The Effects of Exercise on Memory Function Among Young to Middle-Aged Adults: Systematic Review and Recommendations for Future Research

2017 ◽  
Vol 32 (3) ◽  
pp. 691-704 ◽  
Author(s):  
Paul D. Loprinzi ◽  
Emily Frith ◽  
Meghan K. Edwards ◽  
Eveleen Sng ◽  
Nicole Ashpole
Keyword(s):  
Systematic Review ◽  
Acute Exercise ◽  
Controlled Trial ◽  
Memory Function ◽  
Experimental Studies ◽  
Favorable Effect ◽  
Future Research ◽  
Middle Aged ◽  
Middle Aged Adults ◽  
Chronic Training

Objective: To systematically summarize the experimental effects of exercise on cognitive-related memory function among young to middle-aged adults, which has yet to be done in the literature. Data Source: PubMed. Study Inclusion and Exclusion Criteria: Studies were included if they were published in the English language, indexed in PubMed, employed an experimental study design (eg, traditional parallel group randomized controlled trial: either acute intervention or chronic/training intervention study), and conducted among human adults. Studies were excluded if nonhumans (ie, animal models) were studied, if children/adolescents (<18 years) or older adults (>50 years) were evaluated, and if select chronic diseases (eg, diabetes and dementia) were present. Data Extraction: A systematic review approach was employed. Data Synthesis: An extraction table was created synthesizing the key results, and recommendations for future research are emphasized. Results: Among the 17 evaluated studies, 2 were published before the year 2000 (ie, 1998 and 1999), 2 were published in 2007, and the remaining 13 were published in the years 2011 and beyond. This highlights the emergence of this research topic within this age-group (young to middle-aged adults). Among the 17 evaluated studies, 14 were conducted among healthy samples, with 3 conducted among those with a diagnosis of depression. Among the 17 studies, 4 employed a chronic training protocol, with 13 utilizing an acute exercise protocol. Among the 3 experimental studies in the depressed population, all demonstrated a favorable effect of exercise on memory function. Among the 14 trials in the nondepressed population, 10 (71%) demonstrated a favorable effect of exercise on some aspect of memory function. Conclusion: Acute and chronic exercise appears to play a pronounced effect on memory function among young to middle-aged adults. Implications and recommendations for future research are outlined in this systematic review.

Exercise and Implicit Memory: A Brief Systematic Review

2017 ◽  
Vol 121 (6) ◽  
pp. 1072-1085 ◽  
Author(s):  
Paul D. Loprinzi ◽  
Meghan K. Edwards
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Implicit Memory ◽  
Fear Conditioning ◽  
High Intensity ◽  
Acute Exercise ◽  
Memory Function ◽  
Experimental Studies ◽  
Human Studies ◽  
Chronic Exercise

Background Emerging work demonstrates that acute exercise may enhance explicit memory function. No published systematic reviews have evaluated the totality of research examining the effects of exercise on implicit memory function, which was the purpose of this systematic review. Methods Databases (PubMed, PsychInfo, and Sports Discus) were searched to evaluate animal and human experimental studies evaluating the effects of exercise on implicit memory function. Results Among the 10 evaluated studies that met inclusionary criteria for this systematic review, 7 were conducted in animal models (rats or mice), with 3 utilizing human samples. Among the seven animal model studies, all employed a fear conditioning paradigm to evaluate implicit memory performance. All six animal studies employing a chronic exercise paradigm demonstrated evidence for associations between chronic exercise and enhanced fear conditioning. The one animal study evaluating a high-intensity acute bout of exercise showed that high-intensity acute exercise worsened implicit memory retrieval. Among the three human studies, one demonstrated a beneficial effect of acute exercise on implicit memory function. Discussion There is consistent evidence in animal models that chronic exercise enhances implicit memory, as assessed by fear conditioning. However, there have been too few human studies investigating this topic to render any meaningful conclusions regarding the relationship between exercise and cognitive-based implicit memory among humans.

scholarly journals The Influence of Tart Cherry (Prunus cerasus, cv Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1417
Author(s):  
Rachel Kimble ◽  
Karen M. Keane ◽  
John K. Lodge ◽  
Glyn Howatson
Keyword(s):  
Vascular Function ◽  
Controlled Trial ◽  
High Sensitivity ◽  
Metabolic Health ◽  
Cardiometabolic Health ◽  
Middle Aged ◽  
Concentrate Supplementation ◽  
Health Indices ◽  
Before And After ◽  
Middle Aged Adults

Background: Tart Montmorency cherries (MC) have been shown to be rich in anthocyanins and other phytochemicals known to have anti-inflammatory properties and influence pathways that might improve cardiometabolic health. However, there is limited evidence for the longer-term use of tart cherries on these indices. The aim of the current study was to investigate the influence of MC concentrate on cardiometabolic health indices following a 3-month supplementation period. Methods: Fifty middle-aged adults (34 males and 16 females; mean ± SD age: 48 ± 6 years and BMI: 27.6 ± 3.7 kg/m2) completed a randomised, placebo-controlled parallel study in which they either received MC or an isocaloric placebo. Participants drank 30 mL of their allocated treatment twice per day for 3 months. Vascular function (blood pressure [BP], heart rate [HR], pulse wave velocity and analysis [PWV/A], and flow mediated dilation [FMD]) as well as indices of metabolic health (insulin, glucose, lipid profiles, and high sensitivity C reactive protein) were measured following an overnight fast before and after the 3 months. Results: No effect of the intervention between the groups was observed for vascular function or metabolic health variables following the intervention (p > 0.05). However, MC concentrate was shown to be safe and well-tolerated and, importantly, did not have any deleterious effects on these outcomes. In conclusion, MC has no influence on cardiometabolic indices in middle-aged adults.

Prenatal cocaine exposure and its impact on cognitive functions of offspring: a pathophysiological insight

2016 ◽  
Vol 27 (5) ◽  
Author(s):  
Eleana Gkioka ◽  
Laskarina Maria Korou ◽  
Afrodite Daskalopoulou ◽  
Angelica Misitzi ◽  
Eleni Batsidis ◽  
...  
Keyword(s):  
Memory Function ◽  
Experimental Studies ◽  
Clinical Manifestations ◽  
Future Research ◽  
Cocaine Exposure ◽  
Prenatally Exposed ◽  
Prenatal Cocaine Exposure ◽  
Functional Changes ◽  
Cellular Processes ◽  
Neuroendocrine Responses

AbstractIt is estimated that approximately 0.5%–3% of fetuses are prenatally exposed to cocaine (COC). The neurodevelopmental implications of this exposure are numerous and include motor skill impairments, alterations of social function, predisposition to anxiety, and memory function and attention deficits; these implications are commonly observed in experimental studies and ultimately affect both learning and IQ. According to previous studies, the clinical manifestations of prenatal COC exposure seem to persist at least until adolescence. The pathophysiological cellular processes that underlie these impairments include dysfunctional myelination, disrupted dendritic architecture, and synaptic alterations. On a molecular level, various neurotransmitters such as serotonin, dopamine, catecholamines, and γ-aminobutyric acid seem to participate in this process. Finally, prenatal COC abuse has been also associated with functional changes in the hormones of the hypothalamic-pituitary-adrenal axis that mediate neuroendocrine responses. The purpose of this review is to summarize the neurodevelopmental consequences of prenatal COC abuse, to describe the pathophysiological pathways that underlie these consequences, and to provide implications for future research in the field.

scholarly journals A systematic review of mHealth interventions for HIV prevention and treatment among gay, bisexual, and other men who have sex with men

2020 ◽  
Vol 10 (5) ◽  
pp. 1211-1220
Author(s):  
Kimberly M Nelson ◽  
Nicholas S Perry ◽  
Keith J Horvath ◽  
Laramie R Smith
Keyword(s):  
Systematic Review ◽  
Hiv Prevention ◽  
Text Messaging ◽  
Controlled Trial ◽  
The United States ◽  
Current Evidence ◽  
Future Research ◽  
Targeted Prevention ◽  
Prevention And Treatment ◽  
Sex With Men

Abstract The use of mobile health (mHealth) technologies addressing HIV disparities among gay, bisexual, and other men who have sex with men (GBMSM) has increased. A systematic review of mHealth interventions for HIV prevention and treatment among GBMSM was conducted to summarize the current evidence and provide recommendations for future research. PRISMA guidelines were followed (PROSPERO ID: 148452). Studies identified via PubMed, PsychInfo, or Embase were included that (i) were in English, (ii) were published in a peer-reviewed journal prior to July 1, 2019, (iii) presented primary results, (iv) included only GBMSM, and (v) reported the results of an mHealth intervention (e.g., text message, phone/mobile application [app]) to improve HIV prevention or treatment outcomes. Of 1,636 identified abstracts, 16 published studies met inclusion criteria. Eleven studies were conducted in the United States. One study was a fully powered randomized controlled trial (RCT), seven were single-arm pilots with pre–post assessments, four were pilot RCTs, and four tested public health campaigns with post-assessments. Seven developed study-specific apps, five used text messaging, and four used existing social networking apps. Most (81%) targeted prevention outcomes. Nine cited a specific behavioral theory. All studies found that a mHealth approach was feasible and acceptable. All interventions provided evidence of preliminary efficacy or promising trends on primary outcomes. Although mHealth interventions for HIV prevention and treatment appear feasible and acceptable, most published studies are small pilot trials. Additional research assessing the efficacy and mechanisms of mHealth interventions is needed.

scholarly journals Cross-Sectional Examination of Musculoskeletal Pain and Physical Function in a Racially and Socioeconomically Diverse Sample of Adults

2020 ◽  
Author(s):  
Angie L Sardina ◽  
Alyssa A Gamaldo ◽  
Ross Andel ◽  
Shanthi Johnson ◽  
Tamara A Baker ◽  
...  
Keyword(s):  
Physical Function ◽  
Physical Performance ◽  
Musculoskeletal Pain ◽  
Performance Measures ◽  
Healthy Aging ◽  
Functional Limitation ◽  
Future Research ◽  
Middle Aged ◽  
Cross Sectional ◽  
Middle Aged Adults

Abstract Background Musculoskeletal pain alters physiological function, which may be evidenced as early as middle age. Previous research has concluded that middle-aged adults are a high-risk group for musculoskeletal pain and report functional limitations similar to older adults. However, few studies have examined the relationships between musculoskeletal pain and physical function, using objective performance measures in a sample of racially and socioeconomically diverse adults. Thus, this study examined musculoskeletal pain in relation to physical function in middle-aged (30–64 years) White and Black adults and investigated whether the relationship varied by sociodemographic characteristics. Methods This cross-sectional examination incorporated data from the Healthy Aging in Neighborhoods of Diversity across the Life-Span Study. Participants (n = 875) completed measures of musculoskeletal pain and objective measures of physical performance (ie, lower and upper body strength, balance, and gait abnormalities). Physical performance measures were standardized to derive a global measure of physical function as the dependent variable. Results Approximately, 59% of participants identified at least 1 pain sites (n = 518). Multivariable regression analyses identified significant relationships between greater musculoskeletal pain and poorer physical function (β = −0.07, p = .031), in mid midlife (β = −0.04, p = .041; age 40–54) and late midlife (β = −0.05, p = .027; age 55–64). Conclusions This study observed that musculoskeletal pain was associated with poorer physical function within a diverse group of middle-aged adults. Future research should longitudinally explore whether chronic musculoskeletal pain identified at younger ages is associated with greater risk for functional limitation and dependence in later life.

Non-technical skills and otolaryngology: systematic review

2020 ◽  
Vol 134 (5) ◽  
pp. 415-418 ◽  
Author(s):  
R Bannon ◽  
K E Stewart ◽  
M Bannister
Keyword(s):  
Systematic Review ◽  
Assessment Tool ◽  
Controlled Trial ◽  
Technical Skills ◽  
Neck Surgery ◽  
Future Research ◽  
Skill Levels ◽  
Simulated Environments ◽  
Simulation Based ◽  
Randomised Controlled

AbstractObjectivesThis study aimed to assess the published literature on non-technical skills in otolaryngology surgery and examine the applicability of any research to others’ practice, and to explore how the published literature can identify areas for further development and guide future research.MethodsA systematic review was conducted using the following key words: ‘otolaryngology’, ‘otorhinolaryngology’, ‘ENT’, ‘ENT surgery’, ‘ear, nose and throat surgery’, ‘head and neck surgery’, ‘thyroid surgery’, ‘parathyroid surgery’, ‘otology’, ‘rhinology’, ‘laryngology’ ‘skull base surgery’, ‘airway surgery’, ‘non-technical skills’, ‘non technical skills for surgeons’, ‘NOTSS’, ‘behavioural markers’ and ‘behavioural assessment tool’.ResultsThree publications were included in the review – 1 randomised, controlled trial and 2 cohort studies – involving 78 participants. All were simulation-based studies involving training otolaryngology surgeons.ConclusionLittle research has been undertaken on non-technical skills in otolaryngology. Training surgeons’ non-technical skill levels are similar across every tested aspect. The research already performed can guide further studies, particularly amongst non-training otolaryngology surgeons and in both emergency and elective non-simulated environments.

scholarly journals Improved balance in middle-aged adults after 8 weeks of a modified version of Otago Exercise Program: A randomized controlled trial

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0235734
Author(s):  
Rana Almarzouki ◽  
Gurinder Bains ◽  
Everett Lohman ◽  
Bruce Bradley ◽  
Todd Nelson ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Exercise Program ◽  
Middle Aged ◽  
Randomized Controlled ◽  
Middle Aged Adults

scholarly journals Leucine-Enriched Protein Supplementation Increases Lean Body Mass in Healthy Korean Adults Aged 50 Years and Older: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1816
Author(s):  
Yeji Kang ◽  
Namhee Kim ◽  
Yong Jun Choi ◽  
Yunhwan Lee ◽  
Jihye Yun ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Controlled Trial ◽  
Intervention Group ◽  
Dropout Rate ◽  
Protein Supplementation ◽  
Community Dwelling ◽  
Control Group ◽  
Middle Aged ◽  
Middle Aged Adults

Early prevention of sarcopenia could be an important strategy for muscle retention, but most studies have focused on subjects aged 65 or older. Therefore, in this study we investigated the effects of leucine-enriched protein supplementation on muscle condition in a sample including late middle-aged adults. A 12-week intervention was performed for 120 healthy community-dwelling adults by providing either leucine-enriched protein supplement [protein 20g(casein 50%+ whey 40%+ soy 10%, total leucine 3000 mg), vitamin D 800IU(20 ug), calcium 300 mg, fat 1.1 g, carbohydrate 2.5 g] or isocaloric carbohydrate supplement twice per day. Appendicular skeletal muscle mass (ASM) and lean body mass (LBM) were measured by dual-energy X-ray absorptiometry. A total of 111 participants completed the study, with a dropout rate of 9.2%. LBM normalized by body weight (LBM/Wt) was significantly increased (p < 0.001) in the intervention group (0 wk: 63.38 ± 0.85 vs. 12 wk 63.68 ± 0.83 in the intervention group; 0 wk: 63.85 ± 0.82 vs. 12 wk: 63.29 ± 0.81 in the control group). In subgroup analyses, significant differences remained only in subjects between 50 and 64 years of age. We concluded that leucine-enriched protein supplementation can have beneficial effects by preventing muscle loss, mainly for late middle-aged adults.

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