scholarly journals DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Florianne O. L. Vehmeijer ◽  
Leanne K. Küpers ◽  
Gemma C. Sharp ◽  
Lucas A. Salas ◽  
Samantha Lent ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Dna Methylation ◽  
Body Mass ◽  
Association Studies ◽  
Standard Deviation Score ◽  
Correlation Coefficients ◽  
Childhood And Adolescence ◽  
Cross Sectional ◽  
Meta Analyses ◽  
Age Range

Abstract Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10−7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10−4; adolescence Penrichment = 2.10 × 10−7). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity.

scholarly journals The Relationship between Body Mass Index, Obesity, and LINE-1 Methylation: A Cross-Sectional Study on Women from Southern Italy

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Andrea Maugeri ◽  
Martina Barchitta ◽  
Roberta Magnano San Lio ◽  
Giuliana Favara ◽  
Claudia La Mastra ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Dna Methylation ◽  
Body Mass ◽  
Methylation Level ◽  
Molecular Mechanisms ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

Uncovering the relationship between body mass index (BMI) and DNA methylation could be useful to understand molecular mechanisms underpinning the effects of obesity. Here, we presented a cross-sectional study, aiming to evaluate the association of BMI and obesity with long interspersed nuclear elements (LINE-1) methylation, among 488 women from Catania, Italy. LINE-1 methylation was assessed in leukocyte DNA by pyrosequencing. We found a negative association between BMI and LINE-1 methylation level in both the unadjusted and adjusted linear regression models. Accordingly, obese women exhibited lower LINE-1 methylation level than their normal weight counterpart. This association was confirmed after adjusting for the effect of age, educational level, employment status, marital status, parity, menopause, and smoking status. Our findings were in line with previous evidence and encouraged further research to investigate the potential role of DNA methylation markers in the management of obesity.

scholarly journals Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study

Thorax ◽  
2018 ◽  
Vol 73 (6) ◽  
pp. 538-545 ◽  
Author(s):  
Sandra Ekström ◽  
Jenny Hallberg ◽  
Inger Kull ◽  
Jennifer L P Protudjer ◽  
Per Thunqvist ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lung Function ◽  
Airway Obstruction ◽  
Body Mass ◽  
Overweight And Obesity ◽  
School Age Children ◽  
Childhood And Adolescence ◽  
Small Airways ◽  
Cross Sectional ◽  
The Impact

BackgroundFew large prospective studies have investigated the impact of body mass index (BMI) on lung function during childhood.MethodsUsing data collected between 2002 and 2013, we analysed associations between BMI status and lung function (assessed by spirometry) from 8 to 16 years, as well as cross-sectional associations with small airway function (impulse oscillometry) at 16 years in the BAMSE cohort (n=2889). At 16 years, cross-sectional associations with local and systemic inflammation were investigated by analysing FENO, blood eosinophils and neutrophils.ResultsOverweight and obesity at 8 years were associated with higher FVC, but lower FEV1/FVC ratio at 8 and 16 years. In boys, but not girls, obesity at 8 years was associated with a further reduction in FEV1/FVC between 8 and 16 years. In cross-sectional analyses, overweight and obesity were associated with higher frequency dependence of resistance (R5–20) and larger area under the reactance curve (AX0.5) at 16 years. Increased blood neutrophil counts were seen in overweight and obese girls, but not in boys. No association was found between BMI status and FENO. Persistent, but not transient, overweight/obesity between 8 and 16 years was associated with higher R5–20 and AX0.5 and lower FEV1/FVC (−2.8% (95% CI −4.1 to −1.2) in girls and −2.7% (95% CI −4.4 to −1.1) in boys) at 16 years, compared with persistent normal weight.ConclusionIn childhood and adolescence, overweight and obesity, particularly persistent overweight, were associated with evidence of airway obstruction, including the small airways.

scholarly journals Maternal Body Mass Index and Breastfeeding Non-Initiation and Cessation: A Quantitative Review of the Literature

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2684
Author(s):  
Kyoko Nomura ◽  
Sachiko Minamizono ◽  
Kengo Nagashima ◽  
Mariko Ono ◽  
Naomi Kitano
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Normal Weight ◽  
Maternal Body Mass Index ◽  
Review Of The Literature ◽  
Maternal Body ◽  
Cross Sectional ◽  
Quantitative Review ◽  
Increased Risk ◽  
Meta Analyses

This study aims to investigate which maternal body mass index (BMI) categories are associated with the non-initiation or cessation of breastfeeding (BF) based on a quantitative review of the literature. We searched Ovid MEDLINE and EBSCO CINAHL for peer-reviewed articles published between 1946 (MEDLINE) or 1981 (CINAHL), and 2019. Selected studies were either cross-sectional or cohort studies, of healthy mothers and infants, that reported nutrition method (exclusive/full or any) and period (initiation/duration/cessation) of breastfeeding according to maternal BMI levels. Pairwise meta-analyses of 57 studies demonstrated that the pooled odds risks (OR) of not initiating BF among overweight and obese mothers compared to normal weight mothers were significant across 29 (OR 1.33, 95% confidence interval (CI), 1.15–1.54, I2 = 98%) and 26 studies (OR 1.61, 95% CI, 1.33–1.95, I2 = 99%), respectively; the pooled risks for BF cessation were inconsistent in overweight and obese mothers with substantial heterogeneity. However, we found that overweight mothers (n = 10, hazard ratio (HR) 1.16, 95% CI, 1.07–1.25; I2 = 23%) and obese mothers (n = 7, HR 1.45, 95% CI: 1.27–1.65; I2 = 44%) were both associated with an increased risk of not continuing any BF and exclusive BF, respectively. Overweight and obese mothers may be at increased risk of not initiating or the cessation of breastfeeding.

scholarly journals Blood pressure levels and body mass index in Brazilian adults with Down syndrome

2016 ◽  
Vol 134 (4) ◽  
pp. 330-334 ◽  
Author(s):  
Felipe Pucci ◽  
Guilherme Machado ◽  
Edcarlo Solera ◽  
Fernanda Cenovicz ◽  
Christian Arruda ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Down Syndrome ◽  
Body Mass ◽  
Normal Weight ◽  
Class Iii ◽  
Special Schools ◽  
Cross Sectional ◽  
Obesity Class ◽  
Age Range

ABSTRACT CONTEXT AND OBJECTIVE: Increased life expectancy among people with Down syndrome (DS) has introduced new environmental factors that may affect blood pressure (BP) and/or lead to obesity in this population. The aim here was to investigate BP levels and body mass index (BMI) in adults with DS, correlating these data with the patients' sex and age. DESIGN AND SETTING: Analytical cross-sectional observational study conducted in special schools in Curitiba (PR), Brazil. METHODS: 97 adult patients were included. BP was measured in accordance with the established guidelines. BMI was calculated by dividing the weight by the height squared (kg/m2). RESULTS: Sex had no influence on BMI; nor did systolic BP (SBP) or diastolic BP (DBP). The age range was from 18 to 56 years. No correlation was observed between increasing age and greater BMI or BP. Eighty-six individuals (88.7%) presented normal BP, eleven (11.3%) prehypertension and none hypertension. Twenty patients (20.4%) presented BP lower than 90 × 60 mmHg. BMI ranged from 18 to 48 kg/m2 (mean of 28.8 ± 3.92 kg/m2): 21.9% had normal weight; 40.7% were overweight; and 25.3% had obesity class I, 9.9% class II and 2.2% class III. Higher BMI was associated with significantly greater SBP and DBP (P = 0.0175 and P = 0.0015). CONCLUSION: Sex and age did not influence SBP, DBP or BMI in Brazilian adults with DS. Higher BMI was associated with greater BP (both systolic and diastolic).

scholarly journals Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

2020 ◽  
Author(s):  
Gemma C Sharp ◽  
Rossella Alfano ◽  
Akram Ghantous ◽  
Jose Urquiza ◽  
Sheryl L Rifas-Shiman ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Dna Methylation ◽  
Health Outcomes ◽  
Candidate Gene ◽  
Body Mass ◽  
Association Studies ◽  
Meta Analysis ◽  
450K Array ◽  
Total N ◽  
Candidate Gene Studies

AbstractBackgroundAccumulating evidence links paternal adiposity in the peri-conceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans.Methods and findingsIn the Pregnancy And Childhood Epigenetics (PACE) consortium, we conducted a meta-analysis of co-ordinated epigenome-wide association studies (EWAS) of paternal prenatal Body Mass Index (BMI) (with and without adjustment for maternal BMI) in relation to DNA methylation in offspring blood at birth (13 datasets; total n= 4,894) and in childhood (six datasets; total n = 1,982). We found little evidence of association at either time point: for all CpGs, the False Discovery Rate-adjusted P-values were >0.05. In sex-stratified analyses, we found just four CpGs where there was robust evidence of association in female offspring. To compare our findings to those of other studies, we conducted a systematic review, which identified seven studies, including five candidate gene studies showing associations between paternal BMI/obesity and offspring or sperm DNA methylation at imprinted regions. However, in our own study, we found very little evidence of enrichment for imprinted genes.ConclusionOur findings do not support the hypothesis that paternal BMI around the time of pregnancy is associated with offspring blood DNA methylation, even at imprinted regions.Author SummaryPrevious small, mostly candidate gene studies have shown associations between paternal pre-pregnancy BMI and offspring blood DNA methylation. However, in our large meta-analysis of co-ordinated EWAS results from a total of 19 datasets across two timepoints, we found little evidence to support these findings, even at imprinted regions. This does not rule out the possibility of a paternal epigenetic effect in different tissues, at regions not covered by the 450k array, via different mechanisms, or in populations with greater extremes of paternal BMI. More research is warranted to help understand the size and nature of contributions of paternal adiposity to offspring epigenetics and health outcomes.

scholarly journals Prevalencia de las limitaciones funcionales durante el envejecimiento en la población española y su relación con el índice de masa corporal (Prevalence of functional limitations during aging in a representative sample of Spanish population and its relati

Retos ◽  
2018 ◽  
pp. 200-204
Author(s):  
Raquel Leirós-Rodríguez ◽  
Vicente Romo-Pérez ◽  
Anxela Soto-Rodríguez ◽  
José L García-Soidán
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Functional Limitations ◽  
Functional Limitation ◽  
Great Difficulty ◽  
Cross Sectional Study ◽  
Study Data ◽  
Cross Sectional ◽  
Las Mujeres ◽  
Age Range

Objetivo: describir la prevalencia de las limitaciones funcionales y examinar las asociaciones entre IMC, edad, sexo y limitaciones funcionales. Material y Método: en este estudio transversal se emplearon los datos de 5.970 personas mayores de 65 años (rango de edad: 65-94 años) procedentes de la Encuesta Europea de Salud 2014 (EES14) realizados por el Instituto Nacional de Estadística y el Ministerio de Sanidad, Servicios Sociales e Igualdad del Gobierno español. Resultados: los datos mostraron que los hombres tenían una mejor percepción de sus limitaciones funcionales que las mujeres. En todas las variables analizadas, los hombres (sin importar la edad) reportaron menos limitaciones que las mujeres. El índice de masa corporal no obtuvo correlación significativa con el grado de limitación funcional en ninguna de las actividades evaluadas. Conclusiones: las mujeres de 75 años o más y los hombres a partir de los 85 años mostraron una gran dificultad para caminar, subir escaleras, agacharse y transportar cargas de peso medio. De hecho, la edad obtuvo correlaciones significativas con el grado de limitación funcional, al contrario que el índice de masa corporal.Abstract. Objective: to describe the prevalence of functional limitations and examine its association with BMI, age, and sex. Method: in this cross-sectional study, data from 5,970 people aged 65 and over (age range 65-94 years) was retrieved from the European Health Survey 2014 (EES14) conducted by the National Statistics Institute and the Ministry of Health, Services Social and Equality of the Spanish Government. Results: the data showed that men had a better perception of their functional limitations than women. In all variables analyzed, men (regardless of age) reported fewer limitations than women. Body mass index did not correlate significantly with the degree of functional limitation in any of the evaluated activities. Conclusions: women aged 75 years and over and men over 85 years of age showed great difficulty walking, climbing stairs, bending over, and carrying medium weight loads. In fact, age correlated significantly with the degree of functional limitation, unlike body mass index.

scholarly journals Distribution of Tri-Ponderal Mass Index and its Relation to Body Mass Index in Children and Adolescents Aged 10 to 20 Years

2020 ◽  
Vol 105 (3) ◽  
pp. e826-e834
Author(s):  
Hong Kyu Park ◽  
Young Suk Shim
Keyword(s):  
Body Mass Index ◽  
Children And Adolescents ◽  
Body Mass ◽  
Standard Deviation Score ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
Reference Ranges ◽  
Least Mean Square ◽  
Cross Sectional ◽  
Korean Children

Abstract Context Body mass index percentiles are widely used to determine overweight and obesity status in children and adolescents. Their limitations in clinical settings can be addressed. Objective Reference ranges for the tri-ponderal mass index percentiles of Korean children and adolescents are presented for a comparison of their clinical variables with those of body mass index. Design Cross-sectional study. Setting Korea National Health and Nutrition Examination Survey, 2007–2016. Patients Korean children and adolescents aged 10 to 20 years. Main Outcome Measures The age- and sex-specific least mean square parameters (skewness, median, and coefficient of variation) for the tri-ponderal mass index of 9749 subjects aged 10 to 20 years. Results The factors associated with metabolic syndrome, except diastolic blood pressure, were more likely to be worse in the subjects with tri-ponderal mass index values indicative of overweight status than in those with normal tri-ponderal mass index values. Body mass index tends to underestimate obesity-related comorbidities more than tri-ponderal mass index does. Conclusion The tri-ponderal mass index standard deviation score may be advantageous when defining overweight and obesity in children and adolescents.

scholarly journals Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population

2018 ◽  
Vol 50 (3) ◽  
pp. 179-189 ◽  
Author(s):  
Yoshiki Yasukochi ◽  
Jun Sakuma ◽  
Ichiro Takeuchi ◽  
Kimihiko Kato ◽  
Mitsutoshi Oguri ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Genetic Variants ◽  
Japanese Population ◽  
Association Studies ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Susceptibility Loci ◽  
Cross Sectional ◽  
Japanese Subjects

Recent genome-wide association studies have identified various obesity or metabolic syndrome (MetS) susceptibility loci. However, most studies were conducted in a cross-sectional manner. To address this gap, we performed a longitudinal exome-wide association study to identify susceptibility loci for obesity and MetS in a Japanese population. We traced clinical data of 6,022 Japanese subjects who had annual health check-ups for several years (mean follow-up period, 5 yr) and genotyped ~244,000 genetic variants. The association of single nucleotide polymorphisms (SNPs) with body mass index (BMI) or the prevalence of obesity and MetS was examined in a generalized estimating equation model. Our longitudinal exome-wide association studies detected 21 BMI- and five MetS-associated SNPs (false discovery rate, FDR <0.01). Among these SNPs, 16 have not been previously implicated as determinants of BMI or MetS. Cross-sectional data for obesity- and MetS-related phenotypes in 7,285 Japanese subjects were examined in a replication study. Among the 16 SNPs, three ( rs9491140 , rs145848316 , and rs7863248 ) were related to BMI in the replication cohort ( P < 0.05). In conclusion, three SNPs [ rs9491140 of NKAIN2 (FDR = 0.003, P = 1.9 × 10−5), rs145848316 of KMT2C (FDR = 0.007, P = 4.5 × 10−5), and rs7863248 of AGTPBP1 (FDR = 0.006, P = 4.2 × 10−5)] were newly identified as susceptibility loci for BMI.

scholarly journals Parent-child resemblance in body mass index and obesity status and its correlates in China

2021 ◽  
pp. 1-34
Author(s):  
Lu Ma ◽  
Yixin Ding ◽  
Xiaozhong Wen ◽  
Liwang Gao ◽  
Li Zhao ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Weight Status ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Weighted Kappa ◽  
Cross Sectional Study ◽  
School Age Children ◽  
Cross Sectional ◽  
Parent Child

Abstract Objectives: Examine mother-son, mother-daughter, father-son, and father-daughter resemblance in weight status, and potential modifying effects of socio-demographic and childcare characteristics. Design: Cross-sectional study. Setting: School. Participants: 1,973 school-age children and their parents from five mega-cities across China in 2017. Results: Pearson correlation coefficients (r) for body mass index (BMI) of father-son, father-daughter, mother-son, and mother-daughter pairs were 0·16, 0·24, 0·26, and 0·24, respectively, while their weighted kappa coefficients (k) were 0·09, 0·14, 0·04, and 0·15, respectively. Children aged 6–9 years (r ranged from 0·30 to 0·35) had larger BMI correlation with their parents than their counterparts aged 10–14 years or 15–17 years (r ranged from 0·15 to 0·24). Children residing at home (r ranged from 0·17 to 0·27) had greater BMI correlations with their parents than children residing at school/other places. BMI correlation coefficients were significant if children were mainly cared for by their mothers (r ranged from 0·17 to 0·29) but non-significant if they were mainly cared for by others. Only children who ate the same meal as their parents “most times” (r ranged from 0·17 to 0·27) or had dinner with their parents “at most times” (r ranged from 0·21 to 0·27) had significant BMI correlation with their parents. Similarly, children who had dinner with their parents “most times” but not “sometimes,” had significant BMI correlation coefficients. Conclusions: Parent-child resemblance in weight status was modest, and varied by child age, gender, primary caregiver, whether having similar food or dinner with parents in China.

scholarly journals Serum Omentin Levels in Adolescent Girls With Anorexia Nervosa and Obesity

2015 ◽  
pp. 701-709 ◽  
Author(s):  
J. OŚWIĘCIMSKA ◽  
A. SUWAŁA ◽  
E. ŚWIĘTOCHOWSKA ◽  
Z. OSTROWSKA ◽  
P. GORCZYCA ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Weight ◽  
Anorexia Nervosa ◽  
Body Mass ◽  
Standard Deviation Score ◽  
Cross Sectional Study ◽  
Serum Concentrations ◽  
Cross Sectional ◽  
Wide Range

It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin sensitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a wide range of body mass index (BMI) and insulin resistance. In this cross-sectional study omentin-1 serum concentrations were evaluated using commercially available ELISA kit in 47 Polish girls with restrictive anorexia nervosa (AN), 50 with simple obesity (OB) and 39 healthy controls (C). The mean serum omentin-1 concentration in girls with AN was statistically significantly higher than that of C and OB girls. Statistically significant (P<0.0001) negative correlations between the serum concentrations of omentin-1 and body weight (r=−0.73), BMI (r=−0.75), standard deviation score for body mass index (BMI-SDS) (r=−0.75), insulin (r=−0.81) and HOMA-IR index (r=−0.82) were seen in the entire examined population. We conclude, that omentin-1 is the nutritional marker reflecting body weight and insulin resistance. Our findings support the hypothesized role of omentin in maintenance of body weight and regulation of appetite and suggest the adaptation of its secretion to body weight and glucose metabolism.

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