The effects of nanofatty acids on the nervous system

2020 ◽  
Vol 10 (11) ◽  
pp. 1831-1835
Author(s):  
Wei Hao ◽  
Cuiui Wang ◽  
Jia Song ◽  
Ping Zhao ◽  
Gang Li
Keyword(s):  
Lipid Peroxidation ◽  
Nervous System ◽  
Brain Homogenate ◽  
Control Group ◽  
Reduced Body ◽  
Malondialdehyde Content ◽  
The Brain ◽  
Experimental Group ◽  
Plasma Malondialdehyde ◽  
Total Superoxide Dismutase

To investigate the effect of polyunsaturated fatty acids (nanofatty acids) on the nervous system, 90 clean female mice aged 3?5 weeks old were randomly divided into two groups (n = 45). The experimental group was injected with nanofatty acids once every other day for a total of three times, while the control group was injected with the same volume of normal saline. The behavior, weight, plasma, malondialdehyde content in the brain homogenate, and total superoxide disodium alcohol were assessed after the treatments. Mice treated with nanofatty acid were easily provoked, hyperactive, and had significantly reduced body weight as compared to the control mice (P <0.05). These findings suggest that polyunsaturated fatty acid can reduce the levels of lipid peroxidation and the activity of total superoxide dismutase in mice. Our results suggest that nanofatty acid exposure has a protect effect on the nervous system.

scholarly journals Teratogenic effects of lamotrigine on rat fetal brain: a morphometric study

2001 ◽  
Vol 59 (2B) ◽  
pp. 362-364 ◽  
Author(s):  
Nely Silvia Aragão de Marchi ◽  
Reinaldo Azoubel ◽  
Waldir Antonio Tognola
Keyword(s):  
Histological Study ◽  
Fetal Brain ◽  
Morphometric Study ◽  
Control Group ◽  
Test Results ◽  
Point Counts ◽  
Reduced Body ◽  
Group Data ◽  
The Brain ◽  
Experimental Group

A study of the teratogenic activity of an antiepileptic drug - lamotrigine - was carried out in the brain of fetuses of rats who had received the drug. The dosage levels studied corresponded to four times the median effective dose (ED50) in rats. The drug was administered during the organogenesis period. Rats were sacrificed one day prior to term and fetuses were macroscopically examined, weighted and cephalic segments sectioned (Wilson technique), for histological study by stereological analysis, using Merz's grid for drawing and point counts. Cortex, subcortex, ependyma and lateral ventricles were analyzed. The same methodology was applied to the control group; data were compared with by the non-parametric Mann-Whitney statistical analysis test. Results showed that fetuses of the experimental group had reduced body weight at birth, increased volume and diameter of the cerebral structure, increased density of the subcortical layer, and ventricle dilatation .Possible mechanisms of this teratogenicity were discussed.

scholarly journals Astrocytic and microglial response and histopathological changes in the brain of horses with experimental chronic Trypanosoma evansi infection

2008 ◽  
Vol 50 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Karen Regina Lemos ◽  
Luiz Carlos Marques ◽  
Lucia Padilha Cury Thomaz Aquino ◽  
Antonio Carlos Alessi ◽  
Rosangela Zacarias Zacarias
Keyword(s):  
Nervous System ◽  
Mononuclear Cells ◽  
Trypanosoma Evansi ◽  
Control Group ◽  
Reactive Microglia ◽  
The Central Nervous System ◽  
Males And Females ◽  
Microglial Response ◽  
The Brain ◽  
Experimental Group

This study aimed to characterize astrocytic and microglial response in the central nervous system (CNS) of equines experimentally infected with T. evansi. The experimental group comprised males and females with various degrees of crossbreeding, ages between four and seven years. The animals were inoculated intravenously with 10(6) trypomastigotes of T. evansi originally isolated from a naturally infected dog. All equines inoculated with T. evansi were observed until they presented symptoms of CNS disturbance, characterized by motor incoordination of the pelvic limbs, which occurred 67 days after inoculation (DAI) and 124 DAI. The animals in the control group did not present any clinical symptom and were observed up to the 125th DAI. For this purpose the HE histochemical stain and the avidin biotin peroxidase method was used. Lesions in the CNS of experimentally infected horses were those of a wide spread non suppurative meningoencephalomyelitis.The severity of lesions varied in different parts of the nervous system, reflecting an irregular distribution of inflammatory vascular changes. The infiltration of mononuclear cells was associated with anisomorphic gliosis and reactive microglia was identified. The intensity of the astrocytic response in the CNS of the equines infected by T. evansi characterizes the importance of the performance of these cells in this trypanosomiasis. The characteristic gliosis observed in the animals in this experiment suggests the ability of these cells as mediators of immune response. The parasite, T. evansi, was not identified in the nervous tissues.

The features of self-awareness and value orientations in agricultural workers with occupational diseases of the peripheral nervous system

2021 ◽  
pp. 430-441
Author(s):  
Tatyana Yurievna Ledvanova ◽  
Yulia Borisovna Barylnik ◽  
Natal’a Valer’evna Filippova ◽  
Mariya Nikolaevna Nosova ◽  
Sergey Alekseevich Goryunov
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Occupational Diseases ◽  
Well Being ◽  
Value Orientations ◽  
Agricultural Workers ◽  
Control Group ◽  
Self Awareness ◽  
Adaptive Potential ◽  
Experimental Group

The problem of preventing and reducing the level of occupational morbidity among agricultural workers is of particular importance, since occupational diseases are the cause of high disability and mortality rates of the working-age population all over the world. As a research task, the authors made an attempt to identify the features of the interdependence of the components of self-awareness and conflicts in value orientations for the manifestation of the phenomenology of disorders with further designation of the targets of psychotherapy. An experimental psychological study which included 40 agricultural workers with occupational diseases of the peripheral nervous system (experimental group) and without diseases (control group) was carried out using the multilevel personality questionnaire «Adaptability», the self-attitude test questionnaire by V.V. Stolin and S.R. Panteleev, and Schwartz's methodology «Value orientations». As a result of the study, it was found that in the subjects of the experimental group, in contrast to healthy individuals, the hyposthenic type of response prevails, there is the average level of neuropsychic tension, there is no tendency to reactions of the impulsive type, and a high negative and statistically significant relationship between the indicator of conflict in values and the level of personal adaptive potential is identified. The results of the study indicate that among agricultural workers with occupational diseases of the peripheral nervous system, accentuations of the character of the «inhibited» circle prevail, there is an increased level of anxiety and low tolerance to unfavorable factors of professional activity. The dominant personal values at the level of convictions are personal success in accordance with social standards and enjoyment of life, and at the level of behavior — understanding and protecting the well-being of all people and nature, preserving and increasing the well-being of loved ones. With an increase in conflict in value orientations, the adaptive potential of the respondents decreases, and a decrease in the level of self-attitude entails a decrease in adaptation.

scholarly journals ІНТЕНСИВНІСТЬ ПРОЦЕСІВ ПОЛ ТА АКТИВНІСТЬ СИСТЕМИ АНТИОКСИДАНТНОГО ЗАХИСТУ У КРОВІ КОРОПІВ ЗА ДІЇ РІЗНОГО РІВНЯ ВІТАМІНУ Е І СЕЛЕНУ В РАЦІОНІ

2016 ◽  
Vol 18 (3(71)) ◽  
pp. 201-204
Author(s):  
S.V. Yurchak ◽  
O.V. Derenj ◽  
O.I. Vishchur ◽  
Yu.M. Zabytivskyi
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Control Group ◽  
Fish Feed ◽  
Dose Dependent Decrease ◽  
Fat Soluble Vitamins ◽  
And Control ◽  
Dose Dependent ◽  
Experimental Group ◽  
Different Levels

The article consist data about effect of different levels of vitamin E and selenium in the diet of carps during their growing and also informationabout the influence on processes of lipid peroxidation and activity of antioxidant protection in their body.The experiment conducted in three experimental ponds. After wintering there were placed four ears mature females and males carp, six individuals in each group. Supplements of vitamin E administered at a rate of 25 mg/kg and drug «Sel–Plex» the rate of selenium – 0.3 mg/kg were added to further basic diet(BD) of female and male carp first experimental group (EG1). The second experimental group (EG2) received (BD) and vitamin E supplements in an amount of 75 mg / kg, and just as in EG1 – selenium – 0.3 mg/kg of feed.The control group received fish feed without additives vitamins and minerals.Feeding lasted for 30 days, due to the physiological needs of the fish feed. After spawning in fish of research and control group swere taken blood samples for biochemical research.The study led to a dose–dependent decrease (p < 0.01 – 0.001) content of TBA–active products and hydroperoxidase of lipids, but did not significantly effect onsuperoxide dismutase and glutathione peroxidase activity of blood So, the reduction of lipid peroxidation products in the carp’s blood of experimental groups probably was caused by the growth of non–enzymatic level, which is associated with fat–soluble vitamins. 

scholarly journals Analysis of electrogenesis’ changes in mental retardation persons by using computer electroencephalography

2021 ◽  
Vol 11 (11) ◽  
pp. 249-265
Author(s):  
B. Lobasyuk ◽  
L. Bartsevich ◽  
A. Zamkovaya
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mental Retardation ◽  
Theta Rhythm ◽  
Cognitive Activity ◽  
Control Group ◽  
Bioelectrical Activity ◽  
The Central Nervous System ◽  
Beta Rhythms ◽  
The Brain

Justification. Mental retardation is a persistent decrease in human cognitive activity against the background of organic damage to the central nervous system. Neurophysiological diagnostics, in particular electroencephalography (EEG), most adequately reflects the morpho-functional state of the central nervous system, which is the basis of the mechanisms of mental activity, and the originality of the bioelectrical activity of the brain can be considered as the main indicator that determines a decrease in the level of intellectual development and, thereby, characterizes this state. This provision actualizes the search for highly informative indicators of the originality of the bioelectrical activity of the brain in children with intellectual disabilities. Purspose. With the use of periodometric analysis investigate EEG’s indicators and interhemispheric asymmetry of rhythms amplitudes in MR patients. Materials and methods. The EEG was recorded in a state of calm wakefulness with closed eyes with Neuron-Spectrum-2 electroencephalograph. Differences in indicators were tracked using the calculation of the coefficient of compliance (CC), EEG functional asymmetry coefficients in amplitude were determined, too. Results. It was revealed that in MR patients the amplitudes of the rhythms were greater than in healthy subjects. The greatest increase was determined in theta rhythm in the anterior temporal and posterior temporal leads in the left hemispheres. Duration indices in the delta, theta and alpha ranges of the EEG in mental retardation compared with the control group were increased, and the indices of the duration of beta rhythms - decreased. When analyzing FMPA in MR persons it turned out that in right-handers the negativeness of FMPA indices increased, and in left-handers there was an increase in the positivity of FMPA indices. Conclusions 1. With mental retardation, the amplitudes of the rhythms were greater than in healthy people. The greatest increase was determined in theta rhythm in the anterior temporal and posterior temporal leads in the left hemispheres. 2. The indices of duration in the delta, theta and alpha ranges of the EEG of MR subjects were increased, and the indices of the duration of beta rhythms – decreased. 3. When analyzing FMPA in MR persons, it turned out that in right-handers the negativeness of FMPA indices increased, and in left-handers there was an increase in the positivity of FMPA indices.

scholarly journals Walnut Oil Prevents Scopolamine-Induced Memory Dysfunction in a Mouse Model

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1630
Author(s):  
Jianqiao Liao ◽  
Yifan Nai ◽  
Li Feng ◽  
Yimeng Chen ◽  
Mei Li ◽  
...  
Keyword(s):  
Body Weight ◽  
Memory Impairment ◽  
Acetylcholinesterase Activity ◽  
Walnut Oil ◽  
Histological Changes ◽  
Hippocampal Ca1 ◽  
Malondialdehyde Content ◽  
Wet Weight ◽  
The Brain ◽  
Total Superoxide Dismutase

For thousands of years, it has been widely believed that walnut is a kind of nut that has benefits for the human body. Walnut oil, accounting for about 70% of walnut, mainly consists of polyunsaturated fatty acids. To investigate the effect of walnut oil on memory impairment in mice, scopolamine (3 mg/kg body weight/d) was used to establish the animal model during Morris Water Maze (MWM) tests. Walnut oil was administrated orally at 10 mL/kg body weight/d for 8 consecutive weeks. The results showed that walnut oil treatment ameliorated the behavior of the memory-impaired mice in the MWM test. Additionally, walnut oil obviously inhibited acetylcholinesterase activity (1.26 ± 0.12 U/mg prot) (p = 0.013) and increased choline acetyltransferase activity (129.75 ± 6.76 U/mg tissue wet weight) in the brains of scopolamine-treated mice (p = 0.024), suggesting that walnut oil could prevent cholinergic function damage in mice brains. Furthermore, walnut oil remarkably prevented the decrease in total superoxide dismutase activity (93.30 ± 5.50 U/mg prot) (p = 0.006) and glutathione content (110.45 ± 17.70 mg/g prot) (p = 0.047) and the increase of malondialdehyde content (13.79 ± 0.96 nmol/mg prot) (p = 0.001) in the brain of scopolamine-treated mice, indicating that walnut oil could inhibit oxidative stress in the brain of mice. Furthermore, walnut oil prevented histological changes of neurons in hippocampal CA1 and CA3 regions induced by scopolamine. These findings indicate that walnut oil could prevent memory impairment in mice, which might be a potential way for the prevention of memory dysfunctions.

scholarly journals The Effect of Brain Gym on the Learning Concentration of Student in STIKES NU Tuban

2020 ◽  
Vol 11 (1) ◽  
pp. 46
Author(s):  
Hyan Oktodia Basuki ◽  
Hanim Nur Faizah
Keyword(s):  
Student Learning ◽  
Random Sampling ◽  
Control Group ◽  
Test Results ◽  
Working Ability ◽  
Systematic Random Sampling ◽  
Brain Gym ◽  
Implementation Time ◽  
The Brain ◽  
Experimental Group

Introduction: Concentration is an important aspect for a person in achieving learning and is related to the working ability of the brain. Maximum brain performance increases concentration, so that changes in parts of the brain also occur so there will be a decrease in the level of concentration. Objective: The purpose of this study is to compare the influence of the brain gym on student learning at STIKES NU Tuban. Method: The design of this study was Quasy Experimental by designing a pretest-posttest with a control group. The sample uses a systematic random sampling taken by 26 respondents (13 experimental group respondents and 13 control group respondents). Data collection using a questionnaire. Analysis using the Mann Whitney test. Results: Asymp results were obtained. Sig. = 0,000 which means the help of the composition of brain gym for the concentration of student learning. Discussion: Giving brain gym intervention as an ice breaker can make a good contribution to the concentration of student learning. Brain gym can be applied to students, just before the lesson starts or in the middle of the lesson, and the implementation time is approximately 10-15 minutes.

scholarly journals Consequences of Dental Occlusion Enhancement by Means of Metal Crowns on the Animal Model

2019 ◽  
Vol 69 (12) ◽  
pp. 3517-3519
Author(s):  
Ana Ispas ◽  
Antarinia Craciun ◽  
Liana Lascu ◽  
Marcela Elisabeta Barbinta Patrascu ◽  
Mariana Constantiniuc
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Free Radicals ◽  
Wistar Rats ◽  
Vertical Dimension ◽  
Dental Occlusion ◽  
Control Group ◽  
Experimental Group ◽  
Plasma Malondialdehyde

The purpose of this study was to determine whether there is a correlation between induced occlusal trauma and the occurrence of oxidative stress in the hippocampus. Twenty Wistar rats were randomized into three experimental groups and one control group. Animals in the experimental group were cemented modified crowns on molars to induce occlusal trauma in 7, 14 and 30 days. To evaluate the oxidative stress, blood was drawn from the hippocampus at 7, 14 and 30 day intervals. Oxidative stress was evaluated using the following specific tests: determination of plasma malondialdehyde and serum glutathione values. The results of the study demonstrate that malocclusion experienced by raising the vertical dimension in rats resulted in significant reductions in antioxidants and increase level of free radicals.

scholarly journals Prediction and Value of Ultrasound Image in Diagnosis of Fetal Central Nervous System Malformation under Deep Learning Algorithm

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yuehong Zhou
Keyword(s):  
Neural Network ◽  
Central Nervous System ◽  
Nervous System ◽  
Deep Learning ◽  
Ultrasound Examination ◽  
Ultrasound Image ◽  
Control Group ◽  
Test Results ◽  
Experimental Group ◽  
Central Nervous System Malformation

This study was to explore the application of deep learning neural network (DLNN) algorithms to identify and optimize the ultrasound image so as to analyze the effect and value in diagnosis of fetal central nervous system malformation (CNSM). 63 pregnant women who were gated in the hospital were suspected of being fetal CNSM and were selected as the research objects. The ultrasound images were reserved in duplicate, and one group was defined as the control group without any processing, and images in the experimental group were processed with the convolutional neural network (CNN) algorithm to identify and optimize. The ultrasound examination results and the pathological test results before, during, and after the pregnancy were observed and compared. The results showed that the test results in the experimental group were closer to the postpartum ultrasound and the results of the pathological result, but the results in both groups showed no statistical difference in contrast to the postpartum results in terms of similarity ( P > 0.05 ). In the same pregnancy stage, the ultrasound examination results of the experimental group were higher than those in the control group, and the contrast was statistically significant ( P < 0.05 ); in the different pregnancy stages, the ultrasound examination results in the second trimester were more close to the postpartum examination results, showing statistically obvious difference ( P < 0.05 ). In conclusion, ultrasonic image based on deep learning was higher in CNSM inspection; and ultrasonic technology had to be improved for the examination in different pregnancy stages, and the accuracy of the examination results is improved. However, the amount of data in this study was too small, so the representative was not high enough, which would be improved.

scholarly journals Effects of the Brain Wave Modulation Technique Administered Online on Stress, Anxiety, Global Distress, and Affect During the First Wave of the COVID-19 Pandemic: A Randomized Clinical Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Mauro Cozzolino ◽  
Giovanna Celia ◽  
Laura Girelli ◽  
Pierpaolo Limone
Keyword(s):  
Control Group ◽  
Post Intervention ◽  
Brain Wave ◽  
Face To Face ◽  
Wave Modulation ◽  
Modulation Technique ◽  
Before And After ◽  
The Brain ◽  
Experimental Group ◽  
Global Distress

This study aims to evaluate the effects of an innovative mind-body practice named the brain wave modulation technique (BWM-T) on stress, anxiety, global distress, and affect. The technique was administered online through a web-based video conferencing platform. The intervention started on week four of the first quarantine in Italy (week commencing 30th March 2020), for a duration of 4 weeks and ended before lockdown measures were loosened. 310 people participated in the study, mean age 28.73 years old (SD = 9.16), 77.8% women. Of these, about half were randomly assigned to the experimental group and the other half served as controls. Participants completed online psychological tests before and after the intervention. 266 people (144 experimental, 122 controls) completed the post-intervention tests. Consistent with our hypothesis, the study’s findings indicate a reduction in the levels of stress, anxiety, global distress, and negative affect in the experimental group, compared to the control group. Moreover, the experimental group also showed higher levels of positive affect, compared to controls after the intervention. The present findings add to the current literature in suggesting that the BWM-T reduced stress not only when administered face-to face but also when administered online during the COVID-19 pandemic. Moreover, we also noted that the BWM-T has an effect on anxiety, global distress, and affect, which we had not investigated in previous studies.

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