scholarly journals Indole Alkaloids from Vinca major and V. minor Growing in Turkey

2012 ◽  
Vol 7 (6) ◽  
pp. 1934578X1200700
Author(s):  
Fatemeh Bahadori ◽  
Gülaçtι Topçu ◽  
Mehmet Boǧa ◽  
Ayla Türkekul ◽  
Ufuk Kolak ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Radical Scavenging ◽  
Indole Alkaloid ◽  
Aerial Parts ◽  
High Lipid ◽  
Vinca Major ◽  
Alkaloid Extracts ◽  
First Time ◽  
Dpph Radical Scavenging ◽  
High Lipid Peroxidation

A new indole alkaloid, 11-hydroxypolyneuridine, was isolated from Vinca major subsp. major L. and the known indole alkaloids vallesiachotamine and isovallesiachotamine from Vinca minor L. This is the first report on the alkaloids of both Vinca species growing in Turkey; vallesiachotamine and isovallesiachotamine were isolated from a Vinca species for the first time. V. minor may be considered as a new source for these two alkaloids due to their occurrence in high amount in the aerial parts of the plant. The alkaloid extracts of the two Vinca species were found to have high lipid peroxidation inhibitory and DPPH radical scavenging activities. Anticholinesterase activity of the extracts was also very strong.

scholarly journals Comparison of Volatile Constituents, and Antioxidant and Antibacterial Activities of the Essential Oils of Thymus caucasicus, T. kotschyanus and T. vulgaris

2011 ◽  
Vol 6 (1) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Shiva Asbaghian ◽  
Ali Shafaghat ◽  
Khalil Zarea ◽  
Fakhraddin Kasimov ◽  
Farshid Salimi
Keyword(s):  
Antibacterial Activity ◽  
Essential Oils ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Antibacterial Activities ◽  
Dilution Method ◽  
Aerial Parts ◽  
Main Components ◽  
Dpph Radical Scavenging ◽  
Broth Dilution

A comparison of the chemical composition, and antioxidant and antibacterial activities of the essential oils obtained from the aerial parts of Thymus caucasicus, T. kotschyanus, and T. vulgaris was carried out. The oils, obtained by hydrodistillation, were analyzed by GC and GC/MS. Twenty, 29 and 22 compounds representing 94.8%, 96.6% and 98.2% of the essential oils of T. caucasicus, T. kotschyanus and T. vulgaris, respectively, have been identified. The oil of T. caucasicus was characterized by 1,8-cineol (21.5%), thymol (12.6%), β-fenchyl alcohol (8.7%), nerolidol (7.8%), terpinolene (7.2%), α-pinene (7.0%) and myrcene (6.8%). In the oil of T. kotschyanus, carvacrol (24.4%), β-caryophyllene (14.5%), γ-terpinene (12.4%), α-phellandrene (10.8%), p-cymene (9.8%) and thymol (6.8%) were the predominant compounds, whereas the main components of T. vulgaris oil were thymol (43.8%), p-cymene (15.2%), germacrene-D (11.7%), terpinolene (3.4%), carvacrol (3.2%), β-caryophyllene (2.8%) and α-thujene (2.2%). In all three plants oil, hydrocarbon monoterpenes predominated over sesquiterpenes. Antioxidant activities were assessed by determining IC50 values in the DPPH radical scavenging assay. Antibacterial activity was determined by measuring minimum inhibitory concentration (MIC) using the broth dilution method. The essential oils of T. caucasicus, T. kotschyanus and T. vulgaris showed free radical scavenging and antibacterial activity.

scholarly journals Bioactive Phenolics from Carthamus lanatus L.

2003 ◽  
Vol 58 (9-10) ◽  
pp. 704-707 ◽  
Author(s):  
Rilka Taskova ◽  
Maya Mitova ◽  
Bozhanka Mikhova ◽  
Helmut Duddeck
Keyword(s):  
Chlorogenic Acid ◽  
Methanol Extract ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Ethyl Acetate Fraction ◽  
Free Radical Scavenging ◽  
Flavonoid Glycosides ◽  
Aerial Parts ◽  
Free Radical Scavenging Assay ◽  
First Time

AbstractTwo flavonoid aglycons, eight flavonoid glycosides, chlorogenic acid and syringin were isolated from aerial parts of Carthamus lanatus. Isorhamnetin 3-O-β-ᴅ-glucoside and chlorogenic acid were found for the first time in the genus Carthamus and respectively, quercimeritrin, astragalin, kaempferol 3-O-β-ᴅ-sophoroside and syringin in the species. The ethyl acetate fraction of the methanol extract exhibited a higher antioxidant activity than the butanol fraction measured by the α,α-diphenyl-β-picrazylhydrazyl (DPPH) free radical scavenging assay. Cytotoxicity and antioxidant activities of the main constituent, luteolin 7-O-β-D-glucoside, were evaluated.

scholarly journals Phytochemical Analysis and Biological Investigation of Nepeta juncea Benth. Different Extracts

Plants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 646 ◽  
Author(s):  
Majid Sharifi-Rad ◽  
Francesco Epifano ◽  
Serena Fiorito ◽  
José M. Álvarez-Suarez
Keyword(s):  
Inhibitory Concentration ◽  
Methanolic Extract ◽  
Radical Scavenging ◽  
Dry Weight ◽  
Antibacterial Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Phytochemical Analysis ◽  
Biological Investigation ◽  
First Time ◽  
Dpph Radical Scavenging

This study was carried out to screen the amount and the classes of secondary metabolites and to evaluate the antioxidant, cytotoxic, antifungal, and antibacterial activities of the methanolic, ethanolic, and water extracts of the roots, leaves, and flowers of Nepeta juncea Benth. The results show that the highest total phenol (69.54 ± 0.31 mg gallic acid equivalents (GAE)/g dry weight), total flavonoid (41.37 ± 0.17 mg quercetin equivalents (QE)/g dry weight), anthocyanin (6.52 ± 0.21 mg cyanidin/100 g dry weight), and tannin (47.36 ± 0.33 mg catechin/g dry weight) concentrations were recorded in the methanolic extract of the leaves of N. juncea. The gas chromatography–mass spectrometry (GC–MS) analysis of the extracts showed that 1,8-cineole, 4aα-7α-7aα-nepetalactone, β-pinene, terpinen-4-ol, and α-terpineol were the major compounds, respectively. The best 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric-reducing antioxidant, cytotoxic, antifungal, and antibacterial activities were observed for the methanolic extract of the leaves. For the two latter activities, the best activity was revealed on Staphylococcus aureus, Bacillus cereus, and Candida albicans. The minimum inhibitory concentration (MIC) values for the antimicrobial of the methanolic extract from the leaves were in the range of 25–100 µg/mL, whereas the minimum bactericidal concentration (MBC) values were in the range of 50–200 µg/mL. The results reported herein show that, for the first time in the literature, N. juncea is a remarkable source of antioxidant, antifungal, and antibacterial compounds.

scholarly journals Antioxidant poteintial and activity of aerial parts of eight medicinal plants of Uttarakhand, India

2019 ◽  
Vol 48 (2) ◽  
pp. 265-270
Author(s):  
Shakuli Kashyap ◽  
PB Rao ◽  
P Mishra ◽  
Supriya
Keyword(s):  
Radical Scavenging ◽  
Total Phenolic ◽  
Enzymatic Antioxidants ◽  
Antioxidant Power ◽  
Mean Values ◽  
Aerial Parts ◽  
Trolox Equivalent ◽  
Ferric Reducing Antioxidant Power ◽  
Dpph Radical Scavenging ◽  
Gallic Acid Equivalent

The antioxidant potential of aerial parts of eight medicinal plant species were investigated by 1,1- diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, Ferrous ion-chelating (FCA) and ferric reducing antioxidant power assays in five different concentrations and the mean values ranged from 20.39 to 83.01%, 17.21 to 48.62% and 11.70 to 21.65 μg Trolox equivalent/mg extract, respectively. Total phenolic and flavonoid contents ranged from 4.83 to 10.46 μg, gallic acid equivalent/mg extract and 1.12 to 13.11 μg quercitin equivalent/mg extract. Enzymatic antioxidants (Unit/mg fresh weight): superoxide dismutase, catalase and peroxidase values ranged from 14.86 to 49.81, 60.00 to 141.33 and 0.25 to 0.60, respectively. Considering the overall assay M. Pudica can be considered as the potent candidate for displaying antioxidant activity among the experimental plants.

scholarly journals Chemical and Biological Investigation of Some Secondary Metabolites in Atriplex Halimus Growing in Egypt

2012 ◽  
Vol 7 (11) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Amal Kabbash ◽  
Nagwa Shoeib
Keyword(s):  
Multidrug Resistance ◽  
Soluble Fraction ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Flavonoid Glycosides ◽  
Dpph Radical ◽  
Biological Investigation ◽  
Atriplex Halimus ◽  
Aerial Parts ◽  
Dpph Radical Scavenging

The n-BuOH-soluble fraction of the MeOH-CH2Cl2 (1:1) extract of the aerial parts of Egyptian Atriplex halimus L. yielded two new flavonol glycosides, designated as atriplexoside A (1) [3′- O-methylquercetin-4′- O-β-apiofuranoside-3- O-(6″- O-α-rhamnopyranosyl-β-glucopyranoside)] and atriplexoside B (2) [3′- O-methylquercetin-4′- O-(5″″- O-β-xylopyranosyl-β-apiofuranoside)-3- O-(6″- O-α-rhamnopyranosyl-β-glucopyranoside)], together with six known compounds: two phenolic glucosides (3, 4), one ecdysteroid (5), one megastigmane (6) and two methoxylated flavonoid glycosides (7, 8). The structures of the compounds were elucidated by detailed spectroscopic analysis, including HR-ESI-MS and 2D-NMR spectroscopic data. DPPH radical scavenging, antileishmanial and anti-multidrug resistance activities were investigated using the n-BuOH-soluble fraction as well as the isolated compounds. Compound 8 (5- O-methylquercetin-3- O-(6″- O-α-rhamnopyranosyl-β-glucopyranoside) presented marked DPPH radical scavenging, weak antileishmanial and anti-multidrug resistance activity while the other tested compounds showed weaker activities.

scholarly journals Antibacterial, Antiviral, Antioxidant and Antiproliferative Activities of Thymus guyonii Essential Oil

2017 ◽  
Vol 12 (10) ◽  
pp. 1934578X1701201 ◽  
Author(s):  
Assia Zeghib ◽  
Ahmed Kabouche ◽  
Souheila Laggoune ◽  
Claude-Alain Calliste ◽  
Alain Simon ◽  
...  
Keyword(s):  
Essential Oil ◽  
Pathogenic Bacteria ◽  
Radical Scavenging ◽  
Bactericidal Effect ◽  
Dpph Radical ◽  
Aerial Parts ◽  
Colorectal Cell ◽  
Test Concentration ◽  
Dpph Radical Scavenging ◽  
Ht 29

The aerial parts of Thymus guyonii were hydrodistilled in a Clevenger type apparatus and analyzed by GC and GC-MS. 26 components were identified representing 99.8%, with carvacrol (55.6%), thymol (21.2%), o-cymene (9.7%) and δ-terpinene (5.7%) as the major components. T. guyonii essential oil exhibited a good bactericidal effect (MBC/MIC ratio = 2) against all the tested pathogenic bacteria. The essential oil lacks antiviral activity towards coxsackievirus B3 however it showed a good DPPH radical scavenging at 0.5 and 5 mg/mL test-concentrations (15.5±1.2% and 44.3±1.95%, respectively). The essential oil exhibited a proliferation inhibition of Human colorectal cell line HT-29 (30.4±3.4%) at 50 μg/mL test-concentration.

scholarly journals Enzymatic Synthesis of Sorboyl-Polydatin Prodrug in Biomass-Derived 2-Methyltetrahydrofuran and Antiradical Activity of the Unsaturated Acylated Derivatives

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Zhaoyu Wang ◽  
Yanhong Bi ◽  
Rongling Yang ◽  
Xiangjie Zhao ◽  
Ling Jiang ◽  
...  
Keyword(s):  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Initial Reaction Rate ◽  
Initial Reaction ◽  
Unsaturated Ester ◽  
Aliphatic Chain ◽  
Rate Maximum ◽  
Substrate Conversion ◽  
First Time ◽  
Dpph Radical Scavenging

Efficient and highly regioselective synthesis of the potential 6′′-O-sorboyl-polydatin prodrug in biomass-derived 2-methyltetrahydrofuran (2-MeTHF) was achieved usingCandida antarcticalipase B for the first time. Under the optimal conditions, the initial reaction rate, maximum substrate conversion, and 6′′-regioselectivity were as high as 8.65 mM/h, 100%, and 100%, respectively. Kinetic and operational stability investigations evidently demonstrated excellent enzyme compatibility of the 2-MeTHF compared to the traditional organic solvents. With respect to the antioxidant properties, three unsaturated ester derivatives showed slightly lower DPPH radical scavenging activities than the parent agent. Interestingly, further studies also revealed that the antiradical capacities of the acylates decreased with the elongation of the unsaturated aliphatic chain length from C4 to C11. The reason might be attributed to the increased steric hindrance derived from the acyl residues in derivatives.

scholarly journals Monoterpenoid Indole Alkaloids from Catharanthus roseus Cultivated in Yunnan

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001
Author(s):  
Bei Wang ◽  
Lu Liu ◽  
Ying-Ying Chen ◽  
Qiong Li ◽  
Dan Li ◽  
...  
Keyword(s):  
Catharanthus Roseus ◽  
Spectroscopic Data ◽  
Spectroscopic Analysis ◽  
Indole Alkaloids ◽  
Indole Alkaloid ◽  
Monoterpenoid Indole Alkaloids ◽  
Monoterpenoid Indole Alkaloid ◽  
First Time

A new monoterpenoid indole alkaloid, 15,20-dehydro-3α-(2-oxopropyl) coronaridine (1), along with sixteen analogues (2–17) were isolated from the leaves of Catharanthus roseus cultivated in Yunnan. The new alkaloid was elucidated on the basis of extensive spectroscopic analysis, and the known alkaloids were identified by comparison with the reported spectroscopic data. Among them, alkaloid 16 was isolated from Catharanthus for the first time.

DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla

2007 ◽  
Vol 62 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Masateru Ono ◽  
Eriko Oda ◽  
Takemi Tanaka ◽  
Yoshihiko Iida ◽  
Toru Yamasaki ◽  
...  
Keyword(s):  
Radical Scavenging ◽  
Dpph Radical ◽  
Scavenging Effect ◽  
Aerial Parts ◽  
Radical Scavenging Effect ◽  
Dpph Radical Scavenging ◽  
Lippia Triphylla

scholarly journals Chemical Investigation of SomeCapparisSpecies Growing in Egypt and their Antioxidant Activity

2007 ◽  
Vol 4 (s1) ◽  
pp. 25-28 ◽  
Author(s):  
Ahmed R. Hamed ◽  
Khaled A. Abdel-Shafeek ◽  
Nahla S. Abdel-Azim ◽  
Shams I. Ismail ◽  
Faiza M. Hammouda
Keyword(s):  
Antioxidant Activity ◽  
Quantitative Evaluation ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Chemical Investigation ◽  
Dpph Radical ◽  
Densitometric Analysis ◽  
Butanol Fraction ◽  
First Time ◽  
Dpph Radical Scavenging

Capparis cartilagineaandC. desertigrowing in Egypt were investigated for their glucosiolates and rutin content. FromCapparis cartilagineafour isothiocynates were isolated and identified using GC and EI/MS techniques. These compounds were butyl isothiocyanate (1), 6-methylsulphonylhexyl isothiocyanate (2), 7-methylsulphonylheptyl isothiocyanate (3) and 5-benzylsulphonyl-4-pentenyl isothiocyanate (4). In addition to compounds (1) and (2), two other compounds were isolated and identified fromCapparis deserti. These compounds are 3-methylthiopropyl isothiocyanate (5) and [11-(2-butenylthio)6-undecenyl isothiocyanate] (6). Compounds (1), (2), (5) and (6) are reported in this study for the first time fromCapparis deserti. The main flavonoid component in the studied species was isolated and identified as rutin by comparing the data with those reported. Also, quantitative evaluation of rutin in the two species was carried out by TLC-densitometric analysis. The antioxidant activity was done using diphenylpicrylhydrazyl (DPPH) radical scavenging method. The butanol fraction fromC. cartilagineaandC. desertishowed the highest antioxidant properties.

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