scholarly journals A Rare Case of Fibrous Hamartoma of Infancy: A Clinicopathological Diagnosis at a Tertiary Hospital, Eastern Nepal

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
G. Lama ◽  
P. Upadhyaya ◽  
B. Adhikari ◽  
M. Adhikari ◽  
S. Dhakal
Keyword(s):  
Histopathological Examination ◽  
Stellate Cell ◽  
Fibrous Tissue ◽  
Female Child ◽  
Tertiary Hospital ◽  
Fibrous Hamartoma Of Infancy ◽  
Myxoid Matrix ◽  
Proper Diagnosis ◽  
Gross Examination ◽  
Infants And Young Children

Background. Fibrous hamartoma of infancy is a rare soft tissue lesion of infants and young children with characteristic triphasic morphology. Case Description. An 18-month-old female child was presented with complaints of swelling over right leg shin since birth. On examination, a lump of size 7x3 cm was identified which was mobile and nontender. Local excision was performed and tissue sent for histopathological examination. On gross examination, a globular, capsulated, firm to hard tissue had cut section revealing solid grey-white to grey-brown lesion with myxoid areas identified. Microscopic examination revealed a poorly circumscribed lesion comprising intersecting trabeculae of fibrous tissue, areas of immature oval and stellate cell within myxoid matrix, and varying amounts of interspersed mature fat cells. Conclusion. Even though fibrous hamartoma of infancy is a rare benign entity with limited clinical knowledge, proper diagnosis is mandatory as its prognosis is excellent.

Spinal Fibrous Hamartoma of Infancy: Case Report

Neurosurgery ◽  
2004 ◽  
Vol 55 (3) ◽  
pp. E728-E731 ◽  
Author(s):  
Shunsuke Yano ◽  
Kazutoshi Hida ◽  
Kazuo Nagashima ◽  
Yoshinobu Iwasaki
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spinal Cord ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Fibrous Tissue ◽  
Resonance Imaging ◽  
Partial Removal ◽  
Mesenchymal Tissue ◽  
The Central Nervous System ◽  
Fibrous Hamartoma Of Infancy

Abstract OBJECTIVE AND IMPORTANCE: Fibrous hamartoma of infancy (FHI) in the spinal cord is very rare. It is characterized histopathologically by three elements: fibrous, adipose, and myxoid mesenchymal tissues. CLINICAL PRESENTATION: A 10-month-old boy presented with paraparesis. Magnetic resonance imaging showed a large intradural mass that occupied the space between the T10 and L4 levels. INTERVENTION: We performed partial removal of the mass. Histopathological examination of the lesion revealed that it was composed of collagen bundles and fibrous tissue interspersed with adipose tissue, mesenchymal tissue, and glial tissue, and it was diagnosed as FHI. CONCLUSION: FHI in the central nervous system, especially in the spine, is very rare, and the presence of glial tissue admixed with particular components of FHI is quite exceptional.

scholarly journals Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Chen ◽  
Jia Geng ◽  
Ya-lan Tan ◽  
Lian Zhao ◽  
Hui-hui Jia ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Fibrous Tissue ◽  
Operation Time ◽  
Normal Diet ◽  
Treatment Regimens ◽  
Total Length ◽  
Time Required ◽  
Different Characteristics ◽  
Length Of Hospitalization ◽  
Choledochal Malformation

AbstractThe general condition, clinical and pathological characteristics, and treatment regimens of patients prenatally and postnatally diagnosed with congenital choledochal malformation (CM) were analyzed in order to investigate the clinical significance of early diagnosis, treatment, and intervention in CM. We retrospectively analyzed 33 children who were admitted to the Children’s Hospital of Soochow University between 1 March 2010 and 31 May 2019, and their diagnosis of CM was confirmed by radiological, surgical and pathological findings. All the patients were under 36 months of age. The patients were divided into prenatally diagnosed and postnatally diagnosed groups. There were 16 and 17 CM patients in the prenatally and postnatally diagnosed groups, respectively, with a preponderance of females in both groups. Compared with the prenatally diagnosed group, the postnatally diagnosed group had a higher incidence of abdominal pain and vomiting (p < 0.05) and higher AST, GGT, and TB levels (p < 0.05). Although postoperative histopathological examination showed inflammation in both groups, congestion in the cyst walls and fibrous tissue hyperplasia were more significant in the postnatally diagnosed group (p < 0.05). In addition, operation time, length of time required to resume a normal diet after surgery, and total length of hospitalization differed between the 2 groups (p < 0.05), with the prenatally diagnosed group having a relatively longer operation time and taking longer to resume a normal diet after surgery. However, the total length of hospitalization in the prenatally diagnosed group was shorter than that in the postnatally diagnosed group. Compared with prenatally diagnosed CM patients, more symptoms, greater severity of symptoms, and more time to recovery after surgery were observed in postnatally diagnosed CM patients.

scholarly journals Lesion with blue bone-a case report

2018 ◽  
Vol 8 (1) ◽  
pp. 1323-1325
Author(s):  
Laila Mohamed Ilias ◽  
Babitha Alingal Mohammed ◽  
Roshini PS ◽  
Anupama Ponniah ◽  
Poornima Vijayan
Keyword(s):  
Histopathological Examination ◽  
Fibrous Tissue ◽  
Bone Lesion ◽  
Metacarpal Bone ◽  
Cortical Surface ◽  
Bizarre Parosteal Osteochondromatous Proliferation ◽  
X Ray ◽  
Spindle Cells ◽  
Small Bones ◽  
Hands And Feet

Bizzare parosteal osteochondromatous proliferation, or Nora‘s lesion is a unique bone lesion that most often arises in the small bones of hands and feet.  It is characterised by proliferation of chondroid, bony and fibrous tissue, and is occasionally misdiagnosed as a malignant process.  Our case was a 31 yr old lady, who presented with a painless swelling near the 5th metacarpal bone of right hand.  X-ray showed well marginated mineralised mass arising from the cortical surface of the metacarpal bone.  Histopathological examination revealed bizarre parosteal osteochondromatous proliferation composed of varying amounts of cartilage, bone and spindle cells. Cartilage was hypercellular and chondrocytes were enlarged. Ossification was irregular and had a peculiar blue tinctorial quality. 

INCIDENTAL GALL BLADDER CARCINOMA (IGBC) IN CHOLECYSTECTOMY SPECIMENS REMOVED FOR CHOLELITHIASIS

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Dharmpal Godara ◽  
Vijay Pal Singh Dhayal
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Histopathological Examination ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Survival Outcome ◽  
Sectional Study ◽  
Gall Bladder Carcinoma ◽  
Cross Sectional ◽  
Hospital Records

Background: The present study highlights the occurrence of Incidental gallbladder carcinoma (IGBC) detected during histopathological examination in cholecystectomy specimens removed for cholelithiasis. Methods- This is a tertiary hospital based cross-sectional study of 500 cholecystectomy specimens removed during cholelithiasis. Relevant hospital records, histopathology slides and reports were reviewed, re-evaluated and studied. Results: 4(0.80%) cases of incidental gall bladder carcinoma (IGBC) were diagnosed from the histopathological evaluation (HPE) of 500 cholecystectomy specimens, constituting 0.80% of gall bladder specimens received during the study period. The age of the patients with IGBC ranged from 51-80 years. More females were affected than males with a M:F ratio of 1:3. Conclusion: Early detection of IGBC by histopathological examination would have a favourable impact on prognosis and management thereby increasing the survival outcome. Keywords: Cholelithiasis, Incidental Gall Bladder Carcinoma

scholarly journals Sestrin 2 Attenuates Rat Hepatic Stellate Cell (HSC) Activation and Liver Fibrosis via an mTOR/AMPK-Dependent Mechanism

2018 ◽  
Vol 51 (5) ◽  
pp. 2111-2122 ◽  
Author(s):  
Yi-Bing Hu ◽  
Xiao-Ting Ye ◽  
Qing-Qing Zhou ◽  
Rong-Quan Fu
Keyword(s):  
Liver Fibrosis ◽  
Protein Expression ◽  
Hepatic Fibrosis ◽  
Transforming Growth Factor ◽  
Histopathological Examination ◽  
Stellate Cell ◽  
Smooth Muscle Actin ◽  
Mrna Levels ◽  
Alpha Smooth Muscle Actin

Background/Aims: Sestrin 2 is associated with the pathophysiology of several diseases. The aim of this study was to investigate the effects and potential mechanisms of Sestrin 2 in rat hepatic stellate cells (HSCs) during liver fibrogenesis. Methods: In this study, Sestrin 2 protein expression was detected in rat HSC-T6 cells challenged with transforming growth factor-β (TGF-β) and in mice treated with carbon tetrachloride (CCl4), a well-known model of hepatic fibrosis. Next, HSC-T6 cells and fibrotic mice were transfected with lentivirus. The mRNA expression levels of markers of liver fibrosis [alpha-smooth muscle actin (α-SMA) and collagen 1A1 (Col1A1)] were analyzed by quantitative reverse transcription–polymerase chain reaction (RT-PCR). Cell death and proliferation were evaluated by the MTT assay, and biochemical markers of liver damage in serum [alanine transaminase (ALT) and aspartate transaminase (AST)] were also measured using a biochemical analyzer. Histopathological examination was used to evaluate the degree of liver fibrosis, and protein expression [phospho-adenosine monophosphate-activated protein kinase (p-AMPK), AMPK, phospho-mammalian target of rapamycin (p-mTOR), and mTOR] was determined by western blotting. Results: We found that Sestrin 2 was elevated in both the HSC-T6 cell and hepatic fibrosis models. In vitro, overexpression of Sestrin 2 attenuated the mRNA levels of α-SMA and Col1A1, suppressed α-SMA protein expression, and modulated HSC-T6 cell proliferation. In vivo, overexpression of Sestrin 2 reduced the ALT and AST levels as well as the α-SMA and Col1A1 protein expression in the CCl4 model of liver fibrosis. Moreover, the degree of liver fibrosis was ameliorated. Interestingly, overexpression of Sestrin 2 increased p-AMPK but decreased p-mTOR protein expression. Conclusion: Our findings indicate that Sestrin 2 may attenuate the activation of HSCs and ameliorate liver fibrosis, most likely via upregulation of AMPK phosphorylation and suppression of the mTOR signaling pathway.

scholarly journals In vivo evaluation of ziram induced acute toxicity on pathomorphology of broiler chicken

2016 ◽  
Vol 8 (4) ◽  
pp. 2206-2211
Author(s):  
Majid Shafi ◽  
Shayaib A. Kamil ◽  
Masood S. Mir ◽  
S. Adil ◽  
Showkat A. Shah ◽  
...  
Keyword(s):  
Broiler Chicken ◽  
Neuronal Degeneration ◽  
Histopathological Examination ◽  
Lymphoid Cells ◽  
Bursa Of Fabricius ◽  
Poultry Feed ◽  
In Vivo Evaluation ◽  
Vascular Congestion ◽  
Gross Examination

Fungicides are usually used in agriculture and often find their way in poultry feed. Therefore, a study was undertaken to study the in vivo effect of one such fungicide (ziram) induced intoxication on pathomorphology of broiler chicken. After 2 weeks of age the birds were given fungicide (Ziram) in feed as a single oral dose of 100 mg/kg body weight. Out of 10 birds, 3 died due to ziram intoxication (30% mortality rate). Birds that died rapidly showed pronounced neurological signs like convulsions. The carcasses of ziram intoxicated birds appeared dehydrated and their mucous membrane was pale in colour. Marked vascular congestion was observed in brain on gross examination. The livers showed congestion and haemorrhages with necrotic foci. Kidneys and lungs had ecchymotic haemorrhages and heart revealed gelatinization of pericardium, distention and pericarditis. Atrophy of bursa of Fabricius and thymus; hypertrophy of thyroid was found. Histopathological examination revealed neuronal degeneration and necrosis associated with mild gliosis in brain. Lungs, pericardium and epicardium had severe congestion and there was degeneration with separation of myofibers. Glomeruli were congested and frequently revealed hypercellularity. There were sinusoidal congestion and varying degrees of hepatocellular degeneration. Bursa revealed mild depletion of lymphoid cells in few lobules while as thymus showed hypoplasia with depletion of lymphocytes. Thyroid had mild mononuclear cell infiltration and caecum showed marked necrosis and denudation of the mucosa. In conclusion, the depletion of lymphoid tissue from lymphoid organs was suggestive of immunosuppressive and immunomodulatory effects of ziram toxicity in broiler chicken.

scholarly journals Afebrile Seizures as Initial Symptom of Hypocalcemia Secondary to Hypoparathyroidism

2016 ◽  
Vol 07 (S 01) ◽  
pp. S117-S119
Author(s):  
Anastasia Gkampeta ◽  
Eftyxia Kouma ◽  
Anastasia Touliopoulou ◽  
Efstathios Aggelopoulos ◽  
Eleni Vourti
Keyword(s):  
Vitamin D ◽  
Calcium Carbonate ◽  
Blood Gases ◽  
Female Child ◽  
Tertiary Hospital ◽  
Initial Symptom ◽  
Serum Electrolyte ◽  
Laboratory Findings ◽  
Normal Thyroid Function ◽  
25 Oh Vitamin D

ABSTRACTHypocalcemia is rare in childhood and caused, among other conditions, by hypoparathyroidism. DiGeorge syndrome is the most common cause of hypoparathyroidism in childhood. Presentation of a rare cause of hypocalcemia in childhood and the necessity of measuring serum electrolyte levels in patients presenting with afebrile seizures. a 7.5-year-old female child presented with afebrile seizures lasting 5 min with postictal drowsiness. A similar episode 1 month ago is described. On admission, a positive Trousseau sign, papilledema, and long QTc on electrocardiography were detected. Laboratory testing revealed hypocalcemia, increased creatine phosphokinase and phosphate levels, decreased levels of parathormone, with normal thyroid function and normal levels of blood gases. considering the diagnosis of hypoparathyroidism possible, we started on calcium gluconate solution 5% intravenously and calcium carbonate per os. 48 h later, the child transferred to tertiary hospital for further evaluation. The laboratory findings revealed 25-OH Vitamin D deficiency with normal cortisol levels and the absence of autoantibodies. Kidney and brain imaging and also the electroencephalogram were normal. Calcium carbonate, magnesium, and Vitamin D were administered per os. The child discharged from hospital with complete resolution of symptoms. Since then, she is in treatment with calcium carbonate and Vitamin D per os. Hypoparathyroidism is rare in childhood. We underline the necessity of measuring serum electrolyte levels in patients presenting with afebrile seizures.

scholarly journals Lung tuberculosis in a horse caused by Mycobacterium avium subsp. avium of serotype 2: a case report

2008 ◽  
Vol 53 (No. 2) ◽  
pp. 111-116 ◽  
Author(s):  
I. Pavlik ◽  
P. Jahn ◽  
M. Moravkova ◽  
L. Matlova ◽  
F. Treml ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Mycobacterium Avium ◽  
High Resistance ◽  
Histopathological Examination ◽  
Mediastinal Lymph Nodes ◽  
Mycobacterial Infections ◽  
Lung Tuberculosis ◽  
High Age ◽  
Gross Examination

Interstitial pneumonia (2/3 of the lungs were affected) and diffusely enlarged bronchial and mediastinal lymph nodes were diagnosed by gross examination of a dead 16-year-old mare. Based on histopathological examination and the detection of acid-fast rods after staining by the Ziehl-Neelsen technique, tuberculosis was suspected. <I>Mycobacterium avium</I> subsp. <I>avium</I> of serotype 2 and IS<I>901</I>+/IS<I>1245</I>+ genotype was isolated from the pulmonary lymphnode after five-week incubation at 37°C. Due to the fact that horses have a naturally high resistance to mycobacterial infections, the high age of the mare most likely contributed to the development of the disease.

Diagnosing cranial fasciitis based on distinguishing radiological features

2008 ◽  
Vol 2 (5) ◽  
pp. 370-374 ◽  
Author(s):  
Keyne K. Johnson ◽  
Mark J. Dannenbaum ◽  
Meenakshi B. Bhattacharjee ◽  
Anna Illner ◽  
Robert C. Dauser ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Pediatric Population ◽  
Bone Lesion ◽  
Vacuum Extraction ◽  
Histopathological Findings ◽  
Radiological Features ◽  
Cranial Fasciitis ◽  
Lytic Bone Lesion ◽  
Myxoid Matrix ◽  
Painless Mass

Primary skull lesions, albeit rare in the pediatric population, have been well described and classified. These lesions are usually benign and commonly present as a painless mass. The most common lesions are epidermoid, dermoid, and Langerhans cell histiocytosis. Cranial fasciitis, encountered less frequently, is usually not considered in this differential diagnosis. Given such few cases reported, it is commonly misdiagnosed preoperatively. The authors retrospectively reviewed data obtained in 4 patients with cranial fasciitis in whom the diagnosis was based on histopathological findings. In 2 patients the onset of the lesion was spontaneous. One patient had a lesion 4 months following a vacuum extraction and subsequent cephalohematoma formation. One patient developed a lesion following a previous craniectomy. Presentation, imaging studies, and histopathological findings were all reviewed and analyzed. All patients presented with a firm nontender mass. Radiological features included a lytic bone lesion with a mildly sclerotic margin, T1 isodensity, T2 heterogeneous hyperdensity, and heterogeneous enhancement. The enhancing portion was not bright on T2-weighted MR images, likely representing the fibrous component; the nonenhancing portion was bright on T2-weighted images, likely representing the myxoid matrix. Histopathological examination revealed proliferating fibroblasts in a myxoid matrix. Cranial fasciitis is a benign, painless but rapidly growing lesion of the skull mainly limited to the pediatric population. It is histologically similar to nodular fasciitis, a fibroblastic proliferation of varying size. These lesions are often related to trauma but can also be insidious or can develop at a prior craniectomy site. The appropriate clinical picture and distinguishing radiographic features may help to differentiate cranial fasciitis from other lesions of the skull allowing for earlier intervention.

scholarly journals Cerebral gliosarcoma with perivascular involvement in a cat

2019 ◽  
Vol 5 (2) ◽  
pp. 205511691987978
Author(s):  
Patricia Álvarez ◽  
Annette Wessmann ◽  
Mireia Pascual ◽  
Oriol Comas ◽  
Dolors Pi ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Septum Pellucidum ◽  
Soft Mass ◽  
Case Summary ◽  
Fluid Attenuated Inversion Recovery ◽  
History Of ◽  
High Degree ◽  
The Brain ◽  
Clinical Mri ◽  
Gross Examination

Case summary A 5-year-old neutered male domestic shorthair cat presented with an 18-month history of facial tics, and progressive general ataxia, weakness, lethargy and anorexia of 2 weeks’ duration. MRI of the brain showed a well-defined heterogeneous hyperintense mass on T1-weighted and T2-weighted images, with central hypointensity in the rostral commissure and septum pellucidum, and perilesional hyperintensity in fluid-attenuated inversion recovery, suggestive of perilesional oedema. Gross examination in a transverse section of the brain at the level of the septum pellucidum revealed a 0.2 cm brown soft mass. Histopathological examination identified a biphasic neoplastic proliferation of mesenchymal and neuroepithelial cell populations. Fusiform cells were predominately distributed in bundles showing a high degree of anisocytosis and marked immune-positive reaction to vimentin immunochemistry, confirming a sarcomatous origin. Additionally, high numbers of astrocytic cells were identified by an intense immunopositive reaction to glial fibrillary acidic protein and negative reaction to oligodendrocyte transcription factor 2 immunochemistry. Vascular invasion of the neoplasia into the wall of a medium branch of the rostral cerebral artery was present (secondary Scherer structures). Based on these characteristics, the tumour was defined as a gliosarcoma. Gliosarcoma is a recognised astrocytoma grade IV anaplastic glial cell tumour with sarcomatous differentiation. Relevance and novel information To our knowledge, this is the first report describing a cerebral gliosarcoma in a cat including clinical, MRI, macroscopic and histopathological features and immunolabelling characteristics.

Sign in / Sign up

Export Citation Format

Share Document