scholarly journals Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Malin Enarsson ◽  
Tobias Feldreich ◽  
Liisa Byberg ◽  
Christoph Nowak ◽  
Lars Lind ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Plasma Proteins ◽  
Cardiovascular Health ◽  
Smoking Status ◽  
Interleukin 1 ◽  
Heparin Binding ◽  
Cellular Mechanisms ◽  
Cross Sectional ◽  
Fatty Acid Binding ◽  
Beneficial Effects

Abstract Background and Aims A strong cardiorespiratory fitness is suggested to have beneficial effects on cardiovascular risk; the exact mechanisms underlying the cardioprotective effects of fitness remain uncertain. Our aim was to investigate associations between cardiorespiratory fitness and multiple plasma proteins, in order to obtain insights about physiological pathways associated with the effects of exercise on cardiovascular health. Methods In the Prospective investigation of Obesity, Energy and Metabolism (POEM) study (n=444 adults aged 50 years, 50% women), cardiorespiratory fitness was measured by a maximal exercise test on bicycle ergometer with gas exchange (VO2peak) normalized for body lean mass (dual-energy X-ray absorptiometry (DXA)). We measured 82 cardiovascular proteins associated with cardiovascular pathology and inflammation in plasma samples with a proximity extension assay. Results In sex-adjusted linear regression, VO2peak was associated with 18 proteins after Bonferroni correction for multiple testing (p<0.0006). Following additional adjustment for fat mass (DXA), fasting glucose (mmol/L), low-density lipoprotein (LDL, mmol/L), smoking status, waist/hip ratio, blood pressure (mmHg), education level, and lpnr (lab sequence number), higher VO2peak was significantly associated with lower levels of 6 proteins: fatty-acid binding protein-4 (FABP4), interleukin-6 (IL-6), leptin, cystatin-B (CSTB), interleukin-1 receptor antagonist (IL-1RA), and growth differentiation factor 15 (GDF-15), and higher levels of 3 proteins: galanin, kallikrein-6 (KLK6), and heparin-binding EGF-like growth factor (HB-EGF), at nominal p-values (p<0.05). Conclusions We identified multiple novel associations between cardiorespiratory fitness and plasma proteins involved in several atherosclerotic processes and key cellular mechanisms such as inflammation, energy homeostasis, and protease activity, which shed new light on how exercise asserts its beneficial effects on cardiovascular health. Our findings encourage additional studies in order to understand the underlying causal mechanisms for these associations.

Abstract 37: The Association of Cardiorespiratory Fitness and Ideal Cardiovascular Health in the Aerobics Center Longitudinal Study

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Leanna M Ross ◽  
Jacob L Barber ◽  
Xuemei Sui ◽  
Steven N Blair ◽  
Mark A Sarzynski
Keyword(s):  
Longitudinal Study ◽  
Cardiorespiratory Fitness ◽  
Cardiovascular Health ◽  
Smoking Status ◽  
Cross Sectional ◽  
Ideal Cardiovascular Health ◽  
Logistic Regression Models ◽  
Using Data ◽  
Middle Aged Adults ◽  
Aerobics Center Longitudinal Study

Purpose: To examine the cross-sectional association between cardiorespiratory fitness (CRF) and ideal cardiovascular health (CVH) in middle-aged adults. Methods: The association between CRF and ideal CVH score was examined in 11,590 adults (8,865 men, 2,725 women) from the Aerobics Center Longitudinal Study. CRF was measured as duration in minutes from a maximal treadmill test. The AHA’s ideal CVH score was calculated on a 14 point scale using data on smoking status, BMI, physical activity (MET-min/wk), healthy diet, total cholesterol, blood pressure, and fasting plasma glucose recorded between 1987 and 1999. Participants were grouped into categories of inadequate (0-4), average (5-9), and optimum (10-14) based on their CVH score. Three CRF groups were created from age- and sex-specific quintiles based on the previously established cutpoints of treadmill time: low, moderate, and high CRF. We used general linear and logistic regression models adjusted for age, sex, and year of examination to evaluate the association of CRF with ideal CVH score. Results: The mean CVH score for men was 8.4 ± 2.2 and 9.7 ± 2.0 for women. Approximately 33% of men and 57% of women had optimum CVH, while only a small proportion of participants had inadequate CVH (5.1% M, 1.4% F). Treadmill time was moderately correlated (p<0.0001) with CVH score in both men (r=0.56) and women (r=0.50). CRF explained 16% and sex 18% of the variance in CVH score (both p<0.0001). Our adjusted model found that participants in the optimum CVH category had 20% and 43% higher CRF levels than those in the average and inadequate CVH groups (p<0.0001), respectively ( Figure 1 ). The adjusted odds (95% CI) of having optimum CVH were 14.0 (11.0-17.8) and 3.1 (2.4-4.0) times greater for high CRF and moderate CRF, respectively, compared to low CRF (p<0.0001). Discussion: Higher levels of cardiorespiratory fitness are associated with better cardiovascular health profiles in both men and women. Thus, improving fitness represents a strategy to improve cardiovascular and public health.

scholarly journals Association of Tobacco Smoking with Physical Fitness of Military Males in Taiwan: The CHIEF Study

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Fang-Ying Su ◽  
Sheng-Huei Wang ◽  
Henry Horng-Shing Lu ◽  
Gen-Min Lin
Keyword(s):  
Physical Fitness ◽  
Cardiorespiratory Fitness ◽  
Tobacco Smoking ◽  
Smoking Status ◽  
Scoring Systems ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Effective Sample Size ◽  
Cross Sectional ◽  
Run Test

Tobacco smoking has been found associated with lower cardiorespiratory fitness in white and black males; however, few studies have not been conducted to clarify such relationship in Asian males. We performed a cross-sectional study to investigate the association between tobacco smoking status and physical fitness in 3,669 military males, averaged 29.4 years of age, from the cardiorespiratory fitness and hospitalization events in armed forces (CHIEF) study in Taiwan during 2014. There were 1,376 current smokers, and the others were noncurrent smokers. The effective sample size estimated was 1,230 participants, as the margin of error was ±3% at the 99% confidence level. Physical fitness was evaluated by time for a 3000-meter run test (aerobic fitness) and repetitive numbers of 2-minute sit-ups and 2-minute push-ups (anaerobic fitness) where all procedures were standardized by using computerized scoring systems. A multiple linear analysis adjusting for age, service specialty, body mass index, heart rate, alcohol intake, and training frequency was used to determine the relationship. As compared with noncurrent smoking, current smoking was inversely correlated with longer time for a 3000-meter run (β = 15.66 (95% confidence intervals (CI): 10.62, 20.70)) and fewer repetitive numbers of 2-minute sit-ups and 2-minute push-ups (β = −1.53 (95% CI: −2.08, −0.97) and −1.31 (95% CI: −2.12, −0.50), respectively). Our finding reconfirms the concept that tobacco smoking might reduce both aerobic and anaerobic fitness among young Asian males.

The Association of Cardiorespiratory Fitness and Ideal Cardiovascular Health in the Aerobics Center Longitudinal Study

2019 ◽  
Vol 16 (11) ◽  
pp. 968-975
Author(s):  
Leanna M. Ross ◽  
Jacob L. Barber ◽  
Alexander C. McLain ◽  
R. Glenn Weaver ◽  
Xuemei Sui ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Cardiorespiratory Fitness ◽  
Mixed Models ◽  
Cardiovascular Health ◽  
Cross Sectional ◽  
Ideal Cardiovascular Health ◽  
The Poor ◽  
Longitudinal Associations ◽  
Aerobics Center Longitudinal Study

Background: This study examined the cross-sectional and longitudinal associations of cardiorespiratory fitness (CRF) and ideal cardiovascular health (CVH). Methods: CRF and the 7 CVH components were measured in 11,590 (8865 males; 2725 females) adults at baseline and in 2532 (2160 males; 372 females) adults with at least one follow-up examination from the Aerobics Center Longitudinal Study. Ideal CVH score was calculated as a composite of 7 measures, each scored 0 to 2. CVH groups were based on participant point score: ≤7 (poor), 8 to 11 (intermediate), and 12 to 14 (ideal). Analyses included general linear, logistic regression, and linear mixed models. Results: At baseline, participants in the high CRF category had 21% and 45% higher mean CVH scores than those in the moderate and poor CRF categories (P < .001). The adjusted odds (95% confidence interval) of being in the poor CVH group at baseline were 4.9 (4.4–5.4) and 16.9 (14.3–19.9) times greater for individuals with moderate and low CRF, respectively, compared with those with high CRF (P < .001). Longitudinal analysis found that for every 1-minute increase in treadmill time, CVH score increased by 0.23 units (P < .001) independent of age, sex, exam number, and exam year. Conclusions: Higher CRF is associated with better CVH profiles, and improving CRF over time is independently associated with greater improvements in CVH.

Abstract P216: Prevalence of Life’s Simple Seven Cardiovascular Health Metrics in the Million Veteran Program

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Xuan-Mai T Nguyen ◽  
Rachel M Quaden ◽  
Rebecca J Song ◽  
Yuk-Lam Ho ◽  
Kelly Cho ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Total Cholesterol ◽  
Plasma Glucose ◽  
Cardiovascular Health ◽  
Smoking Status ◽  
Dietary Factors ◽  
Cross Sectional ◽  
Ideal Cardiovascular Health ◽  
Us Veterans

Background: While previous studies have reported the prevalence of Life’s Simple Seven (LSS) in the general population, no data exist in a national sample of US veterans. Objective: To assess the prevalence of ideal LSS in a cross-sectional study of 500,000 US Veterans participating in the Million Veteran Program (MVP) from 2011-2016. Methods: We assigned one of three possible values (0=poor, 1=intermediate, 2=ideal) for each of the seven LSS metrics (adiposity /BMI), smoking status, total cholesterol, blood pressure, plasma glucose, diet, physical activity) at baseline using self-reported data and electronic health records. A total score of 0 across all seven metrics indicated overall poor cardiovascular health and a score of 14 indicated ideal cardiovascular health. Results: Complete data on all LSS factors were available for 171,146 Veterans (92% men and mean age 65.5yrs ±11.5 SD). Average LSS score was 6.1 ±1.9. Ideal BMI, smoking status, total cholesterol, blood pressure and plasma glucose (fasting and non-fasting) was present in 23.8%, 30%, 22.2%, 22.5% and 42.9%, respectively, in the study population (Fig). Prevalence of ideal diet was 0.4%. Among dietary factors, recommendation for fruits and vegetables (at least 4.5cups/day) was the least likely to be achieved. Physical activity at the workplace, home or at leisure was reported among 25.6% of Veterans (21.8% intermediate and 3.8% ideal physical activity). Conclusions: Our data show a low prevalence of ideal LSS among Veterans in the MVP, especially diet (0.4%) and physical activity (3.8%). Compared to NHANES 2005-2006 unadjusted prevalence estimates for AHA 2020 goals, Veterans in MVP have a lower prevalence of all ideal LSS metrics except for diet: BMI (23.8 vs 33%), physical activity (3.8 vs 45%), smoking status (30 vs 73%), total cholesterol (22.2 vs 45%) blood pressure (22.5 vs 42%) and glucose (42.9 vs 58%). These findings underscore the need to improve adherence to modifiable lifestyle factors with subsequent reduction in CVD burden among Veterans.

Abstract P287: Cardiorespiratory Fitness is Associated With Ambulatory Blood Pressure in Adolescents

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Eunduck Park ◽  
Devin Volding ◽  
Wendell Taylor ◽  
Wenyaw Chan ◽  
Janet Meininger
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiorespiratory Fitness ◽  
Ambulatory Blood Pressure ◽  
Cardiovascular Health ◽  
Heart Rate Recovery ◽  
Step Test ◽  
Central Adiposity ◽  
Cross Sectional ◽  
Unit Increase

Introduction: Low cardiorespiratory fitness (fitness) and high levels of adiposity are independently associated with higher levels of blood pressure in adolescents. However, it remains uncertain whether the associations between fitness and blood pressure are due to fitness itself or results from lower levels of adiposity. Moreover, there are no studies that have determined the extent to which adiposity, including central adiposity, moderates the association between fitness and 24-hour ambulatory blood pressure (ABP). Hypotheses: 1. Higher levels of fitness will be associated with lower levels of ambulatory systolic (SBP) and diastolic (DBP) blood pressure after adjusting for adiposity and covariates. 2. With adjustments for covariates, adiposity (body mass index [BMI], waist circumference [WC]) will modify the association between fitness and 24-hour SBP and DBP. Methods: A cross-sectional study was conducted in Houston, TX with a sample of 370 adolescents aged 11-16 years. Demographically, the sample was 54% female, 37% African American, 31% Hispanic, 29% non-Hispanic white, and 3% other ethnic/racial groups. Fitness was assessed by a height-adjusted step test and estimated by heart rate recovery, defined as the difference between peak heart rate during exercise and heart rate two minutes post-exercise. Adiposity was measured using dichotomized values for percentiles of BMI (≥ 85 th ) and WC (≥ 50 th ). Ambulatory SBP and DBP (Spacelabs model 90207) were measured every 30-60 minutes over 24 hours on a school day. Mixed-effects regression analysis was used to test the hypotheses with the following covariates: activity, location, and position at the time of each ABP measurement, height, age, sex, ethnicity, sexual maturation level, and mother’s education level. Results: Hypothesis 1: Each unit increase in fitness was associated with a decrease of SBP (-0.058 mmHg, p = 0.001) and DBP (-0.043 mmHg, p < 0.0001) after adjustment for WC and covariates. Each unit increase in fitness was associated with a decrease in SBP (-0.058 mmHg, p = 0.001) and DBP (-0.045 mmHg, p < 0.0001) after adjustment for BMI and covariates. Hypothesis 2: Fitness and BMI ≥ 85 th percentile (or WC ≥ 50 th percentile) interactions were not significantly associated with ambulatory SBP or DBP after adjustment for covariates. Conclusions: Our findings indicate a small but statistically significant inverse effect of fitness on 24-hour ABP in adolescents, and no evidence of a modifying effect of adiposity on this association. Further research is needed to better understand the protective role of fitness on cardiovascular health in adolescents.

scholarly journals Population compliance with national dietary recommendations and its determinants: findings from the ORISCAV-LUX study

2012 ◽  
Vol 108 (11) ◽  
pp. 2083-2092 ◽  
Author(s):  
Ala'a Alkerwi ◽  
Nicolas Sauvageot ◽  
Anne Nau ◽  
Marie-Lise Lair ◽  
Anne-Françoise Donneau ◽  
...  
Keyword(s):  
Nutrition Education ◽  
Cardiovascular Health ◽  
Smoking Status ◽  
Dairy Product ◽  
Normal Weight ◽  
Dietary Guidelines ◽  
Dietary Recommendations ◽  
Cross Sectional ◽  
Dietary Compliance ◽  
Targeted Interventions

The objective of the present study was to determine the proportion of adults meeting national recommendations for food and nutrient intake and to identify the demographic, socio-economic and behavioural factors that may contribute to weaken dietary compliance. ORISCAV-LUX is a cross-sectional study that took place in Luxembourg (2007–8). A representative stratified random sample of 1352 adults aged 18–69 years participated in the nationwide cardiovascular health survey. A FFQ was used to estimate food intake. Radar charts were built to compare graphically the compliance of the participants with different key dietary guidelines on the same set of axes. The thirteen food- and nutrient-based recommendations were scored and summed to create a recommendation compliance index (range − 0·5 to 14). Ordinal logistic regression analyses were performed to determine the factors contributing to poor dietary compliance. Several food- and nutrient-based guidelines were insufficiently respected compared with others. The greatest gaps occurred in the adherence to grain and dairy product consumption guidelines, as well as to total fat and notably to SFA recommendations. Age, country of birth, economic status, smoking status and subject's awareness of the importance of balanced meals emerged as independently associated with weak dietary compliance. Obese subjects conformed more to dietary recommendations compared with normal-weight subjects. The findings underscore the need for specific nutrition education messages along with targeted interventions. Efforts should be continued to increase population awareness of the importance of a healthy lifestyle and a balanced diet.

Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2

2013 ◽  
Vol 45 (6) ◽  
pp. 237-242 ◽  
Author(s):  
Shumpei Fujie ◽  
Motoyuki Iemitsu ◽  
Haruka Murakami ◽  
Kiyoshi Sanada ◽  
Hiroshi Kawano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Cardiorespiratory Fitness ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Peak Oxygen Uptake ◽  
Cross Sectional ◽  
Fatty Acid Binding

Fatty acid binding protein 2 (FABP2) Ala54Thr polymorphism is a candidate gene associated with the risk of cardiovascular disease. Habitual exercise brings higher cardiorespiratory fitness and results in the improvement of cardiovascular disease risk. However, the effect of cardiorespiratory fitness level and FABP2 Ala54Thr polymorphism on the risk of cardiovascular diseases remains unclear. In the present study, a cross-sectional investigation of 837 Japanese men and women was performed to clarify the effects of cardiorespiratory fitness on the relationship between risk of cardiovascular disease and FABP2 Ala54Thr gene polymorphism. The study subjects were divided into high-cardiorespiratory fitness (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The FABP2 Ala54Thr polymorphism did not significantly affect carotid β-stiffness or blood pressure. In the Low-Fit group, carotid β-stiffness, systolic blood pressure, and diastolic blood pressure were higher for individuals with the Ala/Ala genotype compared with those with the Ala/Thr or Thr/Thr genotype, whereas no differences were observed in the High-Fit group. Additionally, serum triglyceride and plasma glucose levels were lower and serum high-density lipoprotein cholesterol levels were higher in the High-Fit group compared with the Low-Fit group; the FABP2 Ala54Thr polymorphism did not significantly affect these parameters. These results suggest that the higher cardiorespiratory fitness may attenuate the changes in central arterial stiffness and blood pressure that are associated with the FABP2 genotype.

Occupational physical activity and cardiovascular disease in the United States

2021 ◽  
pp. oemed-2020-106948
Author(s):  
Tyler D. Quinn ◽  
Patrick L. Yorio ◽  
Peter M. Smith ◽  
Yongsuk Seo ◽  
Geoffrey P. Whitfield ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Leisure Time Physical Activity ◽  
Smoking Status ◽  
The United States ◽  
Occupational Activity ◽  
Occupational Physical Activity ◽  
Cross Sectional ◽  
Never Smokers

BackgroundEmerging evidence, predominately from European and Asian countries, describes opposing effects of occupational physical activity (OPA) and leisure-time physical activity (LTPA) on cardiovascular health. This analysis examined cardiovascular disease (CVD) prevalence associated with OPA and LTPA.MethodsThis cross-sectional analysis of 2015 National Health Interview Survey data (n=16 974) employed logistic regression to estimate odds (OR) of self-reported CVD (coronary heart disease, heart attack, stroke or angina) with self-reported total occupational activity (TOA), occupational exertion (OE), occupational standing and walking (OSW) and LTPA. OPA was measured using two questions: ‘How often does your job involve…’ (1) ‘repeated lifting, pushing, pulling or bending?’ (OE) and (2) ‘standing or walking around?’ (OSW) with responses on a 5-item Likert scale (0=never, 4=always). TOA was categorised similarly after summing OE and OSW scores. LTPA was defined as 0, 1–149 or ≥150 min/week of moderate-to-vigorous activity. All models adjusted for common socioeconomic variables and additional analyses were stratified by sex, smoking status and LTPA.ResultsOdds for CVD were higher when ‘always’ performing TOA (OR 1.99 95% CI 1.12 to 3.53), OE (OR 2.15, 95% CI 1.45 to 3.19) or OSW (OR 1.84, 95% CI 1.07 to 3.17) compared with ‘never’. When restricting to never-smokers, odds for CVD were higher when ‘always’ performing TOA (OR 3.00, 95% CI 1.38 to 6.51) and OE (OR 3.00, 95% CI 1.80 to 5.02) versus ‘never’.ConclusionAssociations of high OPA with CVD were equally apparent across sexes, stronger in lower LTPA levels and stronger in never-smokers. While uncontrolled confounding is still possible, even after extensive adjustment, the seemingly paradoxical adverse associations with OPA and CVD should be investigated further.

Abstract P114: Association of Subjective Social Status With Cardiovascular Health in Hispanics/Latinos

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Lissette Piedra ◽  
Keyword(s):  
Physical Activity ◽  
Social Status ◽  
Cardiovascular Health ◽  
Smoking Status ◽  
Fasting Blood Glucose ◽  
Heart Association ◽  
Subjective Social Status ◽  
Cross Sectional ◽  
Ideal Cardiovascular Health ◽  
Latino Adults

Introduction: Evidence suggests that subjective social status (SSS)—perceived status in the social hierarchy—may be more strongly associated with health than objective markers of social status (OSS), income and education. Compared to persons with high SSS, those with low SSS report poorer self-rated physical health and have higher rates of medical comorbidities. Little is known about the relationship between SSS and ideal cardiovascular health (CVH) profiles defined by the American Heart Association (AHA), particularly among diverse Hispanic/Latino adults. Hypothesis: Higher SSS will be associated with more favorable CVH profiles. Methods: We analyzed baseline HCHS/SOL data † on adults ages 18-74 in 2008-11 (N=15,440). SSS was assessed using the McArthur Scale, a 10-rung “social ladder” to specify social rank (scores range from 1-10; higher scores indicate higher SSS). CVH was defined based on levels of 7 metrics: diet, body mass index (BMI), physical activity, cholesterol, blood pressure, fasting glucose, and smoking status; levels of each metric were categorized as ideal, intermediate and poor using AHA criteria. A composite CVH score was calculated by summing across metrics (scores range from 0-14; higher scores indicate better CVH). Linear and logistic regressions were used to examine cross-sectional associations of SSS with CVH (overall and single metrics), after adjusting for OSS, demographics, Hispanic/Latino group, study center, marital status, insurance, prevalent coronary heart disease, and depressive symptoms (CESD). Results: In multivariate-adjusted models, each one unit increase in SSS* was associated with a higher overall CVH score (β = 0.03, 95% CI 0.004, 0.057, p <0.05); higher SSS was also positively associated with ideal levels of BMI, physical activity, and fasting blood glucose levels (see Table 1). Conclusions: These findings suggest an association between SSS and CVH among diverse Hispanic/Latino adults. Future studies will explore the mechanisms through which SSS may influence CVH.

Screening for the metabolic syndrome in subjects with migraine

Cephalalgia ◽  
2016 ◽  
Vol 37 (12) ◽  
pp. 1180-1188 ◽  
Author(s):  
Sylvie Streel ◽  
Anne-Françoise Donneau ◽  
Nadia Dardenne ◽  
Axelle Hoge ◽  
Adelin Albert ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Large Scale ◽  
Cardiovascular Health ◽  
Smoking Status ◽  
Hdl Cholesterol ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Systematic Screening ◽  
The Metabolic Syndrome ◽  
Low Hdl

Background Metabolic syndrome (MetS) and migraine are known to be associated. This study assessed the risk of MetS and its clinical characteristics in migraine with aura (MA) and without aura (MO) based on a large-scale cross-sectional survey. Methods The study material consisted of 751 participants in the Nutrition, Environment and CardioVascular Health (NESCaV) survey. Diagnosis of migraine was based on the ef-ID migraine questionnaire and MetS was defined according to the Revised-Adult Treatment Panel III criteria. Sociodemographic and risk factors were also recorded. Weighted logistic regression was used to assess the risk of MetS. Results After adjusting for stratification (gender, age, district) and other factors (smoking status, sedentary lifestyle, family history of stroke, myocardial infarction and hypertension), MA subjects were at higher risk of MetS (OR 3.45; 95% CI: 1.63–7.29) while MO individuals were not, when compared to non-migraineurs. When considering MetS components, MA was positively associated with low HDL-cholesterol (OR 2.26; 95% CI: 1.08–4.74), hyperglycemia (OR 2.77; 95% CI: 1.30–5.88) and abdominal obesity (OR 2.03; 95% CI: 1.07–3.86). Conclusion Migraineurs with aura are at higher risk of MetS, suggesting that these subjects, already more exposed to stroke, may benefit from a systematic screening for the metabolic syndrome.

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