that included demographic, medical and fertility-related questions. To analyse the impact of IA on fertility rate, patients were divided into groups according to the age at the time of their diagnosis: ≤30 years (before the peak of reproductive age), between 31 and 40 years (during the peak) and ≥41 years (after the peak).ResultsIn total 628 participants diagnosed with IA were included. Men diagnosed ≤30 years had a lower mean number of children (1.32 (SD 1.14)) than men diagnosed between 31 and 40 years (1.60 (SD 1.35)) and men diagnosed ≥41 years (1.88 (SD 1.14)).This was statistically significant (p=0.0004).The percentages of men diagnosed ≤30 and 31–40 years who were involuntary childless (12.03% vs 10.34% vs 3.98%, p=0.001) and who reported having received medical evaluations for fertility problems (20.61%, 20.69% and 11.36%, p=0.027) were statistically significant higher than men diagnosed ≥41 years.ConclusionsThis is the first study that shows that IA can impair male fertility. Men diagnosed with IA before and during the peak of reproductive age had a lower fertility rate, higher childlessness rate and more fertility problems. Increased awareness and more research into the causes behind this association are urgently needed.

Download Full-text

Epidemiology of High Fertility Status among Women of Reproductive Age in Wonago District, Gedeo Zone, Southern Ethiopia: A Community-Based Cross-Sectional Study

International Journal of Reproductive Medicine ◽

10.1155/2020/2915628 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Medhin Girmay Reda ◽

Girma Tenkolu Bune ◽

Mohammed Feyisso Shaka

Keyword(s):

Cross Sectional Study ◽

Fertility Rate ◽

Reproductive Age ◽

High Fertility ◽

Age At First Birth ◽

Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Number Of Children ◽

Fertility Status

Background. High fertility remains one of the most important public health issues hampering the health and welfare of mothers and the survival of their children in developing nations. In Ethiopia, the high fertility rate has been seen for a long historical period with some pocket areas of high fertility still showing poor improvement. Hence, this study was aimed at determining the magnitude of high fertility status (number of children ever born alive≥5) and associated factors among women of the reproductive age group in Wonago district. Methods. A community-based cross-sectional study was conducted on randomly selected 512 women in Wonago district. Data were collected using a pretested structured interviewer administered questionnaire. Data was entered into EpiData version 3.1 and then analyzed by SPSS version 25. Logistic regression was used to analyze the data, and the adjusted odds ratio with the 95% confidence interval was computed, and a significant association was declared at p value ≤ 0.05. Result. This study revealed that 354 (69.1%) of the respondents have high fertility. High fertility is independently associated with residing in rural area [AOR=4.88, 95% CI: 3.21, 7.86], desire for children [AOR=6.97, 95% CI: 3.24, 11.40], history of under-five child mortality [AOR =5.32, 95% CI: 2.59, 8.43], poor knowledge of contraception [AOR=2.67, 95% CI: 1.66, 4.04], and low wealth tertile [AOR=2.21, 95% CI: 1.51, 3.58]. On the other hand, women with age at first birth above 18 years [AOR=0.34, 95% CI: 0.17, 0.68] and those with birth interval≥24 months [AOR=0, 26, 95% CI: 0.14, 0.49] were less likely to have high fertility. Conclusion and Recommendation. The substantial number of women in the study area has high fertility status far away from the country’s costed implementation plan of reducing the total fertility rate to 3.0. Considering these, much is needed to be done among poor, rural residents, who have not yet attained their desired number of children, and on enhancing the knowledge of mothers towards contraceptive methods.

Download Full-text

The Impact of Bariatric Surgery on Menstrual Abnormalities—a Cross-Sectional Study

Obesity Surgery ◽

10.1007/s11695-020-04840-6 ◽

2020 ◽

Vol 30 (11) ◽

pp. 4505-4509

Author(s):

Anna Różańska-Walędziak ◽

Paweł Bartnik ◽

Joanna Kacperczyk-Bartnik ◽

Krzysztof Czajkowski ◽

Maciej Walędziak

Keyword(s):

Bariatric Surgery ◽

Menstrual Cycle ◽

Cross Sectional Study ◽

Reproductive Age ◽

Obese Women ◽

Sectional Study ◽

Cross Sectional ◽

Contraception Use ◽

Before And After ◽

The Impact

Abstract Introduction Obesity is associated with hyperestrogenism along with other hormonal abnormalities affecting the menstrual cycle. The most effective and decisive method of obesity treatment is bariatric surgery. The aim of this study was to analyze the impact of bariatric surgery on menstrual cycle, the incidence of menstrual abnormalities, hyperandrogenism manifestation, and contraception use. Materials and Methods It was a cross-sectional study of 515 pre-menopausal women who had undergone bariatric surgery between 1999 and 2017 in a bariatric center. Data was collected via anonymous questionnaire, and the questions covered a 1-year period before the surgery and the last year before questionnaire completion. Results Before the surgery, 38.6% of the patients reported irregular menstruations in comparison with 25.0% after bariatric surgery (RR = 0.65; 95%CI 0.53–0.79). The mean number of menstruations per year did not differ before and after surgery (10.2 ± 3.9 vs 10.4 ± 3.3; p < .45). There were no statistically significant differences in terms of prolonged menstruations, acne, and hirsutism prevalence. A total of 14.4% of patients before surgery reported estrogen-based contraception use in comparison with 15.0% after the surgery (p < .95). There were no significant differences in the frequency of OC use (11.0% before surgery vs 13.6% 12 months after the surgery vs 11.5% at the moment of survey administration; p < 0.46). Conclusion Bariatric surgery improves the regularity of the menstrual cycle in obese women in reproductive age. The lack of any changes in the combined hormonal contraception (CHC) use, especially OC, before and after bariatric surgery may be a result of a possibly low level of contraception counseling.

Download Full-text

Contraception and Sexsual Activity as Factor Influenced Leucorrhea

Jurnal Berkala Epidemiologi ◽

10.20473/jbe.v5i32017.371-382 ◽

2017 ◽

Vol 5 (3) ◽

pp. 371

Author(s):

Sari Priyanti

Keyword(s):

Hormonal Contraception ◽

Cross Sectional Study ◽

Childbearing Age ◽

Cross Sectional ◽

The Public ◽

First Sexual Intercourse ◽

Number Of Children ◽

Study Population ◽

The Impact ◽

First Time

ABSTRACTCervical cancer was non communicable desease that worries the public and causes an increase mortality in women. One of the first sign causes of cervical cancer is occourrence of Leucorrhoe. The incidence of Leucorrhoe in women Indonesia by 90% of which >75% of women experience once of leucorrhoe and experience ≥ 2 times by 25%. Leucorrhoe should not be considered an ordinary thing because can be caused to itchy on genetalia, pain during sexsual, infection can be caused odema on genetalia, hot like burned on vagina even the impact if not treated promptly will caused infertility and cancer. Aims of study was to analyze factors of influenced on Leucorrhoe incident. Design of study was cross sectional study. Population was women of childbearing age who use contraceptives in the karang jeruk village, Jatirejo sub district, Mojokerto district in March of 2017. Sample in this study was 33 people. Data analyze with logistic regresion. Result of study showed contraceptive and sexsual activity has significant influenced with leucorrhoe (PR = 10.000; 95% CI= 1,732-57,722 dan PR=8,750; 95% CI=1,466-52,232). Suggestion: should be married and have first sexual intercourse for the first time at the age of ≥ 20 years, limit the number of children not more than 2 as the greater the number of children the greater the risk of Leucorrhoe, and not using hormonal contraception for a along time that more than 2 years. Keywords: contraceptive,sexsual activity, leucorrhoe

Download Full-text

Reduction of Testosterone Levels in Schistosoma Haematobium or Schistosoma Mansoni Infected Men: A Cross-Sectional Study in Two Schistosomiasis-Endemic Areas of the Adamawa Region of Cameroon

10.21203/rs.3.rs-915844/v1 ◽

2021 ◽

Author(s):

Hermine BOUKENG JATSA ◽

Ulrich MEMBE FEMOE ◽

Calvine NOUMEDEM DONGMO ◽

Romuald Issiaka NGASSAM KAMWA ◽

Betrand NONO FESUH ◽

...

Keyword(s):

Genital Tract ◽

Reproductive Function ◽

Serum Testosterone ◽

Cross Sectional Study ◽

Reproductive Age ◽

Serum Testosterone Level ◽

Cross Sectional ◽

Endemic Areas ◽

Age Range ◽

The Impact

Abstract Background: The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated comparing to female genital schistosomiasis. This study aimed to investigate the impact of S. haematobium or S. mansoni infection on the reproductive function of adult men in Tibati and Wouldé, two schistosomiasis endemic areas in the Adamawa region of Cameroon.Methods: A total of 89 men in the reproductive age (range: 14 – 56 years) from two localities were enrolled in the study with 51 in Tibati and 38 in Wouldé. Each participant was submitted to a questionnaire to document data on sociodemographic and stream contact behaviors. A medical examination was performed to measure the circumference of the testes and to evaluate genital tract pathologies. Stool and urine samples were collected and screened for the presence of S. haematobium or S. mansoni ova. Blood serum was use to evaluate the level of transaminases and testosterone.Results: S. haematobium was present only in Tibati with a prevalence of 31.37%. S. mansoni prevalence was 3.92% at Tibati and 44.71% in Wouldé. The intensity of infection was 22.12 ± 9.57 eggs/10 mL for S. haematobium and 128.10 ± 3.76 epg for S. mansoni. Serum transaminases activity and the mean testicular circumference of Schistosoma-positive individuals were close to those of negative ones. The testes size was however higher in S. mansoni-positive individuals than in S. haematobium-positive ones (P < 0.05). The serum testosterone level of S. haematobium and S. mansoni-positive men was significantly reduced by 56.07% (P < 0.001) and 51.94% (P < 0.01) respectively in comparison to that of Schistosoma-negative ones. A significant and negative correlation was established between schistosomiasis and the low level of serum testosterone. Male genital tract pathologies such as scrotal abnormalities, varicocele, nodular epididymis, inguinal hernia and hydrocele were recorded in both Schistosoma-positive and Schistosoma-negative men. However, no significant link was established between schistosomiasis infection and these pathologies.Conclusion: These results demonstrated that infection with S. haematobium or S. mansoni is associated with a low production of the reproductive hormone testosterone, and may be a major cause of male infertility.

Download Full-text

Knowledge, Preference, and Willingness to Pay for Hepatitis B Vaccination Services among Woman of Reproductive Age in Vietnam

BioMed Research International ◽

10.1155/2019/9154918 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7

Author(s):

Anh Tuan Le Nguyen ◽

Xuan Thanh Thi Le ◽

Toan Thanh Thi Do ◽

Cuong Tat Nguyen ◽

Long Hoang Nguyen ◽

...

Keyword(s):

Hepatitis B ◽

Willingness To Pay ◽

Cross Sectional Study ◽

Reproductive Age ◽

Hepatitis B Vaccination ◽

Critical Approach ◽

Cross Sectional ◽

Hbv Vaccine ◽

Number Of Children ◽

Hbv Vaccination

Background. Hepatitis B virus (HBV) vaccine is a critical approach to prevent HBV transmission from mother to child. However, despite high HBV prevalence, evidence about the preference of women of productive age for HBV vaccine in Vietnam was constrained. This study aims to explore the preference and willingness to pay (WTP) for the HBV vaccine in Vietnamese women in productive age. Methods. A cross-sectional study was conducted in Hanoi in April 2016. A structured questionnaire was used to collect information about respondents’ socioeconomic status and knowledge about HBV vaccination. A contingent valuation approach was employed to measure the WTP for the HBV vaccine. Logistic and interval regressions were used to determine the associated factors. Results. Among 807 women, 80.8% were willing to have the vaccine injected which had the average price of 108,600 VND (95% CI, 97,580 VND–119,570 VND). Participants not suffering any diseases during pregnancy were more likely to be willing to pay for the HBV vaccine (OR = 3.41, 95% CI = 1.73–6.70). Not having the antenatal examination at central hospitals and working as farmers/workers were positively correlated with willingness to pay for this vaccine, while the number of children of respondents had a negative correlation with WTP. Conclusions. Our sampled women expressed a high willingness to pay for the vaccine. The price people were willing to pay for the vaccine, however, is equal to half of the actual price. These findings implied needs for better targeted public education interventions about HBV and the involvement of local medical staffs and the media in providing information. Efforts to reduce the price of the vaccine should also be warranted for scaling-up the coverage of this vaccine.

Download Full-text

Study on the Acceptance of Contraceptive Devices Among Married Female Workers of a Garments Factory of Dhaka City

Bangladesh Journal of Physiology and Pharmacology ◽

10.3329/bjpp.v24i1.5731 ◽

1970 ◽

pp. 10-13

Author(s):

Mahjabeen Sultana Begum ◽

Md Altaf Hussain

Keyword(s):

Health Workers ◽

Cross Sectional Study ◽

Reproductive Age ◽

Contraceptive Methods ◽

Cross Sectional ◽

Female Workers ◽

Contraceptive Devices ◽

Desired Family Size ◽

Married Female ◽

The Impact

Over the last decade, the number of garments factories in Bangladesh had increased and employed around 1.5 million women, most of them in their reproductive age, therefore, desired family size and child spacing influenced contraceptive prevalence among the married women.This cross sectional study was conducted in Chancellor Garments Factory, Rayer Bazar, Dhaka, to find out the acceptance of contraceptive methods among the married female workers.Out of 121 workers interviewed, the knowledge of respondents on contraceptive methods was found adequate in 83.47%, some knowledge in 15.70% and no knowledge in 0.83%. 27.5% respondents acquired their knowledge from clinics and 25.83% from health workers. Only 13.22% respondents had the knowledge on non contraceptive uses of condom and 50% of them got this knowledge from radio and television. Of the 88.43% respondents who used contraceptive devices, maximum number used oral pill (57.94%) and only 0.93% used condom. Among the non users of contraceptive methods, 28.56% did not use because their husbands did not agree. Among the contraceptive users, 90.65% had consent of both the partners and 2.8% had the desire of their husbands only.Low income, lack of motivation by health workers, lack of information on contraception, less accessibility and availability of devices, cost of the devices, side effects, misconception, etc. have the impact on the contraceptive acceptance among the female garments workers. Key words: Married female workers, Garments factory, Acceptance of contraceptive method. DOI: 10.3329/bjpp.v24i1.5731Bangladesh J Physiol Pharmacol 2008; 24(1&2) : 10-13

Download Full-text

Demographic and Socio-Cultural Determinants of Intended and Unintended Pregnancies Among Women Under Cancer Treatment in Sistan and Baluchestan Province, Iran

Shiraz E-Medical Journal ◽

10.5812/semj.111304 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Khadijeh Asadisarvestani ◽

Maryam Navaee

Keyword(s):

Cancer Treatment ◽

Cross Sectional Study ◽

Influential Factors ◽

Reproductive Age ◽

Cross Sectional ◽

Number Of Children ◽

Unintended Pregnancies ◽

Wide Range ◽

One Year ◽

Sistan And Baluchestan

Background: One of the main concerns during cancer treatment is the occurrence of pregnancy due to its wide range of complications. Objectives: This study aimed to determine some influential factors on pregnancy during cancer treatment among women of reproductive ages that were under cancer treatment. Methods: This cross-sectional study investigated 133 women of reproductive age, who were under cancer treatment, as well as women who had undergone chemotherapy or radiotherapy up to one year ago in Sistan and Baluchestan Province. Data were collected from three medical centers in Zahedan from 2019 to 2020, using a researcher-made questionnaire. Results: Regarding the pregnancy rate, 23.0% of women had pregnancy during cancer treatment, including unintended (52.0%) and intended (48.0%) pregnancies that 55.0% of these pregnancies led to abortion, and 45.0% to livebirths. The results highlighted that during treatment women with and without pregnancy differed significantly in age (P = 0.001), ethnicity (P = 0.024), husband’s education level (P = 0.014), woman’s occupation (P = 0.021), couple’s agreement on number of children (P = 0.024), and physician consultation about contraceptives (P = 0.048). The main predictors of pregnancy were the woman’s age pregnancy (OR = 0.927, P = 0.011), occupation (OR = 0.358, P = 0.046), and ethnicity (OR = 2.49, P = 0.045). Conclusions: Considering the complications of pregnancy during cancer treatment, health planners should pay more attention to family planning for women under treatment, particularly in less developed regions.

Download Full-text

Factors Associated with Reproductive Age Couples’ Selection of Sterilization in the Era of the National Health Insurance Program

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v7i2.626 ◽

2019 ◽

pp. 110-115

Author(s):

Achmadi S Nugroho ◽

Azhari Azhari ◽

Awan Nurtjahyo ◽

Theodorus Theodorus

Keyword(s):

Cross Sectional Study ◽

Reproductive Age ◽

Cross Sectional ◽

Factors Associated ◽

Number Of Children ◽

Spss Software ◽

Husband Support ◽

Study Participants ◽

Logistic Regression Test ◽

Selection Of

Objective:To assess factors associated withselection of contraceptive sterilization in reproductive age couples in Dr. Mohammad Hoesin Palembang hospital in the era of BPJS. Methods: This cross sectional study was conducted between January - December 2017. Study sample was reproductive age couples (RAC) who were married and came to P2 UGD, maternity room and midwifery ward of Dr. Mohammad Hoesin Palembang hospital and metour inclusion criteria. All study participants were given a questionnaire to assess factors that influence selection of contraceptive methods in women. Data were analyzed using SPSS software version 17. Results: We found a significant relationship between number of children (PR = 3,988; p = 0.016), knowledge level (PR = 3,893; p = 0,024) and husband support (PR = 5,233; p = 0.009) with sterilization contraceptive selection. In addition, there were no significant correlation between age (PR = 2,311, p = 0,210), education level (PR = 1,893, p = 0,331), woman attitude (PR = 1,567, p = 0,758), availability of contraception ( (PR = 1,969, p = 0,342), officer attitude (PR = 1,088, p = 0,000) and information given by officer (PR = 1,378; p = 0,719) 1,310; p = 0.802) with selection of sterilization. With logistic regression test, we found that husband support was the most important factor to selection of sterilization contraception (PR = 4,266, p = 0,040) followed by knowledge (PR = 3,620, p = 0,041). Conclusion:Sterilization selection in reproductive age couples at Dr. Mohammad Hoesin Palembang Hospitalis influenced by female knowledge and husband support. Keywords:sterilization, tubal ligation, vasectomy, reproductive age couple

Download Full-text

Exposure to Bisphenol A Analogs and the Thyroid Function and Volume in Women of Reproductive Age—Cross-Sectional Study

Frontiers in Endocrinology ◽

10.3389/fendo.2020.587252 ◽

2021 ◽

Vol 11 ◽

Author(s):

Justyna Milczarek-Banach ◽

Dominik Rachoń ◽

Tomasz Bednarczuk ◽

Katarzyna Myśliwiec-Czajka ◽

Andrzej Wasik ◽

...

Keyword(s):

Bisphenol A ◽

Thyroid Function ◽

Thyroid Disease ◽

Cross Sectional Study ◽

Reproductive Age ◽

Sectional Study ◽

Women Of Reproductive Age ◽

Cross Sectional ◽

The Impact ◽

The Relationship

Bisphenols (BPs) are commonly known plastifiers that are widely used in industry. The knowledge about the impact of BPs on thyroid function is scarce. Proper thyroid functioning is especially important for women of reproductive age, as hypothyroidism affects fertility, pregnancy outcomes and the offspring. There are no studies analyzing the influence of BPs on thyroid function and volume in non-pregnant young women. The aim of this cross-sectional study was to evaluate the relationship between bisphenol A and its 10 analogs (BPS, BPC, BPE, BPF, BPG, BPM, BPP, BPZ, BPFL, and BPBP) on thyroid function and volume in women of reproductive age. Inclusion criteria were: female sex, age 18–40 years. Exclusion criteria were history of any thyroid disease, pharmacotherapy influencing thyroid function, pregnancy or puerperium, and diagnosis of autoimmune thyroid disease during this study. Venous blood was drawn for measurement of thyrotropin (TSH), free thyroxine, thyroid peroxidase antibodies, thyroglobulin antibodies, BPs. Urine samples were analyzed for: ioduria and BPs. Ultrasound examination of thyroid gland was performed. One hundred eighty participants were included into the study. A negative correlation was found between urine BPC and the thyroid volume (R = −0.258; p = 0.0005). Patients with detected urine BPC presented smaller thyroid glands than those with not-detected urine BPC (p = 0.0008). A positive correlation was found between TSH and urine BPC (R = 0.228; p = 0.002). Patients with detected urine BPC presented higher concentrations of TSH versus those with not-detected urine BPC (p = 0.003). There were no relationships between any of serum BPs as well as the other urine BPs and thyroid function and its volume. The only BP that demonstrated the relationship between thyroid function and its volume was BPC, probably because of its chemical structure that most resembles thyroxine. Exposure to this BP may result in the development of hypothyroidism that could have a negative impact on pregnancy and the offspring.

Download Full-text

Gravidity, contraceptive use and acceptability of a proposed three-baby policy in a municipality of Ghana.

10.21203/rs.3.rs-199399/v1 ◽

2021 ◽

Author(s):

Vivian Ametefi ◽

Emmanuel Appiah-Brempong ◽

Hasehni Vampere ◽

Gloria Obeng Nyarko ◽

Priscilla Aba Aggrey ◽

...

Keyword(s):

Formal Education ◽

Contraceptive Use ◽

Population Control ◽

Linear Regression Analysis ◽

Cross Sectional Study ◽

Reproductive Age ◽

African Countries ◽

Cross Sectional ◽

Number Of Children ◽

Modern Contraceptives

Abstract Background Childbirth and high Total Fertility Rate (TFR) among women is traditionally held in high esteem in many African societies. Therefore, bearing more children serves as a source of dignity to the mother and a resource to the family. However, the menace of large families and increasing populations is a global concern and to many African countries. The use of modern contraceptives is promoted to among other benefits, reduce pregnancies and TFR. A policy was also developed to limit the number of children per couple in Ghana to three. This study determined the factors associated with gravidity, the acceptability of the proposed three-baby per couple policy and the prevalence of modern contraceptives in a Ghanaian Municipality.Methods A descriptive cross-sectional study design was adopted and involved 350 women of reproductive age who had a history of past or present pregnancy. Data were collected using a structured questionnaire and analyzed using descriptive and inferential statistical analysis with the aid of STATA version14.Results The results indicated that 97.39% of the participants had knowledge of modern contraceptives and 33.91% were current users of modern contraceptives. Gravidity showed significant association with age, marital status, educational level, employment status and source of contraceptive (p < 0.001). Participants with no formal education had the highest gravidity (Mean ± SD = 6.0 ± 1.7). Also, 86.29% were aware of the proposed three-baby policy but only 28.37% were willing to accept the policy. A linear regression analysis showed a negative association between age and gravidity (p = 0.018; β= -0.008). The participants’ desired number of children was also statistically significant with gravidity (p < 0.001).Conclusion Efforts towards population control can be challenging due to the low use of modern contraceptives which is effective in reducing the TFR. Also the low acceptability of the proposed three-baby policy amongst reproductive women suggest their desire for more children.

Download Full-text