scholarly journals Bioactive Substances in Safflower Flowers and Their Applicability in Medicine and Health-Promoting Foods

2021 ◽  
Vol 2021 ◽  
pp. 1-23
Author(s):  
I. Adamska ◽  
P. Biernacka
Keyword(s):  
Antioxidant Properties ◽  
Carthamus Tinctorius ◽  
The State ◽  
Bioactive Substances ◽  
Natural Substances ◽  
Obesity And Diabetes ◽  
Wide Range ◽  
Health Promoting ◽  
Anti Inflammatory ◽  
Treatment Of Obesity

Safflower flowers (Carthamus tinctorius) contain many natural substances with a wide range of economic uses. The most famous dye isolated from flower petals is hydroxysafflor A (HSYA), which has antibacterial, anti-inflammatory, and antioxidant properties. This review is aimed at updating the state of knowledge about their applicability in oncology, pulmonology, cardiology, gynecology, dermatology, gastrology, immunology, and suitability in the treatment of obesity and diabetes and its consequences with information published mainly in 2018-2020. They were also effective in treating obesity and diabetes and its consequences. The issues related to the possibilities of using HSYA in the production of health-promoting food were also analyzed.

The Anti-inflammatory Potential of Selected Plant-derived Compounds in Respiratory Diseases

2020 ◽  
Vol 26 (24) ◽  
pp. 2876-2884 ◽  
Author(s):  
Joanna Wieczfinska ◽  
Przemyslaw Sitarek ◽  
Tomasz Kowalczyk ◽  
Ewa Skała ◽  
Rafal Pawliczak
Keyword(s):  
Nadph Oxidase ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
Boswellic Acid ◽  
Natural Substances ◽  
Airway Diseases ◽  
Wide Range ◽  
Oxidase Inhibition ◽  
Nadph Oxidase Inhibition ◽  
Anti Inflammatory

: Inflammation plays a major role in chronic airway diseases like asthma, COPD, and cystic fibrosis. Inflammation plays a crucial role in the worsening of the lung function resulting in worsening symptoms. The inflammatory process is very complexed, therefore the strategies for developing an effective treatment for inflammatory airway diseases would benefit from the use of natural substances. : Parthenolide, apocynin, proanthocyanidins, and boswellic acid present different mechanisms of actions - among others, through NF-κB or NADPH oxidase inhibition, therefore showing a wide range of applications in various inflammatory diseases. Moreover, some of them have also antioxidant properties. : Naturally occurring substances may exert some anti-inflammatory effects by modulating some of the inflammatory pathways. These agents have been used in different cultures for thousands of years and have proven to be relatively safe. : Parthenolide, apocynin, proanthocyanidins, and boswellic acid present different mechanisms of actions - among others, through NF-þB or NADPH oxidase inhibition, therefore showing a wide range of applications in various inflammatory diseases. Moreover, some of them have also antioxidant properties. : This review provides an overview of the anti-inflammatory effects of some of the natural agents and illustrates their great potential as sources of drugs to cover an extensive range of pharmacological effects.

scholarly journals Nutritional value and health-promoting properties of Agaricus bisporus (Lange) Imbach

2018 ◽  
Vol 64 (4) ◽  
pp. 71-81 ◽  
Author(s):  
Iwona Golak-Siwulska ◽  
Alina Kałużewicz ◽  
Siergiej Wdowienko ◽  
Luiza Dawidowicz ◽  
Krzysztof Sobieralski
Keyword(s):  
Agaricus Bisporus ◽  
Nutritional Value ◽  
Unsaturated Fatty Acids ◽  
Antioxidant Properties ◽  
Fruiting Bodies ◽  
Button Mushroom ◽  
Bioactive Substances ◽  
White Button Mushroom ◽  
Wide Range ◽  
Health Promoting

Summary The white button mushroom Agaricus bisporus (Lange) Imbach is an edible mushroom of top economic significance. In recent years the consumption of fruiting bodies of this species has been increasing in Poland. The article characterises the chemical composition and health-promoting properties of white button mushrooms. The latest scientific research confirms that the fruiting bodies of white button mushroom have high nutritional value. They contain good quality proteins, necessary unsaturated fatty acids, fibre, some vitamins and numerous minerals. Apart from that, white button mushroom fruiting bodies contain a wide range of bioactive substances, which have a positive influence on health, such as polysaccharides, glyco-proteins, tocopherols, polyphenols and other antioxidants, e.g. ergothioneine. Apart from the antioxidant properties, the white button mushroom also has anti-inflammatory, antimicrobial, antifungal, anticancer, immunomodulatory, hepatoprotective and anti-atherosclerotic activities.

scholarly journals Comparison of Morphological, Antidiabetic and Antioxidant Properties of Goji Fruits

2020 ◽  
Vol 24 (1) ◽  
pp. 1-14
Author(s):  
Arleta Kruczek ◽  
Ireneusz Ochmian ◽  
Marcelina Krupa-Małkiewicz ◽  
Sabina Lachowicz
Keyword(s):  
Antioxidant Activity ◽  
Positive Impact ◽  
Antioxidant Properties ◽  
Total Content ◽  
Point Of View ◽  
Bioactive Substances ◽  
Health Promoting ◽  
Berry Fruits ◽  
North Western ◽  
Nitrite Content

AbstractThere is a growing public interest in fruits labeled as „superfood” (functional food). A “superfood” should have a high content of bioactive substances with a positive impact on human health. Seven different cultivars of goji berry fruits (Lycium chinense Mill.) grown in north-western Poland were evaluated for its physicochemical parameters, antidiabetic and antioxidant activity, and polyphenol content. The length of 1-year-old shoots ranged from 36 cm (‘Big Lifeberry’) to 82 cm (‘Korean Big’). Cultivars from the group of Big were characterized by the biggest fruits (17.3-24.2 mm) with the greatest weight of 100 fruits (96.7­122.1 g). ‘Big Lifeberry’ contained high amounts of L-ascorbic acid (408 mg 1000/g) and provitamin A (190 mg 1000/g) and showed high antidiabetic (α-amylase IC50=33.4 mg/mL; α-glucosidase IC50=9.9 mg/mL) and antioxidant activity (ABTS·+ 6.21 and FRAP 5.58 mmol T/100 g). ‘Big Lifeberry’ was also characterized by a high total content of polyphenols (43.64 mg 100/g). Furthermore, the nitrite content in all the cultivars tested was at a relatively low level. Among the examined cultivars, the most attractive one concerning the consumers’ point of view of the size, weight and high content of health-promoting compounds is ‘Big Lifeberry’.

scholarly journals Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Jia Hui Wong ◽  
Anna M. Barron ◽  
Jafri Malin Abdullah
Keyword(s):  
Neurodegenerative Disease ◽  
Healthy Aging ◽  
Brain Aging ◽  
Antioxidant Properties ◽  
Centella Asiatica ◽  
Asiatic Acid ◽  
Wide Range ◽  
Anti Inflammatory

Natural products remain a crucial source of drug discovery for accessible and affordable solutions for healthy aging. Centella asiatica (L.) Urb. (CA) is an important medicinal plant with a wide range of ethnomedicinal uses. Past in vivo and in vitro studies have shown that the plant extract and its key components, such as asiatic acid, asiaticoside, madecassic acid and madecassoside, exhibit a range of anti-inflammatory, neuroprotective, and cognitive benefits mechanistically linked to mitoprotective and antioxidant properties of the plant. Mitochondrial dysfunction and oxidative stress are key drivers of aging and neurodegenerative disease, including Alzheimer’s disease and Parkinson’s disease. Here we appraise the growing body of evidence that the mitoprotective and antioxidative effects of CA may potentially be harnessed for the treatment of brain aging and neurodegenerative disease.

scholarly journals Zanjabeel (Zingiber officinale Roscoe.): An Evidence-Based Review of Anti-nociceptive, Anti-inflammatory, Antioxidant, and Antimicrobial Properties

2021 ◽  
pp. 26-35
Author(s):  
Fatima Khan ◽  
Mohd Nayab ◽  
Abdul Nasir Ansari
Keyword(s):  
Therapeutic Potential ◽  
Antioxidant Properties ◽  
Plant Secondary Metabolites ◽  
Zingiber Officinale ◽  
Extensive Study ◽  
The Body ◽  
Wide Range ◽  
Zingiber Officinale Roscoe ◽  
Medicinal Properties ◽  
Anti Inflammatory

Ginger has been appreciated for over 2500-3000 years in many parts of the world due to its numerous scientific properties. The ginger plant (Zingiber officinale Roscoe) belongs to the Zingiberaceae family. It is a known food and flavoring ingredient reputed for its wide range of medicinal properties that have been widely used in Chinese, Ayurvedic, and Unāni Tibb worldwide, since antiquity. Ginger has long been used to cure a variety of ailments, including diarrhea, stomach discomfort, indigestion, and nausea. It is a versatile herb with phenomenal phytotherapeutic and medicinal properties. Active ingredients available in ginger such as 6-gingerol, 6-shogaol, 6-paradol, and zingerone are responsible for upgrading enzyme actions and balancing circulation through rejuvenating the body with physical re-strengthening. Gingerols, the key phenolic plant secondary metabolites responsible for its distinct flavor and health benefits, are found in the rhizome of ginger Extensive study has been undertaken over the last two decades to uncover bioactive ingredients and the therapeutic potential of ginger. This review considers ginger's chemical composition and the most recent study findings on its possible health advantages, such as analgesic, anti-inflammatory, antibacterial, and antioxidant properties due to its phytochemistry. Overall, clinical trials are needed to confirm these prospective various health advantages of ginger in human subjects and the most efficacious dosage, based on the current body of scientific literature.

scholarly journals The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity

Foods ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 37 ◽  
Author(s):  
Inga Matulyte ◽  
Aiste Jekabsone ◽  
Lina Jankauskaite ◽  
Paulina Zavistanaviciute ◽  
Vytaute Sakiene ◽  
...  
Keyword(s):  
Essential Oil ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Inflammatory Activity ◽  
Poly I:C ◽  
Bioactive Substances ◽  
Myristica Fragrans ◽  
Anti Inflammatory ◽  
Nutmeg Essential Oil

Nutmeg (Myristica fragrans) essential oil has antimicrobial, antiseptic, antiparasitic, anti-inflammatory, and antioxidant properties. We have recently demonstrated that hydrodistillation of nutmeg essential oil by applying magnesium aluminometasilicate as an excipient significantly increases both the content and amount of bioactive substances in the oil and hydrolats. In this study, we aimed to compare the antioxidant, antimicrobial, and anti-inflammatory activity of hydrolats and essential oil obtained by hydrodistillation in the presence and absence of magnesium aluminometasilicate as an excipient. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method revealed that magnesium aluminometasilicate did not significantly improved antioxidant activity of both essential oil and hydrolat. Antibacterial efficiency was evaluated by monitoring growth of 15 bacterial strains treated by a range of dilutions of the essential oil and the hydrolats. Essential oil with an excipient completely inhibited the growth of E. faecalis, S. mutans (referent), and P. multocida, whereas the pure oil was only efficient against the latter strain. Finally, the anti-inflammatory properties of the substances were assessed in a fibroblast cell culture treated with viral dsRNR mimetic Poly I:C. The essential oil with an excipient protected cells against Poly I:C-induced necrosis more efficiently compared to pure essential oil. Also, both the oil and the hydrolats with aluminometasilicate were more efficient in preventing IL-6 release in the presence of Poly I:C. Our results show that the use of magnesium aluminometasilicate as an excipient might change and in some cases improve the biological activities of nutmeg essential oil and hydrolats.

scholarly journals Chromato-mass-spectroscopic research of chemical composition of Elaeagnus angustifolia L.

2021 ◽  
Vol 14 (2) ◽  
pp. 179-184
Author(s):  
O. I. Panasenko ◽  
V. I. Mozul ◽  
O. M. Denysenko ◽  
I. I. Aksonova ◽  
T. V. Oberemko
Keyword(s):  
Chemical Composition ◽  
Palmitic Acid ◽  
Isomeric State ◽  
Antioxidant Properties ◽  
Raw Material ◽  
Antidiabetic Activity ◽  
Elaeagnus Angustifolia ◽  
Mass Spectrometric Detector ◽  
Wide Range ◽  
Anti Inflammatory

The aim of the work was chromato-mass-spectroscopic research of chemical composition of Elaeagnus angustifolia L. fruits and leaves and identifying further prospects for the use of this plant in medicine. Materials and methods. Raw materials of Elaeagnus angustifolia L. were selected as objects of study. The tincture was obtained by maceration and the raw material was extracted with methyl alcohol at room temperature for 10 days according to the method of making tinctures. The study of the chemical composition of Elaeagnus angustifolia L. was carried out using gas chromatograph Agilent 7890B GC System (Agilent, Santa Clara, CA, USA) with mass spectrometric detector Agilent 5977 BGC/MSD (Agilent, Santa Clara, CA, USA) and chromatographic column DB-5ms (30 m × 250 mkm × 0,25 mkm). Results. 23 compounds (1 in the isomeric state) in fruits and 20 compounds (2 in the isomeric state) in the leaf of Elaeagnus angustifolia L. were identified. The main components of fruits were sitosterol (phytosterols) – 12.53 %, propyl acetate (esters of carboxylic acids) – 12.60 %, chamazulene (terpenes) – 11.97 % and palmitic acid (fatty acids) – 8.28 %. The main component of leaves were sitosterol (phytosterols) – 17.57 %, 1-(2-hydroxy-5-methylphenyl)-ethanone (ketone) – 8.35 %, phytol (terpenes) – 6.10 %. It is known from the literature that chamazulene has antioxidant, antinociceptive, cytotoxic activity. Sitosterol has anti-inflammatory and antidiabetic activity. Hexadecanoic (palmitic) acid has antimicrobial, antidiabetic and antioxidant properties. Phytol is characterized by a wide range of biological action – antimicrobial, antinociceptive, anti-inflammatory, antioxidant and cytotoxic. Conclusions. Based on the above, the olive can be considered as a source of antimicrobial, antinociceptive, anti-inflammatory, antioxidant, antidiabetic and cytotoxic drugs.

scholarly journals Phytochemical Characterization and Biological Evaluation of the Aqueous and Supercritical Fluid Extracts from Salvia sclareoides Brot

2017 ◽  
Vol 15 (1) ◽  
pp. 82-91
Author(s):  
Daniela Batista ◽  
Pedro L. Falé ◽  
Maria L. Serralheiro ◽  
Maria-Eduarda Araújo ◽  
Catarina Dias ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Supercritical Fluid ◽  
Antioxidant Properties ◽  
Biological Properties ◽  
Biological Evaluation ◽  
Cyclooxygenase 1 ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Β Carotene

AbstractPlants belonging to the genus Salvia (Lamiaceae) are known to have a wide range of biological properties. In this work, extracts obtained from the aerial parts of Salvia sclareoides Brot. were evaluated to investigate their chemical composition, toxicity, bioactivity, and stability under in vitro gastrointestinal conditions. The composition of the supercritical fluid extract was determined by GC and GC-MS, while the identification of the infusion constituents was performed by HPLC-DAD and LC-MS. The in vitro cytotoxicity of both extracts (0-2 mg/mL) was evaluated in Caco-2 cell lines by the MTT assay. The anti-inflammatory and anticholinesterase activities were determined through the inhibition of cyclooxygenase-1 and acetylcholinesterase enzymes, while β-carotene/linoleic acid bleaching test and the DPPH assays were used to evaluate the antioxidant activity. The infusion inhibited cyclooxygenase-1 (IC50 = 271.0 μg/mL), and acetylcholinesterase (IC50 = 487.7 μg/ mL) enzymes, also demonstrated significant antioxidant properties, as evaluated by the DPPH (IC50 = 10.4 μg/mL) and β-carotene/linoleic acid (IC50 = 30.0 μg/mL) assays. No remarkable alterations in the composition or in the bioactivities of the infusion were observed after in vitro digestion, which supports the potential of S. sclareoides as a source of bioactive ingredients with neuroprotective, anti-inflammatory and antioxidant properties.

scholarly journals Opuntia Fruits as Food Enriching Ingredient, the First Step towards New Functional Food Products

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 916 ◽  
Author(s):  
Anna Oniszczuk ◽  
Agnieszka Wójtowicz ◽  
Tomasz Oniszczuk ◽  
Arkadiusz Matwijczuk ◽  
Ahlem Dib ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Antioxidant Properties ◽  
Total Content ◽  
Prickly Pear ◽  
Field Bean ◽  
Bioactive Substances ◽  
Functional Additive ◽  
Bean Flour ◽  
Health Promoting ◽  
Free Phenolic Acids

Prickly pear (Opuntia ficus indica (L.) Mill.) is a rich source of vitamins C, B1, B2, A, and E, minerals such as calcium, potassium, magnesium, iron, and phosphorus, as well as bioactive substances, i.e., carotenoids, betalains, and phenolic compounds. Of these, the phenolic acids, betalains, and flavonoids are notable in that they are largely responsible for the health-promoting properties of this plant. The purpose of the presented research was to first determine the antioxidant properties and the content of polyphenolic compounds (including individual phenolic acids) in prickly pear fruit, then to produce an innovative gluten-free pasta from rice-field bean flour enriched with various amounts of pear prickly fruit. The content of free phenolic acids, the sum of polyphenols and antioxidant properties of pasta were subsequently determined in the supplemented pasta. Chromatographic analysis (HPLC-ESI-MS/MS) showed a wide variety of phenolic acids. In the fruit sample, 14 acids were detected, whereas in the pasta sample without additives, 9. The dominant acid was isoferulic. The total content of free phenolic acids and the sum of polyphenols increased with increasing content of the functional additive. Moreover, the content of individual acids generally increased as the Opuntia fruit was added. The antioxidant activity was also positively correlated with the addition of fruit, with the content of free phenolic acids and the sum of polyphenols. Our research has shown that our innovative pasta with the addition of prickly fruit can become a source of the free phenolic acids indispensable for human health.

scholarly journals Turkish Endemic Achillea Species Protect Human Neuroblastoma SH-SY5Y Cells Against Hydrogen Peroxide-Induced Cytotoxicity

Proceedings ◽  
2020 ◽  
Vol 40 (1) ◽  
pp. 43
Author(s):  
Kübra Uzun ◽  
Ayşe Kübra Karaboğa Arslan
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Phenolic Compounds ◽  
Neurodegenerative Diseases ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Antioxidant Systems ◽  
Human Neuroblastoma ◽  
Wide Range ◽  
Anti Inflammatory

The genus Achillea L. belongs to Asteraceae (Compositae), the largest family of vascular plants. There are 50 species, which of 24 is endemic in this genus in Turkey. Achillae species are used as a tonic, anti-inflammatory, anti-spasmodic, diaphoretic, diuretic and emmenagogic agents and have been used for treatment of hemorrhage, pneumonia, rheumatic pain and wounds healing traditionally. The imbalanced antioxidant systems leads to various pathophysiological conditions such as inflammation, neurodegenerative diseases and cancer. Achillea species have several components; essential oils, sesquiterpenes and phenolic compounds such as flavonoids and phenolic acids. Phenolic compounds and flavonoids are the most important medicinal metabolites of Achillea species. Flavonoids have been reported to exert a wide range of biological activities including anti-inflammatory, antioxidant and anti-tumor effects. This study aimed to assess the in vitro antioxidant properties of the methanol extracts from the aerial parts of A. cucullata (ACME) and A. sieheana (ASME) against hydrogen peroxide (H2O2)-induced oxidative stress in human SH-SY5Y neuronal cells. Our study showed that the ACME and ASME provided neuroprotection against H2O2-induced oxidative stress. In conclusion, ACME and ASME might help in reducing oxidative stress for preventive therapy associated with neurodegenerative diseases and cancer.

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