Decorporation of thorium-228 from the rat by 3,4,3-LIHOPO and DTPA after simulated wound contamination

1995 ◽  
Vol 14 (2) ◽  
pp. 165-169 ◽  
Author(s):  
G.N. Stradling ◽  
S.A. Gray ◽  
M.J. Pearce ◽  
I. Wilson ◽  
J.C. Moody ◽  
...  
Keyword(s):  
Intraperitoneal Injection ◽  
Relative Effectiveness ◽  
The Body ◽  
Local Administration ◽  
Wound Contamination ◽  
Treat Ment ◽  
Treatment Of Wounds ◽  
Efficacy Of Treatment

1 With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treat ment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d. 2 In all cases 3,4,3-LIHOPO was appreciably more effec tive than DTPA although the efficacy of treatment and the relative effectiveness of the ligands decreased rapidly with their delay in administration. 3 Optimum removal with both ligands occurred when initial local administration at 30 min after exposure was followed by repeated intraperitoneal injection at 6 h, 1, 2 and 3 d. Under these conditions the body con tent of 228Th was reduced to 20% of controls after sc injection and 15% after im injection. The correspond ing values using repeated DTPA administration were 80% and 54%. 4 It is concluded that 3,4,3-LIHOPO represents, poten tially, a considerable advance on DTPA, the current agent of choice for the treatment of wounds contami nated by 228Th.

TECHNOLOGICAL INJURIES IN INDUSTRIAL PIG FARMING

2020 ◽  
Vol 1 ◽  
pp. 135-139
Author(s):  
A.A. Stekolnikov ◽  
◽  
M.A. Ladanova ◽  
Keyword(s):  
Local Treatment ◽  
The Body ◽  
The Third ◽  
Closed Type ◽  
Treat Ment ◽  
Industrial Farming ◽  
Industrial Injuries ◽  
Treatment Of Wounds ◽  
Experimental Group ◽  
Infor Mation

Industrial injuries in pig farms of closed type are a very common pathology. Howev-er, nowadays, injury prevention and treat-ment of sick animals in the conditions of industrial pig breeding complex do not bring good results and require improvements. Ac-cording to the literature, there is no infor-mation about the results of the use of oint-ments and immuno- stimulators in the treat-ment of pigs with bitten wounds of the ears, tails and other parts of the body. In this re-gard, we have set a goal to develop therapeu-tic measures for injuries of piglets in a pig breeding complex of a closed type. We ana-lyzed the prevalence of industrial injuries in pigs. During the clinical examination, we studied the specific structures of injuries. The main cause of pigs injuries in industrial farming is cannibalism. In 28 days, 60% of pigs in the second experimental group, showed complete cicatrization of the wound, and 40% of animals showed this process regenerated on 85-95%, meanwhile 2 days they also had complete scarring of the wound. In 28 days, 50% of pigs of the third experimental group had a complete cicatriza-tion of the wound, and for 50% were ob-served scarring of the wound by 75-85%, and only after 4 days they demonstrated the complete scaring of the defect. For the treatment of bitten wounds as a result of developing cannibalism, it is recommended, to use local treatment of wounds with chlor-hexidine solution and argosulfan ointment daily 2 times a day and also to use the im-munostimulator “Ferrovir” in a dose of 1.0 ml/m2 per week. Such scheme of treatment of bitten wounds gives the best therapeutic effect.

scholarly journals ISOLASI, IDENTIFIKASI DAN KARAKTERISASI Vibrio spp. PATOGEN PENYEBAB VIBRIOSIS PADA KERAPU DI BALAI BUDIDAYA AIR PAYAU SITUBONDO

2005 ◽  
Vol 7 (1) ◽  
pp. 80
Author(s):  
Kamiso Handoyo Nitimulyo ◽  
Alim Isnansetyo ◽  
Triyanto Triyanto ◽  
Indah Istiqomah ◽  
Muhammmad Murdjani
Keyword(s):  
Intraperitoneal Injection ◽  
The Body ◽  
Total Length ◽  
Specific Disease ◽  
Pathogenic Vibrio ◽  
Causative Agents ◽  
Development Center ◽  
Aquaculture Development ◽  
Vibrio Spp

This research was conducted to isolate, identify, and characterize pathogenic Vibrio spp., causative agents of vibriosis in grouper at Brackishwater Aquaculture Development Center (BADC), Situbondo. Twenty-nine isolates were isolated from wound, gills, eyes, liver, and ren of grouper with vibriosis on Thiosulphate Citrate Bile Sucrose Agar (TCBSA) medium. Koch Postulate Test was conducted to determine pathogenic Vibrio spp., by intraperitoneal injection to humpback grouper (Cromileptes altivelis) (9-10 cm of total length) at 106 cells/fish in triplicates. Results indicated that the pathogenic Vibrio spp., causative agents of vibriosis in grouper at BADC, Situbondo were identified to be V. alginolyticus, V. anguillarum, V. metchnikovii, V. vulnificus, V. fluvialis, V. furnisii, and V. parahaemolyticus. Infection of the pathogenic Vibrio spp. caused acute mortality within 17-46 hours with specific disease signs like haemorhagic on fins (pinnae pectorales, pinnae abdominales, pinna analis) and also on the body. These results suggested that vibriosis should be monitored and controlled properly and quickly.

The dynamics of cellular factors of the im-mune system of healthy minks, experimentally infected with eimeriidosis, under specific therapy

2020 ◽  
Vol 2 ◽  
pp. 188-195
Author(s):  
Y. E. Kuznetsov ◽  
◽  
N.V. Kuznetsova ◽  
◽  
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
T Lymphocyte ◽  
Defense Mechanism ◽  
The Body ◽  
Control Group ◽  
Treat Ment ◽  
Initial Stage ◽  
Additional Control ◽  
Cellular Factors

The immune response in animals and hu-mans is a biological defense mechanism against negative environmental factors. The immune system is a complex of organs and cells of the body, that reacts (protects) against foreign objects-protozoas and hel-minths. The aim of the study was to investi-gate the dynamics of cellular factors of the immune system of healthy minks, experi-mentally invaded with eimeriidosis against the background of specific immunocorrec-tive therapy. To study the dynamics of T-lymphocytes in the blood of animals, being at the specific immunocorrective therapy, a single-center prospective blind randomized comparative study was conducted in parallel groups. At the initial stage of the study, 56 male minks were isolated from the general population. The first group of clinically healthy animals was the control group. From the second to the sixth groups, animals were spontaneously infected with eimerias and isospores. Animals from the third and fifth groups were treated with coccidiostatic "Stop-coccid". Mink of the 4th and 6th groups received the drug "Ametherm 5%". Minks in the 5th and 6th groups after treat-ment with coccidiostatic were adninistered an immunomodulatory drug of plant origin "Phytodoc-immunostim". The 7th group served as an additional control and received a placebo-water with starch. Thus, the analy-sis of the results of the clinical study showed that the use of specific and immunocorrec-tive therapy has a positive effect on the dy-namics of T-lymphocyte levels in the blood of animals with eimeriidosis. In group 3, where infected minks were treated with "Stop-coccid", the level of T-lymphocytes increased by 35.8% to 41.1%; in the 4th group (administered "Ametherm 5%") the level of T-lymphocytes rose from 35.2% to 42.3%; in the 5th group (administered “Stop-coccid” and immunomodulator) the level of T-lymphocytes changed from 36.5% to 43,0% in the 6-th experimental group (treated "Ametherm 5%" and immunomodu-lator) the level of T-lymphocyte growth from 38.6% to 43.9 per cent.

scholarly journals Modeling of bacterial lipopolysaccharide-induced endometritis in rats and the possibility of its therapy using plasma enriched with soluble platelet factors

2021 ◽  
Author(s):  
M. Potapnev ◽  
K. Pavlov ◽  
O. Doronina ◽  
T. Metelitsa ◽  
E. Anfinogenova ◽  
...  
Keyword(s):  
Inflammatory Process ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Neutrophil Infiltration ◽  
Transforming Growth Factor Β ◽  
The Body ◽  
Bacterial Lipopolysaccharide ◽  
Local Administration ◽  
Neutrophilic Infiltration ◽  
Intravaginal Administration

We presents results of a study on endometritis modeling in rats with double intravaginal administration of bacterial lipopolysaccharide (LPS). The established endometrial inflammatory process was accompanied by a decrease in the weight of animals, an increase in the weight of the uterus, neutrophilic infiltration, edema, and overexpression of cyclooxygenase in endometrium on 30-45 days after the start of endometritis induction. Local intravaginal use of plasma enriched with soluble platelet factors/platelet-rich plasma (PORFT/PRP) caused a decrease in the intensity of the inflammatory process and the rate of neutrophil infiltration of the endometrium, a decrease in the intensity of cyclooxygenase, interleukin-6 and transforming growth factor-β expression, and an increase in the body weight of animals. The conclusion was made on the possibility of creating model of endometritis in rats by double administration of LPS and the ability of local administration of PORFT/PRP to have a therapeutic effect on the inflammatory process in the endometrium.

scholarly journals Особливості лікування ран, уражених личинками Wohlfahrtia magnifica, у собак

2017 ◽  
Vol 19 (77) ◽  
pp. 67-70
Author(s):  
V. Тkachenko
Keyword(s):  
Effective Treatment ◽  
High Efficiency ◽  
The Body ◽  
Experimental Comparison ◽  
Necessary Condition ◽  
Pathogenic Microorganisms ◽  
Treatment Regimens ◽  
Wohlfahrtia Magnifica ◽  
Treatment Of Wounds ◽  
Dead Tissue

The article presents data of research concerning the characteristics of the treatment of wounds affected by the larvae of the fly Wohlfahrtia magnifica. One of the conditions for effective treatment of such wounds is to remove all larvae, cutting of dead tissue correction of the formed pockets and oppression of pathogenic microorganisms on the surface and in the depth of the wound. The larvae are well adapted to parasitism in animal tissues, have highly developed Piratov hooks and small spines all over the body, which help them to remain in the tissue and gradually penetrate deeper. Larvae wolferton flies much damage tissue and cause the appearance of purulent wounds dolgonosova, this pathology is not only parasitological, and one of the problems of veterinary surgery. A necessary condition for effective treatment is removal of all larvae, cutting of dead tissue correction of the formed pockets and oppression of pathogenic microorganisms on the surface and in the depth of the wound. Experimental comparison of different schemes of treatment of wounds, amazed by the larvae of Wohlfahrtia magnifica, and also proved the high efficiency of complex treatment regimens with the use of solution decasino and ointment levomikol in this pathology.

General and Local Cryotherapy in Treatment of Wounds

2015 ◽  
Vol 22 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Аралова ◽  
M. Aralova ◽  
Глухов ◽  
A. Glukhov
Keyword(s):  
Low Temperatures ◽  
Carbonic Acid ◽  
The Body ◽  
Healthy Human ◽  
Venous Ulcers ◽  
Intracellular Ice ◽  
Healing Wounds ◽  
Local Cryotherapy ◽  
Rate Of Cooling ◽  
Treatment Of Wounds

In recent decades, cryotherapy has gained recognition and dissemination in various fields of medicine, the influence of cold on different systems of the body is studied, the mechanism of human adaptation to the action is revealed. There are new technical possibilities of cold generation and modern crynoidal. Cryotherapy is divided into general and local, with the use of moderately low and low temperatures. Local cryotherapy is divided into hardware and software functional tests. Healthy human body to acute cooling meets a number of standard reactions. Depending on the intensity, duration, dynamics, impact, scientists divide the destructive and regenerative cryotherapy, cryosurgery. Modern cryosurgery is a gentle and economical method of eliminating pathological tissues. The main mechanism of action of low temperatures on biological tissue is the formation of intracellular ice, damaging organelles, membranes. The rate of cooling and thawing are important. At the time of cryotherapy, the boundary of the zone of freezing increases in all directions from the edge of the cryo applicator, and the subsequent reaction of cryodestruction are identical at any location of the hearth. For the treatment of venous ulcers, the authors gave a description of the ways of use the snow of carbonic acid, spraying liquid nitrogen on necrotic tissue. Cryotherapy is well defined in treatment of non-healing wounds.

Management of the dead during coronavirus disease 2019 outbreak: Practices and perceptions of forensic practitioners from India

2021 ◽  
pp. 002580242110258
Author(s):  
Vikas P Meshram ◽  
Tanuj Kanchan ◽  
Raghvendra S Shekhawat
Keyword(s):  
Infection Control ◽  
Forensic Medicine ◽  
Health Sector ◽  
The Body ◽  
Local Administration ◽  
Protective Equipment ◽  
Medical Institutions ◽  
Dead Bodies ◽  
The Dead

The coronavirus disease 2019 pandemic has mandated a response from administrative agencies and the health sector globally, however, the number of cases and deaths continue to rise. While management of the living is paramount, the management of the dead is also important. Guidelines for managing the dead have been issued and implemented by various local administrations, in accordance with national and international guidelines. This questionnaire-based research aims to develop an understanding of the knowledge, perceptions and practices of forensic practitioners from India as regards the management of the dead during the coronavirus disease 2019 pandemic. This Pan-India study included 278 forensic medicine experts (249 males and 29 females) working in various hospitals and medical institutions across the country. The questionnaire included various issues involving the management of dead bodies in cases involving coronavirus disease 2019, such as infection control practices, body screening, handling and autopsy, disposal practices, local administrative policies, and available infrastructure and resources. We found that guidelines are mostly being followed across India, barring disparity in issues relating to testing in the dead bodies, the role of local administration in the body disposal, and the use of personal protective equipment while handling bodies and during autopsies. Mortuaries now need to be upgraded, and general infrastructure requires improvement. Periodic training of all stakeholders and assessment of facilities are recommended.

scholarly journals Application of fibrin in drug technology: Achievements and perspectives

2020 ◽  
Vol 74 ◽  
pp. 322-330
Author(s):  
Jakub Rech ◽  
Justyna Wilińska ◽  
Aleksandra Borecka ◽  
Artur Turek
Keyword(s):  
Drug Delivery ◽  
Water Absorption ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Solution Casting ◽  
Drug Delivery Carrier ◽  
Drug Substances ◽  
Drug Technology ◽  
Treatment Of Wounds

In recent years, fibrin has been successfully used as a polymer drug delivery carrier. Passive properties of fibrin provide parenteral and local delivery of drug substances in controlled and prolonged manner and also tissue support, gluing and sealing. Fibrin also has hemostatic and proangiogenic effects. Discs, films, gels, beads and nanoparticles are among the most commonly proposed and used fibrin-based formulations. It is routinely obtained from fibrinogen and thrombin. Fibrin formulation methods are solution casting, dual syringe systems and emulsification. All fibrin formulations become gel after administration and water absorption. Biodegradation and biocompatibility are important advantages of fibrin, which make it possible to implant a formulation without the need to remove the carrier from the body after the drug is released. Fibrin-based drug delivery systems are proposed and applied in the treatment of wounds, infections and cancerous diseases.

scholarly journals Disturbances of extracellular protein metabolism in ceruleininduced pancreatitis

2020 ◽  
Vol 33 (3) ◽  
pp. 121-124
Author(s):  
Nataliia Raksha ◽  
Tetiana Halenova ◽  
Tetiana Vovk ◽  
Olexii Savchuk ◽  
Serhii Berehovyi ◽  
...  
Keyword(s):  
Body Weight ◽  
Chronic Pancreatitis ◽  
Protein Metabolism ◽  
Intraperitoneal Injection ◽  
Diabetes Type ◽  
The Body ◽  
Size Exclusion ◽  
Male Rats ◽  
Diabetes Type 1

AbstractChronic pancreatitis (CP) is still a serious clinical problem due to the significant difficulties in its diagnosis, especially in the initial stages of development. Among the mechanisms that mediate the pathogenesis of CP and lead to pancreatitis-related disorders is unregulated activation of proteolytic enzymes, namely, matrix metalloproteinases (MMPs). The aim of our study was to determine the disturbances of protein metabolism under the conditions of CP alone or in combination with diabetes type 1 (CP+DT1). Herein, CP was induced in the nonlinear male rats by intraperitoneal injection of cerulein (5 µg·kg−1 of body weight; five times during fives day). DT1 was modeled in the rats with CP by a single intraperitoneal injection of streptozotocin (65 mg·kg−1 of the body weight). The levels of MMP-2 and -9 were determined by enzyme-linked immune sorbent assay, and the level of low and middle molecular weight (LMMW) substance was measured spectrophotometrically, while the peptide fractions were analyzed by size exclusion chromatography. The present study revealed a significant increase of MMP-2 and MMP-9 levels in the serum, liver and pancreas of the rats with CP and CP+DT1. Elevated levels of MMPS may act as a factor for the initiation of subsequent cascade of events resulting in the development of pancreatitis-associated complications. Pathogenesis of chronic pancreatitis alone or in combination with diabetes type 1 has been accompanied by the formation and accumulation of LMMW substance, changes in peptide composition and level of individual peptides in the tissues of the rats. Such alterations are among key triggers of amplification of metabolic disorders under chronic pancreatitis.

scholarly journals A review and updated classification of pollen gathering behavior in bees (Hymenoptera, Apoidea)

2019 ◽  
Vol 71 ◽  
pp. 171-208 ◽  
Author(s):  
Zachary M. Portman ◽  
Michael C. Orr ◽  
Terry Griswold
Keyword(s):  
Behavioral Plasticity ◽  
Relative Effectiveness ◽  
Plant Morphology ◽  
The Body ◽  
Intermediate Step ◽  
Pollen Collection ◽  
The Face ◽  
Species Comparisons ◽  
Mix And Match

Pollen is the primary protein and nutrient source for bees and they employ many different behaviors to gather it. Numerous terms have been coined to describe pollen gathering behaviors, creating confusion as many are not clearly-defined or overlap with existing terms. There is a need for a clear yet flexible classification that enables accurate, succinct descriptions of pollen gathering behaviors to enable meaningful discussion and comparison. Here, we classify the different pollen gathering behaviors into two main classes: active and incidental pollen collection. Active pollen collection is subdivided into six behaviors: scraping with the extremities, buzzing, rubbing with the body and/or scopae, rubbing with the face, tapping, and rasping. In addition to the active and incidental pollen gathering behaviors, many bees have an intermediate step in which they temporarily accumulate pollen on a discrete patch of specialized hairs. Each behavior is described and illustrated with video examples. Many of these behaviors can be further broken down based on the variations found in different bee species. Different species or individual bees mix and match these pollen collecting behaviors depending on their behavioral plasticity and host plant morphology. Taken together, the different behaviors are combined to create complex behavioral repertoires built on a foundation of simple and basic steps. This classification sets the groundwork for further research on various topics, including behavioral plasticity in different species, comparisons between generalists and specialists, and the relative effectiveness of different pollen gathering behaviors.

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