scholarly journals Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-14 ◽  
Author(s):  
Asra Iftikhar ◽  
Bilal Aslam ◽  
Maryam Iftikhar ◽  
Wafa Majeed ◽  
Mehwish Batool ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Glycosylated Hemoglobin ◽  
Radical Scavenging ◽  
Herbal Medicines ◽  
Underlying Mechanism ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Glut 4 ◽  
Wide Range ◽  
Treatment Of Diabetes

Caesalpinia bonduc has been used in herbal medicines for the treatment of a wide range of diseases from decades. The present study has explored the remedial potential and underlying mechanism of polyphenol extract of Caesalpinia bonduc in alloxanized diabetic rats. HPLC/MS analysis confirmed the presence of phenolics in considerable concentrations in Caesalpinia bonduc extract. Administration of different doses (250 and 500 mg/kg) of CPP extract to hyperglycemic rats for 8 weeks restored blood and serum glucose, insulin, glycosylated hemoglobin, leptin, amylin, and carbohydrate metabolizing enzymes level towards normal compared to alloxanized diabetic group. The effect of CPP extract on various genes such as Pdx-1, Ins-1, ngn-3, GLUT-4, and IRS-1 in insulin signaling pathway and Traf-4, Traf-6, and Mapk-8 in MAPK downstream JNK cascade was examined through qRT-PCR to access the core molecular mechanism involved in CPP-induced recovery of diabetes. Results have revealed that CPP extract reduced oxidative stress in pancreatic β cells by restoring free radical scavenging potential, reducing the mRNA expression of Mapk-8, Traf-4, and Traf-6, and increasing the Pdx-1, Ins-1, ngn-3, GLUT-4, and IRS-1 expression ensuing regeneration of β cells and subsequent insulin release from pancreas. The results obtained in this study recommend that CPP extract may be a promising therapeutic restorative agent in the treatment of diabetes mellitus.

scholarly journals Evaluation of Antihyperglycemic potential of homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in Streptozotocin Induced diabetic Rats.

2021 ◽  
Vol 19 (3) ◽  
pp. 02-17
Author(s):  
Aditya Dilipkumar Patil ◽  
Charusheela Dilipkumar Patil ◽  
Dilipkumar Kondiba Patil
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance Test ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Holistic Approach ◽  
Tolerance Test ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Treatment Of Diabetes

INTRODUCTION – Diabetes Mellitus is an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathy a science of ultra-molecular doses with a holistic approach is used in treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes, nosodes and animal parts. Insulinum, Pancreatinum and Uranium nitricum is used in homeopathy for treatment of Diabetes Mellitus. However no any preclinical studies have been investigated for the anti-diabetic effect and its safety. METHODS – Homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in 6C (1012) dilution factor were used to examine antihyperglycemic effects in streptozotocin induced diabetic rats. After 28 days treatment bodyweight, Hematology, Biochemistry (serum glucose, urea, creatinine, SGPT, SGOT, ALP, Triglyceride and HDL-cholesterol), Oral Glucose Tolerance Test, HbA1C with histopathology of (Liver, Kidney, Pancreas) was measured. RESULTS – After Streptozotocin induction, the animals have shown significant increase in the fasting blood glucose level (p

scholarly journals Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats

Cholesterol ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Gholamreza Komeili ◽  
Mohammad Hashemi ◽  
Mohsen Bameri-Niafar
Keyword(s):  
Total Cholesterol ◽  
Glycosylated Hemoglobin ◽  
Diabetic Rats ◽  
Male Rats ◽  
Peganum Harmala ◽  
Hydroalcoholic Extract ◽  
End Of Treatment ◽  
Total Antioxidant ◽  
Treatment Of Diabetes ◽  
Different Doses

The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200–230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin (HbA1C) were determined. STZ-induced diabetic rats showed significant changes in the values of glucose, triglycerides, total cholesterol, LDL-c, MDA, TAC, ALT, AST, GGT, bilirubin, and HbA1C in comparison with normal rats. Administration of the extract to diabetic rats resulted in a remarkable decrease in glucose, lipid profiles, MDA, ALT, AST, GGT, bilirubin, and HbA1C levels and increase in TAC relative to diabetic group. The results of this study indicated that hydroalcoholic extract of Peganum harmala seeds possesses antidiabetic and hypolipidemic activities and could be useful in treatment of diabetes.

scholarly journals Betulinic Acid Inhibits ROS-Mediated Pyroptosis in Spinal Cord Injury by Augmenting Autophagy via the AMPK-mTOR-TFEB Signaling Pathway

2020 ◽  
Author(s):  
Chenyu Wu ◽  
Huanwen Chen ◽  
Rong Zhuang ◽  
Yongli Wang ◽  
Xinli Hu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Signaling Pathway ◽  
Betulinic Acid ◽  
Neurological Diseases ◽  
Underlying Mechanism ◽  
Autophagy Flux ◽  
Wide Range ◽  
Cord Injury

Abstract Background：Spinal cord injury (SCI) results in a wide range of disabilities. Its complex pathophysiological process limits the effectiveness of many clinical treatments. Betulinic acid (BA) has been shown to be an effective treatment for some neurological diseases, but it has not been studied in SCI. In this study, we assessed the role of BA in SCI and investigated its underlying mechanism. Methods：Using a mouse model of SCI, survival and functional outcomes following injury were assessed. Western blotting, ELISA, and immunofluorescence techniques were employed to analyze levels of autophagy, mitophagy, and pyroptosis; ROS- and AMPK-related signaling pathways were also examined. Results：Our results showed that BA significantly improves functional recovery following SCI. Furthermore, autophagy, mitophagy, ROS-activity and pyroptosis were implicated in the mechanism of BA in the treatment of SCI. Specifically, our results suggest that BA restored autophagy flux following injury, which induces mitophagy to eliminate the accumulation of ROS and subsequently inhibits pyroptosis. Further mechanistic studies revealed that BA likely regulates autophagy and mitophagy via the AMPK-mTOR-TFEB signaling pathway. Conclusion: BA can significantly promote the recovery following SCI and that it may be a promising therapy for SCI.

scholarly journals Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2438 ◽  
Author(s):  
Sahar Sarmasti Emami ◽  
Derek Zhang ◽  
Xiaolong Yang
Keyword(s):  
Signaling Pathway ◽  
Hippo Pathway ◽  
Underlying Mechanism ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway ◽  
Cellular Processes ◽  
Wide Range ◽  
Future Direction ◽  
The Hippo Pathway

The Hippo pathway is an emerging tumor suppressor signaling pathway involved in a wide range of cellular processes. Dysregulation of different components of the Hippo signaling pathway is associated with a number of diseases including cancer. Therefore, identification of the Hippo pathway regulators and the underlying mechanism of its regulation may be useful to uncover new therapeutics for cancer therapy. The Hippo signaling pathway includes a set of kinases that phosphorylate different proteins in order to phosphorylate and inactivate its main downstream effectors, YAP and TAZ. Thus, modulating phosphorylation and dephosphorylation of the Hippo components by kinases and phosphatases play critical roles in the regulation of the signaling pathway. While information regarding kinase regulation of the Hippo pathway is abundant, the role of phosphatases in regulating this pathway is just beginning to be understood. In this review, we summarize the most recent reports on the interaction of phosphatases and the Hippo pathway in tumorigenesis. We have also introduced challenges in clarifying the role of phosphatases in the Hippo pathway and future direction of crosstalk between phosphatases and the Hippo pathway.

scholarly journals Anti-oxidative Activity of Nepalese Traditional Anti-diabetic Medicines

2014 ◽  
Vol 14 (2) ◽  
pp. 151-154
Author(s):  
HP Devkota ◽  
A Adhikari-Devkota ◽  
S Yahara ◽  
P Basnet
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Herbal Medicines ◽  
Punica Granatum ◽  
Herbal Drugs ◽  
Strong Activity ◽  
Disease States ◽  
Methanolic Extracts ◽  
Oxidative Property ◽  
Treatment Of Diabetes

Chronic overproduction of free radicals in human body has a role in numerous disease states including diabetes. Proper use of antioxidants may help in the prevention and/or treatment of diabetes. For the management of diabetes, a combination of herbal drugs is being practiced traditionally in Nepal. These herbal medicines might have a good correlation to anti-oxidative properties. Anti-oxidative property was evaluated with the methanolic extracts of nineteen common traditional anti-diabetic medicines by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. Among the evaluated herbal medicines, Phyllanthus emblica, Punica granatum, Syzygium cumini, Terminalia bellirica and Terminalia chebula showed potent radical scavenging activity. The activities of P. emblica, T. bellirica and T. chebula were more potent than that of ascorbic acid. Some of the reported popular hypoglycemic herbal drugs did not show strong activity. Therefore strong anti-oxidative herbal drugs in combination with hypoglycemic drugs might have better results in the management of diabetes. DOI: http://dx.doi.org/10.3126/njst.v14i2.10429   Nepal Journal of Science and Technology Vol. 14, No. 2 (2013) 151-154

scholarly journals Antidiabetic effect of Coccinia grandis (L.) Voigt (Cucurbitales: Cucurbitaceae) on streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolizing enzymes

2018 ◽  
Vol 5 (11) ◽  
pp. 683-698
Author(s):  
Meenatchi Packirisamy ◽  
Purushothaman Ayyakkannu ◽  
Maneemegalai Sivaprakasam
Keyword(s):  
Glycosylated Hemoglobin ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Perennial Herb ◽  
Optimum Dose ◽  
Oral Glucose ◽  
Metabolizing Enzymes ◽  
Coccinia Grandis ◽  
Treatment Of Diabetes

Coccinia grandis (L.) Voigt (Cucurbitales: Cucurbitaceae) is a climbing perennial herb, growing throughout India and it is widely used in the traditional treatment of diabetes. The aim of present study was to evaluate the antidiabetic potential of the mature unripe of Coccinia grandis in streptozotocin (STZ)-induced diabetic rats with special reference to carbohydrate metabolizing enzymes. The optimum dose of Coccinia grandis extract (GCE) was determined by oral glucose tolerance test. The effects of CGE were compared with glibenclamide. Oral administration of Coccinia grandis extract at a concentration of 250 mg/kg body weight once daily to diabetic rats for the period of 30 days resulted in significant reduction in the levels of plasma glucose and glycosylated hemoglobin. Administration of CGE showed a significant increase in the levels of glycolytic enzymes and glycogen content and decrease in the levels of gluconeogenic enzymes in the liver of diabetic treated rats. The anti-hyperglycemic effect of the extract was comparable with glibenclamide, a known hypoglycemic drug. Present findings provide experimental evidence that the fruits of C. grandis have potential antidiabetic activity which might be used as a functional food and safe remedy for the treatment of diabetes and associated complications.

scholarly journals Antidiabetic and Antioxidative Effect of Jiang Tang Xiao Ke Granule in High-Fat Diet and Low-Dose Streptozotocin Induced Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Dan-Dan Zhao ◽  
Na Yu ◽  
Xiao-Ke Li ◽  
Xin Fang ◽  
Qian-qian Mu ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Low Density Lipoprotein ◽  
Herbal Medicines ◽  
Density Lipoprotein ◽  
Positive Control ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
High Fat ◽  
Naturally Occurring ◽  
Alanine Aminotransferase Activity

Diabetes mellitus (DM), a kind of metabolic disease, is increasing over the last four decades in the world. The purpose of this study was to investigate the effect of Jiang Tang Xiao Ke (JTXK) granule, a naturally occurring ingredient from Chinese herbal medicines, on serum glucose, lipids, and oxidative stress in DM rats induced by high-fat diet and streptozotocin. JTXK granule 9 g/kg (based on crude herb equivalent) and pioglitazone 1.5 mg/kg (as a positive control for comparison) were orally administrated to DM rats for 4 weeks. Results showed that administration of JTXK granule reduced serum glucose, total cholesterol, triglyceride, and low density lipoprotein levels (by 12%, 33%, 57%, and 44%, resp.) but increased high-density lipoprotein level by 69%, compared with the drug-untreated DM rats. Serum malondialdehyde and nitric oxide levels were lowered (by 34% and 52%, resp.) associated with the elevation in serum superoxide dismutase levels (by 60%) after JTXK granule treatment. In addition, JTXK granule suppressed serum alanine aminotransferase activity (up to 50%) and alleviated pathological changes of pancreas and liver tissues in DM rats. The beneficial changes of pioglitazone on biomarkers were also found in DM rats. These findings suggested that JTXK granule may be an alternative medicine for the management of DM.

Evaluation of efficacy of Bombax ceiba extract and its major constituent, mangiferin in streptozotocin (STZ)-induced diabetic rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Sushil Bhargava ◽  
Mamta B. Shah
Keyword(s):  
Glycogen Content ◽  
Serum Glucose ◽  
Hplc Method ◽  
Diabetic Rats ◽  
Major Constituent ◽  
High Density Lipoproteins ◽  
Hydroalcoholic Extract ◽  
Medicinal Use ◽  
Treatment Of Diabetes ◽  
And Oxidative Stress

AbstractObjectivesBased on the ethno-medicinal use of Bombax ceiba leaf, in the treatment of diabetes, the present study is aimed at evaluation of antidiabetic potential of leaf extract and its major constituent mangiferin.MethodsEfficacy of hydroalcoholic extract of Bombax ceiba leaf (BCL, 200 and 400 mg/kg body wt.) and mangiferin (MF, 20 mg/kg body wt) was studied in streptozotocin (STZ)-induced diabetic rats and associated complications visually, retinopathy, cardiopathy and nephropathy. After 20 days, serum glucose, lipid profiles, glycol-hemoglobin % (HbA1c%), liver enzymes activity and glycogen content, and histopathology of the pancreas were corroborated. The study was coxswained for development of validated RP-HPLC method for the estimation of MF in BCL.ResultsThe results demonstrated significant reductions in the levels of glucose (p<0.001), glycated hemoglobin (HbA1c%, p<0.001), cholesterol, triglycerides and low-density lipoproteins, and concurrent elevation of high density lipoproteins level in the groups administered BCL and MF relative to the controls. It significantly reversed most of the altered metabolic and oxidative stress parameters and histopathological changes. Mangiferin content in BCL was found to be 0.04%w/w.ConclusionsThe anti-diabetic effects of BCL may be attributed to its ability to enhance insulin release, antioxidant and hypolipidemic potential.

scholarly journals Effects of Powder, Extracts, and Components of Ganoderma Lucidum in Treatment of Diabetes

2021 ◽  
Vol 29 (4) ◽  
pp. 86-101
Author(s):  
Mansooreh Sadat Mojani Qomi ◽  
◽  
Monireh Hatami ◽  
Keyword(s):  
Blood Sugar ◽  
Ganoderma Lucidum ◽  
Essential Fatty Acids ◽  
Glycosylated Hemoglobin ◽  
Essential Amino Acids ◽  
Diabetic Patients ◽  
Active Compounds ◽  
Wide Range ◽  
Treatment Of Diabetes ◽  
Medicinal Properties

Ganoderma lucidum is known in China and Japan as Ling-Zhi and Reishi. Due to medicinal properties and different nutritional compositions, ganoderma lucidum is currently used in food products. It contains essential fatty acids, essential amino acids, and a wide range of polysaccharides; all of which seem to be effective in lowering blood sugar level. This study aims to review the anti-diabetic and hypoglycemic effects of various powders, extracts, and components of ganoderma lucidum, by searching articles in Persian and English published from 2001 to 2020 in SID, MagIran, Scopus, PubMed, Web of Science and Google Scholar databases using the keywords: Active compounds, ganoderma lucidum, diabetes mellitus, hyperglycemia. The results showed that ganoderma lucidum uptake in most cases reduced fasting blood sugar, glycosylated hemoglobin, and insulin resistance in diabetic patients due to the its active compounds including the extracted polysaccharides, proteins and triterpenoids. Moreover, its antioxidant and anti-inflammatory properties seems to reduce the complications of diabetes. In conclusion, the consumption of ganoderma lucidum in diabetic patients can be effective in controlling and preventing the disease, although more studies are needed on its effective dose, side effects and toxicity in human samples.

scholarly journals Physiochemical and nutritional evaluation of whole kumquat fruits powder and its protective effect on thyroid hormones and blood sugar levels in diabetic rats

2023 ◽  
Vol 83 ◽  
Author(s):  
H. M. A. Al-Sayed ◽  
M. A. Abdelaleem ◽  
H. A. Shawky
Keyword(s):  
Thyroid Hormones ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Normal Diet ◽  
Total Phenolic ◽  
Albino Rats ◽  
Antioxidant Power ◽  
Trolox Equivalent

Abstract The present study was conducted to evaluate the chemical composition, antioxidant activity and hypoglycemic effects of whole kumquat (Ku) powder in diabetic rats fed a high-fat-high-cholesterol (HFHC) diet. The antioxidant activities were evaluated using stable 1,1-diphenyl 2-picrylhydrazyl (DPPH) free radical scavenging method, 2,2´-azinobis (3-ethyl benzo thiazoline-6-sulphonic acid) radical cation (ABTS) and Ferric reducing antioxidant power (FRAP). Total phenolic content was (51.85 mg GAE/g) and total flavonoid content was (0.24 mg Cateachin Equivalent, CE/g). DPPH and ABTS values were 3.32 and 3.98 mg Trolox equivalent (TE)/g where FRAP value was 3.00 mM Fe2+/kg dry material. A total of 90 albino rats were used in the present study. Rats group were as follows: normal diet; normal treated (2, 4, and 6% Ku.), diabetic rats (non-treated), diabetic + HFHC diet (non-treated), HFHC (non-treated), Diabetic (treated), HFHC (treated) and Diabetic + HFHC (treated). The diets were followed for 8 weeks. Blood samples were collected at the end of the experiment. Serum glucose was recorded and thyroid hormones (T4, Thyroxine and T3, Triiodothyronine) were conducted. Diet supplemented with Kumquat at different concentrations have a hypoglycemic effect and improve the thyroid hormones of both diabetic rats and HFHC diabetic rats.

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