scholarly journals Tumour-Associated Macrophages (TAMs) in Colon Cancer and How to Reeducate Them

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
M. A. F. Yahaya ◽  
M. A. M. Lila ◽  
S. Ismail ◽  
M. Zainol ◽  
N. A. R. Nik Mohd Afizan
Keyword(s):  
Tumour Progression ◽  
Inflammatory Cells ◽  
Anticancer Therapy ◽  
Tumour Microenvironment ◽  
M1 Macrophages ◽  
Suitable Candidate ◽  
M1 Macrophage ◽  
The Subject ◽  
The Relationship

Tumour-associated macrophage (TAM) serves as the site in which most inflammatory cells coreside. It plays an important role in determining the progression and metastasis of a tumour. The characteristic of TAM is largely dependent on the stimuli present in its tumour microenvironment (TME). Under this environment, however, M2 macrophages are found to be in abundance compared to M1 macrophages which later promote tumour progression. Numerous studies have elucidated the relationship between TAM and the progression of tumour; hence, TAM has now been the subject of interest among researchers for anticancer therapy. This review discusses the role of TAM in colorectal cancer (CRC) and some of the potential candidates that could reeducate TAM to fight against CRC. It is with hope that this review will serve as the foundation in understanding TAM in CRC and helping other researchers to select the most suitable candidate to reeducate TAM that could assist in enhancing the tumouricidal activity of M1 macrophage and eventually repress the development of CRC.

Living with Barren Truths: A Tale of Triumphalism and Tribulations of a Technology

2021 ◽  
pp. 097168582110159
Author(s):  
Sital Mohanty ◽  
Subhasis Sahoo ◽  
Pranay Kumar Swain
Keyword(s):  
Gender Discrimination ◽  
New Technologies ◽  
The Body ◽  
Social Scientists ◽  
Social Fact ◽  
Science Technology ◽  
The Subject ◽  
And Gender ◽  
The Relationship

Science, technology and human values have been the subject of enquiry in the last few years for social scientists and eventually the relationship between science and gender is the subject of an ongoing debate. This is due to the event of globalization which led to the exponential growth of new technologies like assisted reproductive technology (ART). ART, one of the most iconic technological innovations of the twentieth century, has become increasingly a normal social fact of life. Since ART invades multiple human discourses—thereby transforming culture, society and politics—it is important what is sociological about ART as well as what is biological. This article argues in commendation of sociology of technology, which is alert to its democratic potential but does not concurrently conceal the historical and continuing role of technology in legitimizing gender discrimination. The article draws the empirical insights from local articulations (i.e., Odisha state in eastern India) for the understandings of motherhood, freedom and choice, reproductive right and rights over the body to which ART has contributed. Sociologically, the article has been supplemented within the broader perspectives of determinism, compatibilism alongside feminism.

scholarly journals Calculators as Facilitators of Understanding Computational and Mathematical Contexts

2019 ◽  
Vol 1 (1) ◽  
pp. 177-183
Author(s):  
Jan Guncaga ◽  
Lilla Korenova ◽  
Jozef Hvorecky
Keyword(s):  
Soft Skills ◽  
Real Life ◽  
Theoretical Background ◽  
Learning Processes ◽  
Complex Phenomenon ◽  
Learning To Learn ◽  
Life Problems ◽  
The Subject ◽  
The Relationship

AbstractLearning is a complex phenomenon. Contemporary theories of education underline active participation of learners in their learning processes. One of the key arguments supporting this approach is the learner’s simultaneous and unconscious development of their ability of “learning to learn”. This ability belongs to the soft skills highly valued by employers today.For Mathematics Education, it means that teachers have to go beyond making calculations and memorizing formulas. We have to teach the subject in its social context. When the students start understanding the relationship between real-life problems and the role of numbers and formulas for their solutions, their learning becomes a part of their tacit knowledge. Below we explain the theoretical background of our approach and provide examples of such activities.

scholarly journals Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?

2021 ◽  
Vol 22 (12) ◽  
pp. 6222
Author(s):  
Kacper Szewczyk ◽  
Aleksandra Chojnacka ◽  
Magdalena Górnicka
Keyword(s):  
Vitamin E ◽  
Metabolic Disorders ◽  
Tissue Concentration ◽  
Biological Properties ◽  
Biological Role ◽  
Future Research ◽  
The Past ◽  
The Subject ◽  
The Relationship

Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the highest content in food products. Nevertheless, α-tocopherol is the main form of vitamin E with the highest tissue concentration. The α- forms of both tocopherols and tocotrienols are considered as the most metabolically active. Currently, research results indicate also a greater antioxidant potential of tocotrienols than tocopherols. Moreover, the biological role of vitamin E metabolites have received increasing interest. The aim of this review is to update the knowledge of tocopherol and tocotrienol bioactivity, with a particular focus on their bioavailability, distribution, and metabolism determinants in humans. Almost one hundred years after the start of research on α-tocopherol, its biological properties are still under investigation. For several decades, researchers’ interest in the biological importance of other forms of vitamin E has also been growing. Some of the functions, for instance the antioxidant functions of α- and γ-tocopherols, have been confirmed in humans, while others, such as the relationship with metabolic disorders, are still under investigation. Some studies, which analyzed the biological role and mechanisms of tocopherols and tocotrienols over the past few years described new and even unexpected cellular and molecular properties that will be the subject of future research.

New Agendas for Special Education Policy: What the National Reports Haven't Said

1987 ◽  
Vol 53 (4) ◽  
pp. 295-299 ◽  
Author(s):  
Marleen Pugach ◽  
Mara Sapon-Shevin
Keyword(s):  
Special Education ◽  
Education Policy ◽  
Educational Reform ◽  
Special Focus ◽  
Special Education Policy ◽  
The Past ◽  
The Subject ◽  
The Impact ◽  
The Relationship

The calls for educational reform that have dominated the professional and lay literature for the past few years have been decidedly silent in discussing the role of special education either as a contributor or a solution to the problems being raised. As an introduction to this “Special Focus” on the relationship between general educational reform and special education, this article summarizes some of the more prominent reports with regard to their treatment (and nontreatment) of special education. The impact of proposed reforms for the conceptualization and operation of special education is the subject of the five articles that follow.

scholarly journals Novel Parameterized Distance Measures on Hesitant Fuzzy Sets with Credibility Degree and Their Application in Decision-Making

Symmetry ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 557 ◽  
Author(s):  
Jiaru Li ◽  
Fangwei Zhang ◽  
Qiang Li ◽  
Jing Sun ◽  
Janney Yee ◽  
...  
Keyword(s):  
Decision Making ◽  
Fuzzy Sets ◽  
Cardinal Number ◽  
Decision Makers ◽  
Distance Measures ◽  
Hesitant Fuzzy Set ◽  
Hesitant Fuzzy Sets ◽  
The Subject ◽  
The Relationship

The subject of this study is to explore the role of cardinality of hesitant fuzzy element (HFE) in distance measures on hesitant fuzzy sets (HFSs). Firstly, three parameters, i.e., credibility factor, conservative factor, and a risk factor are introduced, thereafter, a series of novel distance measures on HFSs are proposed using these three parameters. These newly proposed distance measures handle the relationship between the cardinal number and the element values of hesitant fuzzy set well, and are suitable to combine subjective and objective decision-making information. When using these functions, decision makers with different risk preferences are allowed to give different values for these three parameters. In particular, this study transfers the hesitance degree index to a credibility of the values in HFEs, which is consistent with people’s intuition. Finally, the practicability of the newly proposed distance measures is verified by two examples.

scholarly journals The Relationship Between Age and Happiness Varies by Income

2021 ◽  
Author(s):  
Dimiter Toshkov
Keyword(s):  
Income Distribution ◽  
Old Age ◽  
European Social Survey ◽  
Demographic Variables ◽  
Social Survey ◽  
Middle Income ◽  
The Subject ◽  
Using Data ◽  
The Relationship

AbstractThe link between age and happiness has been the subject of numerous studies. It is still a matter of controversy whether the relationship is U-shaped, with happiness declining after youth before bouncing back in old age, or not. While the effect of age has been examined conditional on income and other socio-demographic variables, so far, the interactions between age and income have remained insufficiently explored. Using data from the European Social Survey, this article shows that the nature of the relationship between age and happiness varies strongly with different levels of relative income. People in the lowest decile of the income distribution experience a ‘hockey stick’: a deep decline in self-reported happiness until around age 50–55 and a small bounce back in old age. The classic U-curve is found mostly in the middle-income ranks. For people at the top of the income distribution, average happiness does not vary much with age. These results demonstrate the important role of income in moderating the relationship between age and happiness.

scholarly journals Från studerande i pedagogik till forskningsledare i utbildningsvetenskap

2018 ◽  
Vol 23 (5) ◽  
pp. 137-157
Author(s):  
Christina Gustafsson
Keyword(s):  
Educational Science ◽  
Student Groups ◽  
Third Stream ◽  
Critical Skills ◽  
Teacher Researcher ◽  
The Subject ◽  
The Relationship ◽  
Administrator Role ◽  
Scientific Achievements

The first part of the article reports a few daily reflections from my last years of work focusing the teacher role, the researcher role, the administrator role and the role of the teacher/researcher in third stream activities. The progress can be summarized quite negatively - less time dedicated to heterogeneous student groups, changing opportunities to achieve analytical and critical skills, increased governance in scientific achievements, reduced collegial "power" and reduced interest to be engaged in third stream activities. The second part of the article is about the relationship between education/pedagogy, didactics/curriculum studies and educational science. Didactics was discussed as part of improving research basis for prospective and active teachers. One conclusion is that more than fifteen years of discussion hardly favored the subject of education, but highlighted the importance of subject didactics. Another conclusion is that neither the introduction of educational science became the solution to research appeals for teachers and teacher education as originally thought. Accordingly, more than thirty years of discussion first about finding the relationship between pedagogy and didactics and then to clarify the relationship to educational science has hardly led to any illumination regarding the boundaries of the subject of education.

scholarly journals MicroRNAs in the tumour microenvironment: big role for small players

2013 ◽  
Vol 20 (5) ◽  
pp. R257-R267 ◽  
Author(s):  
Patsy Soon ◽  
Hippokratis Kiaris
Keyword(s):  
Clinical Characteristics ◽  
Experimental Studies ◽  
Anticancer Therapy ◽  
Tumour Microenvironment ◽  
Regulatory Role ◽  
Tumour Stroma ◽  
Physiological Processes ◽  
Non Coding Rnas

MicroRNAs (miRNAs) represent a class of small non-coding RNAs with an important regulatory role in various physiological processes as well as in several pathologies including cancers. It is noteworthy that recent evidence suggests that the regulatory role of miRNAs during carcinogenesis is not limited to the cancer cells but they are also implicated in the activation of tumour stroma and its transition into a cancer-associated state. Results from experimental studies involving cells culturedin vitroand mice bearing experimental tumours, corroborated by profiling of clinical cancers for miRNA expression, underline this role and identify miRNAs as a potent regulator of the crosstalk between cancer and stroma cells. Considering the fundamental role of the tumour microenvironment in determining both the clinical characteristics of the disease and the efficacy of anticancer therapy, miRNAs emerge as an attractive target bearing important prognostic and therapeutic significance during carcinogenesis. In this article, we will review the available results that underline the role of miRNAs in tumour stroma biology and emphasise their potential value as tools for the management of the disease.

scholarly journals ENDOMARKETING E DIVERSIDADE: OS IMPACTOS DA AUTOESTIMA DO COLABORADOR PARA A EMPRESA.

2021 ◽  
Vol 9 (209) ◽  
pp. 1-13
Author(s):  
Victor Lima De Queiroz
Keyword(s):  
Work Environment ◽  
Interpersonal Relationships ◽  
Professional Performance ◽  
Diversity And Inclusion ◽  
Work Atmosphere ◽  
The Subject ◽  
Interpersonal Development ◽  
The Impact ◽  
The Relationship

The purpose of this article is to analyze the role of Endomarketing in the construction of the work atmosphere. It will be investigated the impact that investments or lack of investments in Endomarketing actions create regarding to employee's perception of their work environment and the interpersonal relationships within the organization . The author intends to focus specifically on how issues of diversity and inclusion can affect positively and / or negatively the professional and interpersonal development of employees and, consequently, be reflected on the team and company results. It will discussed the issues involving the subject and the impact of his/her social spheres in the relationship between the co-workers and in professional performance, the role of managers in mediating these aspects will be taken in consideration as well.

Fotografia e arti visive nella progettualitŕ di Ico Parisi

TERRITORIO ◽  
2012 ◽  
pp. 137-144
Author(s):  
Lucia Tenconi
Keyword(s):  
Architectural Design ◽  
Graphic Representation ◽  
The Subject ◽  
The Relationship

A day of studies held at the Politecnico in Milan dedicated to Ico Parisi has re-launched the project for publication of a monographic volume dedicated to the multi-faceted work of the this architect from Como. This project offers the opportunity to reconsider the role of photography in Parisi's designs, where a snapshot was never a detailed, truthful, immutable reproduction of reality, but a symbolic and critical representation of the subject mediated by the author, a source of creative inspiration, more images and the concretisation of utopian places. Following the evolution of Parisi's poetics through his experiences in the photographic field, this essay shows the development of the relationship between graphic representation and architectural design, which became progressively closer until the two expressive realms almost completely overlapped, and photography itself became architecture.

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