Effects of the Protein-Bound Polysaccharide Preparation, PSK on Spontaneous Breast Cancer in Mice

1988 ◽  
Vol 16 (4) ◽  
pp. 286-293 ◽  
Author(s):  
T. Fujii ◽  
K. Saito ◽  
Y. Oguchi ◽  
K. Matsunaga ◽  
Y. Kobayashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Weight ◽  
Tumour Size ◽  
Survival Rates ◽  
Test Group ◽  
Normal Diet ◽  
The Other ◽  
Control Population ◽  
Body Weights ◽  
Spontaneous Tumours

The protein-bound polysaccharide preparation, PSK was tested for its ability to suppress carcinogenesis in spontaneous tumours in C3H/OuJ mice. They were divided into two groups of 40 individuals each. A normal diet was given to one group, establishing a control population, while the other group had 2% PSK added to their feed. Amount of feed consumed, body weight and tumour size were recorded weekly for 1 year. Within 15 weeks, 90% of the control population had developed tumours. In the test group the incidence of cancer and the number of tumours was significantly suppressed, and survival rates were improved. The amount of feed consumed and body weights of control and test groups were about the same.

Chronic effect of exercise on liver cholesterol of normal and hypercholesteremic rats

1963 ◽  
Vol 205 (3) ◽  
pp. 453-456 ◽  
Author(s):  
Philip D. Gollnick
Keyword(s):  
Exercise Program ◽  
Normal Diet ◽  
The Other ◽  
Liver Cholesterol ◽  
Albino Rats ◽  
Cholesterol Diet ◽  
Trained Group ◽  
Sprague Dawley ◽  
Cholesterol Accumulation ◽  
Body Weights

Two groups of male albino rats of the Sprague-Dawley strain, with average initial body weights of about 265 g, were trained for 22 weeks on an exercise program of swimming one-half hour daily in water at 35 C. One trained group was fed a normal diet containing 18% casein. The other trained group received an isocaloric diet containing 1% cholesterol which was designed to produce hypercholesteremia. Two nonexercised groups, one fed the normal and the other the 1% cholesterol diet, served as controls. The adrenals and heart ventricles of both trained groups were larger than their respective controls. Exercise had no hypocholesteremic effect on the sera of either trained group. Fat and cholesterol accumulation in the livers of rats fed the 1% cholesterol diet were not affected by training, but training significantly lowered the fat and cholesterol of the livers of the normal rats.

Maintenance rations for Merino sheep. IV. The performance of adult Merino ewes fed daily and weekly at three levels of energy intake

1957 ◽  
Vol 8 (1) ◽  
pp. 75 ◽  
Author(s):  
PK Briggs ◽  
MC Franklin ◽  
GL McClymont
Keyword(s):  
Body Weight ◽  
Sodium Chloride ◽  
Energy Intake ◽  
Survival Rates ◽  
Experimental Period ◽  
The Body ◽  
Merino Sheep ◽  
Wool Production ◽  
Body Weights ◽  
The Mean

Dry adult Merino ewes were fed at daily or weekly intervals on oat grain at levels which provided 4.0, 3.0, or 2.0 lb starch equivalent (S.E.) per sheep per week. The experimental periods were 223, 223, and 181 days respectively. Differences between the mean body weights of the ewes a t the three levels of feeding were highly significant (P < 0.001). Body weight varied only slightly and no losses occurred in ewes fed weekly at the rate of 4.0 lb S.E. per head. Ewes fed daily a t this level had a significantly greater mean body weight (P < 0.001) a t the conclusion of the 223-day experimental period. The addition of a sodium chloride supplement did not improve the body weight or wool production of ewes fed weekly a t the level of 4.0 lb S.E. The mean body weight of ewes fed at the levels of 3.0 or 2.0 lb S.E. per head declined over the first 12 and 18 respectively and thereafter remained relatively constant. There were no significant differences at these levels of feeding between groups fed daily and weekly in respect of body weight, wool production, or survival rates. Ewes fed a t the level of 4.0 lb S.E. grew significantly more wool than those given 3.0 lb S.E. (P < 0.001). Losses were negligible in all groups except those fed a t the level of 2.0 lb S.E. In these groups there were few deaths in the first 16 weeks, but in the subsequent 10 weeks losses totalled 17.1 per cent. Ewes fed a t the level of 2.0 lb S.E. consumed their rations at a significantly slower rate (P < 0.01) than did those fed a t the level of 4.0 lb S.E.

scholarly journals Spontaneous and experimental poisoning of cattle by Palicourea aeneofusca in the region of Pernambuco and induction of conditioned food aversion

2015 ◽  
Vol 46 (1) ◽  
pp. 138-143 ◽  
Author(s):  
Luiz Bezerra de Brito ◽  
Raquel Feitosa Albuquerque ◽  
Brena Pessoa Rocha ◽  
Samuel Salgado Albuquerque ◽  
Stephen Tomas Lee ◽  
...  
Keyword(s):  
Body Weight ◽  
Single Dose ◽  
Lithium Chloride ◽  
Test Group ◽  
Aversive Conditioning ◽  
Feeding Tube ◽  
The Other ◽  
Control Group ◽  
Food Aversion ◽  
Conditioned Food Aversion

ABSTRACT: The objective of this study was to describe the epidemiological, clinical, and pathological aspects of Palicourea aeneofusca poisoning in cattle in the region of Pernambuco, Brazil and to determine if it is possible to induce food aversion by P. aeneofusca poisoning in cattle raised under extensive management conditions. To determine the occurrence of poisoning, 30 properties were visited in five municipalities of the region of Pernambuco. Three outbreaks of poisoning of cattle were monitored. To induce conditioned food aversion by the consumption of P. aeneofusca, 12 animals were randomly distributed into two groups of six animals each. Cattle were weighed and received green P. aeneofusca leaves in their trough at a dose of 35mg kg-1 body weight for spontaneous consumption. The control group (CG) animals received water (1ml kg-1 body weight) via a feeding tube after the first ingestion of the plant, while the other animals, constituting the aversion test group (ATG), underwent induced aversion with lithium chloride (LiCl - 175mg kg-1 body weight) via a feeding tube. For the ATG cattle, the aversion to P. aeneofusca induced by a single dose of LiCl persisted for 12 months. In contrast, the CG animals continued to consume the plant in all tests performed, indicating the absence of aversion. This study showed that aversive conditioning using LiCl was effective in preventing poisoning by P. aeneofusca for a period of at least 12 months.

Antioxidant potential of thyme extract: alleviation of N-nitrosodiethylamine-induced oxidative stress

2008 ◽  
Vol 27 (3) ◽  
pp. 215-221 ◽  
Author(s):  
P Rana ◽  
G Soni
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Test Group ◽  
Normal Diet ◽  
Lower Degree ◽  
Control Group ◽  
Albino Rats ◽  
Stress Induction ◽  
And Control

Protective role of thyme extract against N-nitrosodiethylamine (NDEA)-induced oxidative stress has been evaluated in albino rats. For this, one group of rats were fed diet supplemented with thyme extract (0.5%) and served as the test group, whereas animals of the other group fed on normal diet served as the control group. The rats were fed on respective diets for a period of 2 weeks after which stress was induced to half the animals of each group by i.p. administration of NDEA at 200 mg/kg body weight. Animals were killed 48 h post stress-induction period. Feed intake and body weight decreased significantly in both test and control groups, the effect being less in test group. Increase in osmotic fragility and in-vitro lipid peroxidation (LPO) on stress induction was of lower degree in the test group. NDEA toxicity was mainly reflected in liver as evidenced by increased activities of plasma aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase. The effect was of lower degree in test group as compared with that in the control group. Increase in urea levels observed following NDEA administration was also of lower degree in test groups. Blood glutathione (GSH) levels increased more so in test group compared with control group on stress induction. The activities of superoxide dismutase (SOD), peroxidase (Px), and catalase (CAT) activities decreased significantly on stress induction in erythrocytes. LPO increased in all the tissues through varying degree, and the increase was appreciably of lower degree in test group. The activity of SOD increased significantly in both test and control group on stress induction, whereas activities of Px and CAT decreased following NDEA treatment, and the effects were of lower degree in test group. Thus, supplementation of diet with thyme extract can improve antioxygenic potential and hence help to prevent oxidative stress.

scholarly journals DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway

2021 ◽  
Vol 11 ◽  
Author(s):  
Ming Niu ◽  
Ming Shan ◽  
Yang Liu ◽  
Yanni Song ◽  
Ji-guang Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Dna Repair ◽  
Survival Rates ◽  
The Other ◽  
Poor Survival ◽  
Induced Apoptosis ◽  
Cell Growth And Proliferation

Breast cancer (BRCA) is one of the most deadly cancers worldwide, with poor survival rates that could be due to its high proliferation. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is implicated in numerous diseases, including cancers. However, its role in BRCA is unclear. In this study, we used bioinformatic analyses of the ONCOMINE, UALCAN, and GEPIA databases to determine the expression pattern of DCTPP1 in BRCA. We found that elevated DCTPP1 levels correlate with poor BRCA prognosis. DCTPP1 silencing inhibited BRCA cell proliferation and induced apoptosis in vitro, as well as in vivo. Our data show that this tumorigenic effect depends on DNA repair signaling. Moreover, we found that DCTPP1 is directly modulated by miR-378a-3p, whose downregulation is linked to BRCA progression. Our results showed down-regulation of miR-378a-3p in BRCA. Upregulation of miR-378a-3p, on the other hand, can inhibit BRCA cell growth and proliferation. This study shows that reduced miR-378a-3p level enhances DCTPP1 expression in BRCA, which promotes proliferation by activating DNA repair signaling in BRCA.

scholarly journals Metaplastic Breast Cancer: Mesenchymal Subtype Has Worse Survival Outcomes

2021 ◽  
Author(s):  
Enver Özkurt ◽  
Selman Emiroğlu ◽  
Neslihan Cabioğlu ◽  
Hasan Karanlık ◽  
Semen Önder ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Tumour Size ◽  
Survival Rates ◽  
Multivariate Logistic Regression Analysis ◽  
Disease Free Survival ◽  
Survival Outcomes ◽  
Significant Difference

Abstract PurposeMetaplastic breast carcinoma (MBC) is a rare type of breast cancer that accounts for 0.2-1% of all breast cancers. To date, there are only few institutional studies comparing survival rates between different subtypes. In this retrospective cohort study, we aim to evaluate factors effecting survival rates of different subtypes of MBC.MethodsThis retrospective cohort study observed 118 non-metastatic MBC patients record extracted from 15,244 breast cancer cases between December 2000 and December 2020. In order to analyse factors effecting survival rates of mesenchymal subtype of MBC, all cases are classified as mesenchymal (n=45) and other (n=48). Twenty-five cases that could not be sub-classified due to the missing data. Univariate and multivariate logistic regression analysis were performed to define factors associated with survival rates.ResultsOf the 15,244 cases, 118 (0.8%) were non-metastatic MBC. 105 were triple negative and 12 were non-luminal HER2. There was no significant difference between mesenchymal and other subgroups for age, median tumour size, AJCC staging, and type of surgery. Of the five local recurrences with known subgroup, four of them had mesenchymal subtype. It is demonstrated that mesenchymal subtype was significantly associated with worse 5-year disease-free survival and disease specific survival (HR: 2.35 [1.01-5.48], p=0.049 and HR: 3.16 [1.06-9.47], p=0.040 with 95% CI respectively).ConclusionThis study is one of the few studies presenting the survival outcomes of subtypes of MBCs. Nonetheless, it is the only study demonstrating that mesenchymal subtype had worse survival outcomes. Further studies are needed to determine the outcome of different subtypes of MBCs.

Evaluation of Exogenous Laccase Enzyme Treated Finger Millet Straw on Body Weight Gain, DM Intake and Nutrient Digestibility in Heifers

2021 ◽  
Author(s):  
Vidya Pradeep Kumar ◽  
Ramya G. Rao ◽  
A. Dhali ◽  
Vandana Thammiaha ◽  
Manpal Sridhar
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Finger Millet ◽  
Body Weight Gain ◽  
Test Group ◽  
Nutrient Digestibility ◽  
Control Group ◽  
Widespread Application ◽  
Body Weights ◽  
Effect Of Feeding

Background: Fungal laccases have widespread application in a number of biotechnological processes including the biodegradation of lignin. Their low yield in the native state limits their practical use in the deconstruction of lignocellulosic biomass for feeding ruminants. Enzymes in bulk quantities are required to treat biomass which has got greater product consistency and less lot to lot variations. The present study was an attempt to evaluate the effect of feeding finger millet straw treated with exogenous laccases in heifers.Methods: The effect of feeding exogenous laccases obtained from immobilized Schizophyllum commune (MTCC 11893) on body weight gain, dry matter intake and nutrient digestibility in heifers was evaluated in three groups of heifers (4-each) with body weights ranging between 275 ± 47.12 to 276.75 ± 64.48kg. The control group received ad lib. finger millet straw treated with only production media (GI). Test group 1 (GII) received ad lib. straw treated with laccase rich media in a 3:5 (w/v) ratio, while test group 2 (GIII) received ad lib. straw treated in a 4:5 (w/v) ratio. Result: After 14- days of feeding, gain in body weights for GI, GII and GIII were 277.9 ± 68.47; 277.50 ± 46.43 and 278.85 ± 37.22 respectively with an overall increase of 1.15, 4.25 and 3.60 kgs. No significant variation (P greater than 0.05) was observed with regard to DMD (%) between the groups which was 46 ± 5.8 for the control animals and 41±13.0 and 41± 3.4 in G2 and G3 groups. Though significant variations were observed digestibility studies proved inconclusive. Though preliminary results indicate that applying lignin degrading enzymes as feed supplements could enhance digestibility of crop residues in ruminants.

scholarly journals Effects of selection for independent changes in two highly correlated body weight traits of mice

1977 ◽  
Vol 29 (2) ◽  
pp. 133-145 ◽  
Author(s):  
J. C. McCarthy ◽  
D. P. Doolittle
Keyword(s):  
Body Weight ◽  
Response Selection ◽  
The Other ◽  
Index Selection ◽  
Correlated Responses ◽  
Body Weights ◽  
Independent Culling ◽  
Selection For ◽  
Highly Correlated

SUMMARYMice were selected for high and low body weight at 5 and at 10 weeks of age. Selection was performed (1) separately for each trait, and (2) for various combinations of the two traits, using (a) independent culling levels and (b) restricted indices. Two-way selection for each trait separately gave large responses and correlated responses. Selection by independent culling levels intended to increase 5-week weight while restricting change in 10-week weight gave no demonstrable response; selection by culling levels intended to decrease 5-week weight while restricting change in 10-week weight resulted in decreases in body weights at both ages. Index selection, intended to change weight at one age while holding that at the other age constant, was generally successful. Observed responses did not conform very well with predicted responses for either index or culling levels selection. The significance of these observations in regard to the problem of selection involving restriction of traits is discussed.

Body weights, carcass characteristics, fat content, and their relationships in ganders of the Selected Chinese and Synthetic strains, and Embden-sired strain crosses

2005 ◽  
Vol 85 (4) ◽  
pp. 455-461
Author(s):  
J. N. B. Shrestha ◽  
A. A. Grunder
Keyword(s):  
Body Weight ◽  
Egg Production ◽  
Liver Weight ◽  
Abdominal Fat ◽  
The Other ◽  
Carcass Weight ◽  
Similar Proportion ◽  
Chinese Strain ◽  
Body Weights ◽  
Total Fat

In 1986, 247 ganders of the Selected Chinese and Selected Synthetic strains, and Large Embden and Small Embden- sired strain crosses at the Greenbelt farm of the Centre for Food and Animal Research in Ottawa, Canada, were evaluated. The Chinese and Synthetic (developed from the Pilgrim, Chinese and Hungarian) strains had been selected for four generations to increase egg production over a 24-wk laying period and body weight at 16 wk of age, and simultaneously decrease total fat content. Two Embden strains, Large and Small, denoting contrasting body sizes, had been imported from the United States of America for potential use in crossbreeding as terminal sire strains. Strains and strain crosses were ranked from high to low, for body weights at 9 and 16 wk of age, liveweight at slaughter and eviscerated carcass weight. Large Embden × Selected Chinese were largest followed by Small Embden × Selected Synthetic and Small Embden × Selected Chinese strain crosses, in turn followed by the Selected Chinese and Selected Synthetic strains. Small Embden-sired crosses were not significantly different except for body weight at 9 wk of age and eviscerated carcass weight. The Large Embden × Selected Chinese strain cross had a dressing percent of 63, significantly higher than 60–61% for the remaining strains or strain crosses. In general, the ranking of strains and strain crosses for liver weight was similar to rankings for body weights, except that the Small Embden-sired crosses were not significantly different from the Selected Chinese strain, and the Small and Large Embden-sired Selected Chinese crosses had similar liver weight. The Selected Synthetic strain had a significantly smaller neck than that of the other strains and strain crosses; Small Embden-sired crosses were not significantly different. Large Embden × Selected Chinese and Small Embden × Selected Synthetic strain crosses and the Selected Chinese strain had similar neck weight. When fat was expressed as a percentage of carcass weight, the strains and strain crosses had similar proportion of abdominal fat. On the other hand the Large Embden × Selected Chinese strain cross had significantly more intestinal fat (4.83%) than any of the strains and strain crosses (2.97 to 3.73%) and a similar proportion of total fat (10.87%) to the Small Embden × Selected Chinese strain cross (8.79%) but significantly more than the remaining strains and strain crosses (7.53 to 8.20%). The correlations of body weights at 9 and 16 wk of age with eviscerated carcass weight (0.65 and 0.90), abdominal fat weight (0.32 and 0.59), intestinal fat weight (0.27 and 0.55) and total fat weight (0.23 and 0.47) were deemed potentially useful. The correlations between percentage of fat parameters and body weights were low (0.20 a n d 0.37) or negligible. The inherent potential in the large-bodied Embden strain for growth can complement the small-bodied Selected Chinese strain that excels in egg production, fertility and hatchability to produce a strain cross with considerable promise for commercial production of goose meat. Key words: Chinese strain, Synthetic strain, Embden strain, body weights, abdominal and intestinal fat

Phenotypic and genetic characteristics of growth of Peking ducklings under Egyptian conditions

1988 ◽  
Vol 110 (1) ◽  
pp. 179-190
Author(s):  
Gh. A. El-Sayiad ◽  
I. F. M. Marai ◽  
E. A. Afifi
Keyword(s):  
Body Weight ◽  
Genetic Correlations ◽  
The Body ◽  
The Other ◽  
Genetic Characteristics ◽  
Retarded Growth ◽  
Body Weights ◽  
Different Ages ◽  
Growth Character ◽  
Successive Generations

SummaryPeking ducklings were classified at 6 weeks of age according to their body weights in two categories: R, below the overall mean of the flock which were considered as retarded growth; and L, those of body weight equal to the overall mean and above which were considered as large. From each group, males and females were chosen to be parents of the next generation in a ratio 1:5 at 6 months of age and four systems of matings were conducted: RR, LL, RL and LR.At all ages studied the large ducklings were significantly heavier than retarded growth ones and had significantly greater body gain, during the two successive generations.The RL and LR matings were heavier than the RR and LL groups at the different ages studied, indicating an effect of heterosis and that the retarded growth character is controlled by few pairs of genes. The differences due to mating systems were not significant either in body weight or body gain, except in body weight at 18 and 24 weeks and relative gain at 6 weeks of age in which the differences were significant (P <0·05) in the second generation.The other environmental factors studied were sex, month of hatch and 6-week body weight.Heritability estimates were 0·489, 0·509, 0·576, 0·346, 0·713, 0·809, 0·651 and 0·386 for body weight at hatch 4, 6, 8, 12, 16, 18 and 24 weeks of age, respectively, using the data which were adjusted for the effects of sex, month of hatch, 6-week body weight and mating system. The same estimates were 0·482, 0·554, 0·578, 0·352, 0·713, 0·808, 0·650 and 0·386, respectively, using the same data but adjusted for month of hatch and sex only.Phenotypic and genetic correlations between body weights at different ages for the two sets of data were estimated. The phenotypic correlations were negative between body weight at hatch and each of the body weights at 16 and 18 weeks of age for the two corrected sets of data. The genetic correlations were negative between hatch weight and each of the other body weights for the two adjusted sets of data and between body weight at 4 weeks of age and each of the body weights at 16, 18 and 24 weeks only for the first set of data. Phenotypic and genetic correlations between the body weights in older birds were highly positive.

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