THEORETICALLY MODELING MICROARRAY WITH THE CHEMICAL EQUILIBRIUM AND THERMODYNAMICS

2005 ◽  
Vol 03 (02) ◽  
pp. 477-490
Author(s):  
MEI XU
Keyword(s):  
Data Analysis ◽  
Theoretical Model ◽  
Chemical Equilibrium ◽  
Chemical Thermodynamics ◽  
Microarray Technology ◽  
Microarray Hybridization ◽  
Fundamental Theory ◽  
Array Design ◽  
Cellular Processes ◽  
Hybridization Reaction

To date, the idea that microarray may shed the light on cellular processes by identifying groups of genes that appear to be co-expressed seems to remain a dream. This is partly because that there are some blank (meaning the knowledge is unavailable) or even erroneous areas in the fundamental theory in this field. This paper attempts to present the digest of microarray hybridization system with chemical thermodynamics, theoretically clarifying some misunderstandings and looking for answers to some critical questions around this technology, such as the mechanisms and conditions of quantitative measuring by hybridization reaction, the reasons of inconsistency of the data and the analysis results and the solutions, how to analyze the data, etc. A theoretical model for the next generation of microarray is proposed. We believe that this model is universal, laying the foundation for microarray technology from array design through the data analysis.

scholarly journals The Role of Eco-Friendly Edible Insect Restaurants in the Field of Sustainable Tourism

2020 ◽  
Vol 17 (11) ◽  
pp. 4064 ◽  
Author(s):  
Jinsoo Hwang ◽  
Hyunjoon Kim ◽  
Ja Young Choe
Keyword(s):  
Data Analysis ◽  
Theoretical Model ◽  
South Korea ◽  
Behavioral Intentions ◽  
Word Of Mouth ◽  
Sustainable Tourism ◽  
Positive Influence ◽  
Edible Insect

The purpose of this study is to apply the concept of a green image in order to explore how to form behavioral intentions in the context of eco-friendly edible insect restaurants. This study analyzed 444 samples collected in South Korea in order to evaluate the theoretical model including 12 hypotheses. The data analysis results showed that a green image has a positive influence on attitude. In addition, attitude helps to increase desire, which in turn positively affects two sub-dimensions of behavioral intentions, such as intentions to use and word-of-mouth intentions.

scholarly journals Humanizing care through the valuation of the human being: resignification of values and principles by health professionals

2007 ◽  
Vol 15 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Dirce Stein Backes ◽  
Magda Santos Koerich ◽  
Alacoque Lorenzini Erdmann
Keyword(s):  
Grounded Theory ◽  
Data Analysis ◽  
Theoretical Model ◽  
Qualitative Study ◽  
Professional Practice ◽  
Health Professionals ◽  
Human Being ◽  
Multiprofessional Team ◽  
Human Skills ◽  
South Of Brazil

This qualitative study aimed to find the values and principles steering health professionals' practice, in order to reach the values guiding humanization. The study took place between October and November 2005, when 17 professionals from a multiprofessional team at a hospital in the South of Brazil were interviewed in three different samples. The methodology used for comparative data analysis and interpretation was based on Grounded Theory, resulting in the creation of a theoretical model, guided by "humanizing care through the valuation of the human being". Data demonstrated that new competencies can be developed, which are capable of provoking a resignification of values and principles guiding humanization, with a view to reaching personal/professional accomplishments through work, allying technical and human skills in professional practice and experiencing humanized care.

scholarly journals Super-Resolution Microscopy of Chromatin

Genes ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 493 ◽  
Author(s):  
Birk
Keyword(s):  
Gene Regulation ◽  
Data Analysis ◽  
Super Resolution ◽  
Fluorescence Labeling ◽  
Cellular Processes ◽  
Direct Assessment ◽  
Chromatin Interactions ◽  
Resolution Imaging ◽  
Super Resolution Microscopy ◽  
Insight Into

Since the advent of super-resolution microscopy, countless approaches and studies have been published contributing significantly to our understanding of cellular processes. With the aid of chromatin-specific fluorescence labeling techniques, we are gaining increasing insight into gene regulation and chromatin organization. Combined with super-resolution imaging and data analysis, these labeling techniques enable direct assessment not only of chromatin interactions but also of the function of specific chromatin conformational states.

Investigating Determinants and Interaction Quality Effects on Tourists' Intention to Use Mobile Tourism Guide

2015 ◽  
Vol 12 (01) ◽  
pp. 1550005 ◽  
Author(s):  
Numtip Trakulmaykee ◽  
Parichard Benrit
Keyword(s):  
Data Analysis ◽  
Theoretical Model ◽  
Least Squares ◽  
Diffusion Theory ◽  
Relative Advantage ◽  
Intention To Use ◽  
Interaction Quality ◽  
Innovation Diffusion Theory ◽  
Innovation Characteristics ◽  
The Relationship

This study investigates model of tourist intention in the context of mobile tourism guide (MTG). We extend the innovation diffusion theory with the interaction quality construct. Partial least squares is used for data analysis. The results show four innovation characteristics such as relative advantage, compatibility, complexity and trialability significantly related to international tourists' intention to use MTG. Furthermore, the interaction quality has an impact on the relationship between lack of complexity and tourists' intention to use MTG. We propose theoretical model for mobile research and provides an important guideline for development and implementation.

scholarly journals The Curse of Normalization

2002 ◽  
Vol 3 (4) ◽  
pp. 375-379 ◽  
Author(s):  
Olaf Wolkenhauer ◽  
Carla Möller-Levet ◽  
Fatima Sanchez-Cabo
Keyword(s):  
Microarray Data ◽  
Regulation Of Gene Expression ◽  
Short Review ◽  
Biological Variation ◽  
Experimental Designs ◽  
Microarray Technology ◽  
Gene Expression Microarray ◽  
Expression Microarray ◽  
Cellular Processes ◽  
The Many

Despite its enormous promise to further our understanding of cellular processes involved in the regulation of gene expression, microarray technology generates data for which statistical pre-processing has become a necessity before any interpretation of data can begin. The process by which we distinguish (and remove) non-biological variation from biological variation is callednormalization. With a multitude of experimental designs, techniques and technologies influencing the acquisition of data, numerous approaches to normalization have been proposed in the literature. The purpose of this short review is not to add to the many suggestions that have been made, but to discuss some of the difficulties we encounter when analysing microarray data.

scholarly journals ColiCoords: A Python package for the analysis of bacterial fluorescence microscopy data

2019 ◽  
Author(s):  
Jochem H. Smit ◽  
Yichen Li ◽  
Eliza M. Warszawik ◽  
Andreas Herrmann ◽  
Thorben Cordes
Keyword(s):  
Data Analysis ◽  
Fluorescence Microscopy ◽  
Single Molecule ◽  
Statistical Significance ◽  
Reproducible Research ◽  
Cellular Processes ◽  
Analysis Package ◽  
Microscopy Data ◽  
The Cost ◽  
Single Molecule Localization Microscopy

AbstractSingle-molecule fluorescence microscopy studies of bacteria provide unique insights into the mechanisms of cellular processes and protein machineries in ways that are unrivalled by any other technique. With the cost of microscopes dropping and the availability of fully automated microscopes, the volume of microscopy data produced has increased tremendously. These developments have moved the bottleneck of throughput from image acquisition and sample preparation to data analysis. Furthermore, requirements for analysis procedures have become more stringent given the requirement of various journals to make data and analysis procedures available. To address this we have developed a new data analysis package for analysis of fluorescence microscopy data of rod-like cells. Our software ColiCoords structures microscopy data at the single-cell level and implements a coordinate system describing each cell. This allows for the transformation of Cartesian coordinates of both cellular images (e.g. from transmission light or fluorescence microscopy) and single-molecule localization microscopy (SMLM) data to cellular coordinates. Using this transformation, many cells can be combined to increase the statistical significance of fluorescence microscopy datasets of any kind. Coli-Coords is open source, implemented in the programming language Python, and is extensively documented. This allows for modifications for specific needs or to inspect and publish data analysis procedures. By providing a format that allows for easy sharing of code and associated data, we intend to promote open and reproducible research.The source code and documentation can be found via the project’s GitHub page.

scholarly journals Conception Profile of Students in Class XI.1 Science on Chemical Equilibrium Materials with Pogil Learning Model to Reduce Misconception

2020 ◽  
Vol 5 (9) ◽  
pp. 681-687
Author(s):  
Ifsantin Silma Rizqiyah ◽  
Suyatno Sutoyo ◽  
Leny Yuanita
Keyword(s):  
Data Analysis ◽  
Data Collection ◽  
Learning Strategies ◽  
Diagnostic Test ◽  
Subject Matter ◽  
Chemical Equilibrium ◽  
Learning Model ◽  
Learning Activities ◽  
Student Misconceptions ◽  
Chemistry Learning

Misconceptions can be caused due to a person's low understanding of a concept, as a result it will influence a person in understanding and connecting between existing knowledge principles. Several studies were conducted to find out what strategies can be used to reduce student misconceptions, especially in chemistry lessons. The purpose of this study is to describe the concept profile of students after using the POGIL learning model to reduce student misconceptions. The subjects in this study were students of class XI.1 Science who had received chemistry learning about chemical equilibrium. The data collection instruments used included observation sheets of learning activities and tests of understanding the concept of multiple choice reasoned and accompanied by the level of confidence of students (three tier). Data analysis was carried out descriptively with a three tier diagnostic test. The results of the analysis of the student's misconception profile that have been obtained are then mapped individually and personally. The results showed that the profile of students 'conception after learning using the POGIL learning model, most of the students' conceptions experienced positive changes with the translation of students with initial misconceptions, not knowing the concept changed to knowing the concept, and students who remained on the profile knew the concept but still there are students who are still in the misconception profile. Through the results of this study, it is hoped that it will be useful for education practitioners in choosing alternative learning strategies in delivering chemical equilibrium subject matter and as a reference for overcoming students who are still experiencing misconceptions.

scholarly journals Promoting a Safe Environment in Our Cities: Towards a Theoretical Model of “Moral Deficit” for Appropriate Psychopathic Therapy

2020 ◽  
Vol 17 (14) ◽  
pp. 4968
Author(s):  
David Coldwell ◽  
Sarah Coldwell
Keyword(s):  
Data Analysis ◽  
Theoretical Model ◽  
Urban Environment ◽  
Secondary Data ◽  
Urban Environments ◽  
Classical Approach ◽  
Safe Environment ◽  
Extant Literature ◽  
Therapeutic Measures ◽  
Selection Of

The increasing reported incidents of knife crime in cities and the release on parole of “rehabilitated” violent criminals are creating an unsafe urban environment. Such occurrences suggest that measures taken to address psychopathic-oriented behaviour may have been ineffective because the individual’s degree of “moral deficit” is not fully accounted for in the application of specific therapies. This study developed a theoretical model of “moral deficit” that is aligned with the appropriateness of therapy, ranging from the extreme “classical approach” of total confinement justified by a belief in the incurability of psychopaths to the modern therapy that aims to reintegrate the psychopath with society using “moralizing therapy”. Analysis of secondary data from extant literature was used to develop the theoretical model of “moral deficit”. Secondary data analysis suggests that the extent of psychopathic “moral deficit” may be an important factor in the selection of appropriate therapeutic measures for psychopathy treatment and the rehabilitation of psychopaths as law-abiding members of society. We conclude that a specific type of psychopathic moral deficit may have an important bearing on the appropriateness of treatment. It is recommended that the treatment of psychopathy makes greater provision for the extent and type of psychopathic “moral deficit” in assessing the most appropriate applications for the treatment of psychopathy and promoting the safety of urban environments.

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