scholarly journals The Spread of Caudal Analgesia in Children: A Mathematical Model

1986 ◽  
Vol 14 (2) ◽  
pp. 140-144 ◽  
Author(s):  
P. Busoni ◽  
T. Andreuccetti
Keyword(s):  
Mathematical Model ◽  
Body Weight ◽  
Local Anaesthetic ◽  
Young Patients ◽  
Older Children ◽  
Caudal Analgesia

A mathematical model correlating the spread of analgesia to the dose of local anaesthetic and to age or body weight was found analysing the data of 763 caudal blocks in children from age one day to twelve years. Two graphs have been plotted: (1) spread of analgesia, dose, age and (2) spread of analgesia, dose, weight. Both age and weight can be used as predictors to determine the desired level of analgesia, but weight is more useful in very young patients while age is a better guide in older children.

Effect of Sorafenib on Sex Hormone Levels in Male Swiss Albino Mice

2021 ◽  
pp. 3883-3888
Author(s):  
Surekha D. Shetty ◽  
Laxminarayana Bairy K. ◽  
AM Prasad ◽  
Satheesha Nayak B. ◽  
Ashwini Aithal P.
Keyword(s):  
Body Weight ◽  
Semen Analysis ◽  
Young Patients ◽  
Differentiated Thyroid Carcinoma ◽  
Positive Control ◽  
Vital Role ◽  
Reproductive Age ◽  
Control Group ◽  
Swiss Albino Mice ◽  
Albino Mice

Background: Hormones play a vital role in initiating and maintenance of male reproductive or testicular function which includes the production of androgens and spermatozoa. Testosterone is essential for the initiation and maintenance of spermatogenesis. FSH is responsible for the stimulation of spermatogenesis. Semen analysis and hormone evaluation are essential parameters in the diagnosis of infertility in males. Objective: The aim of the present study is to evaluate the effect of sorafenib on FSH and intratesticular testosterone levels in male Swiss albino mice. Materials and Methods: The animals were segregated into control, positive control, and treatment groups (n=6). Treatment group received 25, 50 and 100 mg/kg body weight of sorafenib orally for seven consecutive days at intervals of 24 hours between two administrations. Positive control group received 100 mg/kg body weight of imatinib. The animals were sacrificed at the end of 1st, 2nd, 4th, 5th, 7th and 10th week after the last exposure to sorafenib. Results: The intratesticular testosterone level was significantly (P<0.05) reduced in treated groups and severe effect was observed on week 4th and 5th weeks. FSH level was increased significantly (P<0.05) in sorafenib treated groups of mice. Conclusion: The administration of sorafenib does affect testosterone and FSH level significantly, but this effect is reversible once the drug is withdrawn. This finding may help the clinicians to plan and address the fertility-related issues in young patients of reproductive age who are being treated with sorafenib for advanced renal cell carcinoma, hepatocellular carcinoma and differentiated thyroid carcinoma.

scholarly journals EPID-13. A POPULATION-BASED ANALYSIS OF CNS TUMOR DIAGNOSES, TREATMENT, AND SURVIVAL IN CONGENITAL AND INFANT AGE GROUPS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii321-iii321
Author(s):  
Muriel Hart ◽  
Amy Mellies ◽  
Alina Beltrami ◽  
Ahmed Gilani ◽  
Adam Green
Keyword(s):  
Age Groups ◽  
Young Patients ◽  
High Grade Glioma ◽  
Population Based ◽  
Cns Tumors ◽  
Low Grade ◽  
Tumor Type ◽  
Older Children ◽  
Embryonal Tumors ◽  
Chi Square

Abstract BACKGROUND Congenital (&lt;3 months) and infant (3 to 11 months) brain tumors are biologically different from tumors in older children, but epidemiology of these tumors has not been studied comprehensively. Insight into epidemiological differences could help tailor treatment recommendations by age and increase overall survival (OS). METHODS Population-based data from the SEER 18 registries was obtained for 14,493 0-19-year-olds diagnosed with CNS tumors between 1990 and 2015. Incidence, treatment, and survival were analyzed using Chi-square and Kaplan-Meier analyses. RESULTS Between the &lt;3 month, 3–5 month, 6–11 month, and 1–19 year age groups, tumor type distribution differed significantly (p&lt;0.001); high-grade glioma (HGG) was most common in the &lt;3-month-olds, while low-grade glioma (LGG) was most common in the other groups. 5-year OS for all tumors was 36.7% (&lt;3 months), 56.0% (&lt;3–5 months), 63.8% (6–11 months), and 74.7% (1–19 years) (log rank p&lt;0.001). OS by tumor type was worst for &lt;3-month-olds with LGG, medulloblastoma, and other embryonal tumors; OS was worst for 3-5-month-olds with ependymoma, &lt;1-year-olds collectively with atypical teratoid-rhabdoid tumor, and 1-19-year-olds with HGG (log rank p&lt;0.02 for all tumor types). &lt;3-month-olds were least likely to receive any treatment for each tumor type and least likely to undergo surgery for all except HGG. &lt;1-year-olds were far less likely than 1-19-year-olds to undergo radiation for embryonal tumors, as expected, but were also less likely to undergo chemotherapy. CONCLUSIONS Congenital/infant CNS tumors differ pathologically, therapeutically, and prognostically from those in older children. Treatment changes could help address poorer outcomes for these young patients.

scholarly journals Relation between swine weight and morphometric measurements

2020 ◽  
Vol 9 (9) ◽  
pp. e891998013
Author(s):  
Mônica Calixto Ribeiro de Holanda ◽  
Marco Aurélio Carneiro de Holanda ◽  
Leandro Ricardo Rodrigues de Lucena
Keyword(s):  
Mathematical Model ◽  
Body Weight ◽  
Regression Models ◽  
Hip Circumference ◽  
Morphometric Measurements ◽  
Large White ◽  
Male And Female ◽  
Lactation Phase ◽  
Relationship Of ◽  
The Relationship

Objective was to define a mathematical model that better explain the relationship of the animals weight depending not only on the animals age but also on the animals morphometric measurements. 40 piglets, half Duroc-Large White blood, were used, 20 males and 20 females, from 3 to 35 days of age (lactation phase) initially weighing 1.518 ± 0.121 kg and from 36 to 66 days of age (calving phase) with a body weight of 7.010 ± 0.704 kg. The animals were weighed weekly on a digital balance. The relationship of animal weight, age and morphometric measurements of male and female piglets were performed using regression models: existing, linear and power. The models were evaluated according to nine criterialinear model was the most adequate to explain the weight of male pigs, while for female pigs was the power. The age of the pig, the shank and palette length, as well as the circumference of the shank jointly explain the weight of the male piglets. The weight of females is explained jointly by age, body length, thorax and hip circumference.

Pediatric Dental Patients’ Attitudes to Rubber Dam

2013 ◽  
Vol 38 (2) ◽  
pp. 139-141 ◽  
Author(s):  
A McKay ◽  
M Farman ◽  
H Rodd ◽  
H Zaitoun
Keyword(s):  
Local Anaesthetic ◽  
Pediatric Patients ◽  
Young Patients ◽  
Hospital Setting ◽  
Radiographic Examination ◽  
Dental Patients ◽  
Rubber Dam ◽  
Negative Score ◽  
Anaesthetic Procedure ◽  
Acceptance Levels

Objectives: To explore young patients’ experiences of rubber dam (RD) and determine how personal and clinical factors may influence opinions. Study design: A self-completed questionnaire was developed to capture pediatric patients’ experiences of treatment under RD in a hospital setting. Patients’ acceptance of RD and perceptions of how well it was explained to them were recorded on a 10cm Visual Analogue Scale (VAS), where zero represented the most negative score. The following clinical variables were also recorded: type of RD; procedure undertaken; use of local anaesthetic and procedure duration. Results: One hundred children (52 male, 48 female) with a mean age of 11.8 years (SD=2.29; range 7-17 years) participated. Overall, acceptance of RD was satisfactory (mean VAS=5.0). Patients were happy with the explanation of why RD was used (mean VAS=7.7). The type of RD, use of local anaesthetic, procedure undertaken and duration of the procedure did not significantly influence acceptance levels. However, RD was significantly less acceptable to patients who underwent radiographic examination whilst wearing the RD (P&lt; 0.05, t-test). Nearly five times as many patients expressed concern at being seen wearing RD when taken to the radiography department (39.2%, n=20/51), compared to those who were reportedly self-conscious about RD when treated only on the paediatric dentistry clinic (8.2%, n=4/49). Conclusions: The use of RD appears acceptable physically and psychologically to most pediatric patients, however, visibility of the RD to others was a potential concern to some children.

PENICILLIN THERAPY OF LATE CONGENITAL SYPHILIS

PEDIATRICS ◽  
1948 ◽  
Vol 1 (5) ◽  
pp. 601-616
Author(s):  
RALPH V. PLATOU ◽  
JOHN T. KOMETANI
Keyword(s):  
Body Weight ◽  
Congenital Syphilis ◽  
Single Agent ◽  
Previous Treatment ◽  
Spinal Fluid ◽  
Older Children ◽  
Total Dosage ◽  
Intramuscular Injections ◽  
Interstitial Keratitis ◽  
Penicillin Therapy

Though no valid comparisons can be made until more patients have been treated and followed for a longer time, it seems to us that penicillin used alone is at least as effective as any other single agent for the treatment of late congenital syphilis. To what extent treatment or time alone contribute to improvements cannot yet be stated. Most of the clinical and serologic indications of healing developed rather slowly; in only a few patients with the most superficial lesions were there objective signs of improvement during therapy. The treatment schedules we employed are similar to those previously recommended for infants. At present we advise a total dosage comprising at least 100,000 units commercial penicillin per kilogram body weight, divided into 100 equal intramuscular injections and given at two to three hour intervals around the clock for eight or more days. Therapeutic reactions, entirely febrile in nature, have all been transient and benign. There were no deaths. We believe that the simplicity, safety and convenience of these plans make them preferable to the more costly, hazardous, and time-consuming older methods; further-more, they effectively curtail the appallingly high delinquency rates formerly prevailing. Results were significantly better for children treated under six years of age than they were for older children, and also for those who had normal spinal fluid before treatment; they were suggestively but not significantly better among those for whom the larger dosage schedules were used. Outcome was significantly worse in those who had received previous treatment of any sort. There were just three relapse—two defined only serologically, and one by a questionable recurrence of interstitial keratitis. About a quarter of those with latent congenital syphilis have become seronegative. The poorest results ensued for patients with clinical neurosyphilis; two children from this group continued to exhibit definite deterioration. For interstitial keratitis, results were most gratifying in two patients treated within a month of onset. Seventy-two per cent of all patients with late congenital syphilis so far treated with penicillin and followed for more than two months are clinically well and have negative serologic reactions or progressively declining titers.

scholarly journals Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 152 ◽  
Author(s):  
Nina Hanke ◽  
Claudia Kunz ◽  
Meinolf Thiemann ◽  
Harald Fricke ◽  
Thorsten Lehr
Keyword(s):  
Body Weight ◽  
Clinical Investigation ◽  
Young Patients ◽  
Study Data ◽  
Pbpk Modeling ◽  
Dose Selection ◽  
Clinical Phase ◽  
Protein Therapeutic ◽  
Pediatric Glioblastoma ◽  
Dose Recommendations

The protein therapeutic and CD95L inhibitor asunercept is currently under clinical investigation for the treatment of glioblastoma and myelodysplastic syndrome. The purpose of this study was to predict the asunercept pharmacokinetics in children and to give dose recommendations for its first use in pediatric glioblastoma patients. A physiologically-based pharmacokinetic (PBPK) model of asunercept in healthy and diseased adults was successfully developed using the available clinical Phase I and Phase II study data. This model was then extrapolated to different pediatric populations, to predict the asunercept exposure in children and to find equivalent starting doses. Simulation of the asunercept serum concentration-time curves in children between 1–18 years of age shows that a dosing regimen based on body weight results in a similar asunercept steady-state exposure in all patients (pediatric or adult) above 12 years of age. For children between 1–12 years, higher doses per kg body weight are recommended, with the highest dose for the very young patients. Translational PBPK modeling is strongly encouraged by regulatory agencies to help with the initial dose selection for pediatric trials. To our knowledge, this is the first report of pediatric PBPK to support the dose selection of a therapeutic protein before its administration to children.

scholarly journals The Role of Age, Neutrophil Infiltration and Antibiotics Timing in the Severity of Streptococcus pneumoniae Pneumonia. Insights from a Multi-Level Mathematical Model Approach

2020 ◽  
Vol 21 (22) ◽  
pp. 8428
Author(s):  
Guido Santos ◽  
Julio Vera
Keyword(s):  
Mathematical Model ◽  
Streptococcus Pneumoniae ◽  
High Risk ◽  
Young Patients ◽  
Alveolar Epithelium ◽  
Neutrophil Infiltration ◽  
Aged Patients ◽  
Effective Response ◽  
Multi Level

Bacterial pneumonia is one of the most prevalent infectious diseases and has high mortality in sensitive patients (children, elderly and immunocompromised). Although an infection, the disease alters the alveolar epithelium homeostasis and hinders normal breathing, often with fatal consequences. A special case is hospitalized aged patients, which present a high risk of infection and death because of the community acquired version of the Streptococcus pneumoniae pneumonia. There is evidence that early antibiotics treatment decreases the inflammatory response during pneumonia. Here, we investigate mechanistically this strategy using a multi-level mathematical model, which describes the 24 first hours after infection of a single alveolus from the key signaling networks behind activation of the epithelium to the dynamics of the local immune response. With the model, we simulated pneumonia in aged and young patients subjected to different antibiotics timing. The results show that providing antibiotics to elderly patients 8 h in advance compared to young patients restores in aged individuals the effective response seen in young ones. This result suggests the use of early, probably prophylactic, antibiotics treatment in aged hospitalized people with high risk of pneumonia.

Growing up with a pacemaker

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
P Poels ◽  
J Vermeulen ◽  
M Gewillig ◽  
B Meyns ◽  
R Willems
Keyword(s):  
Sinus Node ◽  
Young Patients ◽  
Structural Heart Disease ◽  
Older Children ◽  
University Hospitals ◽  
School Sports ◽  
Sports Club ◽  
Node Disease ◽  
Strongly Agree ◽  
Coping With Illness

Abstract   Indications for pacemakers in young children are rare. In our university hospitals, on average 8 patients/year received a pacemaker in this age group between 2001 and 2015 for a drainage area of 4 million people. In 28% this is for congenital heart block and in 69% for bradycardia after surgical repair of congenital structural heart disease. Despite the extensive range of patient information about pacemakers, we felt a need for targeted material for young patients, who have an indication for a pacemaker, and their family. We wanted to provide this information to this specific group in a creative, accessible and clear way, taking into account their way of thinking. In addition, we also wanted to involve the near and wider environment of the child (family, school, sports club, etc.), and to provide them with tools to better deal with the medical situation. For the little children we created a stop-motion story in which sinus node disease (SND) and AV block (AVB) are represented by a character: Bob Sparkle (Bob Prikkel in Dutch for SND) and Boris Sparkle (Boris Prikkel for AVB). Bob and Boris get into trouble and are rescued by Pacemaker, the third character in the films. This story is preceded by an informative part for parents and older children in which the normal functioning and conduction system of the heart is explained. Based on the films, we designed customized information brochures for +12 and −12 year-old children. The brochure for +12 includes the same information as the adult version, but in more comprehensible language. The figures Bob and Boris were added throughout this brochure as a sort of common thread. For the −12 group we designed 2 reading books in which the story of Bob / Boris is told. The −12 booklets can be included in a cover along with the +12 brochure, so that the parents can estimate for themselves what is most suitable for their child. We conducted a survey on how this information was received by patients and their relatives.61 families were contacted by e-mail to fill in a questionnaire using a 5-point Likert Scale. The survey assessed the following three items: graphic design, intelligibility and aid in coping with illness. Currently we have received answers from 12 patients or their relatives. Overall, there was a positive reception of the different informative tools (agree or strongly agree: booklets: 92.6%; brochure: 77.2%; films: 81.3%). Funding Acknowledgement Type of funding source: None

scholarly journals Treatment of Bronchopneumonia with Spiramycine (Rovamycine)

2019 ◽  
Vol 16 (9-10) ◽  
pp. 396-402
Author(s):  
Soejono Soejono ◽  
Moeljono S. Trastotenojo ◽  
Harsoyo N.
Keyword(s):  
Body Weight ◽  
Side Effects ◽  
Child Health ◽  
Older Children ◽  
A Value ◽  
One Year

Fifty-seven children with bronchopneumonia, comprising 32 male and 25 female, were admitted to the Department of Child Health, Dr. Kariadi Hospital, Semarang, during the period of May 1972 - May 1973. Varying in ages between 16 days and 7 years, 36 of them were less than one year old. They were treated with spiramycine (Rovamycine) given orally in a dosage of 50 mg/kg body weight daily in three divided doses. The failure was 9 out of 57 cases (15.8%) and in infants 7 out of 36 cases (19.4%). The culture of infants revealed 36.1% staphylococcus and in older children showed 4.8%. All cases of staphylococcus as a single cause which was treated with spiramycine gave good results. No side effects of spiramycine were noted. The study showed that spiramycine has a value in the treatment of childhood bronchopneumonia especially in staphylococcal injections in infants.

Sign in / Sign up

Export Citation Format

Share Document