scholarly journals A Case-Control Study Indicates that no Association Exists Between Polymorphisms of IL-33 and IL-1RL1 and Preeclampsia

2016 ◽  
Vol 38 (4) ◽  
pp. 1406-1414 ◽  
Author(s):  
Xiaoyan Ren ◽  
Mingzhen Guo ◽  
Caili Liu ◽  
Tao Huang ◽  
Qiang Li ◽  
...  
Keyword(s):  
Late Onset ◽  
Hereditary Disease ◽  
Chinese Han ◽  
Chi Square ◽  
Allelic Discrimination ◽  
Chi Square Test ◽  
Hardy Weinberg Equilibrium ◽  
And Control ◽  
Early Late ◽  
Control Study

Background/Aims: Preeclampsia (PE) is a systemic inflammatory response syndrome involving varieties of cytokines, and previous studies have shown that IL-33 and its receptor IL-1RL1 play pivotal roles in the development of it. As a polygenetic hereditary disease, it is necessary to study the gene analysis for PE. Therefore, the present study was to determine whether IL-33 rs3939286 and IL-1RL1 rs13015714 associated with susceptibility to PE in Chinese Han women. Methods: 1,031 PE patients and 1,298 controls were enrolled and the genotyping for rs3939286 in IL-33 and rs13015714 in IL-1RL1 was performed by TaqMan allelic discrimination real-time PCR. Hardy-Weinberg equilibrium (HWE) was examined to ensure the group representativeness and Pearson's chi-square test was used to compare the differences in genetic distributions between the two groups. Results: No significant differences in genotypic and allelic frequencies of the two polymorphisms loci were observed between cases and controls. There were also no significant differences in genetic distributions between mild/severe and early/late-onset PE and control groups. Conclusion: Although our data suggested that the polymorphisms of IL-33 rs3939286 and IL-1RL1 rs13015714 might not be critical risk factors for PE in Chinese Han women, the results need to be validated in different nations.

scholarly journals Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Nonsyndromic Cleft Lip and/or Palate

2015 ◽  
Vol 26 (6) ◽  
pp. 561-565 ◽  
Author(s):  
Márcia Waltrick-Zambuzzi ◽  
Patricia Nivoloni Tannure ◽  
Thays Cristine dos Santos Vieira ◽  
Leonardo Santos Antunes ◽  
Fábio Lourenço Romano ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Taqman Assay ◽  
Control Group ◽  
Chi Square ◽  
Polymorphic Genotype ◽  
Chi Square Test ◽  
Hardy Weinberg Equilibrium ◽  
Cobalamin Metabolism ◽  
And Control

The aim of this study was to evaluate the association of the polymorphisms in TCN2 (rs1801198) gene and in MTRR (rs1801394) gene with nonsyndromic cleft lip and/or palate (NSCL/P) in a Brazilian population. Genomic DNA was extracted from buccal cells. The polymorphisms in TCN2 (rs1801198) and MTRR (rs1801394) genes were genotyped by carrying out real-time PCR and Taqman assay. Chi-square test was used to determine the association between genotype and allele frequencies with NSCL/P and NSCL/P subgroups (cleft lip only, cleft lip and palate, and cleft palate only). Eight hundred and sixty seven unrelated individuals (401 cases with NSCL/P and 466 individuals without cleft) were evaluated. Genotype distributions of TCN2 and MTRR polymorphisms were in Hardy-Weinberg equilibrium. The TCN2 polymorphic genotype GG was identified in 16.7% of the NSCL/P group and in 14.1% of the non-cleft group (p>0.05). Similarly, the frequency of MTRR genotype (GG) was similar in NSCL/P group (15.5%) and control group (17.8%) (p>0.05). Multivariate analysis showed an association between MTRR and the subgroup that the mother smoked during pregnancy (p=0.039). Our findings did not demonstrate an association between TCN2 polymorphisms and NSCL/P, however suggests an association between MTRR and NSCL/P etiology

scholarly journals Faktor Risiko Tuberkulosis Paru pada Masyarakat di Wilayah Kerja Puskesmas Bambu Apus Kota Tangerang Selatan

2019 ◽  
Vol 3 (2) ◽  
pp. 112-117
Author(s):  
Rony Darmawansyah Alnur ◽  
Rismawati Pangestika
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Health Center ◽  
Chi Square ◽  
Bivariate Data ◽  
Work Area ◽  
Chi Square Test ◽  
And Control ◽  
Control Study ◽  
Tuberculosis Risk

ABSTRACT Pulmonary tuberculosis is a contagious disease that is still a problem in the world of health until now. Pulmonary tuberculosis attacks the lungs caused by Mycrobacterium tuberculosis. Indonesia is included in a country with a high burden of tuberculosis, ranking 4th as a contributor to tuberculosis after India, China and South Africa.This study aims to determine internal risk factors that can cause pulmonary tuberculosis in the Dhuafa population. This type of research is analytical with a case control Study. The sample study was divided into case and control samples totaling 30 people with pulmonary tuberculosis and 30 people non-pulmonary tuberculosis. Univariate data were analyzed descriptively and bivariate data were analyzed by Chi-Square test with a 95% confidence level. The results of this studied showed that the risk factors that was the caused of the incidence of pulmonary tuberculosis in the work area of ​​Bambu Apus Health Center were a household contact with patient pulmonary tuberculosis. (OR: 3.5; 95% CI: 1.112-11,017; p = 0.028) and habit of smoking family at home (OR: 4,333; 95% CI: 1,203-15,605; p = 0,020). The education level and occupancy density were variables that have no relationship with the incidence of pulmonary tuberculosis in the work area of ​​Bambu Apus Health Center. Keywords: Pulmonary Tuberculosis, Risk Factors, Dhuafa

scholarly journals Do diabetes and family history influence the rheumatoid arthritis? - results from a case-control study

1970 ◽  
Vol 10 (4) ◽  
pp. 230-234
Author(s):  
MM Efterkharian ◽  
Z Basiri ◽  
KM Kashani
Keyword(s):  
Rheumatoid Arthritis ◽  
Family History ◽  
Case Control Study ◽  
Case Control ◽  
Chi Square ◽  
Chi Square Test ◽  
History Of ◽  
Diabetes Family History ◽  
And Control ◽  
Control Study

Introduction: Up to now, several studies have been performed about the role of different factors on incidence and severity of Rheumatoid arthritis (RA) in the world. This 2009 study was carried out to investigate the association between History of diabetes and Family history of RA with RA incidence in Hamedan, a western city of Iran. Methods: As a case-control study, information from 128 cases and 130 controls, matched for age and Sex, were collected by questionnaire and analyzed using SPSS (chi-square test). Results: In case and control groups, females were 116 and 118 persons respectively and the rest were males. Statistical analysis showed that there is significant and no significant association between Family history of RA and history of diabetes with RA respectively. Conclusion: Considering previous global investigations on these topics and the results of our study, it seems that more studies will be needed to describe the association between history of diabetes and RA, but about another checked risk factor, there is a definite significant association between family history of RA and RA. Keywords: Rheumatoid arthritis; diabetes; family history; risk factors. DOI: http://dx.doi.org/10.3329/bjms.v10i4.9492 BJMS 2011; 10 (4): 230-234

scholarly journals Toll-like Receptor 2 Polymorphisms Impose Considerable Impacts On Acute Myelocytic Leukemi Occurrence

2020 ◽  
Author(s):  
Hong Qu ◽  
Yongfang Chen ◽  
Wenjing Zeng ◽  
Xiaohua Huang ◽  
Shuqin Cheng
Keyword(s):  
Control Group ◽  
Acute Myelocytic Leukemia ◽  
Genotype Distribution ◽  
Toll Like Receptor ◽  
Chi Square ◽  
Myelocytic Leukemia ◽  
Chi Square Test ◽  
Hardy Weinberg Equilibrium ◽  
Toll Like Receptor 2 ◽  
And Control

Abstract Background: This research aimed to explore the genetic association of Toll-like receptor 2 (TLR2) gene polymorphisms with acute myelocytic leukemia (AML) susceptibility in Chinese population.Methods: Firstly, the genotypes of TLR2 polymorphism were detected in 148 AML patients and 126 healthy controls by polymerase chain reaction (PCR). The genotype distribution of every polymorphism in the control group was detected whether conformed to Hardy-Weinberg equilibrium (HWE). The genotype frequency difference of TLR2 polymorphism between the case and control groups was compared by chi-square test and odds ratio (OR) with 95% confidence interval (95%CI) was calculated to express the risk of AML resulted from genetic variant of TLR2.Results: For TLR2 rs3804099 polymorphism, the heterozygous genotype TC was detected the significantly lower frequency in AML patients than that in the controls (P=0.031), so was C allele (P=0.021), which showed that rs3804099 was associated with the decreased the risk of AML (OR=0.580, 95%CI=0.354-0.953; OR=0.641, 95%CI=0.438-0.938). Similarly, GG genotype and G allele of rs1898830 also showed the obviously association with the risk reduction of AML (GG vs. AA: OR=0.430, 95%CI=0.200-0.924, G vs. A: OR=0.644, 95%CI=0.451-0.919). However, no significant association was found in rs7656411 with AML.Conclusions: TLR2 rs3804099 and rs1898830 polymorphisms may be the protective factors for AML, but not rs7656411.

HUBUNGAN ANTARA USIA, PARITAS, PEKERJAAN DAN INDEK MASSA TUBUH DENGAN KEJADIAN PROLAP ORGAN PANGGUL BERDASARKAN SKOR PELVIC ORGAN PROLAPSE QUANTIFICATION

2019 ◽  
Vol 2 (1) ◽  
pp. 39-44
Author(s):  
Ermawati Ermawati ◽  
Hafni Bachtiar
Keyword(s):  
Pelvic Organ Prolapse ◽  
Case Control Study ◽  
Pelvic Organ ◽  
Case Control ◽  
T Test ◽  
Pelvic Organ Prolapse Quantification ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Prolap organ panggul merupakan kondisi yang mempengaruhi kualitas hidup wanita. Prolaps organ panggul ini dapat disebabkan oleh perlukaan sewaktu proses persalinan, proses penuaan, komposisi jaringan pada seorang wanita, batuk- batuk kronis, atau sering melakukan pekerjaan berat. Pengenalan dini prolaps terkait dengan prognosis pemulihan anatomik dan fungsional organ panggul. Hingga kini, penerapannya dalam dunia klinis belum banyak sehingga pelatihan dan pembelajaran lebih lanjut tentang pelvic organ prolapse quantification (POPQ) jelas diperlukan. Penelitian ini dilakukan dengan metode case control study di polikilinik Obgin RSUP. Dr. M. Djamil Padang mulai bulan September 2013 sampai jumlah sampel terpenuhi sebanyak 98 orang. Dengan 49 orang kelompok kontrol dan 49 orang kelompok kasus .Analisis dilakukan untuk menilai hubungan usia, paritas, pekerjaan dan indek massa tubuh dengan kejadian prolap organ panggul berdasarkan skor POPQ. Data disajikan dalam bentuk tabel. Data diuji dengan t test dan chi square test. Jika p<0,05 menunjukan hasil yang bermakna. Terdapat hubungan yang bermakna antara usia dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 27,871.terdapat hubungan yang bermakna antara paritas dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 52,970.Dari analisa statistik pekerjaan tidak bisa di uji secara statistik.indek massa tubuh tidak terdapat hubungan yang bermakna terhadap kejadian prolap organ panggul.(p>0,05)

Resorbable Collagen Barrier Impeding the Extrusion of Obturating Material in Primary Molars Undergoing Resorption – A Randomized Clinical Trial

2021 ◽  
Vol 45 (5) ◽  
pp. 312-316
Author(s):  
Mishra Neha Sanjeev ◽  
Harsimran Kaur ◽  
Sandeep Singh Mayall ◽  
Rishika ◽  
Ramakrishna Yeluri
Keyword(s):  
Test Group ◽  
Primary Molars ◽  
Control Group ◽  
Chi Square ◽  
Significance Level ◽  
Significant Difference ◽  
Chi Square Test ◽  
Group A ◽  
Group B ◽  
And Control

Objective: To evaluate the effectiveness of placing a resorbable collagen barrier in impeding the extrusion of obturation material in primary molars undergoing resorption. Study design: All the 94 canals in 47 mandibular molars were allocated to 2 groups- Group ‘A’- 47 canals with collagen barrier (Test group) and Group ‘B’- 47 canals without collagen barrier (Control group) based on randomization protocol. Pulpectomy was performed and obturation of both test and control canals were radiographically assessed. Pearson’s chi – square test was applied to analyze the results. The significance level was predetermined at p &lt; 0.05. Results: Among the test group, 93.6% of the canals showed no extrusion while, 6.4% showed visible extrusion of the material outside the apex. In the control group, 83% showed no extrusion whereas 17% of the canals showed visible extrusion outside the apex. But no significant difference was noted (p&gt;0.05). Conclusion: The placement of resorbable collagen barrier in the apical third of the canal prevented the extrusion of obturating material beyond the apex in resorbing primary molars.

scholarly journals Pengaruh Pemberian Bubur Labu Kuning dan Daging Ayam Terhadap Peningkatan BB pada Bayi Gizi Kurang

2018 ◽  
Vol 1 (1) ◽  
pp. 046
Author(s):  
Yusni Podungge ◽  
Puspita Sukmawaty Rasyid
Keyword(s):  
Normal Weight ◽  
Chicken Meat ◽  
The Body ◽  
Control Group ◽  
Chi Square ◽  
Sample Number ◽  
Work Area ◽  
Equivalent Control ◽  
Chi Square Test ◽  
And Control

Undernutrition in infants is a condition where the baby does not growand develop optimally because of the unfulfilled intake of nutritionsubstances in the body. Under-nutrition in infants can be overcome bythe provision of balanced nutritious foods, one sign of improvednutrition can be seen from normal weight gain for age. One of the foodsthat can boost the improvement of nutrients is a food that containsproteins and vitamins, such as yellow pumpkin and chicken, whereyellow pumpkin contains vitamin A and chicken meat as a source ofanimal protein that contains good nutrients. The purpose of this studywas to analyze the effect of yellow pumpkin and chicken meat onweight growing infant 12 months in work area of Talaga JayaCommunity Health Center. The research method used experimentalresearch model with design non equivalent control group for eachgroup of intervention and control. Sampling using purposive samplingaccording to inclusion and exclusion criteria. With a sample number of30 malnourished infants less than 12 months of age. Analyticaltechniques was used in the chi square test. The result of this researchwas showed that value of chi square count 22,634 highger than chisquare table Df 1 = 3,841. There was influence giving yellow pumpkinpumper and chicken to enhancement nutritional weight infant weight12 month in work area Puskesmas Talaga Jaya. The conclusion wasthe provision of pumpkin porridge can raise the weight of infants lessthan 12 months of age as a benchmark nutritional improvements ininfants less nutrition.

scholarly journals HUBUNGAN PREEKLAMPSIA BERAT DENGAN KOMPLIKASI PADA JANIN DI RSUD ABDUL 2 WAHAB SJAHRANIE SAMARINDA 3 TAHUN 2017-2018

2019 ◽  
Vol 7 (2) ◽  
pp. 74-84
Author(s):  
Mita Maulida Rifqiya Faiza ◽  
Novia Fransiska Ngo ◽  
Ika Fikriah
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Labor ◽  
Fetal Death ◽  
Severe Preeclampsia ◽  
Chi Square ◽  
Neonatal Asphyxia ◽  
Uteroplacental Blood Flow ◽  
And Control ◽  
Control Study

Preeclampsia defined as new onset of hypertension and proteinuria after 20 weeks of gestation. Preeclampsia is one of the three main causes of maternal mortality with an incidence of 128,273 each year or around 5.3% in Indonesia. Preeclampsia is classified as preeclampsia without severe features and severe preeclampsia. Severe preeclampsia can be a problem, both in the mother and the fetus due to vascular vasospasm. If uteroplacental blood flow to the fetus is limited, the fetus can be born under low birth weight (LBW), preterm birth, intra uterine fetal death, and low Apgar score. The aim of this research is to determine the correlation of severe preeclampsia with fetal complication, that is intra uterine fetal death (IUFD), preterm labor, neonatal asphyxia, and low birth weight (LBW). The design of this research is case control study with 46 sample for both case and control groups. The data analysis used chi-square for 2x2 table and likelihood ratio for 2x3 table. The results of this this research is showed that there was correlation between severe preeclampsia with preterm labor (p=0,000)and severe preeclampsia with low birth weight (p=0,000), there was no correlation between severe preeclampsia with IUFD (p=0,822) and severe preeclampsia with neonatal asphyxia (p=0,060)

scholarly journals FAKTOR RISIKO KESEGARAN JASMANI SISWI SMA MUHAMMADIYAH 1 PONOROGO Risk Factors of Physical Fitness among Female Student in Muhammadiyah 1 Ponorogo High School

2020 ◽  
Vol 15 (2) ◽  
pp. 73
Author(s):  
Ikanov Safitri ◽  
R. Bambang Wirjatmadi
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
High School ◽  
Haemoglobin Level ◽  
Case Control Study ◽  
Female Students ◽  
Chi Square ◽  
Low Protein ◽  
Chi Square Test ◽  
Control Study

Physical fi tness is the ability of each individual to carry out various daily activities without feeling fatigue. Physical fi tness is useful as a supporting capacity for the physical activity of children therefore it is expected to improve their health and achievement. Factors that infl uence physical fi tness include genetics, age, gender, physical activity, nutritional status, food intake, haemoglobin level, resting time and smoking habits. The purpose of this study was to analyze the risk factors of physical fi tness among female students in Muhammadiyah 1 Ponorogo High School. This case control study included 50 female students and divided into 25 cases and 25 controls. Chi-Square test was used to analyze the relationships between variables. The results showed that there was an association between protein adequacy (p=0.023) OR = 11.3 and haemoglobin levels (p=0.049) OR = 9.3 with physical fi tness. While the adequacy of iron (p=0.345) did not associated with physical fi tness. Student with low protein adequacy and haemoglobin level have respectively 11.3 and 9.3 times higher risk of having low physical fi tness than student with good protein adequacy and haemoglobin level.

Double diapering facilitates hip maturation in newborns: a prospective randomised control study

2020 ◽  
Author(s):  
Wei C. Lee ◽  
Hsuan K. Kao ◽  
Mei C. Chen ◽  
Wen E Yang ◽  
Shih M. Chu ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Gestational Age ◽  
Birth Rate ◽  
Hip Dysplasia ◽  
Alpha Angle ◽  
First Year ◽  
Type I ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Abstract Background Maintaining the hips in flexion and abduction posture is a common recommendation to facilitate hip maturation in infants. Double diapering helps to maintain a baby’s hips in flexion and abduction posture, but the efficacy of double diapers in hip development has never been verified. We investigated whether double diapering results in greater improvement of the alpha angle in the first months of life. Methods This prospective randomised control study enrolled newborns with Graf type IIa hips. Babies were assigned to the double-diaper or single-diaper group. Parents were instructed on proper hip positioning, except for diapering. Change in the alpha angle from newborn to 1 month after birth, rate of improvement to bilateral Graf type I hips in 1 month, and number of ultrasound examinations and orthopaedic clinic visits in the first year were compared between the two groups. For babies with bilateral IIa hips, we used the averaged data from both hips, and for babies with unilateral IIa hips, we used the data from the IIa hips. Results Seventy newborns with 102 type IIa hips were included from January to December 2017. They were allocated to the double-diaper group (N=33) and single-diaper group (N=37). With a comparable sex ratio, gestational age, and newborn alpha angle, the double-diaper group had a greater increase of alpha angles in 1 month than the single-diaper group (+7.9° vs. +5.2°, t-test, p=0.011). Twenty-eight babies in the double-diaper group (84.8%) and 20 babies in the single-diaper group (54.1%) improved to having bilateral Graf type I hips (chi-square test, p=0.006). Subsequent clinical visits and hip ultrasounds before 1 year were significantly reduced in the double-diaper group. Conclusions Our results support double diapering for enhancing hip maturation in babies with Graf type IIa hips. The amount of improvement may not indicate double diapering as a treatment for hip dysplasia, but its effects in immature hips are noteworthy in reducing further clinical and ultrasound follow-ups.

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