Incidence and characteristics of arterial thromboemboli in patients with COVID-19

Abstract Background Studies have reported COVID-19 as an independent risk factor for arterial thromboemboli. Methods From a cross-sectional sample, we determined the incidence and location of arterial thromboemboli (myocardial infarction, ischemic stroke, peripheral artery), stratified by COVID-19 status, in the RECOVER database, which included data on patients at 45 United States medical centers in 22 states. Epidemiological factors, clinical characteristics and outcomes were collected through a combination of individual chart review and automatic electronic query and recorded in REDCap®. We investigated the association of baseline comorbidities on the development of arterial thromboemboli and analyzed results based on the presence or absence of concomitant COVID-19 infection, testing this association with Chi-squared. We also described use of anticoagulants and statins. Results Data were collected on 26,974 patients, of which 13,803 (51.17%) tested positive for COVID-19. Incidence of arterial thromboemboli during hospitalization was 0.13% in patients who tested positive for COVID-19 and 0.19% in patients who tested negative. Arterial thromboemboli tended to be more common in extremities than in core organs (heart, kidney, lung, liver) in patients with COVID-19, odds ratio 2.04 (95% CI 0.707 – 5.85). Patients with COVID-19 were less likely to develop an arterial thrombus when on baseline statin medication (p=0.014). Presence of metabolic syndrome predicted presence of core arterial thrombus (p=0.001) and extremity arterial thrombus (p=0.010) in those with COVID-19. Arterial thromboemboli were less common in patients with COVID-19 than in those who tested negative for COVID-19. Conclusions Presence of a composite metabolic syndrome profile may be associated with arterial clot formation in patients with COVID-19 infection.

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Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2008-2278 ◽

2009 ◽

Vol 94 (7) ◽

pp. 2558-2564 ◽

Cited By ~ 79

Author(s):

Umer Saleem ◽

Mahyar Khaleghi ◽

Nils G. Morgenthaler ◽

Andreas Bergmann ◽

Joachim Struck ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Odds Ratio ◽

Density Lipoprotein ◽

Model Assessment ◽

Cross Sectional ◽

Logistic Regression Models ◽

Bottom Quartile ◽

Novel Biomarkers ◽

Carboxy Terminal

Context: Stress-mediated hypothalamic-pituitary-adrenal axis activation, regulated by arginine vasopressin (AVP), may have a role in the pathophysiology of metabolic syndrome (MetSyn). Objective: The objective of the study was to investigate whether plasma C-terminal provasopressin fragment (copeptin), a surrogate for circulating AVP, was associated with measures of insulin resistance and presence of MetSyn. Design, Setting, and Participants: This was a multicenter, community-based study, investigating novel biomarkers for vascular disease. Participants included 1293 African-Americans (AA) (64 ± 9 yr) and 1197 non-Hispanic whites (NHW) (59 ± 10 yr) belonging to hypertensive sibships. Main Outcome Measures: Plasma copeptin levels were measured by an immunoluminometric assay. MetSyn was defined per Adult Treatment Panel III criteria. Generalized estimating equations were used to assess whether plasma copeptin was associated with measures of insulin resistance and MetSyn. Results: The prevalence of MetSyn was 50% in AA and 49% in NHW. In each group, after adjustment for age and sex, plasma copeptin levels significantly correlated with body mass index, fasting plasma glucose and insulin, homeostasis model assessment of insulin resistance, triglycerides, and (inversely) high-density lipoprotein cholesterol (P < 0.05 for each variable). In multivariable logistic regression models that adjusted for age, sex, smoking, statin use, serum creatinine, education, physical activity, and diuretic use, plasma copeptin levels in the highest quartile were associated with an increased odds ratio of having MetSyn compared with bottom quartile: odds ratio (95% confidence interval) in AA, 2.07 (1.45–2.95); in NHW, 1.74 (1.21–2.5). Conclusions: Our findings indicate a novel cross-sectional association between plasma copeptin and measures of insulin resistance and MetSyn.

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Weight Gain Predicts Metabolic Syndrome among North Korean Refugees in South Korea

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18168479 ◽

2021 ◽

Vol 18 (16) ◽

pp. 8479

Author(s):

Yoon Jung Kim ◽

Yo Han Lee ◽

Yun Jeong Lee ◽

Kyeong Jin Kim ◽

Sin Gon Kim

Keyword(s):

Metabolic Syndrome ◽

Body Composition ◽

Body Weight ◽

Weight Gain ◽

South Korea ◽

Weight Change ◽

Odds Ratio ◽

P Value ◽

Cross Sectional ◽

North Korean Refugees

Previous cross-sectional studies showed that immigrants from low-income to high-income countries have higher risk of cardiovascular disease and type 2 diabetes mellitus. We investigated the association between weight gain during the resettlement in South Korea and risk of metabolic syndrome (MetS) among North Korean refugees (NKRs) in this cross-sectional study. In total, 932 NKRs aged 20–80 years in South Korea voluntarily underwent health examination from 2008 to 2017. We compared the risk of MetS and its components between the weight gain group (gained ≥5 kg) and the non-weight gain group (gained <5 kg, maintained or lost body weight) during resettlement in South Korea after defection from North Korea. Multiple logistic regression analysis predicted odds ratio of MetS on the basis of weight change, adjusting for covariates and current body mass index (BMI). We also evaluated the difference in body composition of NKRs between two groups. The prevalence of MetS in the weight gain group was 26%, compared to 10% in the non-weight gain group (p-value < 0.001). The weight gain group had a two-fold higher risk of MetS than the non-weight gain group after adjusting for current BMI (odds ratio 1.875, p-value = 0.045). The prevalence of central obesity, impaired fasting glucose, elevated blood pressure, and hypertriglyceridemia were higher in the weight gain group than the non-weight gain group (36% vs. 12%, p-value < 0.001; 32% vs. 19%, p-value < 0.001; 34 vs. 25%, p-value = 0.008; 19% vs. 13%, p-value = 0.025, respectively). The analysis of body composition showed that the percentage of body fat in the weight gain group was higher than in the non-weight gain group, indicating increased fat mass rather than muscle mass in the weight gain group as their body weight increased during resettlement (33.4 ± 6.53% vs. 28.88 ± 7.40%, p < 0.005). Excess weight gain after defection from North Korea increased the risk of MetS among NKRs in South Korea. It is necessary to monitor weight change among NKRs and their effect on their metabolic health in the long term.

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Hyperhomocysteinemia Concurrent with Metabolic Syndrome Is Independently Associated with Chronic Kidney Disease among Community-Dwelling Adults in an Urban Korean Population

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17186810 ◽

2020 ◽

Vol 17 (18) ◽

pp. 6810

Author(s):

Hana Moon ◽

Hae-Jin Ko ◽

A-Sol Kim

Keyword(s):

Metabolic Syndrome ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Odds Ratio ◽

Central Obesity ◽

Cross Sectional Study ◽

Community Dwelling ◽

Sectional Study ◽

Cross Sectional ◽

The Difference

Elevated homocysteine (Hcy) levels and metabolic syndrome (MetS) are associated with chronic kidney disease (CKD). We investigated the combined effects of hyperhomocysteinemia (HHcy) and MetS on CKD among community-dwelling adults in an urban area of South Korea. We also identified the combination of HHcy and individual MetS components associated with the maximal risk of CKD. A retrospective cross-sectional study involving 19,311 health examinees between 2 January 2011 and 31 December 2015 was conducted. The participants were divided into four groups—namely, the HHcy−/MetS−, HHcy−/MetS+, HHcy+/MetS−, and HHcy+/MetS+ groups. CKD was defined as a low eGFR <60 mL/min/1.73 m2 or albuminuria. The HHcy+/MetS+ group had a higher risk of CKD than the HHcy−/MetS+ group (odds ratio (OR): 1.750, p = 0.002 for males; OR: 3.224, p < 0.001 for females). The HHcy+/MetS+ group had a higher CKD risk than the HHcy+/MetS− group; however, the difference was not statistically significant (OR: 1.070, p = 0.712 for males; OR: 1.847, and p < 0.074 for females). HHcy concurrent with MetS increased the CKD risk. Among the combinations of HHcy and MetS components, the coexistence of HHcy and central obesity had the greatest effect on CKD. Therefore, the timely detection and treatment of HHcy and MetS are important for preventing CKD.

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Prevalensi dan Determinan Sindrom Metabolik pada Kelompok Eksekutif di Jakarta dan Sekitarnya

Kesmas National Public Health Journal ◽

10.21109/kesmas.v6i2.110 ◽

2011 ◽

Vol 6 (2) ◽

pp. 85 ◽

Cited By ~ 1

Author(s):

Sudijanto Kamso ◽

Purwantyastuti Purwantyastuti ◽

Dharmayati Utoyo Lubis ◽

Ratna Juwita ◽

Yull Kurnia Robbi ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

High Density Lipoprotein ◽

Odds Ratio ◽

Multiple Logistic Regression Analysis ◽

Density Lipoprotein ◽

High Density ◽

Blood Analysis ◽

Cross Sectional ◽

Executive Group

Data tentang faktor-faktor yang berhubungan dengan sindrom metabolik pada kelompok eksekutif di Indonesia yang diperlukan untuk upaya pencegahan penyakit kardiovaskular sangat terbatas. Penelitian ini bertujuan untuk mengetahui prevalensi dan determinan sindrom metabolik pada kelompok eksekutif. Penelitian dilakukan di Jakarta dan sekitarnyadengan menggunakan rancangan cross sectional. Jumlah responden yaitu 220 orang eksekutif laki-laki dan 68 orang eksekutif wanita. Pengumpulan data dilakukan dengan pengukuran antropometri, analisis biokimia darah, analisis asupan makanan, pengukuran angka stres, dan pengukuranindeks aktivitas. Analisis regresi logistik ganda dilakukan untuk mengetahui hubungan beberapa independen variabel dengan dependen variabel. Analisis ini menghasilkan indeks massa tubuh (overweight, odds ratio (OR) = 5,54; obesitas, OR = 7,44) dan rasio total kolesterol/high density lipoprotein (HDL)-kolesterol (OR = 8,83) sebagai determinan sindrommetabolik pada kelompok eksekutif. Penelitian ini menunjukkan bahwa pemeriksaan profil lipid dan pengukuran antropometri sederhana yang teratur pada kelompok eksekutif penting dilakukan untuk mendeteksi risiko sindrom metabolik.Kata kunci: sindrom metabolik, kelompok eksekutif, antropometriAbstractAvailable datas on metabolic syndrome among Indonesian executives are limited, despite the fact of the importance of these data for cardiovaskular prevention. The objective of this study was to assess prevalence of metabolic syndrome and its associations between anthropometric measures, lipid profiles, blood pressure, nutrient intakes, and life style in executive group. A cross sectional study was undertaken in some factoriesin Jakarta, using multistage random sampling. The respondents were 287 executives, 219 male and 68 female. Data were collected through anthropometric measurements, biochemical blood analysis, nutrient intake, stress score, and activity index assessment. Multiple logistic regression analysis used to assess associations between independent variables and metabolic syndrome. This study showed that body mass index (overweight, odds ratio (OR) = 5,54; obesity, OR = 7,44) and ratio serum total cholesterol to high density lipoprotein (HDL)-cholesterol (OR = 8,83) were potential determinants of metabolic syndrome. This study shows the importance ofroutine check of lipid profile, blood pressure, and simple anthropometric assessment to detect the risk of metabolic syndrome in the elderly.Key words: metabolic syndrome, executive group, antropometric

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Longitudinal SARS-CoV-2 serosurveillance of over ten thousand health care workers in the Providence Oregon cohort.

10.1101/2020.08.16.20176107 ◽

2020 ◽

Author(s):

Rom Leidner ◽

Angi Frary ◽

Julie Cramer ◽

David Ball ◽

Roshanthi Weerasinghe ◽

...

Keyword(s):

Odds Ratio ◽

High Rate ◽

Detection Methods ◽

High Risk Population ◽

Cross Sectional ◽

Medical Centers ◽

Care Workers ◽

Voluntary Testing ◽

Frontline Healthcare Workers ◽

Job Role

ABSTRACT Frontline healthcare workers (HCW) are a high-risk population for SARS-CoV-2 infection. Here we present results from a large serosurveillance study of 10,019 asymptomatic HCW conducted during April-May 2020, in eight hospital medical centers across the state of Oregon, USA during the initial peak of the pandemic. Free and voluntary testing was performed at 14 +/- 3 day intervals, over a 4-week window at each site, utilizing a lab-developed ELISA based on the Epitope Diagnostics COVID-19 nucleocapsid IgG detection Kit. We identified 253 SARS-CoV-2 IgG seropositive individuals among 10,019 total participants, representing a cross-sectional seroprevalence of 2.53%. Subgroup analysis identified differential seropositivity by job role, ranging from 8.03% among housekeepers, odds ratio 3.17 (95% CI 1.59-5.71), to 0.00% among anesthesiologists, odds ratio 0.00 (95% CI 0-0.26), both of which were significant. Over the course of the study, 17 seroconversions (0.25%) and 101 seroreversions (1.50%) were identified. Self-reported SARS-CoV-2 swab qPCR testing, when compared with subsequent serology on study, showed only modest agreement, κ = 0.47 (95% CI 0.32-0.62). Overall, these findings demonstrate relatively low seroprevalence and very low seroconversion rates among HCW in Oregon, USA, over a period in which aggressive social distancing measures were in place. The high rate of seroreversion observed in this cohort, and the relatively high discordance between SARS-CoV-2 serology and swab qPCR, highlight limitations of current detection methods, and stress the need for development of novel assessment methodologies to more accurately identify exposure (and/or immunity) to SARS-CoV-2 in this population.

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Glucocorticoid receptor haplotype and metabolic syndrome: the Lifelines cohort study

Acta Endocrinologica ◽

10.1530/eje-16-0534 ◽

2016 ◽

Vol 175 (6) ◽

pp. 645-651 ◽

Cited By ~ 9

Author(s):

Vincent L Wester ◽

Jan W Koper ◽

Erica L T van den Akker ◽

Oscar H Franco ◽

Ronald P Stolk ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Glucocorticoid Receptor ◽

Odds Ratio ◽

Population Based ◽

Nucleotide Polymorphisms ◽

Cross Sectional ◽

Younger Men ◽

Education Status ◽

Interaction With Age

Objective An excess of glucocorticoids (Cushing’s syndrome) is associated with metabolic syndrome (MetS) features. Several single-nucleotide polymorphisms (SNPs) in the glucocorticoid receptor (GR) gene influence sensitivity to glucocorticoids and have been associated with aspects of MetS. However, results are inconsistent, perhaps due to the heterogeneity of the studied populations and limited samples. Furthermore, the possible association between functional GR SNPs and prevalence of MetS remains unexplored. Design Cross-sectional population-based cohort study. Methods MetS presence and carriage of functional GR SNPs (BclI, N363S, ER22/23EK, GR-9beta) were determined in 12 552 adult participants from Lifelines, a population-based cohort study in the Netherlands. GR SNPs were used to construct GR haplotypes. Results Five haplotypes accounted for 99.9% of all GR haplotypes found. No main effects of functional GR haplotypes on MetS were found, but the association of GR haplotype 4 (containing N363S) with MetS was influenced by interaction with age, sex and education status (P < 0.05). Stratified analysis revealed that haplotype 4 increased MetS presence in younger men (at or below the median age of 47; odds ratio 1.77, P = 0.005) and in people of low education status (odds ratio 1.48, P = 0.039). Conclusions A glucocorticoid receptor haplotype that confers increased sensitivity to glucocorticoids appears to increase the risk of metabolic syndrome, but only among younger men and less educated individuals, suggesting gene–environment interactions.

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Factors associated to the human papillomavirus in women with cervical cancer

Rev Rene ◽

10.15253/2175-6783.20202143681 ◽

2020 ◽

Vol 21 ◽

pp. e43681

Author(s):

Daiany Helena Stein Guedes ◽

Bruno Henrique Fiorin ◽

Marcos Vinicius Ferreira dos Santos ◽

Kátia Cirlene Gomes Viana ◽

Flávia Batista Portugal ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Odds Ratio ◽

Secondary Data ◽

Cross Sectional Study ◽

Cross Sectional ◽

Factors Associated ◽

Multiple Sex Partners ◽

Chi Squared ◽

Level Of Significance

Objective: to analyze the factors associated with the human papillomavirus as related to cervical cancer. Methods: cross-sectional study carried out using secondary data from 75 medical records. The chi-squared and Fisher’s exact tests were used, considering papillomavirus infections as an outcome. Odds ratio were used to measure the effect, and the level of significance adopted was 5%. Results: the characteristics associated to the infection by the papillomavirus were: being 24 years old or younger (odds ratio=19.11; p=0.001), having finished high school or higher education (odds ratio=4.06; p=0.031), having multiple sex partners (odds ratio=5.50; p=0.028), and having not gone through menopause (p=0.009). Conclusion: sexual behavior and socioeconomic issues are related to cervical cancer as associated with the papillomavirus infection.

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Individual risk factors of metabolic syndrome in adult patients with GH deficiency: a cross-sectional case-control study

Endocrine Abstracts ◽

10.1530/endoabs.35.p939 ◽

2014 ◽

Author(s):

Ivayla Uzunova ◽

Georgi Kirilov ◽

Sabina Zacharieva ◽

Alexander Shinkov ◽

Anna-Maria Borissova ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Case Control Study ◽

Gh Deficiency ◽

Case Control ◽

Adult Patients ◽

Individual Risk ◽

Cross Sectional ◽

Individual Risk Factors ◽

Control Study

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Hubungan Pengetahuan, Usia Dan Paritas Dengan Kejadian Komplikasi Kehamilan Pada Ibu Hamil Trimester Iii Di Rumah Sakit Ibu Dan Anak Aisyiyah Samarinda

KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat ◽

10.24903/kujkm.v5i2.835 ◽

2020 ◽

Vol 5 (2) ◽

pp. 83

Author(s):

Siti Komariah ◽

Hary Nugroho

Keyword(s):

Odds Ratio ◽

P Value ◽

Cross Sectional ◽

Purposive Sampling

Latar Belakang:Komplikasi kehamilan adalah kegawat daruratan obstetrik yang dapat menyebabkan kematian pada ibu dan bayi. Penyebab komplikasi kehamilan diantaranya kurangnya pengetahuan ibu tentang deteksi dini kehamilannya, usia pasien < 20 tahun dan > 35 tahun serta anak lebih dari 3.Tujuan :Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, usia dan paritas dengan kejadian komplikasi kehamilan pada ibu hamil trimester III.Metode Penelitian:Jenis penelitian observasional analitik dengan pendekatan cross sectional. Teknik pengambilan sampel menggunakan purposive sampling, sehingga sampel adalah ibu hamil trimester III yang berkunjung di Rumah Sakit Ibu dan Anak Aisyiyah Samarinda berjumlah 84 orang. Analisis yang digunakan uji chi square.Hasil : Hasil penelitian menunjukkan terdapat responden yang memiliki pengetahuan kurang baik, terdapat usia berisiko antara < 20 tahun dan > 35 tahun, terdapat paritas berisiko > 3 orang anak dan komplikasi kehamilan berupa hipertensi, anemia, preeklempsia dan plasenta previa. Ada hubungan pengetahuan dengan kejadian komplikasi kehamilan (p value : 0,001 < α : 0,05 dan odds ratio : 6,800 > 1). Ada hubungan usia dengan kejadian komplikasi kehamilan (p value : 0,003 < α : 0,05 dan odds ratio : 5,837 > 1). Ada hubungan paritas dengan kejadian komplikasi kehamilan (p value : 0,002 < α : 0,05 dan odds ratio : 6,250 > 1).Kesimpulan: Terdapat pengetahuan kurang baik berjumlah 27 responden (32,1%), usia berisiko (< 20 tahun dan ≥ 35 tahun) berjumlah 25 responden (29,8%), paritas berisiko (1 atau ≥ 3 orang anak) berjumlah 21 responden (25%) dan ada komplikasi kehamilan berjumlah 18 responden (21,4%), Ada hubungan pengetahuan, usia dan paritas dengan kejadian komplikasi kehamilan pada ibu hamil trimester III di Rumah Sakit Ibu dan Anak Aisyiyah Samarinda.

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