The clinical features of chronic intestinal schistosomiasis-related intestinal lesions

Abstract Background Chronic intestinal schistosomiasis has been reported to be associated with colonic polyps, colorectal cancer and ulcerative colitis. We aim to investigate the clinical characteristics of intestinal-related lesions caused by chronic intestinal schistosomiasis japonicum. Methods Patients with and without chronic intestinal schistosomiasis were retrospectively enrolled from the endoscopy center of Wuhan Union Hospital from September 1, 2014, to June 30, 2019 with a ratio of 4:1. The characteristics of infected intestinal segments were analyzed in patients with chronic intestinal schistosomiasis. We also compared the characteristics of intestinal-related lesions, including colorectal polyps, colorectal cancer (CRC), ulceration or erosion of the intestinal mucosa and hemorrhoids, between the two groups. Results A total of 248 patients with chronic intestinal schistosomiasis and 992 patients without chronic intestinal schistosomiasis were analyzed. The most common sites of chronic intestinal schistosomiasis were the sigmoid colon (79.0%) and rectum (84.7%). The frequency of intestinal polyps (64.5% vs. 42.8%, p < 0.001), especially rectal polyps (62.5% vs. 45.0%, p = 0.002), in the intestinal schistosomiasis group was significantly higher than that in the control group. Morphologically, type IIa polyps were more common in the schistosomiasis enteropathy group (68.5% vs. 60.7%, p = 0.001). Female patients with intestinal schistosomiasis had a higher detection rate of CRC than women in the control group (13.8% vs. 5.4%, p = 0.017). There was no significant difference in the incidence of ulcerative colitis between the two groups (0.8% vs. 0.6%, p = 0.664). In addition, the schistosomiasis enteropathy patients had a higher detection rate of internal hemorrhoids (58.9% vs. 51.0%, p = 0.027). Conclusions Chronic intestinal schistosomiasis mainly involved the rectum and sigmoid colon and was more likely to induce intestinal polyps, especially rectal polyps and internal hemorrhoids. Women with chronic schistosomiasis have a higher risk of colorectal cancer.

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The clinical features of chronic intestinal schistosomiasis-related intestinal lesions

10.21203/rs.3.rs-61805/v1 ◽

2020 ◽

Author(s):

Xian Qin ◽

Cai-Yuan Liu ◽

Yi-Lin Xiong ◽

Tao Bai ◽

Lei Zhang ◽

...

Keyword(s):

Colorectal Cancer ◽

Ulcerative Colitis ◽

Sigmoid Colon ◽

Detection Rate ◽

Control Group ◽

Intestinal Polyps ◽

Intestinal Schistosomiasis ◽

Rectal Polyps ◽

Significant Difference ◽

Internal Hemorrhoids

Abstract Background Chronic intestinal schistosomiasis has been reported to be associated with colonic polyps, colorectal cancer and ulcerative colitis. We aim to investigate the clinical characteristics of intestinal-related lesions caused by chronic intestinal schistosomiasis japonicum. Methods Patients with and without chronic intestinal schistosomiasis were retrospectively enrolled from the endoscopy center of Wuhan Union Hospital from September 1, 2014, to June 30, 2019 with a ratio of 4:1. The characteristics of infected intestinal segments were analyzed in patients with chronic intestinal schistosomiasis. We also compared the characteristics of intestinal-related lesions, including colorectal. polyps, colorectal cancer (CRC), ulceration or erosion of the intestinal mucosa and hemorrhoids, between the two groups. Results A total of 248 patients with chronic intestinal schistosomiasis and 992 patients without chronic intestinal schistosomiasis were analyzed. The most common sites of chronic intestinal schistosomiasis were the sigmoid colon (79.0%) and rectum (84.7%). The frequency of intestinal polyps (64.5%vs42.8%, p < 0.001), especially rectal polyps (62.5%vs45.0%, p = 0.002), in the intestinal schistosomiasis group was significantly higher than that in the control group. Morphologically, type IIa polyps were more common in the schistosomiasis enteropathy group (68.5%vs60.7%, p = 0.001). Female patients with intestinal schistosomiasis had a higher detection rate of CRC than women in the control group (13.8%vs5.4%, p = 0.017). There was no significant difference in the incidence of ulcerative colitis between the two groups (0.8%vs0.6%, p = 0.664). In addition, the schistosomiasis enteropathy patients had a higher detection rate of internal hemorrhoids (58.9%vs51.0%, p = 0.027). Conclusions Chronic intestinal schistosomiasis mainly involved the rectum and sigmoid colon and was more likely to induce intestinal polyps, especially rectal polyps and internal hemorrhoids. Women with chronic schistosomiasis have a higher risk of colorectal cancer.

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Bevacizumab in neoadjuvant treatment of patients with liver metastases from colorectal carcinoma

Archive of oncology ◽

10.2298/aoo1003075n ◽

2010 ◽

Vol 18 (3) ◽

pp. 75-78

Author(s):

Ivan Nikolic ◽

Svetlana Pavin ◽

Biljana Kukic ◽

Bogdan Bogdanovic ◽

Miroslav Ilic ◽

...

Keyword(s):

Colorectal Cancer ◽

Liver Metastases ◽

Neoadjuvant Treatment ◽

Hepatic Metastases ◽

Response Rates ◽

Control Group ◽

Significant Difference ◽

Experimental Group ◽

Selection Of Patients ◽

Selection Of

Background: Liver metastases are the leading cause of death in patients with colorectal cancer. Despite advances in chemotherapy, surgical resection of hepatic metastases is still considered the only curative options. However, the majority of patients have inoperable disease at presentation. Perioperative chemotherapy is the most successful way for improved selection of patients for resection. The aim of the study was to demonstrate if and to what extent does bevacizumab, introduced in chemotherapy, increase response rates, and development of liver metastases. Methods: Our study included 50 patients who were divided in two groups. The experimental group included patients who were treated with bevacizumab plus chemotherapy, and the control group included patients who were treated with chemotherapy only. Results: The comparison showed that the patients who were treated with bevacizumab became candidates for resection of liver metastases in higher percentage (85%:52%). In addition, distribution of patients regarding the development of metastases resulted in statistically significant difference. Ratio between the patients with good response from the experimental and the control group was 67%:39%. Ratio of patients with stable disease was 26%:48%, and of patients with progressive disease, it was 7%:3%. The estimate of margin after resection was statistically insignificant. Conclusion: Bevacizumab in combination with chemotherapy in therapy of liver metastases from primary colorectal cancer improves and increases response rates and development of liver metastases.

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Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer

Journal of Investigative Medicine ◽

10.1136/jim-2021-002047 ◽

2021 ◽

pp. jim-2021-002047

Author(s):

Angélica Araceli Ramírez-Guerrero ◽

Christian Octavio González-Villaseñor ◽

Evelia Leal-Ugarte ◽

Melva Gutiérrez-Angulo ◽

Mario Ramírez-Flores ◽

...

Keyword(s):

Colorectal Cancer ◽

Angiogenesis Inhibitor ◽

Cross Sectional Study ◽

Control Group ◽

Corticotropin Releasing Hormone ◽

Allelic Discrimination Assay ◽

Allelic Discrimination ◽

Cross Sectional ◽

Releasing Hormone ◽

Significant Difference

Colorectal cancer (CRC) is the third most common cancer and one of the main causes of death around the world. Multiple lines of evidence have suggested the role of the corticotropin-releasing hormone (CRH) family in CRC induction, including the low expression of corticotropin-releasing hormone receptor 2 (CRHR2), which is an angiogenesis inhibitor and inflammatory modulator. Previous research suggests that CRHR2 expression in colonic intestinal cells can regulate migration, proliferation and apoptosis through the modulation of several pathways. The aim of this study was to analyze the association of the rs10250835, rs2267716 and rs2267717 variants of CRHR2 gene with CRC in the Mexican population in order to consider its predictive value in CRC. This cross-sectional study included a group of 187 unrelated patients with sporadic CRC and a control group of 191 healthy blood donors. DNA extraction from peripheral blood was carried out using the Miller method. Identification of the rs10250835 variant was performed using PCR-restriction fragment length polymorphism (RFLP) and the rs2267716 and rs2267717 variants using TaqMan allelic discrimination assay. The minor allele homozygous CC of the rs2267716 variant of CRHR2 showed significant difference between CRC and control group (p=0.025), as well as the GCA haplotype (p=0.007), corresponding to the rs10250835, rs2267716 and rs2267717 variants, respectively. Our results suggest that the rs2267716 variant and GCA haplotype of CRHR2 represent a risk factor for CRC development in Mexican patients.

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Modified Pro-Self Pain Control to Increase Activity in Patients with Colorectal Cancer

Nurse Media Journal of Nursing ◽

10.14710/nmjn.v7i1.15128 ◽

2017 ◽

Vol 7 (1) ◽

pp. 56

Author(s):

Khoirunnisa’ Munawaroh ◽

Untung Sujianto ◽

Mardiyono Mardiyono

Keyword(s):

Colorectal Cancer ◽

Experimental Design ◽

Activities Of Daily Living ◽

Pain Control ◽

Daily Living ◽

Intervention Group ◽

Control Group ◽

Patients With Cancer ◽

Katz Index ◽

Significant Difference

Background: Barriers to performing activities of daily living are common complaints of patients with cancer. One of the factors causing these barriers is pain. A modified pro-self pain control is a method used to enhance the patients’ ability to cope with pain to increase their activity.Purpose: This study aimed to evaluate the modified pro-self pain control to increase activity in patients with colorectal cancer undergoing chemotherapy.Methods: The present study employed an experimental design. Patients with colorectal cancer undergoing chemotherapy were randomly assigned to the intervention group (n=24) and the control group (n=24). The patients in the control group were given a standard hospital intervention, while the patients in the intervention group were given the modified pro-self pain control for nine days. The data were collected using the instrument of KATZ index and analyzed using the independent t-test.Results: The result of this study showed that there was a higher increase of activity among the patients in the intervention group than in the control group. Independent t-test showed that there was a significant difference between the intervention group and the control group (p=0.00).Conclusion: The modified pro-self pain control was found more effective to increase the activity in patients with colorectal cancer undergoing chemotherapy than that of the standard hospital intervention.

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P187 The significance of netrin-1 level in the clinical activity of ulcerative colitis, its association between TNF-α and IL-6

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.316 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S232-S232

Author(s):

H Korkmaz ◽

K Fidan

Keyword(s):

Ulcerative Colitis ◽

Proinflammatory Cytokines ◽

Activity Index ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Clinical Activity ◽

Tnf Α ◽

Significant Difference ◽

And Control ◽

Control Study

Abstract Background In this study, we investigated the importance of netrin-1 levels in ulcerative colitis (UC) in clinical activity of the disease, and its association with other proinflammatory cytokines IL-6 and TNF-α. Methods This study is a type of case–control study. Sixty-seven patients with UC (36 of them activation, 31 of remission) and 50 healthy controls were included in the study. UC patients; ‘Truelove Witts clinical activity index by remission (n = 31), mild activation (n = 21), moderate activation (n = 6) and severe activation (n = 9) were divided into groups. Netrin, IL-6 and TNF-α measurements in plasma samples were performed using enzyme-linked immunosorbent assay kit. Results Between the patient group and the control group; there was a statistically significant difference between netrin-1, IL-6, TNF-α, neutrophil, platelet (p < 0.05 for all). The plasma netrin-1 mean of UC with severe activation group (139.21 ± 48.09 pg/ml) was statistically significantly higher than that of the mild activation (p = 0,037), remission group (p = 0,001) and control group(p = 0,011). The plasma netrin-1 mean of UC with moderate activation group was statistically significantly higher than that of the mild activation(p = 0,045) and remission group(p = 0,004). Conclusion Our results reveal that plasma netrin-1 levels have been shown to be associated with UC activation, similar to proinflammatory cytokines such as TNF-α and IL-6, in UC.

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INVESTIGATION OF ENTEROCOCCUS FAECALIS POPULATION IN PATIENTS WITH POLYP AND COLORECTAL CANCER IN COMPARISON OF HEALTHY INDIVIDUALS

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201900000-28 ◽

2019 ◽

Vol 56 (2) ◽

pp. 141-145 ◽

Cited By ~ 3

Author(s):

Maryam GERAVAND ◽

Parviz FALLAH ◽

Mojtaba Hedayat YAGHOOBI ◽

Fatemeh SOLEIMANIFAR ◽

Malihe FARID ◽

...

Keyword(s):

Colorectal Cancer ◽

Enterococcus Faecalis ◽

Copy Number ◽

Healthy People ◽

Control Group ◽

Healthy Individuals ◽

Faecal Flora ◽

Copy Numbers ◽

Significant Difference ◽

The Mean

ABSTRACT BACKGROUND: Colorectal cancer is one of the most commonly diagnosed cancers around the world. One of the factors involved in the development of colorectal cancer is the changes in the normal flora of the intestine. OBJECTIVE: In this study, the mean copy number of Enterococcus faecalis in people with polyps and people with colorectal cancer has been evaluated in comparison with healthy controls. METHODS: In this study, 25 patients with colorectal cancer and 28 patients with intestinal polyps were selected and stool specimens were taken. In addition, 24 healthy individuals were selected as control group. Extraction of bacterial DNA from the stool sample were performed. The molecular methods of PCR for confirmation of standard strain and absolute Real Time PCR (qRT-PCR) method were used to evaluate the number of Enterococcus faecalis in the studied groups. RESULTS: The results of this study indicate that the mean copy number of Enterococcus faecalis in patients with colorectal cancer was 11.2x109 per gram of stool, and in patients with polyps was 9.4x108 per gram of stool. In healthy people, this number was 9x108 per gram of stool. There was a significant difference between the implicit copy numbers in the three groups. (P<0.05). CONCLUSION: Enterococcus faecalis in faecal flora of people with colorectal cancer was significantly higher than those with polyps and healthy people. This could potentially signify the ability of this bacterium to induce colorectal cancer. More studies are needed to prove this theory.

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Adjuvant chemotherapy with uracil-tegafur (UFT) for stage III colorectal cancer: Final results of randomized trials by the National Surgical Adjuvant Study of Colorectal Cancer (NSAS-CC)

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.4049 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 4049-4049 ◽

Cited By ~ 2

Author(s):

T. Hamaguchi ◽

K. Shirao ◽

Y. Moriya ◽

S. Yoshida ◽

S. Kodaira ◽

...

Keyword(s):

Colorectal Cancer ◽

Rectal Cancer ◽

Colon Cancer ◽

Adjuvant Chemotherapy ◽

Hazard Ratio ◽

Stage Iii ◽

Control Group ◽

Significant Difference ◽

Resected Stage

4049 Background: In the latter 1990s, no consensus was reached as to whether adjuvant chemotherapy was standard treatment for completely resected stage III colorectal cancer in Japan. At that time, we started two randomized controlled trials to clarify the role of adjuvant chemotherapy of stage III colon and rectal cancer in the same time. Methods: Patients with completely resected stage III cancer of the colon or rectum (PS, 0 to 2; age, 20 to 75 years; no other adjuvant therapy) were eligible for these trials. Patients were registered within 6 weeks after surgery and were randomly assigned to receive surgery alone (control group) or surgery followed by treatment with UFT (400 mg/m2/day), given for 5 consecutive days per week for 1 year (UFT group). The target number of patients was 500 for colon cancer and 400 for rectal cancer (hazard ratio = 0.67, one-sided a= 0.05, β= 0.2). The primary endpoint was relapse-free survival (RFS), and the secondary end point was overall survival (OS). Results: Between October 1996 and April 2001, a total of 334 patients with colon cancer and 276 with rectal cancer were enrolled. Four ineligible patients were excluded; data from the remaining 332 patients with colon cancer and 274 with rectal cancer were analyzed. The patients’ characteristics were similar in the groups. Analysis of the results of follow-up until March 2006, at least 5 years after surgery in all patients (median follow-up period, 6.2 years), showed no significant difference in RFS or OS in colon cancer. In rectal cancer, however, RFS and OS were significantly better in the UFT group than in the control group. The only grade 4 toxicity was diarrhea, occurring in 1 patient with colon cancer and 1 patient with rectal cancer. Conclusions: Postoperative adjuvant chemotherapy with UFT is well tolerated and improved RFS and OS in patients with stage III rectal cancer. In colon cancer, the expected benefits were not obtained (hazard ratio = 0.67). [Table: see text] No significant financial relationships to disclose.

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The Effects of Moderate Neuromuscular Blockade Combined with Transverse Abdominal Plane Block on Surgical Space Conditions During Laparoscopic Colorectal Surgery: A Randomised Clinical Study

10.21203/rs.3.rs-820460/v1 ◽

2021 ◽

Author(s):

Fang Ke ◽

Zijin Shen ◽

Cheng Wu ◽

Lin Zhang ◽

Rong Dong

Keyword(s):

Colorectal Cancer ◽

Laparoscopic Surgery ◽

Neuromuscular Blockade ◽

Intervention Group ◽

Ordinal Scale ◽

Control Group ◽

Sacral Promontory ◽

Pain Scores ◽

Significant Difference ◽

Space Conditions

Abstract Background Deep neuromuscular blockade may be beneficial on surgical space conditions during laparoscopic surgery. The effects of moderate neuromuscular blockade combined with transverse abdominal plane block (TAPB) on the surgical space conditions during laparoscopic surgery has not been described. We investigated if moderate neuromuscular blockade combined with TAPB would be associated with similar surgical space conditions compared with deep neuromuscular blockade. Methods Eighty patients undergoing elective laparoscopic surgery for colorectal cancer were randomly divided into two groups. The intervention group was treated with moderate neuromuscular blockade (train-of-four (TOF) count between 1 and 3) combined with TAPB (M group), while the control group was treated with deep neuromuscular blockade (D group), with a TOF count of 0 and a post-tetanic count (PTC) ≥ 1. Both groups received the same anesthesia management. The distance between the sacral promontory and the umbilical skin during the operation was compared between the two groups. The surgeon scored the surgical space conditions according to a five-point ordinal scale. Patients’ pain scores were evaluated eight hours after the operation. Results The 95% confidence intervals of the difference in the distance from the sacral promontory to the umbilical skin between the groups were − 1.45–0.77cm. According to the preset non-inferior standard of 1.5cm, (-1.45, ∞) completely fell within (-1.50, ∞), and the non-inferior effect test was qualified. There was no significant difference in the surgical rating score between the two groups. The dosage of rocuronium in group D was significantly higher than that in group M (P < 0.01). The M group had significantly lower pain scores than the D group eight hours after the operation (P < 0.05). Conclusions In laparoscopic colorectal cancer surgery, moderate neuromuscular blockade combined with TAPB can provide surgical space conditions similar to those of deep neuromuscular blockade, and at the same time, reduces the use of muscle relaxants, relieves postoperative pain within 4 hours after operation, shorten the time to extubation and stay in PACU. Trial registration: chictr.org.cn (ChiCTR2000034621), registered on 12, July, 2020

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Effectiveness of ColorApp Mobile Application for Health Education and Promotion on Colorectal Cancer: A Quasi-Experimental Study (Preprint)

10.2196/preprints.15487 ◽

2019 ◽

Cited By ~ 1

Author(s):

Nor Azwany Yaacob ◽

Muhamad Fadhil Mohamad Marzuki ◽

Najib Majdi Yaacob ◽

Shahrul Bariyah Ahmad ◽

Muhammad Radzi Abu Hassan

Keyword(s):

Colorectal Cancer ◽

Mobile Application ◽

Intervention Group ◽

Control Group ◽

The Public ◽

Screening Participation ◽

Significant Difference ◽

Quasi Experimental ◽

Knowledge And Attitude ◽

And Control

BACKGROUND Background: Lack of knowledge and poor attitude is one of the barriers to colorectal cancer screening participation. Printed material such as pamphlets and posters were the main approach in health education on disease prevention. Current information technology advancement had seen an increasing trend of the public to read from websites and mobile app using their smartphone. Thus, health information dissemination should also be diverted to the current trend of information search. Increase in knowledge and awareness will hopefully increase the screening participation and prevent late detection of diseases such as colorectal cancer. OBJECTIVE This study aimed to assess the effectiveness of ColorApp mobile applications in improving the knowledge and attitude on colorectal cancer among user aged 50 years old and above who are the population at risk for the disease in Kedah. METHODS Methods: A quasi-experimental study has been conducted involving 100 participants in Kedah, Malaysia. Participants from five randomly selected community empowerment program in Kota Setar district was chosen as the intervention group while Kuala Muda district was chosen as the control group. Participants were given a self-administered validated questionnaire on knowledge and attitude towards colorectal cancer. A usable mobile application, the ColorApp (Colorectal Cancer Application) was developed as a new educational tool on colorectal cancer prevention. The intervention group were given 2 weeks to use the ColorApp. The same questionnaire was redistributed to both groups after two weeks. The mean percentage score for knowledge and attitude between groups were compared using Repeated Measure ANCOVA. RESULTS Result: There was no significant difference of age, sex, highest education level, current occupation, and diabetic status between the two groups. The number of smokers was significantly higher in intervention groups as compared to control group and it has been controlled during analysis. There was a significant difference in mean knowledge score between intervention and control group with regards to time [Huynh Feldt: F (1,95) = 19.81; p < 0.001]. However, there was no significant difference in mean attitude score between intervention and control group with regards to time [F (1,95) = 0.36, p = 0.550]. CONCLUSIONS Conclusion: The mobile application can be one of the adjunct approaches in educating the public on colorectal cancer.

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Effect of Kampo medicine Juzen-taiho-to on adverse events induced by cetuximab.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.4_suppl.396 ◽

2011 ◽

Vol 29 (4_suppl) ◽

pp. 396-396

Author(s):

S. Morimoto ◽

M. Shimada ◽

N. Kurita ◽

T. Iwata ◽

M. Nishioka ◽

...

Keyword(s):

Colorectal Cancer ◽

Adverse Events ◽

Cancer Patients ◽

Patient Characteristics ◽

Infusion Reaction ◽

Kampo Medicine ◽

Control Group ◽

Recurrent Colorectal Cancer ◽

Skin Reactions ◽

Significant Difference

396 Background: Cetuximab is now considered a standard treatment for advanced or unresectable colorectal cancer, unfortunately patients suffer a skin reaction as the main indication of the toxicity of cetuximab. It is recently reported that Kampo medicine (Goshajinkigan) is considered to be an effective agent for the neuropathy of oxaliplatin. Kampo medicine “Juzen-taiho-to” (TJ-48, Tsumura CO. Ltd.), which consists of 10 component herbs, is known as a tonic agent which improves the general systemic condition of cancer patients by reducing the adverse effects of chemotherapy, radiation therapy, and surgical treatment and to inhibit metastases. The aim of this study was to clarify the efficacy of TJ-48 for adverse events associated with cetuximab therapy. Methods: From 2009, cetuximab was administered initially at a dose of 400 mg/m2 followed by weekly infusions at 250 mg/m2 to 20 patients with non-resectable or recurrent colorectal cancer. Eighteen patients received oral administration of 7.5 g/day of TJ-48 (TJ-48 group) every day in the first course and 7 patients did not receive TJ-48 (Control group). Adverse events were evaluated for every course according to CTCAE version 3.0. Results: There was no statistically significant difference between the two groups based on any of patient characteristics. No patients complained of persistent Grade 3 infusion reaction. The percentage of Grade 2 or more skin reactions in each course tended to be lower in the TJ-48 group compared with the Control group (TJ-48 group 34% vs control group 57%). Incidence of Grade 2 anorexia in the TJ-48 group was significantly lower than in the Control group (TJ-48 group 34% vs control group 71%, p=0.03). There were no differences regarding tumor response between the two groups. Conclusions: TJ-48 is useful to prevent anorexia in non-resectable or recurrent colorectal cancer patients treated with cetuximab regimen. [Table: see text]

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