scholarly journals Comparison of the Hemostatic Activity of Quercus persica Jaub. & Spach. (Oak) With Ferric Sulfate in Bony Crypts

2015 ◽  
Vol 21 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Mohammad Reza Nabavizadeh ◽  
Arman Zargaran ◽  
Fariborz Moazami ◽  
Fatemeh Askari ◽  
Safoora Sahebi ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Sulfate Solution ◽  
Ferric Sulfate ◽  
Control Group ◽  
Hemostatic Effect ◽  
Hemostatic Activity ◽  
Cotton Pellet ◽  
The Common ◽  
Group 2 ◽  
Bleeding Score

Effective tissue hemostasis in periapical surgical site is important in the procedures. Plants with large amount of tannins may act as a local hemostatic agent. We aimed to compare the hemostatic effect of the extract of Quercus persica with one of the common hemostatic material used in periapical surgery. Six standardized bone holes were prepared in the calvaria of 5 Burgundy rabbits. Two hemostatic medicaments were tested for their hemostatic effect and were compared with control defects: Group 1, cotton pellet soaked in 15.5% ferric sulfate solution; Group 2, cotton pellet soaked in pure ethanolic extract of Q. persica. Bleeding score between the groups was compared. The ferric sulfate group exhibited significantly less bleeding than the other 2 groups. Q. persica was found to cause more hemostasis than the control group at 4 and 5 minutes but there were no significant differences between normal saline and Q. persica extract in bleeding control.

scholarly journals In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

2021 ◽  
Author(s):  
Maria Vitoria Oliveira Dantas ◽  
Paula Lima Nogueira ◽  
Filipe de Oliveira Lima ◽  
Denis Candeia Pereira Oliveira ◽  
Emanuelly Nara Severiano Gomes ◽  
...  
Keyword(s):  
Chloride Solution ◽  
Bleeding Time ◽  
Controlled Trial ◽  
Ethanolic Extract ◽  
Analysis Data ◽  
Control Group ◽  
Randomized Controlled ◽  
Hemostatic Activity ◽  
Post Hoc

Abstract Objective The objective of this study was to evaluate the hemostatic activity of the sap from Jatropha mollissima (Pohl) Baill. in rats. Materials and Methods Twenty-four Wistar rats were randomized into four groups (n = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of J. mollissima, in a concentration of 25 and 40 mg·mL1, respectively; the MO group was treated with Monsel’s solution and the control group SC with a 0.9% sodium chloride solution. Statistical Analysis Data were submitted to the Kurskal–Wallis’ test, followed by Dunn’s post hoc (p < 0.05). Results There was a significant reduction in the bleeding time of the group from the JM25 extract (p = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 (p > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group (p = 0.001). Monsel’s solution showed significant bleeding, six times greater than the control group SC. Conclusion The J. mollissima extract, in the concentration of 25 mg·mL1, showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.

Evaluation of anti-inflammatory potential of the ethanolic extract of the Saussurea lappa root (costus) on adjuvant-induced monoarthritis in rats

2016 ◽  
Vol 27 (1) ◽  
Author(s):  
Hend M. Tag ◽  
Howayda E. Khaled ◽  
Hayat A.A. Ismail ◽  
Nahla S. El-Shenawy
Keyword(s):  
Rheumatoid Arthritis ◽  
Ethanolic Extract ◽  
Autoimmune Disorder ◽  
Positive Control ◽  
Control Group ◽  
Saussurea Lappa ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Different Doses ◽  
Group 1

Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by polyarticular symmetrical arthritis. The prevalence of RA is consistent worldwide, affecting about 0.5%–1.0% of the population. The aim of this study was to investigate whetherAnimals were divided into eight groups (n=5/group). Group 1 acted as control, group 2 presented the AA rats (positive control), and groups 3, 4, and 5 were treated with different doses ofThe

scholarly journals CYP2D6 Genotype in Relation to Liver Toxicity Due to Tetrabenazine in Iraqi Patients with Hyperkinetic Movement Disorders

2020 ◽  
Vol 29 (2) ◽  
pp. 8-16
Author(s):  
Zainab A. Abbood ◽  
Shatha H. Ali ◽  
Nawfal M. Sheaheed
Keyword(s):  
Movement Disorders ◽  
Liver Enzymes ◽  
Liver Toxicity ◽  
Neurodegenerative Disorder ◽  
Enzyme Polymorphism ◽  
Controlled Study ◽  
Control Group ◽  
Cyp2d6 Genotype ◽  
The Common ◽  
Group 2

Abstract The  common types of movement disorders are ; dystonia which is a syndrome  of  repetitive muscle contractions. While , Huntington disease is autosomal dominant progressive neurodegenerative disorder, which is characterized by involuntary movements (“chorea”). Tetrabenazine therapy has been shown to effectively control this movements compared with placebo. Design the proper dosing approach for patients treated with tetrabenazine with genotype polymorphisms and their hepatic effect on patients. A prospective case controlled study was carried on 50 patients whom    divided into 2 groups :first group involved 25 patients who had chorea, and group 2 included  patients with dystonia, whom treated with (tetrabenazine) for three months. In addition to control group involved 25 healthy subjects . Blood samples were collected at the beginning and after three months  to assess  liver function  in relation to genetic polymorphism of CYP 450 2D6 enzyme for both groups and measuring the plasma concentration of tetrabenazine , alpha and beta  dyhdrotetrabenazine. The results show a significant CYP 450 2D6 enzyme polymorphism. And elevations of liver enzymes in the patient indicate hepatotoxicity of tetrabenazine and its metabolites, Determination a genotype of the CYP 450 2D6  genes in Iraqi patients, in relation  to the safety and efficacy of tetrabenazine  .

scholarly journals Association of SCN5A gene polymorphism with dilated cardiomyopathy

2021 ◽  
Vol 17 (4) ◽  
pp. 564-569
Author(s):  
S. Yu. Nikulina ◽  
O. O. Kuznetsova ◽  
A. A. Chernova ◽  
G. V. Matyushin ◽  
A. A. Gurazheva ◽  
...  
Keyword(s):  
Polymorphic Locus ◽  
Rare Allele ◽  
Control Group ◽  
Genetic Studies ◽  
Homozygous Genotype ◽  
The Common ◽  
Group 2 ◽  
Artery Disease ◽  
Scn5a Gene ◽  
Group 1

Subjects and methods. The study included patients with IDC (group 1; n=111, 89.2% men, average age 51.7±9.7 years) and ICM (group 2; n=110, 91.5% men, average age 58.7±8.4 years). All patients (IDC and ICM) underwent coronary angiography. Based on the anamnesis data and instrumental studies, those patients who could be said to have no risk factors for the development of dilatation of the heart cavities were identified in the group 1. And those patients who were reliably diagnosed with coronary artery disease were in the group 2, that is, dilatation of the heart cavities is due to a previous myocardial infarction, existing angina pectoris. The control group (n=121, average age 53.6±4.8 years) included patients who had no manifestations of cardiovascular diseases. The patients underwent laboratory and instrumental studies, as well as molecular and genetic studies of the A/G polymorphism of the SCN5A gene (rs1805124).Results. In the group with IDC 51.4% of patients were carriers of the common homozygous AA genotype, the heterozygous AG genotype-40.5%, and the rare homozygous GG genotype-8.1%. In the control group 63.3% of patients were identified as carriers of a homozygous genotype by a common allele, and 33.5% were carriers heterozygous genotype, and homozygous genotype for a rare allele – 3.2%. The analysis revealed a statistically significant decrease in the frequency of carrying the homozygous AA genotype in patients with IDC compared to the control group of the rs1805124 polymorphism of the SCN5A gene. In the group of patients with ICM, the А allele (69.5% vs. 80.1%, p=0.003) and the AA genotype (50.9% vs. 63.3%, p=0.030) were significantly less common than in the control group. The rare homozygous GG genotype was statically more common in patients with ICM compared to the control group (11.8% vs. 3.2%, p=0.004). Also, the G allele in the group of patients with ICM was detected statically significantly more often than in the control group (30.5% vs. 19.9%, p= 0.003).Conclusion. The polymorphic locus rs1805124 of the SCN5A gene is associated with both IDC and ICM. Homozygous genotype AA and allele A are conditionally protective factors for the development of these conditions in men.

scholarly journals Effect of propolis extract on hematotoxicity and histological changes induced by Salmonella enterica serovar Typhimurium in BALB/c mice

2016 ◽  
Vol 68 (2) ◽  
pp. 385-391 ◽  
Author(s):  
Preeti Kalia ◽  
Neelima Kumar ◽  
Kusum Harjai
Keyword(s):  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Control Group ◽  
Hematological Indices ◽  
Propolis Extract ◽  
Serovar Typhimurium ◽  
Ameliorative Effect ◽  
Group 2

Typhoid fever, a life-threatening disease, causes several pathological changes due to the involvement of one or more organs. In the present study, the effect of typhoid on hematological indices and spleen histology in infected mice were investigated. The ameliorative efficacy of the ethanolic extract of propolis was tested and compared with treatment with the typhoid drug, cefixime. BALB/c mice were divided into six groups: group1 was the normal control, group 2 was infected with Salmonella enteric serovar Typhimurium, group 3 was Salmonella infected and treated with cefixime, groups4 and 5 were Salmonella-infected mice treated with 100mg and 300mg of propolisrespectivelyandgroup6 was given only 300 mg propolis without infection. Mice were sacrificedafter completion of treatment and examination of spleenhistology and hematological studies were performed. Significant differences were observed in the propolis-treated group of mice as compared to the infected group without antibiotic, further confirming the ameliorative effect of propolis on Salmonella enterica serovar Typhimurium-induced toxicity in mice.

scholarly journals Prophylactic Effect of Ethanolic Extract of Saussurea Costus Roots Against Hepato- Renal Toxicity Induced by Diazinon in Chickens

2020 ◽  
Vol 13 (2) ◽  
pp. 34-51
Author(s):  
Alaa K. Hamad ◽  
Mariam Kadhem
Keyword(s):  
Morphological Changes ◽  
Clinical Signs ◽  
Ethanolic Extract ◽  
Inflammatory Cells ◽  
The Body ◽  
Control Group ◽  
Central Vein ◽  
Histopathological Changes ◽  
Group 2 ◽  
Group 1

The study was performed to investigate the prophylactic role of Saussurea costus roots in the functional and histological changes caused by diazinon in the liver and kidneysin chickens. 18 chickens were used of Arbor Acres strain at 54 days of age and 1300-1500 gm average of body weight was used for this purpose. The birds were divided into 3 groups equally (6chicken in each groups), Group 1: served as a control negative received distilled water 1 ml. Group 2: served as a positive control group, received diazinon at a dose of 0.2 mg/kg/day. Group 3: were given an ethanolic extractof Saussurea costus at dose 300 mg/kg, then after one hour administrated diazinon at the dose of 0.2 mg/kg/day, this group served as a prophylactic group. The doses were given orally once daily for 4 weeks.The results of group 2 showed clinical signs such as ruffled feathers, salivation, diarrhea, breathing from the mouth, teary eyes, drooping of wings. The body weights of the chickens and weights of the liver and kidneys of group 2 significantly declined (p≤ 0.05) compared with groups 1 and 3. There was a significant decrease (p≤ 0.05) in WBC count, lymphocyte, total protein, albumin, GSH, SOD, CAT, and GPX levels, while a significant increase (p≤0.05) in heterophil, ALT, AST, creatinine, urea, uric acid, and MDA compared with group 1. The gross examination of the liver and kidney of group 2 were pale, easily crumbles and smaller than that of group 1. Histopathological changes of the liver of group 2 including congested and dilated central vein, vacuolated cytoplasm of hepatocytes, focal necrotic tissue filled with inflammatory cells, thickening of the bile duct, thickening wall of the portal artery. fibroblast in portal area, dilated sinusoid. Histopathological changes of the kidney including dilatation of renal tubule, hemorrhage, and atrophy in the glomerulus. we concluded that administration of ethanolic extractof Saussurea costus resulted in amelioration of the morphological changes in diazinon treated chickens, improved parameters and restored the parameters to near normal compared with group 1. These results revealed that Saussurea costus roots acts as an antioxidant substance and has a hepatic and renoprotective effect against toxicity induced by diazinon.

scholarly journals Estrogenic Activity of Mahoni Seed Ethanolic Extract [Swietenia mahogany (L.) Jacq] on Uterus Weight, Bone Density and Mamae Gland Proliferation on Ovariectomized Rats

2020 ◽  
Vol 11 (2) ◽  
pp. 75
Author(s):  
Poppy Anjelisa Zaitun Hasibuan ◽  
Rosa Gloria Sitanggang ◽  
Robbani Syahfitri Angkat
Keyword(s):  
Bone Density ◽  
Estrogenic Activity ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Group 2 ◽  
Post Hoc

Menopause is a hypoestrogenic condition due to decreased function of the ovary. During menopause there is no reserved ovum in the ovary, as a result the synthesis of estrogen by the follicles does not take place. Deficiency of estrogen can lead to discomfort and decrease in the women quality of life. Therefore, supplements from natural resources to reduce menopausal symptoms will be needed. The objectives of the study were to determine the effect of mahogany seeds ethanolic extract (MSEE) on the development of uterus, bone density, and mammae gland proliferation on ovariectomized rats. Extract was made by maceration using 96% ethanol as the solvent, then the study of estrogenic effect was carried out on 30 female rats which were divided into 6 groups. Group 1 (normal control), group 2 (positive control) given estradiol dose of 0.18 mg/kg body weight (BW), group 3 (negative control) given Na-CMC 1% and group 4, 5, 6 given MSEE orally for 14 consecutive days with doses of 50, 100, 200 mg/kg BW. Data were analysed using ANOVA then continued with Tukey HSD Post Hoc test to see the differences between the treatments. The results of the study showed that MSEE was able to increase the weight of the uterus, the length of estrus phase in the estrus cycle, bone density and the mammae gland proliferation of rats. The results concluded that MSEE has phytoestrogenic effect on ovariectomized rats.Keywords: phytoestrogen, ovariectomy, uterus weight, bone density, mammae proliferation

scholarly journals Uji Potensi Metabolit Sekunder Ekstrak Kulit Buah Petai (Parkia speciosa Hassk) terhadap Kadar Kreatinin dan Ureum Tikus Secara Spektrofotometri UV-Vis

KOVALEN ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. 143-151
Author(s):  
Joni Tandi ◽  
Heru Khairul Muttaqin ◽  
Kiki Rizki Handayani ◽  
Sri Mulyani ◽  
Recky Patala
Keyword(s):  
Laboratory Experiment ◽  
Effective Dose ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Normal Control Group ◽  
Male Rats ◽  
Control Group ◽  
Treatment Groups ◽  
Group 2 ◽  
Group 1

This study aims to determine the effectiveness of bitter beans peels (Parkia speciosa Hassk)  extract on creatinine and urea levels, and the effective dose of the exctract on creatinine and urea levels. This research was a laboratory experiment using 25 rats which were divided into five treatment groups, each group consisting of 5 rats. Group 1 (normal control), group 2 (negative control) were given suspension of Na-CMC, groups 3, 4, and 5 respectively given petai rind ethanolic extract doses of 300, 400 and 500 mg/kg. The results showed that petai fruit (Parkia speciosa hassk) peels extract had an effect on creatinine and urea levels of diabetes hypercholesterolemia male rats by an effective dose of 300 mg/kg which has an effect on creatinine levels by an average of 0.38 mg/dL and ureum levels by an average of 12.9 mg/dL. Keywords: petai fruit peels extract, secondary metabolite, creatinine, ureum, Streptozotocin

scholarly journals Anti-Inflammatory Activity of Mimosa hamata (Willd.)

2019 ◽  
Vol 9 (5-s) ◽  
pp. 34-39
Author(s):  
N. I. Khan ◽  
B.C. Hatapakki
Keyword(s):  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Control Group ◽  
Albino Rats ◽  
Significant Activity ◽  
Dependent Manner ◽  
Paw Edema ◽  
Cotton Pellet ◽  
Cotton Pellet Granuloma ◽  
Anti Inflammatory

Anti-inflammatory activity of ethanolic extract of roots, stems and leaves Mimosa hamata was investigated at the doses of 200 and 400 mg/kg using carrageenan induced paw edema and cotton pellet granuloma technique in albino rats. The stem extracts showed significant activity in dose dependent manner as compared to control group. The observations suggested that the extract of M. hamata were effective in exudative and proliferative phases of inflammation i.e. in acute and chronic inflammation. The results obtained indicate that M. hamata has an anti-inflammatory activity that supports the folk medicinal use of the plant. Keywords: Mimosa hamata, anti-inflammatory activity, carrageenan induced paw edema, cotton pellet granuloma.

scholarly journals АНАЛИЗ ЭФФЕКТИВНОСТИ ОДНОКОМПОНЕНТНЫХ И КОМБИНИРОВАННЫХ ГЕМОСТАТИЧЕСКИХ СРЕДСТВ

Innova ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 25-29
Author(s):  
Д.С. Солдатова ◽  
А.И. Бежин ◽  
И.В. Литвиненко
Keyword(s):  
Liver Injury ◽  
Tranexamic Acid ◽  
Collagen Matrix ◽  
Control Group ◽  
Active Components ◽  
Hemostatic Effect ◽  
Comparative Aspect ◽  
Hemostatic Activity ◽  
Comparison Groups ◽  
Group A

Stopping bleeding during operations on parenchymal organs remains an urgent and unsolved task of medicine. One of the ways to stop it is local hemostatic sponges, which contain several active components. Objective: to study the effectiveness of new experimental hemostatic sponges based on collagen with the addition of hemostatic components. Materials and methods: hemostatic activity was evaluated in an experiment on modeling profuse parenchymal bleeding on the liver and spleen in 110 rats. We studied the amount of blood loss of new hemomtatic sponges based on collagen with the addition of: cryoprecipitate 10 %; cryoprecipitate and tranexamic acid; tranexamic acid 9%; chitosan and caproferr; hemoblock 2%; hemoblock 5%; hemoblock and tranexamic acid in a comparative aspect. The comparison groups were a control group, a hemostatic sponge "Вelkozin", " Zelenaya dubrava" and a gauze napkin. Results: the most effective sample was hemostatic sponge with 9% tranexamic acid, the decrease in the indicator relative to the control group was 83% (387 mg) for liver injury and 79% (284 mg) for spleen injury. Conclusion: the collagen matrix is a suitable carrier for one hemostatic component. This combination makes it possible to achieve the maximum hemostatic effect and the possibility of using these experimental samples in conditions of parenchymal bleeding.

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