scholarly journals Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Mohammed S. Al-saggaf
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Antimicrobial Activities ◽  
Ag Nps ◽  
Propolis Extract ◽  
Deacetylation Degree ◽  
Microbial Infections ◽  
Healing Of Wounds ◽  
Inhibition Zones ◽  
The Individual

Skin wounds are frequently influenced with microbial infections and inflammation, which need innovative agents for disputing them. Chitosan (Csn) was extracted from larvae of BSF “black soldier fly, Hermetia illucens” and ethanolic propolis extract (Pro) was employed for synthesizing silver nanoparticles (Ag-NPs), using facile biogenic protocol. The BSF-Csn was acquired with a yield of 1.56%, 91.3% deacetylation degree, and 88.600 Dalton molecular weight. The Ag-NPs were effectually biosynthesized using Pro, with a mean diameter of 8.73 nm and zeta potential of -21.34 mV. The antimicrobial activities assessment of insect Csn, Pro, synthesized Ag-NPs with Pro, and their composite against skin pathogens (Staphylococcus aureus and Candida albicans) revealed the elevated efficiency of the individual agents and the superior action of their composite (Csn/Pro/Ag-NPs), with 26.3 and 23.4 mm inhibition zones and inhibitory concentrations of 35.0 and 45.0 μg/mL from the composite toward S. aureus and C. albicans, respectively, which exceeded the actions of commercial antibiotics. The treatment of rat’s wounds with this composite promisingly led to faster healing of wounds and absence of inflammation and infection signs. The powerful actions of Csn/Pro/Ag-NPs as antimicrobial and wound healing composite strongly advocate their applications for skin protection, disinfection, and regeneration.

scholarly journals Glucuronoxylan-mediated silver nanoparticles: green synthesis, antimicrobial and wound healing applications

RSC Advances ◽  
2017 ◽  
Vol 7 (68) ◽  
pp. 42900-42908 ◽  
Author(s):  
Gulzar Muhammad ◽  
Muhammad Ajaz Hussain ◽  
Muhammad Amin ◽  
Syed Zajif Hussain ◽  
Irshad Hussain ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Biological Applications ◽  
Ag Nps

Hydrogel forming polysaccharides are attracting attention for the design of diverse nature silver nanoparticles (Ag NPs) with potential biological applications.

scholarly journals Silver nanoparticles: synthesis through chemical methods in solution and biomedical applications

2011 ◽  
Vol 9 (1) ◽  
pp. 7-19 ◽  
Author(s):  
Jorge García-Barrasa ◽  
José López-de-Luzuriaga ◽  
Miguel Monge
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Metal Nanoparticles ◽  
Biomedical Applications ◽  
Antiviral Agent ◽  
Ag Nps ◽  
Chemical Methods ◽  
Precise Control ◽  
Nanoparticles Synthesis ◽  
Inorganic Nanomaterials

AbstractChemical methods provide an easy way to synthesize silver nanoparticles (Ag NPs) in solution. These metal nanoparticles have a great potential for biomedical applications as an antibacterial, antifungal, and antiviral agent or in wound healing. The adjustment of the parameters involved in these reactions permits a precise control over the size, shape, monodispersity, and the surfaces of the nanoparticles. These nanoparticles are being used in the design of new hybrid organic-inorganic or inorganic nanomaterials for biomedical applications.

scholarly journals Starch-Capped Silver Nanoparticles Impregnated into Propylamine-Substituted PVA Films with Improved Antibacterial and Mechanical Properties for Wound-Bandage Applications

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2112 ◽  
Author(s):  
Mudassir Iqbal ◽  
Hadia Zafar ◽  
Azhar Mahmood ◽  
Muhammad Bilal Khan Niazi ◽  
Muhammad Waqar Aslam
Keyword(s):  
Silver Nanoparticles ◽  
Wound Dressing ◽  
Antibacterial Properties ◽  
Antimicrobial Activities ◽  
Sem Analysis ◽  
Ag Nps ◽  
Blend Film ◽  
Physical Strength ◽  
Vis Spectroscopy ◽  
Average Size

This research endeavor aims to develop polyvinyl alcohol (PVA) based films capable of blends with silver nanoparticles (Ag–NPs) for improved antibacterial properties and good mechanical strength to widen its scope in the field of wound dressing and bandages. This study reports synthesis of propylamine-substituted PVA (PA–PVA), Ag–NPs via chemical and green methods (starch capping) and their blended films in various proportions. Employment of starch-capped Ag–NPs as nanofillers into PVA films has substantially improved the above-mentioned properties in the ensuing nanocomposites. Synthesis of PA–PVA, starch-capped Ag–NPs and blended films were well corroborated with UV/Vis spectroscopy, FTIR, NMR, XRD and SEM analysis. Synthesized Ag–NPs were of particle shape and have an average size 20 nm and 40 nm via green and chemical synthesis, respectively. The successful blending of Ag–NPs was yielded up to five weight per weight into PA–PVA film as beyond this self-agglomeration of Ag–NPs was observed. Antibacterial assay has shown good antimicrobial activities by five weight per weight Ag–NPs(G)-encapsulated into PA–PVA blended film, i.e., 13 mm zone inhibition against Escherichia coli and 11 mm zone inhibition against Staphylococcus aureus. Physical strength was measured in the terms of young’s modulus via tensile stress–strain curves of blended films. The five weight per weight Ag–NPs(G)/PA–PVA blend film showed maximum tensile strength 168.2 MPa while three weight per weight Ag–NPs(G)/PVA blend film showed highest values for ultimate strain 297.0%. Ag–NPs embedment into PA–PVA was resulted in strong and ductile film blend than pristine PA–PVA film due to an increase in hydrogen bonding. These good results of five weight per weight Ag–NPs(G)/PA–PVA product make it a potent candidate for wound dressing application in physically active body areas.

scholarly journals Antimicrobial activities of crude solvent extract and synthesized silver nanoparticles of Opuntia ficus-indica L. Cladodes

2020 ◽  
Vol 49 (4) ◽  
pp. 1085-1093
Author(s):  
IF Bahis ◽  
Mahmoud Moustafa ◽  
Hussein Al-Wadi
Keyword(s):  
Silver Nanoparticles ◽  
Crude Extract ◽  
Klebsiella Oxytoca ◽  
Antimicrobial Activities ◽  
Maximum Activity ◽  
Moderate Activity ◽  
Ag Nps ◽  
Opuntia Ficus Indica ◽  
Maximum Inhibition ◽  
Significant Difference

Opuntia ficus-indica cladodes was examined for their antimicrobial activities by using crude extract and synthesized silver nanoparticles against human pathogenic microbial strains, namely Staphylococcus aureus, Klebsiella pneumoniae, Klebsiella oxytoca, Proteus mirabilis and Candida albicans. All extracts demonstrated moderate activity against the tested microbes in a range between 0.53 and 2.33 cm. The maximum inhibition activity was found to be against K. pneumoniae while the lowest against S. aureus. Synthesized silver nanoparticles (Ag-NPs) showed inhibition activities between 1.82 and 2.03 cm. The maximum activity was recorded against K. oxytoca, while the lowest activities against P. mirabilis. In context of antimicrobial activity, there was no significant difference either solvent crude extract or synthesized silver nanoparticles against tested microbes. Therefore, crude extracts of O. ficus-indica cladodes or Ag-NPs could be used as an alternative natural drug.

scholarly journals Synthesis, Characterization, and Evaluation of Antimicrobial Activities of Chitosan and Carboxymethyl Chitosan Schiff-Base/Silver Nanoparticles

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ahmed M. Khalil ◽  
Reham A. Abdel-Monem ◽  
Osama M. Darwesh ◽  
Ahmed I. Hashim ◽  
Afaf A. Nada ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Antimicrobial Activities ◽  
Carboxymethyl Chitosan ◽  
Acidic Media ◽  
Tem Analysis ◽  
Inhibition Zones ◽  
In Situ Reactions

Schiff-bases of chitosan (CS) and carboxymethyl chitosan (CMCS)/silver nanoparticles (AgNPs) have been synthesized, characterized, and evaluated as antimicrobial agents against two Gram +ve bacteria (Bacillus cereus and Staphylococcus aureus) and two Gram −ve bacteria (Escherichia coli and Pseudomonas aeruginosa) in addition to Candida albicans as a fungus. The in situ reactions of CS and/or CMCS with some pyrazole aldehyde derivatives in acidic media containing silver nitrate to yield silver nanoparticles loaded onto CS and CMCS/Schiff-bases were carried out. Characterizations of the prepared compounds via FTIR spectroscopy, SEM, TEM, and TGA were carried out. Schiff-bases/silver nanoparticles of CS and CMCS showed higher antimicrobial activity than the blank CS and CMCS. The presence of AgNO3 (3% wt%) displayed high antibacterial efficiencies with inhibition zones in the extent of 19–39 mm. TEM analysis showed that the size of the silver nanoparticles is in the range of 4–28 nm for the prepared nanocomposites.

scholarly journals Green Synthesis, Characterization and Antimicrobial activity of Silver Nanoparticles from the Extract of Lagerstroemia speciosa

2021 ◽  
Vol 37 (3) ◽  
pp. 648-655
Author(s):  
Vinit Prakash ◽  
Harpreet Kaur ◽  
Anjana Kumari ◽  
Manoj Kumar ◽  
Sumeet Gupta ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Kidney Diseases ◽  
Ethanolic Extract ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Ag Nps

Lagerstroemia speciosais commonly known as Banaba or Jarul which is used to get rid of various ailments such as fever, urinary infection, decongestion, diarrhoea, mouth ulcers, astringent, diabetes mellitus, kidney diseases, abdominal pains etc. The present work, describes the green synthesis of silver nanoparticles from ethanolic extract of fruits of L.speciosa (Ls-Ag NPs) and their analysis for antimicrobial activities. The characterisation of so obtained nanoparticles have been carried out with help of Field emission scanning electron microscopy (FESEM) and High-resolution transmission electron microscopy (HRTEM). Further, antimicrobial activities of ethanolic extract of fruits of L.speciosa(Ee-Ls), silver oxide (Ag2O), and Ls-Ag NPs have been examined by using well-diffusion method against two bacterial strains: Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative) and one fungal strain: Aspergillus niger.It has been observed that the biosynthesized Ls-Ag NPs possess much effective antimicrobial activity against selected strains as compared to Ee-Ls and Ag2O.

scholarly journals A Facile Method for the Fabrication of Silver Nanoparticles Surface Decorated Polyvinyl Alcohol Electrospun Nanofibers and Controllable Antibacterial Activities

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2486 ◽  
Author(s):  
Yan Yang ◽  
Zhijie Zhang ◽  
Menghui Wan ◽  
Zhihua Wang ◽  
Xueyan Zou ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Silver Nanoparticles ◽  
Polyvinyl Alcohol ◽  
Size Distribution ◽  
Antibacterial Properties ◽  
Electrospun Nanofibers ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Ag Nps ◽  
Particles Size Distribution

Polyvinyl alcohol (PVA) electrospun nanofibers (NFs) are ideal carriers for loading silver nanoparticles (Ag NPs) serving as antibacterial materials. However, it is still a challenge to adjust the particles size, distribution, and loading density via a convenient and facile method in order to obtain tunable structure and antimicrobial activities. In this study, Ag NPs surface decorated PVA composite nanofibers (Ag/PVA CNFs) were fabricated by the solvothermal method in ethylene glycol, which plays the roles of both reductant and solvent. The morphology and structure of the as-fabricated Ag/PVA CNFs were characterized by scanning electron microscopy, transmission electron microscopy, selected area electron diffraction, X-ray diffraction, UV-visible spectroscopy, and Fourier transform infrared spectroscopy. Ag NPs had an average diameter of 30 nm, the narrowest size distribution and the highest loading density were successfully decorated on the surfaces of PVA NFs, at the AgNO3 concentration of 0.066 mol/L. The antibacterial properties were evaluated by the methods of absorption, turbidity, and growth curves. The as-fabricated Ag/PVA hybrid CNFs exhibit excellent antimicrobial activities with antibacterial rates over 98%, especially for the sample prepared with AgNO3 concentration of 0.066 mol/L. Meanwhile, the antibacterial effects are more significant in the Gram-positive bacteria of Staphylococcus aureus (S. aureus) than the Gram-negative bacteria of Escherichia coli (E. coli), since PVA is more susceptive to S. aureus. In summary, the most important contribution of this paper is the discovery that the particles size, distribution, and loading density of Ag NPs on PVA NFs can be easily controlled by adjusting AgNO3 concentrations, which has a significant impact on the antibacterial activities of Ag/PVA CNFs.

Biosynthesis of silver nanoparticles from Citrobacter freundii as antibiofilm agents with their cytotoxic effects on human cells

2020 ◽  
Vol 21 ◽  
Author(s):  
Muhamad Ali K. Shakhatreh ◽  
Omar F. Al-Rawi ◽  
Samer F. Swedan ◽  
Karem H. Alzoubi ◽  
Omar F. Khabour ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antimicrobial Agents ◽  
Dermal Fibroblast ◽  
Membrane Integrity ◽  
Fibroblast Cell ◽  
Antimicrobial Activities ◽  
Human Cells ◽  
Citrobacter Freundii ◽  
Ag Nps ◽  
Cytotoxic Effects

Background: Nanomaterials have recently been identified for their potential benefits in the areas of medicine and pharmaceuticals. Among these nanomaterials, silver nanoparticles (Ag-NPs) have been widely utilized in the fields of diagnostics, antimicrobials, and catalysis. Objective: To investigate the potential utility of Citrobacter freundii in the synthesis of silver nanoparticles (Ag-NPs), and to determine the antimicrobial activities of the Ag-NPs produced. Methods: Aqueous Ag+ ions were reduced when exposed to C. freundii extract and sunlight, leading to formation of AgNPs. Qualitative microanalysis for the synthesized Ag-NPs was done using UV-vis spectrometry, energy dispersive X-ray analysis (EDX), and scanning and transmission electron microscopy. The hydrodynamic size and stability of the particles were detected using dynamic light scattering (DLS) analysis. The Ag-NPs’ anti-planktonic and anti-biofilm activities against Staphylococcus aureus and Pseudomonas aeruginosa, which are two important skin and wound pathogens, were investigated. The cytotoxicity on human dermal fibroblast cell line was also determined. Results: Ag-NPs were spherical with a size range between 15 to 30 nm. Furthermore, Ag-NPs displayed potent bactericidal activities against both S. aureus and P. aeruginosa and showed noticeable anti-biofilm activity against S. aureus biofilms. Ag-NPs induced minor cytotoxic effects on human cells as indicated by a reduction of cell viability, a disruption of plasma membrane integrity, and apoptosis induction. Conclusion: Ag-NPs generated in this study might be a future potential alternative to be used as antimicrobial agents in pharmaceutical applications for wound and skin related infections.

scholarly journals Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model

Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 902
Author(s):  
Vajravathi Lakkim ◽  
Madhava C. Reddy ◽  
Roja Rani Pallavali ◽  
Kakarla Raghava Reddy ◽  
Ch Venkata Reddy ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Multidrug Resistant ◽  
Biomedical Science ◽  
Resistant Bacteria ◽  
Zone Of Inhibition ◽  
Ag Nps ◽  
Bacteriolytic Activity ◽  
Vis Spectroscopy

Green nanotechnology has significant applications in various biomedical science fields. In this study, green-synthesized silver nanoparticles, prepared by using Catharanthus roseus and Azadirachta indica extracts, were characterized using UV–Vis spectroscopy, dynamic light scattering, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. Silver nanoparticles (Ag NPs) synthesized from leaf extracts of C. roseus and A. indica effectively inhibited the growth of multidrug-resistant (MDR) bacteria isolated from patients with septic wound infections. The maximum bacteriolytic activity of the green-synthesized Ag NPs of C. roseus and A. indica against the MDR bacterium K. Pneumoniae was shown by a zone of inhibition of 19 and 16 mm, respectively. C. roseus Ag NPs exhibited more bacteriolytic activity than A. indica Ag NPs in terms of the zone of inhibition. Moreover, these particles were effective in healing wounds in BALB/c mice. Ag NPs of C. roseus and A. indica enhanced wound healing by 94% ± 1% and 87% ± 1%, respectively. Our data suggest that Ag NPs from C. roseus and A. indicia ameliorate excision wounds, and wound healing could be due to their effective antimicrobial activity against MDR bacteria. Hence, these Ag NPs could be potential therapeutic agents for the treatment of wounds.

scholarly journals Green synthesis of silver nanoparticles (Ag-NPs) from Olea dioica Roxb., leaf extracts and its biological activity

Biomedicine ◽  
2020 ◽  
Vol 39 (4) ◽  
pp. 544-549
Author(s):  
G. K. Pratap ◽  
Manjula Shantaram
Keyword(s):  
Silver Nanoparticles ◽  
Medicinal Plants ◽  
Green Synthesis ◽  
Leaf Extract ◽  
Synthesis Method ◽  
Antimicrobial Activities ◽  
Sem Analysis ◽  
Nano Particles ◽  
Ag Nps ◽  
Leaf Extracts

Introduction and Aim: The silver nanoparticles have attained a special place in the area of nanotechnology because of their different biological applications. Fabrication of nanoparticles using green synthesis is  done because of its wide applications in different fields such as biomedical, medicine, agriculture and food engineering. This study is to develop an easy and eco-friendly method for the synthesis of Ag-NPs using leaf extracts of the medicinal plant. Materials and Methods: The medicinal plants are rich sources of various medicinal properties. Olea dioica Roxb., leaf extract was used to investigate the effects of Ag-NPs having antibacterial activity and antioxidant capacity.  The plant leaf extract contains flavonoids, alkaloids, saponins, and phenolic compounds which acts as reducing and stabilizing agents. The green synthesized silver nanoparticles were characterized by various techniques like UV- visible spectrophotometer, FTIR spectroscopy, and SEM analysis. Results: The synthesis of sliver nanoparticles from plant source, and analysis of nano particles by UV-Vis spectra, SEM and FTIR. The biological evaluations of Ag-NPs indicated an excellent inhibitory efficacy, antioxidant and antimicrobial activity for their future applications in medicine. Conclusion: The synthesized silver nanoparticles exhibited potent antioxidant and antimicrobial activities against Gram-positive and Gram-negative bacteria. The silver (Ag-NPs) nanoparticles synthesized by the pot green synthesis method proves its potential use in various medical applications. Keywords: Silver nanoparticles; Medicinal plants; Ag-NPs; Olea dioica Roxb.,

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