Recurrent Neural Hidden Markov Model for High-order Transition

Author(s):  
Tatsuya Hiraoka ◽  
Sho Takase ◽  
Kei Uchiumi ◽  
Atsushi Keyaki ◽  
Naoaki Okazaki

We propose a method to pay attention to high-order relations among latent states to improve the conventional HMMs that focus only on the latest latent state, since they assume Markov property. To address the high-order relations, we apply an RNN to each sequence of latent states, because the RNN can represent the information of an arbitrary-length sequence with their cell: a fixed-size vector. However, the simplest way, which provides all latent sequences explicitly for the RNN, is intractable due to the combinatorial explosion of the search space of latent states. Thus, we modify the RNN to represent the history of latent states from the beginning of the sequence to the current state with a fixed number of RNN cells whose number is equal to the number of possible states. We conduct experiments on unsupervised POS tagging and synthetic datasets. Experimental results show that the proposed method achieves better performance than previous methods. In addition, the results on the synthetic dataset indicate that the proposed method can capture the high-order relations.

2014 ◽  
pp. 126-136
Author(s):  
Аndrey G. Velikanov

Considers the aspects of architecture as a language able to express the current state and to prophetically indicate the upcoming changes. The aesthetic value of a construction cannot be perceived just as a separate entity, but it can be cognized in the context and not only a visual one, in space. It is necessary to see the entire complex of the accompanying phenomena, all the flow of the unfolding metaphors and values. In the model in view the figure of the author-creator must be reconsidered as no longer conforming to today's reality. The development of the Stalinist Empire style, as well as its transformations, is considered as one of the specific phenomena in the history of well-known constructions


2020 ◽  
Author(s):  
Mariya Andriyanova ◽  
Aslanli Aslanli ◽  
Nataliya Basova ◽  
Viktor Bykov ◽  
Sergey Varfolomeev ◽  
...  

The collective monograph is devoted to discussing the history of creation, studying the properties, neutralizing and using organophosphorus neurotoxins, which include chemical warfare agents, agricultural crop protection chemical agents (herbicides and insecticides) and medicines. The monograph summarizes the results of current scientific research and new prospects for the development of this field of knowledge in the 21st century, including the use of modern physicochemical methods for experimental study and theoretical analysis of biocatalysis and its mechanisms based on molecular modeling with supercomputer power. The book is intended for specialists who are interested in the current state of research in the field of organophosphorus neurotoxins. The monograph will be useful for students, graduate students, researchers specializing in the field of physical chemistry, physicochemical biology, chemical enzymology, toxicology, biochemistry, molecular biology and genetics, biotechnology, nanotechnology and biomedicine.


2019 ◽  
Vol 14 (1-2) ◽  
pp. 295-297
Author(s):  
Sergej A. Borisov

For more than twenty years, the Institute of Slavic Studies of the Russian Academy of Sciences celebrates the Day of Slavic Writing and Culture with a traditional scholarly conference.”. Since 2014, it has been held in the young scholars’ format. In 2019, participants from Moscow, St. Petersburg, Kazan, Togliatti, Tyumen, Yekaterinburg, and Rostov-on-Don, as well as Slovakia, the Czech Republic, Hungary, and Romania continued this tradition. A wide range of problems related to the history of the Slavic peoples from the Middle Ages to the present time in the national, regional and international context were discussed again. Participants talked about the typology of Slavic languages and dialects, linguo-geography, socio- and ethnolinguistics, analyzed formation, development, current state, and prospects of Slavic literatures, etc.


Author(s):  
Andrey S. KIRILLOV ◽  
Aleksandr P. PYSHKO ◽  
Andrey A. ROMANENKO ◽  
Valery I. YARYGIN

The paper describes an overview of the history of development and the current state of JSC “SSC RF-IPPE” reactor research and test facility designed for assembly, research and full-scale life energy tests of space nuclear power plants with a thermionic reactor. The leading specialists involved in development and operation of this facility are represented. The most significant technological interfaces and upgrade operations carried out in the recent years are discussed. The authors consider the use of an oil-free pumping system as part of this facility during degassing and life testing. Proposed are up-to-date engineering solutions for development of the automated special measurement system designed to record NPP performance, including volt-ampere characteristics together with thermophysical and nuclear physical parameters of a ground prototype of the space nuclear power plant. Key words: reactor research and test facility, thermionic reactor, life energy tests, oil-free pumping system, automated special measurement system, volt-ampere characteristics.


2020 ◽  
Vol 2 (1) ◽  
pp. 115-130
Author(s):  
R. R. Palekha ◽  

Introduction. Right understanding is the most live, interesting and, at the same time, the uncertain and changeable area of researches which takes the central place as in the general theory of the right, and gains the increasing value in industry jurisprudence that is connected with its considerable teoretiko-methodological and applied potential which is shown in spheres of lawmaking and law-enforcement activity. Thus, right understanding represents research tools of the subject of knowledge which allow to study all range legal and, the based on them, state phenomena for the purpose of obtaining reliable knowledge of state and legal reality. In this regard integrative approach in right understanding which has rich history of the formation and development is of special interest, allows to perceive the right as integrally complete phenomenon, as much as possible retrieves its regulatory abilities and, provides achievement of criteria of scientific research: comprehensiveness, objectivity, historicism. Materials and Methods. In article an attempt of the analysis of integrative approach in right understanding from a position of history of origin of his ideas and assessment of the current state is made. A result of studying of scientific literature, generalization and comparison of the different points of view fat formulation of author’s determination of category “right understanding” and submission of the evidence-based integrative theory of right understanding which as much as possible conforms to requirements of time and has essential regulatory and guarding potential. Results. In article the category right understanding is comprehensively considered, different integrative theories of right understanding from a position of their origin and development are submitted, the value of modern integrative approach in right understanding is shown, perspectives of its further development are evaluated. Discussion and Conclusion. The author comes to the conclusion about the theoretical and methodological consistency and inevitability of the integrative approach in law understanding, which acts as a scientifically grounded type of legal thinking capable of comprehending the law on a truly scientific basis.


2020 ◽  
Vol 963 (9) ◽  
pp. 30-43
Author(s):  
M.Yu. Orlov

Studying the current state of cartography and ways of further developing the industry, the role of the map in the future of the society, new methods of promoting cartographic products is impossible without a deep scientific analyzing all the paths, events and factors influencing its formation and development throughout all the historic steps of cartographic production in Russia. In the article, the history of cartographic production in Russia is considered together with the development of private, state and military cartography, since, despite some differences, they have a common technical, technological and production basis. The author describes the stages of originating, formation and growth of industrial cartographic production from the beginning of the XVIII century until now. The connection between the change of political formations and technological structures with the mentioned stages of maps and atlases production is considered. Each stage is studied in detail, a step-by-step analysis was carried out, and the characteristics of each stage are described. All the events and facts are given in chronological order, highlighting especially significant moments influencing the evolution of cartographic production. The data on the volumes of printing and sales of atlases and maps by commercial and state enterprises are presented. The main trends and lines of further development of cartographic production in Russia are studied.


Author(s):  
Andrea Harris

The Conclusion briefly examines the current state of the New York City Ballet under the auspices of industrial billionaire David H. Koch at Lincoln Center. In so doing, it to introduces a series of questions, warranting still more exploration, about the rapid and profound evolution of the structure, funding, and role of the arts in America through the course of the twentieth century. It revisits the historiographical problem that drives Making Ballet American: the narrative that George Balanchine was the sole creative genius who finally created an “American” ballet. In contrast to that hagiography, the Conclusion reiterates the book’s major contribution: illuminating the historical construction of our received idea of American neoclassical ballet within a specific set of social, political, and cultural circumstances. The Conclusion stresses that the history of American neoclassicism must be seen as a complex narrative involving several authors and discourses and crossing national and disciplinary borders: a history in which Balanchine was not the driving force, but rather the outcome.


2019 ◽  
Vol 11 (2) ◽  
pp. 324-333
Author(s):  
Tobias Kelly

Abstract This short essay offers a broad and necessarily incomplete review of the current state of the human rights struggle against torture and ill-treatment. It sketches four widespread assumptions in that struggle: 1) that torture is an issue of detention and interrogation; 2) that political or security detainees are archetypal victims of torture; 3) that legal reform is one of the best ways to fight torture; and 4) that human rights monitoring helps to stamp out violence. These four assumptions have all played an important role in the history of the human rights fight against torture, but also resulted in limitations in terms of the interventions that are used, the forms of violence that human rights practitioners respond to, and the types of survivors they seek to protect. Taken together, these four assumptions have created challenges for the human rights community in confronting the multiple forms of torture rooted in the deep and widespread inequality experienced by many poor and marginalized groups. The essay ends by pointing to some emerging themes in the fight against torture, such as a focus on inequality, extra-custodial violence, and the role of corruption.


2021 ◽  
Vol 16 (2) ◽  
pp. 1-31
Author(s):  
Chunkai Zhang ◽  
Zilin Du ◽  
Yuting Yang ◽  
Wensheng Gan ◽  
Philip S. Yu

Utility mining has emerged as an important and interesting topic owing to its wide application and considerable popularity. However, conventional utility mining methods have a bias toward items that have longer on-shelf time as they have a greater chance to generate a high utility. To eliminate the bias, the problem of on-shelf utility mining (OSUM) is introduced. In this article, we focus on the task of OSUM of sequence data, where the sequential database is divided into several partitions according to time periods and items are associated with utilities and several on-shelf time periods. To address the problem, we propose two methods, OSUM of sequence data (OSUMS) and OSUMS + , to extract on-shelf high-utility sequential patterns. For further efficiency, we also design several strategies to reduce the search space and avoid redundant calculation with two upper bounds time prefix extension utility ( TPEU ) and time reduced sequence utility ( TRSU ). In addition, two novel data structures are developed for facilitating the calculation of upper bounds and utilities. Substantial experimental results on certain real and synthetic datasets show that the two methods outperform the state-of-the-art algorithm. In conclusion, OSUMS may consume a large amount of memory and is unsuitable for cases with limited memory, while OSUMS + has wider real-life applications owing to its high efficiency.


2021 ◽  
Vol 22 (3) ◽  
pp. 1388
Author(s):  
Natalia Maćkowska ◽  
Monika Drobna-Śledzińska ◽  
Michał Witt ◽  
Małgorzata Dawidowska

Distinct DNA methylation signatures, related to different prognosis, have been observed across many cancers, including T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematological neoplasm. By global methylation analysis, two major phenotypes might be observed in T-ALL: hypermethylation related to better outcome and hypomethylation, which is a candidate marker of poor prognosis. Moreover, DNA methylation holds more than a clinical meaning. It reflects the replicative history of leukemic cells and most likely different mechanisms underlying leukemia development in these T-ALL subtypes. The elucidation of the mechanisms and aberrations specific to (epi-)genomic subtypes might pave the way towards predictive diagnostics and precision medicine in T-ALL. We present the current state of knowledge on the role of DNA methylation in T-ALL. We describe the involvement of DNA methylation in normal hematopoiesis and T-cell development, focusing on epigenetic aberrations contributing to this leukemia. We further review the research investigating distinct methylation phenotypes in T-ALL, related to different outcomes, pointing to the most recent research aimed to unravel the biological mechanisms behind differential methylation. We highlight how technological advancements facilitated broadening the perspective of the investigation into DNA methylation and how this has changed our understanding of the roles of this epigenetic modification in T-ALL.


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