scholarly journals Review of Current Applications of Immunohistochemistry in Pediatric Nonneoplastic Gastrointestinal, Hepatobiliary, and Pancreatic Lesions

2017 ◽  
Vol 12 ◽  
pp. 117739011769014
Author(s):  
Joseph de Nanassy ◽  
Dina El Demellawy
Keyword(s):  
Pediatric Population ◽  
Diagnostic Workup ◽  
Diagnostic Interpretation ◽  
Wide Range ◽  
The Everyday ◽  
Primary Identification

Immunohistochemical (IHC) stains are widely used by pathologists for a variety of considerations in the diagnostic workup of pediatric nonneoplastic lesions in gastrointestinal (GI), hepatic, biliary, and pancreatic lesions. The pathologic changes cover a wide range and types of presentations, including inflammatory (bacterial and viral), metaplastic, posttransplant lymphoproliferative, autoimmune, metabolic, degenerative, developmental, and genetic conditions, among others. The everyday practical value of IHC stains covers primary identification, confirmation, differential, and/or exclusionary roles in the hands and eyes and minds of the practitioners. This article is intended to review and discuss the currently available IHC stains for a variety of pediatric GI, hepatobiliary, and pancreatic lesions as encountered in the day-to-day practice of pathologists and clinicians. It reflects the most recent methods and types of IHC stains with the stated aim of helping to provide a quick reference for diagnostic considerations and thereby facilitate the workup of a broad range of GI and related conditions in a pediatric population. The tables provide a handy reference on a wide range of IHC stains for commonly encountered lesions covering a variety of pediatric GI, hepatobiliary, and pancreatic conditions that are amenable to light microscopic diagnostic interpretation.

Conclusion

2018 ◽  
Author(s):  
Matthew S. Seligmann
Keyword(s):  
Corporal Punishment ◽  
Social Reform ◽  
Alcohol Intake ◽  
Religious Practice ◽  
Royal Navy ◽  
The Poor ◽  
Wide Range ◽  
The Everyday ◽  
Push Forward ◽  
The Common

As this book has shown the common conception that ‘Churchill’s “radical phase” was cast to the winds’ when he was put in charge of the Navy in October 1911, although well established in the literature, is not, in fact, accurate.1 The radical President of the Board of Trade, eager to improve the lives of the poor, became the radical Home Secretary, no less enthusiastic for social reform, who then became the radical First Lord of the Admiralty, imbued with both a desire and, perhaps more importantly, a will to intervene in order to better conditions for those who served in the Royal Navy. Accordingly, he embarked upon a major programme of improvement across a wide range of different areas all of which affected the everyday life of sailors. Alcohol intake, sexual behaviour, religious practice, corporal punishment, as well as pay and equality of progression, all came under the spotlight while Churchill was First Lord. Of course, not all of the new measures were successful and not all were progressive in the modern understanding of the term, but all of them represented significant attempts to push forward a radical agenda for change....

«Oттeпeль»: экoнoмикa и пoвceднeвнocть

2016 ◽  
Vol 43 (3) ◽  
pp. 338-374
Keyword(s):  
Economic Policy ◽  
Scientific Revolution ◽  
Daily Life ◽  
Price Policy ◽  
Ordinary People ◽  
Wide Range ◽  
The Everyday ◽  
Consumer Services ◽  
The 1960S ◽  
In The Beginning

This article investigates the influence of Soviet economic policy on the daily life of Siberian townspeople in the 1960s using a wide range of official and personal sources. In particular, it examines how the Soviet state provided the population with food, enacted price policy and currency reform, and implemented housing programs and consumer services. This article also employs popular memoirs to explore the involvement of the scientific revolution in the beginning of the formation of a socially oriented economy. It also provides a novel perspective on the changes that impacted the everyday lives of ordinary people during the period of Khrushchev’s “Thaw.”

Immunosuppression-Related Fibroproliferative Polyps: A Substantial Subset of Acquired Pediatric Mucocutaneous Polyps

2008 ◽  
Vol 11 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Briana C. Gleason ◽  
Sara O. Vargas
Keyword(s):  
Pediatric Population ◽  
Distinct Group ◽  
Biopsy Material ◽  
Skin Tag ◽  
Chromosome 22Q11 ◽  
Wide Range ◽  
Chromosomal Breakpoints ◽  
Immunosuppressed Patients ◽  
Fibroepithelial Polyps ◽  
The Common

A distinct group of fibroproliferative polyps of the tongue arising in immunosuppressed children and often associated with chromosomal breakpoints at chromosomes 9p34 or 22q11 was recently described. Based on this finding, we reviewed fibroepithelial polyps arising in nonlingual sites in the pediatric population to investigate a possible relationship with immunosuppression. We identified 8 fibroepithelial polyps arising in 6 immunosuppressed patients (4 males and 2 females, median age 17 years) in a wide range of mucocutaneous sites. Histologic features were identical to the common fibroepithelial polyp, or skin tag, with a variably collagenous fibrovascular core covered by unremarkable squamous epithelium. No viral cytopathic changes were identified in any case. Although cytogenetic studies were not performed on any of the biopsy material, 1 patient had a constitutional deletion of chromosome 22q11. We suggest that there may be a relationship between these polyps and the previously described tongue lesions and that immunosuppression may be an important factor in their pathogenesis.

Survey of opioid tapering practices of pediatric healthcare providers: A national perspective

2017 ◽  
Vol 13 (1) ◽  
pp. 59 ◽  
Author(s):  
Deborah Fisher, PhD, RN, PPCNP-BC ◽  
Suzanne W. Ameringer, PhD, RN
Keyword(s):  
Nurse Practitioners ◽  
Online Survey ◽  
Medical Center ◽  
Pediatric Population ◽  
Healthcare Providers ◽  
Physician Assistants ◽  
Pediatric Pain ◽  
Wide Range ◽  
Opioid Tapering ◽  
Pediatric Healthcare

Objective: The purpose of this study was to describe the current opioid tapering practice.Design: Cross-sectional, online, survey research.Participants: Pediatric healthcare providers from a national sample of practicing nurse practitioners, physician assistants, and physicians who participate in five different pediatric pain and/or palliative care list serves.Results: One hundred four participants responded to the survey. The respondents were predominantly physicians (n = 58, 62 percent). The majority of respondents worked in an academic children's medical center (n = 50, 52 percent). The average number of years in pediatric practice was 16 (mean = 16.33, range of 0-45 years). Of the 104 respondents, only 22 (27 percent) had a written protocol for opioid tapering. Use of expert consultants such as pharmacists or pediatric pain management teams varied. The majority of respondents (n = 46, 44 percent) seldom or never consult a pharmacist. Only 22 percent (n = 17) almost always or always consult a pediatric pain team. There was a wide range of personal tapering rate preferences. Conclusions: This study provided a baseline assessment of pediatric opioid tapering practices by pediatric healthcare providers. Results revealed a marked variation in practice patterns that may indicate deficits in the assessment and management of opioid withdrawal in children. The need for the development of assessment-based opioid tapering guidelines for the pediatric population is long overdue.

scholarly journals The Feeling of Numbers: Emotions in Everyday Engagements with Data and Their Visualisation

Sociology ◽  
2017 ◽  
Vol 52 (4) ◽  
pp. 830-848 ◽  
Author(s):  
Helen Kennedy ◽  
Rosemary Lucy Hill
Keyword(s):  
Empirical Study ◽  
Making Sense ◽  
Wide Range ◽  
The Everyday ◽  
The Relationship

This article highlights the role that emotions play in engagements with data and their visualisation. To date, the relationship between data and emotions has rarely been noted, in part because data studies have not attended to everyday engagements with data. We draw on an empirical study to show a wide range of emotional engagements with diverse aspects of data and their visualisation, and so demonstrate the importance of emotions as vital components of making sense of data. We nuance the argument that regimes of datafication, in which numbers, metrics and statistics dominate, are characterised by a renewed faith in objectivity and rationality, arguing that in datafied times, it is not only numbers but also the feeling of numbers that is important. We build on the sociology of (a) emotions and (b) the everyday to do this, and in so doing, we contribute to the development of a sociology of data.

scholarly journals Serbian Society at the Beginning of the 20th Century. “Militarization of Everyday”

2020 ◽  
Vol 12 (6) ◽  
pp. 28-45
Author(s):  
Ya. V. Vishnyakov
Keyword(s):  
Twentieth Century ◽  
Everyday Life ◽  
20Th Century ◽  
The Political ◽  
The Balkans ◽  
Wide Range ◽  
The Everyday ◽  
Balkan Countries ◽  
Eastern Question ◽  
The Impact

During the 19th and early 20th centuries, the Eastern question and the search for ways to solve it occupied a central place in the politics of both Russia and European states. With his decision was closely linked the process of formation of the young Balkan countries. Serbia, whose formation of a new statehood typologically coincides with a change in the system of European international relations of the 19th and early 20th centuries, played an important role in the events of the Eastern question, while claiming to be the Yugoslav “Piemont”. However, it was the war by the beginning of the twentieth century. It became, both for Serbia and other countries of the region, not only a means of gaining state sovereignty, but also the main way to resolve its own interstate contradictions, which took place against the background of an external factor - the impact on the political processes of the Balkans of the Great Powers. These factors led to the natural militarization of the everyday life of Serbian society. The presence in the everyday consciousness of the people of the image of a hostile “other” became one of the main ways of internal consolidation of the country, when attitudes towards war, pushing the values of peaceful life to the background, created a special basic consensus in the state development of Serbia at the beginning of the 20th century, and the anthropological role of the military factor was essential influenced the underlying processes that took place in the country at the beginning of the twentieth century. In the conditions of a new stage of destruction of the Balkans along the ethno-political line, the factor of militarization of everyday life again becomes an important element of the historical policy of the Balkan countries and the construction of a “new past”. In this regard, the understanding of many problems and possible scenarios for the development of the current Balkan reality is linked to this phenomenon. Thus, the study of the impact on the political life of Serbia at the beginning of the twentieth century of special "extra-constitutional" institutions is important for a wide range of researchers, including for a systematic analysis of the crisis in the territory of the former SFRY.Author declares the absence of conflict of interests.

scholarly journals The current state of virtualization of sociocultural activity

2021 ◽  
pp. 156-162
Author(s):  
Евгения Михайловна Юркова
Keyword(s):  
Interpersonal Communication ◽  
Scientific Literature ◽  
Rapid Development ◽  
Work Processes ◽  
Information Tools ◽  
Current State ◽  
Wide Range ◽  
The Everyday ◽  
The Subject ◽  
The Individual

В виду бурного развития компьютерных технологий и внедрения информационных средств в повседневную и рабочую жизнь личности мы наблюдаем процесс виртуализации не только культуры, но и социально-культурной активности. В статье рассматривается виртуализация социально-культурной активности в современных условиях. Цель исследования - определить тенденции виртуализации социально-культурной активности. Объект - социально-культурная активность. Предмет - современное состояние виртуализации социально-культурной активности. Задачи исследования: обозначить актуальность рассматриваемой темы; изучить научную литературу по вопросу о негативных тенденция виртуализации социально-культурной активности; определить сущность терминов «виртуализация» и «виртуальная реальность», «виртуализация культуры», «виртуализация социально-культурной активности»; перечислить самые актуальные технологии виртуальной активности; выявить негативные тенденции виртуализации социально-культурной активности. Данный процесс, по мнению автора, является следствием глобальной информатизации, в том числе и социокультурной сферы. По мнению автора, современное состояние виртуализации социально-культурной активности имеет как положительные, так и отрицательные стороны. К положительным автор относит возможность использования безграничного пространства для творчества и самореализации, а также развитие широкого спектра предоставляемых обучающих программ - мастер-классы, марафоны, курсы и прочее; сохранение межличностного общения с помощью современных мессенджеров и приложений и упрощение коммуникации рабочих процессов. В работе приводятся и негативные стороны процесса виртуализации социокультурной активности, такие как гедонистичность, обезличивание и стандартизация личности, чрезмерная свобода действий. В заключение автор отмечает, что значимость негативных тенденций возрастает и процесс виртуализации социально-культурной активности может быть контролируемым, а именно - трансляция качественного цензурного контента, ограничение деструктивных действий, блокировка нарушителей. In view of the rapid development of computer technologies and the introduction of information tools into the everyday and working life of the individual, we see the process of virtualization not only of culture, but also of sociocultural activity. The paper discusses the virtualization of sociocultural activity in modern conditions. The purpose of the study is to identify trends in the virtualization of sociocultural activity. The object is sociocultural activity. The subject is the current state of virtualization of sociocultural activity. Research objectives are: to indicate the relevance of the topic; to study scientific literature on the issue of negative trends in virtualization of sociocultural activity; to determine the essence of the terms "virtualization" and "virtual reality", "culture virtualization", "virtualization of sociocultural activity"; to list the most relevant virtual activity technologies; and to identify negative trends in virtualization of sociocultural activity. This process, according to the author, is a consequence of global informatization, including the sociocultural sphere. According to the author, the current state of virtualization of sociocultural activity has both positive and negative aspects. As positive aspects, the author includes the possibility of using unlimited space for creativity and self-realization, as well as the development of a wide range of training programs provided - master classes, marathons, courses, etc.; maintaining interpersonal communication using modern instant messengers and applications and simplifying communication of work processes. The work also cites the negative aspects of the process of virtualization of sociocultural activity, such as hedonism, depersonalization and standardization of the person, excessive freedom of action. In conclusion, the author notes that the importance of negative trends is increasing and the process of virtualization of sociocultural activity can be controlled, namely, the translation of high-quality censorship content, limiting destructive actions, and blocking violators.

scholarly journals My tummy hurts – a case report of abdominal pain and macrocytic anemia caused by hypothyroidism

2018 ◽  
Vol 2018 ◽  
Author(s):  
Kewan Hamid ◽  
Neha Dayalani ◽  
Muhammad Jabbar ◽  
Elna Saah
Keyword(s):  
Abdominal Pain ◽  
Pediatric Population ◽  
Financial Burden ◽  
Macrocytic Anemia ◽  
Chronic Abdominal Pain ◽  
List Type ◽  
Thyroid Disorder ◽  
Significant Morbidity ◽  
Delay In Diagnosis ◽  
Wide Range

Summary A 6-year-old female presented with chronic intermittent abdominal pain for 1 year. She underwent extensive investigation, imaging and invasive procedures with multiple emergency room visits. It caused a significant distress to the patient and the family with multiple missing days at school in addition to financial burden and emotional stress the child endured. When clinical picture was combined with laboratory finding of macrocytic anemia, a diagnosis of hypothyroidism was made. Although chronic abdominal pain in pediatric population is usually due to functional causes such as irritable bowel syndrome, abdominal migraine and functional abdominal pain. Hypothyroidism can have unusual presentation including abdominal pain. The literature on abdominal pain as the main presentation of thyroid disorder is limited. Pediatricians should exclude hypothyroidism in a patient who presents with chronic abdominal pain. Contrast to its treatment, clinical presentation of hypothyroidism can be diverse and challenging, leading to a delay in diagnosis and causing significant morbidity. Learning points: Hypothyroidism can have a wide range of clinical presentations that are often nonspecific, which can cause difficulty in diagnosis. In pediatric patients presenting with chronic abdominal pain as only symptom, hypothyroidism should be considered by the pediatricians and ruled out. In pediatric population, treatment of hypothyroidism varies depending on patients’ weight and age. Delay in diagnosis of hypothyroidism can cause significant morbidity and distress in pediatrics population.

scholarly journals Beauty class and the practice of beautification among lower middle-class young women

2018 ◽  
Vol 1 ◽  
pp. 00010
Author(s):  
Ninik Tri Ambarwati
Keyword(s):  
Middle Class ◽  
Young Women ◽  
Lower Class ◽  
The Other ◽  
White Skin ◽  
Lower Middle Class ◽  
Wide Range ◽  
The Everyday

Beauty class is a place for a woman to share experiences in applying makeup. The participants in the beauty class obtain tips and trick or some specific ways of applying makeup. The participants in this class can directly practice the knowledge on how to apply makeup on their faces. The beauty class phenomenon has existed in Indonesia since 2000. Beauty class becomes a trend which attracts young women. Beauty class becomes a place where ideal beauty is constructed, for instance, white skin for body and face, thick eyebrows, long eyelashes, pointed nose, oval face, and pink lips. This research aims to see the consumption practice by lower-class young women at the beauty class in Yogyakarta. This research uses ethnography method by attending and observing the beauty class and having an interview with two active participants in the beauty class. This research shows that 1). Makeup has become a part of the everyday lifestyle of young women. 2). Beautification practice is determined by some beauty standards identified by the other party, in this case, cosmetics industry, and beauty blogger. 3). Beauty class opens an access for lower-middle-class women to use a wide range of cosmetics palette and tools that beyond what they can afford.

scholarly journals Intubation Related Laryngeal Injuries in Pediatric Population

2021 ◽  
Vol 9 ◽  
Author(s):  
Karma Lambercy ◽  
Laurence Pincet ◽  
Kishore Sandu
Keyword(s):  
Pediatric Patients ◽  
Pediatric Population ◽  
Laryngeal Edema ◽  
Anatomical Site ◽  
Vocal Cords ◽  
Small Children ◽  
Airway Stenosis ◽  
Wide Range ◽  
Life Threatening ◽  
Retention Cysts

Introduction: Laryngeal intubation related lesions (LIRL) in pediatric patients cause extreme morbidity in both elective and emergency settings. It has a wide range of presentations from minor laryngeal edema to a life-threatening airway obstruction. We report here our units' experience with LIRL in neonates, infants, and small children.Material and Methods: This is a retrospective monocentric cohort study between January 2013 and April 2019.Results: Thirty-nine patients with intubation lesions were included in the study. We looked at the lesions type, characteristics, management, and outcome. Half the patients were premature and having comorbidities. Main LIRL were subglottic stenosis (31%), ulcers (26%), granulations (18%), retention cysts (18%), posterior glottic stenosis (13%), and vocal cords edema (5%). Unfavorable lesions causing airway stenosis were associated with an intubation duration of over 1 week and were an important factor in causing airway stenosis (p < 0.05). The endoscopic treatment performed for these lesions was lesion and anatomical site-specific. Tracheostomy was needed in five patients, and was avoided in another two. Seven patients (18%) received open surgery prior to their decannulation.Conclusions: LIRL management is challenging and stressful in the pediatric population and optimal treatment could avoid extreme morbidity in them. Intubation duration and associated comorbidities are important factors in deciding the severity of these lesions. Protocols to prevent the formation of these lesions are critical.

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